Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0589 | 0.4016 | 0.5305 |
Giardia lamblia | Methyltransferase like 2 | 0.019 | 0.0074 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0255 | 0.0716 | 0.0864 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0417 | 0.2316 | 0.2981 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.067 | 0.4811 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0631 | 0.4425 | 0.5834 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0526 | 0.3387 | 0.4459 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0198 | 0.0154 | 0.0108 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.067 | 0.4811 | 0.6337 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0943 | 0.7504 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0943 | 0.7504 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.067 | 0.4811 | 0.6357 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0943 | 0.7504 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0631 | 0.4425 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0612 | 0.4234 | 0.5599 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.067 | 0.4811 | 0.6376 |
Trichomonas vaginalis | conserved hypothetical protein | 0.019 | 0.0074 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0631 | 0.4425 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0631 | 0.4425 | 0.5834 |
Echinococcus multilocularis | geminin | 0.0183 | 0 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0526 | 0.3387 | 0.443 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0526 | 0.3387 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0417 | 0.2316 | 0.2981 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0631 | 0.4425 | 0.5834 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1137 | 0.9422 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.067 | 0.4811 | 0.6376 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0631 | 0.4425 | 0.4383 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.067 | 0.4811 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.067 | 0.4811 | 0.6376 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0453 | 0.2671 | 0.3495 |
Leishmania major | hypothetical protein, conserved | 0.019 | 0.0074 | 0.5 |
Onchocerca volvulus | 0.0589 | 0.4016 | 0.325 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0508 | 0.3208 | 0.4155 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0631 | 0.4425 | 0.5856 |
Loa Loa (eye worm) | hypothetical protein | 0.106 | 0.8658 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.067 | 0.4811 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0508 | 0.3208 | 0.4188 |
Brugia malayi | hypothetical protein | 0.0326 | 0.1412 | 0.1348 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0943 | 0.7504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.1412 | 0.0461 |
Schistosoma mansoni | methyltransferase-related | 0.019 | 0.0074 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0449 | 0.263 | 0.3708 |
Onchocerca volvulus | 0.1098 | 0.9036 | 0.9517 | |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0217 | 0.0339 | 0.0356 |
Mycobacterium ulcerans | thioesterase | 0.0526 | 0.3387 | 0.443 |
Mycobacterium ulcerans | polyketide synthase | 0.067 | 0.4811 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0589 | 0.4016 | 0.3889 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0612 | 0.4234 | 0.5599 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0359 | 0.1738 | 0.224 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0508 | 0.3208 | 0.4188 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0409 | 0.2237 | 0.2574 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0631 | 0.4425 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0631 | 0.4425 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0417 | 0.2316 | 0.2941 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1687 | 0.0823 |
Brugia malayi | AMP-binding enzyme family protein | 0.0589 | 0.4016 | 0.3971 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0198 | 0.0154 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0631 | 0.4425 | 0.5834 |
Loa Loa (eye worm) | fatty acid synthase | 0.0623 | 0.4342 | 0.4318 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0194 | 0.0112 | 0.0052 |
Brugia malayi | AMP-binding enzyme family protein | 0.0194 | 0.0112 | 0.0039 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0516 | 0.329 | 0.4329 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0631 | 0.4425 | 0.5856 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.067 | 0.4811 | 0.6357 |
Echinococcus granulosus | geminin | 0.0183 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.