Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1745 | 0.6063 |
Schistosoma mansoni | protein kinase C mu | 0.0036 | 0.0279 | 0.0793 |
Echinococcus granulosus | N chimaerin | 0.0036 | 0.0279 | 0.049 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0036 | 0.0279 | 0.0279 |
Schistosoma mansoni | protein phosphatase 2C | 0.0018 | 0.0077 | 0.0218 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.0615 | 0.1745 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0036 | 0.0279 | 0.0793 |
Onchocerca volvulus | 0.0036 | 0.0279 | 0.7715 | |
Echinococcus multilocularis | protein kinase c iota type | 0.0086 | 0.0843 | 0.0843 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0444 | 1 |
Echinococcus granulosus | protein kinase c eta type | 0.0036 | 0.0279 | 0.049 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.005 | 0.0444 | 0.0779 |
Echinococcus multilocularis | N chimaerin | 0.0036 | 0.0279 | 0.0279 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0037 | 0.0291 | 0.0291 |
Brugia malayi | RhoGAP domain containing protein | 0.0036 | 0.0279 | 0.0939 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0077 | 0.0266 |
Schistosoma mansoni | protein kinase C | 0.0043 | 0.0362 | 0.1027 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0036 | 0.0279 | 0.097 |
Schistosoma mansoni | phd/f-box containing protein | 0.0018 | 0.0077 | 0.0218 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0232 | 0.248 | 0.248 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0018 | 0.0077 | 0.0218 |
Brugia malayi | Protein kinase domain containing protein | 0.0037 | 0.0291 | 0.098 |
Onchocerca volvulus | 0.0043 | 0.0362 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0925 | 0.2626 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.005 | 0.0444 | 0.1544 |
Schistosoma mansoni | jumonji domain containing protein | 0.0066 | 0.0615 | 0.1745 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.005 | 0.0444 | 0.1544 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0342 | 0.1188 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0342 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0093 | 0.0925 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.005 | 0.0444 | 0.0444 |
Schistosoma mansoni | serine/threonine kinase | 0.005 | 0.0444 | 0.1261 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0018 | 0.0077 | 0.0077 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.005 | 0.0444 | 0.0779 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0342 | 0.7213 |
Onchocerca volvulus | 0.0036 | 0.0279 | 0.7715 | |
Schistosoma mansoni | unc-13 (munc13) | 0.0043 | 0.0362 | 0.1027 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0521 | 0.5701 | 0.5701 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0018 | 0.0077 | 0.0134 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0018 | 0.0077 | 0.0077 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0077 | 0.0258 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0036 | 0.0279 | 0.097 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0342 | 0.0342 |
Toxoplasma gondii | AGC kinase | 0.005 | 0.0444 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0077 | 0.0266 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0043 | 0.0362 | 0.0635 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0049 | 0.0432 | 0.8814 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0342 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0362 | 0.1258 |
Schistosoma mansoni | protein kinase C mu | 0.0037 | 0.0291 | 0.0827 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0342 | 0.3791 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0342 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0077 | 0.0266 |
Brugia malayi | diacylglycerol kinase | 0.0036 | 0.0279 | 0.0939 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0342 | 1 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0036 | 0.0279 | 0.0793 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0066 | 0.0615 | 0.0615 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0036 | 0.0279 | 0.0793 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0036 | 0.0279 | 0.0279 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.005 | 0.0444 | 0.0779 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0521 | 0.5701 | 0.5701 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.005 | 0.0444 | 0.0444 |
Plasmodium vivax | JmjC domain containing protein | 0.0018 | 0.0077 | 0.5 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0036 | 0.0279 | 0.0279 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.005 | 0.0444 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.248 | 0.8616 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0018 | 0.0077 | 0.0077 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0036 | 0.0279 | 0.049 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1745 | 0.6063 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0444 | 0.1544 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.005 | 0.0444 | 0.0779 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0036 | 0.0279 | 0.0793 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.005 | 0.0444 | 0.1544 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0342 | 0.115 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.005 | 0.0444 | 1 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0018 | 0.0077 | 0.0077 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0066 | 0.0615 | 0.1079 |
Schistosoma mansoni | unc-13 (munc13) | 0.0043 | 0.0362 | 0.1027 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.0294 | 0.5 |
Echinococcus multilocularis | protein kinase c eta type | 0.0036 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | raf kinase | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0342 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0037 | 0.0291 | 0.1013 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0036 | 0.0279 | 0.049 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0326 | 0.3524 | 1 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0036 | 0.0279 | 0.5511 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0077 | 0.0258 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0018 | 0.0077 | 0.0134 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.0615 | 0.2068 |
Echinococcus granulosus | phd:f box containing protein | 0.0018 | 0.0077 | 0.0134 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.005 | 0.0444 | 0.0444 |
