TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.365 | Formula: C20H15N5O2
H donors: 0 H acceptors: 3 LogP: 3.38 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1=NN(C(=O)C1/N=N/c1ccc2c(c1)cccc2)C(=O)c1ccncc1
InChi: 1S/C20H15N5O2/c1-13-18(20(27)25(24-13)19(26)15-8-10-21-11-9-15)23-22-17-7-6-14-4-2-3-5-16(14)12-17/h2-12,18H,1H3/b23-22+
InChiKey: CGZXHGCNAPWCCI-GHVJWSGMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Furin-like cysteine rich region family protein	0.0153	0.0969	0.0969
Brugia malayi	Hexokinase family protein	0.0391	0.2906	0.2906
Entamoeba histolytica	hexokinase 1	0.1262	1	0.5
Trypanosoma cruzi	hexokinase, putative	0.1262	1	1
Schistosoma mansoni	tyrosine kinase	0.0081	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0153	0.0972	0.5799
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0168	0.1091	0.6522
Giardia lamblia	Methyltransferase like 2	0.0048	0.0114	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0081	0.0387	0.0387
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0013	0.0013
Echinococcus granulosus	single minded 2	0.0054	0.0167	0.0167
Brugia malayi	hypoxia-induced factor 1	0.0182	0.1207	0.1207
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0665	0.0665
Echinococcus granulosus	hexokinase	0.1262	1	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0129	0.0777	0.4587
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0545	0.0545
Loa Loa (eye worm)	hexokinase type II	0.1262	1	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0074	0.0074
Echinococcus granulosus	epidermal growth factor receptor	0.0082	0.0394	0.0394
Schistosoma mansoni	aryl hydrocarbon receptor	0.0059	0.0205	0.0205
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0236	0.1646	1
Brugia malayi	RNA, U transporter 1	0.0099	0.0533	0.0533
Echinococcus multilocularis	hexokinase type 2	0.1262	1	1
Mycobacterium ulcerans	thioesterase	0.0131	0.0797	0.4682
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0013	0.0003
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0116	0.067	0.067
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0013	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0147	0.0927	0.0927
Plasmodium vivax	hexokinase, putative	0.1262	1	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0168	0.1091	0.6541
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0153	0.0969	0.0969
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0054	0.0168	0.0795
Brugia malayi	jmjC domain containing protein	0.0043	0.0074	0.0074
Onchocerca volvulus		0.1262	1	1
Trypanosoma cruzi	hexokinase, putative	0.1262	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0058	0.0201	0.0201
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0116	0.067	0.067
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.004	0.0049	0.0039
Schistosoma mansoni	voltage-gated potassium channel	0.0127	0.0756	0.0756
Schistosoma mansoni	methyltransferase-related	0.0048	0.0114	0.0114
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0122	0.0122
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0197	0.1331	0.1331
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0013	0.0003
Schistosoma mansoni	hypothetical protein	0.0035	0.0013	0.0013
Loa Loa (eye worm)	beta-ketoacyl synthase domain-containing protein	0.004	0.0049	0.0049
Echinococcus granulosus	insulin receptor	0.0049	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0372	0.2752	0.2752
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0665	0.0665
Brugia malayi	PHD-finger family protein	0.0035	0.0013	0.0013
Echinococcus granulosus	hexokinase type 2	0.1262	1	1
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.001	0.001
Leishmania major	hexokinase, putative	0.1262	1	1
Brugia malayi	Hexokinase family protein	0.1262	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0108	0.0608	1
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0168	0.1091	0.6337
Mycobacterium ulcerans	thioesterase TesA	0.0131	0.0797	0.4682
Loa Loa (eye worm)	hexokinase	0.0792	0.6172	0.6172
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0049	0.0124	0.0124
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.004	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0082	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2051	0.2051
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0168	0.1091	0.6541
Schistosoma mansoni	hexokinase	0.1262	1	1
Treponema pallidum	hexokinase (hxk)	0.1262	1	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0053	0.0053
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0158	0.1011	0.6023
Brugia malayi	Bromodomain containing protein	0.0035	0.0013	0.0013
