Detailed information for compound 1627510

Basic information

Technical information
  • TDR Targets ID: 1627510
  • Name: 4-(tert-butyl-methylcarbamoyl)cubane-1-carbox ylic acid
  • MW: 261.316 | Formula: C15H19NO3
  • H donors: 1 H acceptors: 3 LogP: 0.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(C)(C)C)C(=O)C12C3C4C2C2C1C3C42C(=O)O
  • InChi: 1S/C15H19NO3/c1-13(2,3)16(4)11(17)14-5-8-6(14)10-7(14)9(5)15(8,10)12(18)19/h5-10H,1-4H3,(H,18,19)
  • InChiKey: ISMZDXJDNNRLTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(tert-butyl-methyl-carbamoyl)cubane-1-carboxylic acid
  • 4-[(tert-butyl-methylamino)-oxomethyl]-1-cubanecarboxylic acid
  • 4-((tert-Butyl(methyl)amino)carbonyl)-1-cubanecarboxylic acid
  • AIDS-148234
  • AIDS148234
  • NSC679805
  • NCI60_028541

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0092 0.0092
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0076 0.0076
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0052 0.0076 0.0667
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0092 0.0016
Onchocerca volvulus 0.0056 0.0092 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0092 0.0092
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0052 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0092 0.0092
Echinococcus granulosus serotonin receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis geminin 0.0177 0.0522 0.0522
Brugia malayi Serotonin receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0076 0.0076
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0052 0.0076 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Onchocerca volvulus 0.0056 0.0092 0.5
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0092 0.0016
Leishmania major silent information regulator 2, putative 0.0349 0.1136 0.1069
Brugia malayi larval opioid receptor 0.0056 0.0092 0.0092
Mycobacterium ulcerans NAD-dependent deacetylase 0.0052 0.0076 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0092 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0092 0.0092
Echinococcus granulosus chromatin regulatory protein sir2 0.0349 0.1136 0.1136
Schistosoma mansoni biogenic amine receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0092 0.0092
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0052 0.0076 0.0076
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0092 0.0092
Echinococcus granulosus neuropeptide receptor 0.0056 0.0092 0.0092
Echinococcus granulosus allatostatin A receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0092 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0349 0.1136 0.1136
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0092 0.0092
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0092 0.0092
Brugia malayi G-protein coupled receptor 0.0056 0.0092 0.0092
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0052 0.0076 0.0076
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0177 0.0522 0.0522
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.2837 1 1
Schistosoma mansoni serine/threonine protein kinase 0.2837 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.2837 1 1
Onchocerca volvulus 0.0056 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus somatostatin receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0092 0.0092
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0092 0.0092
Trypanosoma brucei protein kinase, putative 0.2837 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Echinococcus granulosus geminin 0.0177 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus multilocularis sex peptide receptor 0.0056 0.0092 0.0092
Brugia malayi neuropeptide F receptor 0.0056 0.0092 0.0092
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0092 0.0016
Brugia malayi Dopamine receptor 0.0056 0.0092 0.0092
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.2837 1 1
Schistosoma mansoni amine GPCR 0.0056 0.0092 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0076 0.0076
Brugia malayi AKH receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0092 0.0092
Echinococcus multilocularis mitogen activated protein kinase 0.2837 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni neuropeptide receptor 0.0056 0.0092 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0092 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0092 0.0092
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0092 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0076 0.5
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0092 0.0092
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0092 0.0092
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0092 0.0092
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni adenoreceptor 0.0056 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi RE15519p 0.0056 0.0092 0.0092
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.2837 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0052 0.0076 0.0667
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.2837 1 1
Echinococcus granulosus hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis chromatin regulatory protein sir2 0.0349 0.1136 0.1136
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Mycobacterium ulcerans Sir2-like regulatory protein 0.0052 0.0076 0.5
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Brugia malayi Dopamine receptor protein 2 0.0056 0.0092 0.0092
Echinococcus granulosus g protein coupled receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Echinococcus multilocularis serotonin receptor 0.0056 0.0092 0.0092
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0092 0.0092
Echinococcus granulosus mitogen activated protein kinase 0.2837 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0092 0.0092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0349 0.1136 0.1136
Entamoeba histolytica hypothetical protein, conserved 0.0052 0.0076 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0349 0.1136 0.1069
Echinococcus granulosus g protein coupled receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) transcriptional regulator 0.0349 0.1136 0.1069
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0056 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Brugia malayi Dopamine receptor protein 1 0.0056 0.0092 0.0092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0052 0.0076 0.0076
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0092 0.0092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0349 0.1136 0.1069
Onchocerca volvulus 0.0056 0.0092 0.5
