Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | adenosylhomocysteinase | 0.0733 | 0.9698 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0733 | 0.9698 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0733 | 0.9698 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0265 | 0.0817 | 0.049 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0733 | 0.9698 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0733 | 0.9698 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0326 | 0.198 | 0.2041 |
Brugia malayi | Adenosylhomocysteinase | 0.0733 | 0.9698 | 0.9687 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0733 | 0.9698 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0453 | 0.4394 | 0.4531 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0733 | 0.9698 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0326 | 0.198 | 0.2041 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0733 | 0.9698 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0733 | 0.9698 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0301 | 0.1506 | 0.1553 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0453 | 0.4394 | 0.4531 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0733 | 0.9698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.198 | 0.1266 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0453 | 0.4394 | 0.4531 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0733 | 0.9698 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0733 | 0.9698 | 0.9671 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0733 | 0.9698 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0733 | 0.9698 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0733 | 0.9698 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0453 | 0.4394 | 0.4531 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0733 | 0.9698 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0733 | 0.9698 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0733 | 0.9698 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.