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0064	0.0246	0.128
Schistosoma mansoni	tyrosine kinase	0.0049	0.0124	0.0124
Brugia malayi	Cytochrome P450 family protein	0.004	0.0053	0.0053
Echinococcus granulosus	hexokinase	0.1262	1	1
Leishmania major	hypothetical protein, conserved	0.0048	0.0114	0.0065
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0158	0.1011	0.6023
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0182	0.1207	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0013	0.0013
Brugia malayi	jmjC domain containing protein	0.0115	0.0665	0.0665
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0158	0.1011	0.6044
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0158	0.1011	0.1011
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0104	0.0576	0.2941
Toxoplasma gondii	3-oxoacyl-acyl-carrier protein synthase I/II, putative	0.004	0.0049	0.0039
Loa Loa (eye worm)	TK/INSR protein kinase	0.0049	0.0124	0.0124
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0158	0.1011	0.581
Mycobacterium ulcerans	putative regulatory protein	0.0043	0.0081	0.0197
Brugia malayi	PAS domain containing protein	0.0059	0.0205	0.0205
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0168	0.1091	0.6337
Loa Loa (eye worm)	hypothetical protein	0.0401	0.2993	0.2993
Trypanosoma brucei	beta-ketoacyl-ACP synthase	0.004	0.0049	0.0039
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0049	0.0122	0.0505
Brugia malayi	Hexokinase family protein	0.0792	0.6172	0.6172
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0131	0.0797	0.4398
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0013	0.0003
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0074	0.0074
Toxoplasma gondii	hexokinase	0.1262	1	1
Echinococcus multilocularis	peregrin	0.0035	0.0013	0.0013
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0074	0.0074
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0104	0.0576	0.3299
Schistosoma mansoni	tyrosine kinase	0.0153	0.0969	0.0969
Mycobacterium leprae	Polyketide synthase Pks13	0.0236	0.1646	1
Loa Loa (eye worm)	hexokinase	0.1262	1	1
Mycobacterium ulcerans	polyketide synthase Pks9	0.0104	0.0576	0.3299
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2051	0.2051
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0472	0.0472
Echinococcus multilocularis	snurportin 1	0.0372	0.2752	0.2752
Toxoplasma gondii	type I fatty acid synthase, putative	0.0112	0.0641	0.0631
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0147	0.0927	0.5519
Onchocerca volvulus		0.0058	0.0201	0.0188
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0113	0.0649	0.3791
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0318	0.0318
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0299	0.2161	0.2161
Loa Loa (eye worm)	hexokinase	0.0391	0.2906	0.2906
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.009	0.0457	0.2593
Echinococcus multilocularis		0.0047	0.0111	0.0111
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.004	0.0049	0.5
Schistosoma mansoni	importin beta-1	0.0035	0.001	0.001
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0131	0.0797	0.4711
Echinococcus multilocularis	hexokinase	0.1262	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0201	0.0201
Echinococcus granulosus	epidermal growth factor receptor	0.0153	0.0969	0.0969
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0124	0.0124
Onchocerca volvulus		0.1262	1	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0158	0.1011	0.6023
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0446	0.0446
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0861	0.6734	0.6734
Schistosoma mansoni	tyrosine kinase	0.0081	0.0387	0.0387
Onchocerca volvulus		0.0147	0.0927	0.0915
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2752	0.2752
Echinococcus multilocularis	hexokinase	0.1262	1	1
Loa Loa (eye worm)	hypothetical protein	0.0265	0.1884	0.1884
Plasmodium falciparum	hexokinase	0.1262	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0116	0.067	0.067
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0168	0.1091	0.6337
Trypanosoma brucei	hexokinase, putative	0.1262	1	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0127	0.076	0.4452
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0158	0.1011	0.6044
Mycobacterium ulcerans	polyketide synthase Pks13	0.0236	0.1646	1
Echinococcus multilocularis	transfer RNA-Lys	0.0043	0.0081	0.0081
Brugia malayi	bHLH-PAS transcription factor	0.0043	0.0081	0.0081
Schistosoma mansoni	single-minded	0.0059	0.0205	0.0205
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0153	0.0972	0.5799