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0052 0.0076 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0092 0.0092
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0092 0.0092
Schistosoma mansoni biogenic amine receptor 0.0056 0.0092 0.0092
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.2837 1 1
Schistosoma mansoni opsin-like receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0092 0.0092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0349 0.1136 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0092 0.0092
Brugia malayi G-protein coupled receptor 0.0056 0.0092 0.0092
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0092 0.0092
Echinococcus granulosus fmrfamide receptor 0.0056 0.0092 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0092 0.0092
Echinococcus granulosus sex peptide receptor 0.0056 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0076 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0092 0.0092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0092 0.0092
Brugia malayi NAD-dependent deacetylase SIRT1 0.0052 0.0076 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2837 1 1
Brugia malayi Melatonin receptor type 1A 0.0056 0.0092 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.2837 1 1
Onchocerca volvulus 0.0056 0.0092 0.5
Echinococcus granulosus neuropeptide receptor 0.0056 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2837 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0349 0.1136 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0349 0.1136 0.1136
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0092 0.0092
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0056 0.0092 0.0092
Giardia lamblia Kinase, CMGC MAPK 0.2837 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi GnHR receptor homolog 0.0056 0.0092 0.0092
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0052 0.0076 0.0076
Schistosoma mansoni neuropeptide receptor 0.0056 0.0092 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.2837 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0052 0.0076 0.0076
Schistosoma mansoni neuropeptide receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0052 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus multilocularis serotonin receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0092 0.0092
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0092 0.0092
Schistosoma mansoni neuropeptide receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0092 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0092 0.0092
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0092 0.0092
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0349 0.1136 0.1069
Onchocerca volvulus 0.0056 0.0092 0.5
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0349 0.1136 0.1069
Onchocerca volvulus 0.0056 0.0092 0.5
Onchocerca volvulus 0.0056 0.0092 0.5
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0052 0.0076 0.5
Giardia lamblia Hypothetical protein 0.0349 0.1136 0.1069
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0092 0.0092
Onchocerca volvulus 0.0056 0.0092 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni histamine h1 receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0092 0.0092
Schistosoma mansoni biogenic amine receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.2837 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0092 0.0092
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0092 0.0092
Schistosoma mansoni opsin-like receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Plasmodium vivax NAD-dependent deacetylase, putative 0.0052 0.0076 0.5
Brugia malayi sulfakinin receptor protein 0.0056 0.0092 0.0092
Echinococcus multilocularis mitogen activated protein kinase 3 0.2837 1 1
Brugia malayi ORL1-like opioid receptor 0.0056 0.0092 0.0092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0052 0.0076 0.0076
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0092 0.0016
Schistosoma mansoni amine GPCR 0.0056 0.0092 0.0092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0349 0.1136 1
Onchocerca volvulus 0.0056 0.0092 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0092 0.0092
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0092 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus granulosus orexin receptor type 2 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0056 0.0092 0.0092
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0349 0.1136 0.1069
Schistosoma mansoni amine GPCR 0.0056 0.0092 0.0092
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0092 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0092 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0177 0.0522 0.0522
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0092 0.0092
Schistosoma mansoni myosin xvIII 0.0056 0.0092 0.0092
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0092 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.2837 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0349 0.1136 0.1136
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0092 0.0016
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi putative neuropeptide receptor 0.0056 0.0092 0.0092
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0092 0.0092
Echinococcus granulosus mitogen activated protein kinase 3 0.2837 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Brugia malayi Serotonin receptor 0.0056 0.0092 0.0092
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Schistosoma mansoni opsin-like receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0092 0.0092
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0349 0.1136 0.1136
Echinococcus multilocularis somatostatin receptor 0.0056 0.0092 0.0092
Brugia malayi neuropeptide F receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Onchocerca volvulus 0.0056 0.0092 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0092 0.0092
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0092 0.0092
Echinococcus granulosus g protein coupled receptor 0.0056 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0092 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.2837 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0092 0.0092
Brugia malayi hypothetical protein 0.0056 0.0092 0.0092
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0092 0.0092
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0092 0.0016

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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