Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.032 | 0.0871 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.032 | 0.0871 | 0.0613 |
Entamoeba histolytica | protein kinase, putative | 0.032 | 0.0871 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.032 | 0.0871 | 0.0509 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.032 | 0.0871 | 0.0509 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1476 | 0.6904 | 0.6781 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.032 | 0.0871 | 0.0955 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.032 | 0.0871 | 0.5 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.032 | 0.0871 | 0.0955 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0305 | 0.0791 | 0.172 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0305 | 0.0791 | 0.172 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0593 | 0.2297 | 0.1991 |
Brugia malayi | protein kinase C3,putative | 0.0233 | 0.0418 | 0.0045 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0233 | 0.0418 | 0.0037 |
Brugia malayi | Protein kinase c protein 2 | 0.1756 | 0.8366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1702 | 0.8085 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.1843 | 0.8819 | 0.8772 |
Loa Loa (eye worm) | hypothetical protein | 0.1476 | 0.6904 | 0.8519 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.032 | 0.0871 | 0.0509 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0402 | 0.13 | 0.481 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0566 | 0.2154 | 1 |
Toxoplasma gondii | AGC kinase | 0.032 | 0.0871 | 0.6103 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0305 | 0.0791 | 0.172 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0566 | 0.2154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0308 | 0.0249 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0226 | 0.0382 | 0.0341 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0273 | 0.0627 | 0.0255 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Brugia malayi | protein kinase C II. | 0.0593 | 0.2297 | 0.2399 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0246 | 0.0483 | 0.2574 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0379 | 0.1177 | 0.4065 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0269 | 0.0608 | 0.3708 |
Brugia malayi | C1-like domain containing protein | 0.0233 | 0.0418 | 0.0045 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.032 | 0.0871 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.252 | 0.3023 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0226 | 0.0382 | 0.0341 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1476 | 0.6904 | 0.6781 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0273 | 0.0627 | 0.0255 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0233 | 0.0418 | 0.0037 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0682 | 0.2763 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1476 | 0.6904 | 0.6781 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.032 | 0.0871 | 0.0509 |
Echinococcus multilocularis | protein kinase c iota type | 0.0546 | 0.2052 | 0.1736 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0215 | 0.0324 | 0.1505 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.2069 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.032 | 0.0871 | 0.0509 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.032 | 0.0871 | 0.0955 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0402 | 0.13 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1843 | 0.8819 | 0.8772 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0367 | 0.1116 | 0.5182 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.0627 | 0.0649 |
Mycobacterium ulcerans | polyketide synthase | 0.0379 | 0.1177 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0402 | 0.13 | 0.481 |
Onchocerca volvulus | 0.0354 | 0.1047 | 0.2794 | |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0354 | 0.1047 | 0.1176 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0233 | 0.0418 | 0.0386 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.032 | 0.0871 | 0.0613 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0379 | 0.1177 | 0.4065 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0718 | 0.2946 | 0.3212 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0379 | 0.1177 | 0.4065 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0402 | 0.13 | 0.481 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0593 | 0.2297 | 0.1991 |
Brugia malayi | Protein kinase domain containing protein | 0.032 | 0.0871 | 0.0613 |
Schistosoma mansoni | unc-13 (munc13) | 0.0273 | 0.0627 | 0.0255 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0379 | 0.1177 | 0.4065 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.032 | 0.0871 | 0.0955 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.032 | 0.0871 | 0.0509 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.032 | 0.0871 | 0.0955 |
Echinococcus granulosus | protein kinase c iota type | 0.0546 | 0.2052 | 0.1736 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0379 | 0.1177 | 0.4065 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.031 | 0.0817 | 0.3792 |
Loa Loa (eye worm) | raf kinase | 0.0226 | 0.0382 | 0.0341 |
Entamoeba histolytica | protein kinase, putative | 0.032 | 0.0871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0273 | 0.0627 | 0.0255 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0402 | 0.13 | 0.6033 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.032 | 0.0871 | 0.0509 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0379 | 0.1177 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0354 | 0.1047 | 0.4861 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0402 | 0.13 | 0.6033 |
Schistosoma mansoni | protein kinase C | 0.0273 | 0.0627 | 0.0255 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.153 | 0.7185 | 0.8872 |
Brugia malayi | Protein kinase domain containing protein | 0.0233 | 0.0418 | 0.0045 |
Brugia malayi | AMP-binding enzyme family protein | 0.0354 | 0.1047 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium ulcerans | thioesterase TesA | 0.0315 | 0.0848 | 0.2064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.032 | 0.0871 | 0.0509 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0315 | 0.0848 | 0.3934 |
Onchocerca volvulus | 0.0273 | 0.0627 | 0.103 | |
Schistosoma mansoni | unc-13 (munc13) | 0.0273 | 0.0627 | 0.0255 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.032 | 0.0871 | 0.0509 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.032 | 0.0871 | 0.0509 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0593 | 0.2297 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.0871 | 0.0955 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0593 | 0.2297 | 0.2743 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.032 | 0.0871 | 0.0955 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0233 | 0.0418 | 0.0386 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.032 | 0.0871 | 0.0509 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2069 | 1 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0379 | 0.1177 | 0.5463 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0233 | 0.0418 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium ulcerans | polyketide synthase | 0.0402 | 0.13 | 0.481 |
Brugia malayi | Hr1 repeat family protein | 0.032 | 0.0871 | 0.0613 |
Schistosoma mansoni | serine/threonine protein kinase | 0.032 | 0.0871 | 0.0509 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0226 | 0.0382 | 0.0341 |
Schistosoma mansoni | atypical protein kinase C | 0.0546 | 0.2052 | 0.1736 |
Brugia malayi | Protein kinase domain containing protein | 0.032 | 0.0871 | 0.0613 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0379 | 0.1177 | 0.5463 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0379 | 0.1177 | 0.5463 |
Entamoeba histolytica | protein kinase, putative | 0.032 | 0.0871 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.032 | 0.0871 | 0.0509 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.032 | 0.0871 | 0.0509 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0315 | 0.0848 | 0.2064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2069 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0315 | 0.0848 | 0.2064 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0233 | 0.0418 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0379 | 0.1177 | 0.0996 |
Loa Loa (eye worm) | fatty acid synthase | 0.0374 | 0.1151 | 0.1305 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0402 | 0.13 | 0.481 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0226 | 0.0382 | 0.1656 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0402 | 0.13 | 0.6033 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0233 | 0.0418 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0566 | 0.2154 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.032 | 0.0871 | 0.0955 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0402 | 0.13 | 0.481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0367 | 0.1116 | 0.5182 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0566 | 0.2154 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0272 | 0.062 | 0.288 |
Onchocerca volvulus | 0.0659 | 0.264 | 0.9485 | |
Schistosoma mansoni | protein kinase C mu | 0.0233 | 0.0418 | 0.0037 |
Echinococcus granulosus | NDR protein kinase | 0.032 | 0.0871 | 0.0509 |
Echinococcus granulosus | unc 13 munc13 | 0.0273 | 0.0627 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0382 | 0.0341 |
Trichomonas vaginalis | AGC family protein kinase | 0.032 | 0.0871 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 25 % | Induction of cell death in human U937 cells assessed at 1 to 100 microM after 24 hrs by trypan blue exclusion method relative to untreated control | ChEMBL. | 22537679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.