Echinococcus granulosus	importin subunit beta 1	0.0035	0.001	0.001
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.005	0.013	0.0558
Mycobacterium tuberculosis	Hypothetical protein	0.0048	0.0114	0.0455
Onchocerca volvulus		0.0792	0.6172	0.6167
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0102	0.056	0.055
Entamoeba histolytica	hexokinase 2	0.1262	1	0.5
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0126	0.0126
Echinococcus granulosus	hexokinase	0.1262	1	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0013	0.0013
Brugia malayi	hexokinase type II	0.0401	0.2993	0.2993
Mycobacterium tuberculosis	Conserved protein	0.0048	0.0114	0.0455
Schistosoma mansoni	voltage-gated potassium channel	0.0127	0.0756	0.0756
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.008	0.0376	0.0366
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0168	0.1091	0.6541
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1331	0.1331
Mycobacterium ulcerans	polyketide synthase MbtD	0.0049	0.0122	0.0454
Onchocerca volvulus	Fatty acid synthase homolog	0.0284	0.2042	0.2031
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2051	0.2051
Brugia malayi	Methyltransferase-like protein 4	0.0048	0.0114	0.0114
Mycobacterium ulcerans	polyketide synthase	0.0168	0.1091	0.6522
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0013	0.0003
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0126	0.0126
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0158	0.1011	0.6044
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0158	0.1011	0.6023
Echinococcus multilocularis	hexokinase	0.1262	1	1
Echinococcus multilocularis	insulin receptor	0.0049	0.0124	0.0124
Echinococcus granulosus	peregrin	0.0035	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0049	0.0124	0.0124
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.004	0.0049	0.0049
Onchocerca volvulus		0.1262	1	1
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.004	0.0049	0.5
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.004	0.0049	0.0049
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0158	0.1011	0.581
Loa Loa (eye worm)	hypothetical protein	0.0401	0.2993	0.2993
Echinococcus multilocularis	epidermal growth factor receptor	0.0082	0.0394	0.0394
Leishmania major	hexokinase, putative	0.1262	1	1
Onchocerca volvulus	Hexokinase homolog	0.0792	0.6172	0.6167
Onchocerca volvulus		0.0043	0.0081	0.0067
Mycobacterium ulcerans	polyketide synthase	0.0158	0.1011	0.6023
Mycobacterium ulcerans	fatty acid synthase Fas	0.005	0.013	0.0508
Onchocerca volvulus		0.0275	0.1962	0.1951
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0108	0.0608	1
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0201	0.0201
Brugia malayi	Importin beta-1 subunit	0.0035	0.001	0.001
Loa Loa (eye worm)	hexokinase	0.1262	1	1
Loa Loa (eye worm)	acyl carrier protein	0.0073	0.0317	0.0317
Brugia malayi	hypothetical protein	0.0286	0.2051	0.2051
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0082	0.0394	0.0394
Echinococcus multilocularis	epidermal growth factor receptor	0.0153	0.0969	0.0969
Echinococcus granulosus	snurportin 1	0.0372	0.2752	0.2752
Loa Loa (eye worm)	fatty acid synthase	0.0156	0.0994	0.0994
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0049	0.0124	0.0124
Toxoplasma gondii	type I fatty acid synthase, putative	0.0168	0.1091	0.1082
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0116	0.067	0.067
Trypanosoma brucei	hexokinase	0.1262	1	1
Schistosoma mansoni	tyrosine kinase	0.0082	0.0394	0.0394
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0147	0.0927	0.0927
Trypanosoma brucei	hexokinase	0.1262	1	1
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative	0.004	0.0049	0.0039
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0127	0.076	0.4452
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0168	0.1091	0.6522
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0127	0.076	0.4155
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0236	0.1646	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.004	0.0049	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.767	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.532	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.716	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.192	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.139	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.134	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.014	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1979627

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1627784