Schistosoma mansoni | jumonji domain containing protein | 0.0018 | 0.0077 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0241 | 0.2574 | 0.8946 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Schistosoma mansoni | vav2 | 0.0036 | 0.0279 | 0.0793 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Brugia malayi | diacylglycerol kinase | 0.0036 | 0.0279 | 0.0939 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0043 | 0.0362 | 0.0362 |
Brugia malayi | RhoGAP domain containing protein | 0.0036 | 0.0279 | 0.0939 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0444 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Brugia malayi | protein kinase C II. | 0.0093 | 0.0925 | 0.3113 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.0615 | 0.2137 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0036 | 0.0279 | 0.097 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.005 | 0.0444 | 0.1544 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0018 | 0.0077 | 0.5 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0036 | 0.0279 | 0.0939 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0077 | 0.0258 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0444 | 0.1261 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.005 | 0.0444 | 0.1544 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.005 | 0.0444 | 0.0444 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0077 | 0.0266 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0444 | 0.1261 |
Echinococcus multilocularis | muscleblind protein | 0.0167 | 0.1745 | 0.1745 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0037 | 0.0291 | 0.1013 |
Echinococcus granulosus | NDR protein kinase | 0.005 | 0.0444 | 0.0779 |
Schistosoma mansoni | atypical protein kinase C | 0.0086 | 0.0843 | 0.2391 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.0615 | 0.1745 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0444 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0444 | 0.1261 |
Echinococcus granulosus | myotubularin protein 13 | 0.0036 | 0.0279 | 0.049 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0521 | 0.5701 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0444 | 0.1495 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0093 | 0.0925 | 0.3216 |
Echinococcus granulosus | protein kinase C gamma type | 0.029 | 0.3126 | 0.5483 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0232 | 0.248 | 0.248 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0037 | 0.0291 | 0.0827 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0037 | 0.0291 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2878 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0232 | 0.248 | 0.4349 |
Schistosoma mansoni | rac gtpase activating protein | 0.0036 | 0.0279 | 0.0793 |
Brugia malayi | protein kinase C3,putative | 0.0037 | 0.0291 | 0.098 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0036 | 0.0279 | 0.0939 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.005 | 0.0444 | 0.1544 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0444 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0066 | 0.0615 | 0.1079 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.0615 | 0.2068 |
Brugia malayi | C1-like domain containing protein | 0.0037 | 0.0291 | 0.098 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.005 | 0.0444 | 0.1544 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0326 | 0.3524 | 1 |
Brugia malayi | RhoGEF domain containing protein | 0.0036 | 0.0279 | 0.0939 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0342 | 0.06 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.005 | 0.0444 | 0.0444 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0018 | 0.0077 | 0.0134 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0093 | 0.0925 | 0.0925 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0036 | 0.0279 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Echinococcus granulosus | protein kinase c iota type | 0.0086 | 0.0843 | 0.1478 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0036 | 0.0279 | 0.049 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0037 | 0.0291 | 0.0827 |
Brugia malayi | Muscleblind-like protein | 0.0167 | 0.1745 | 0.587 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0066 | 0.0615 | 0.0615 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0037 | 0.0291 | 0.0511 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0294 | 0.5 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0036 | 0.0279 | 0.0279 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0279 | 0.0793 |
Echinococcus granulosus | muscleblind protein | 0.0167 | 0.1745 | 0.3061 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0077 | 0.0266 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0036 | 0.0279 | 0.0793 |
Brugia malayi | Protein kinase c protein 2 | 0.0277 | 0.2973 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.005 | 0.0444 | 0.0444 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0444 | 0.1495 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0342 | 0.7213 |
Brugia malayi | Pleckstrin Homology Domain | 0.0036 | 0.0279 | 0.0939 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0077 | 0.0258 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0444 | 0.1261 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0043 | 0.0362 | 0.0362 |
Echinococcus multilocularis | phd:f box containing protein | 0.0018 | 0.0077 | 0.0077 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0018 | 0.0077 | 0.0134 |
Echinococcus multilocularis | serine threonine protein kinase | 0.029 | 0.3126 | 0.3126 |
Echinococcus granulosus | neuropeptide s receptor | 0.0521 | 0.5701 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0326 | 0.3524 | 0.3524 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0326 | 0.3524 | 0.6182 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0018 | 0.0077 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0077 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0279 | 0.097 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0036 | 0.0279 | 0.0279 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0342 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0167 | 0.1745 | 0.1745 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0342 | 0.097 |
Brugia malayi | Hr1 repeat family protein | 0.005 | 0.0444 | 0.1495 |
Echinococcus granulosus | unc 13 munc13 | 0.0043 | 0.0362 | 0.0635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 58 % | Inhibition of GST-tagged HIV1 integrase and C-terminal His6-tagged HIV1 integrase dimerization at 100 uM after 3 hrs by AlphaScreen-based dimerization assay | ChEMBL. | 22483582 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.