Detailed information for compound 16279

Basic information

Technical information
  • TDR Targets ID: 16279
  • Name: 4-[2-(1H-indol-3-yl)ethyl]-N-[4-methoxy-3-(4- methylpiperazin-1-yl)phenyl]piperidine-1-carb oxamide
  • MW: 475.626 | Formula: C28H37N5O2
  • H donors: 2 H acceptors: 1 LogP: 4.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N1CCN(CC1)C)NC(=O)N1CCC(CC1)CCc1c[nH]c2c1cccc2
  • InChi: 1S/C28H37N5O2/c1-31-15-17-32(18-16-31)26-19-23(9-10-27(26)35-2)30-28(34)33-13-11-21(12-14-33)7-8-22-20-29-25-6-4-3-5-24(22)25/h3-6,9-10,19-21,29H,7-8,11-18H2,1-2H3,(H,30,34)
  • InChiKey: MLYDWVQYHWPBIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[2-(1H-indol-3-yl)ethyl]-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-1-piperidinecarboxamide
  • 4-[2-(1H-indol-3-yl)ethyl]-N-[4-methoxy-3-(4-methylpiperazino)phenyl]piperidine-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1d (5-HT1d) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 332 aa 21.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 362 aa 33.4 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1b (5-HT1b) receptor   386 aa 310 aa 21.6 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Echinococcus granulosus neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 332 aa 21.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.0 %
Schistosoma mansoni adenoreceptor Serotonin 1d (5-HT1d) receptor   374 aa 348 aa 27.3 %
Echinococcus granulosus dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1b (5-HT1b) receptor   386 aa 371 aa 26.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 30.8 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 354 aa 20.1 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum Rhodopsin, putative Serotonin 1d (5-HT1d) receptor   374 aa 372 aa 19.6 %
Echinococcus granulosus biogenic amine 5HT receptor Serotonin 1d (5-HT1d) receptor   374 aa 402 aa 33.8 %
Onchocerca volvulus Forkhead box protein biniou homolog Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.3 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 1b (5-HT1b) receptor   386 aa 350 aa 18.6 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 1d (5-HT1d) receptor   374 aa 359 aa 32.0 %
Echinococcus multilocularis serotonin receptor Serotonin 1b (5-HT1b) receptor   386 aa 393 aa 32.3 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   374 aa 315 aa 21.0 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Serotonin 1d (5-HT1d) receptor   374 aa 326 aa 36.2 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 334 aa 24.0 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 363 aa 34.4 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Brugia malayi sulfakinin receptor protein Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 23.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 1b (5-HT1b) receptor   386 aa 359 aa 22.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus multilocularis neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Serotonin 1d (5-HT1d) receptor   374 aa 349 aa 34.7 %
Brugia malayi GnHR receptor homolog Serotonin 1b (5-HT1b) receptor   386 aa 335 aa 21.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 33.4 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Schistosoma mansoni neuropeptide receptor Serotonin 1d (5-HT1d) receptor   374 aa 309 aa 24.3 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus multilocularis calpain 5 0.0036 0.0095 0.0062
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0063 0.0241
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0263
Schistosoma mansoni hypothetical protein 0.0076 0.062 0.1177
Brugia malayi neuropeptide F receptor 0.0076 0.062 0.1177
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0082 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.01 0.0929 0.1763
Onchocerca volvulus 0.0053 0.0318 0.1074
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Brugia malayi Dopamine receptor protein 2 0.0076 0.062 0.1177
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.0334 0.0633
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.062 0.0589
Schistosoma mansoni biogenic amine receptor 0.0076 0.062 0.1177
Schistosoma mansoni biogenic amine receptor 0.0076 0.062 0.1177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.062 0.0589
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Toxoplasma gondii cathepsin B 0.0098 0.0907 0.6119
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0063 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Onchocerca volvulus 0.0076 0.062 0.2353
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0283 1
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.062 0.1802
Brugia malayi Melatonin receptor type 1A 0.0076 0.062 0.1177
Echinococcus multilocularis calpain family protein 1, d 0.0071 0.0543 0.0512
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0191
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Schistosoma mansoni neuropeptide receptor 0.0076 0.062 0.1177
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.062 0.1802
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0124 0.0235
Trypanosoma brucei prolyl endopeptidase 0.0127 0.128 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.062 0.1177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Leishmania major oligopeptidase b 0.0051 0.0283 0.1805
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Schistosoma mansoni calpain C (C02 family) 0.0036 0.0095 0.0181
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.062 0.0589
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma cruzi oligopeptidase b 0.0051 0.0283 0.0767
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0191
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0054 0.0334 0.0633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Onchocerca volvulus 0.006 0.0402 0.1431
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0081 0.0677 0.1178
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Brugia malayi neuropeptide F receptor 0.0076 0.062 0.1177
Schistosoma mansoni neuropeptide receptor 0.0076 0.062 0.1177
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0318 0.0285
Loa Loa (eye worm) hypothetical protein 0.0282 0.329 0.6198
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Schistosoma mansoni opsin-like receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0116
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.0334 0.0633
Echinococcus granulosus serotonin receptor 0.0076 0.062 0.1802
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Echinococcus multilocularis sex peptide receptor 0.0076 0.062 0.0589
Entamoeba histolytica cysteine protease, putative 0.0053 0.0318 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.062 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Schistosoma mansoni hypothetical protein 0.0054 0.0334 0.0633
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0318 0.0603
Brugia malayi Metabotropic glutamate receptor precursor. 0.0059 0.0395 0.0749
Brugia malayi calpain family protein 1 0.0096 0.0873 0.1656
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.329 0.6244
Schistosoma mansoni calpain-7 (C02 family) 0.0036 0.0095 0.0181
Brugia malayi Serotonin receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Schistosoma mansoni adenoreceptor 0.0076 0.062 0.1177
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.062 0.1802
Schistosoma mansoni amine GPCR 0.0076 0.062 0.1177
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.062 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0318 0.3255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.329 0.6244
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) glutamate receptor 0.0059 0.0395 0.0636
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0063 0.012
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.062 0.0589
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0294 0.0558
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.062 0.0589
Brugia malayi putative neuropeptide receptor 0.0076 0.062 0.1177
Brugia malayi RE15519p 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0434 0.5269 1
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0318 0.0603
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.062 0.1177
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0054 0.0334 0.0519
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Brugia malayi Dopamine receptor 0.0076 0.062 0.1177
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0054 0.0334 0.0301
Loa Loa (eye worm) hypothetical protein 0.0096 0.0873 0.1554
Onchocerca volvulus Prolyl endopeptidase homolog 0.0127 0.128 0.5143
Echinococcus multilocularis orexin receptor type 2 0.0076 0.062 0.0589
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0318 0.0488
Brugia malayi G-protein coupled receptor 0.0076 0.062 0.1177
Schistosoma mansoni biogenic amine (5HT) receptor 0.0224 0.2534 0.481
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.062 0.1802
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Echinococcus granulosus sex peptide receptor 0.0076 0.062 0.1802
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0063 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0033 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0124 0.0235
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.062 0.1177
Echinococcus multilocularis cathepsin b 0.0282 0.329 0.3267
Echinococcus multilocularis cysteine protease 0.0053 0.0318 0.0285
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.062 0.1069
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0318 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Loa Loa (eye worm) hypothetical protein 0.0103 0.0961 0.1724
Schistosoma mansoni histamine h1 receptor 0.0076 0.062 0.1177
Schistosoma mansoni neuropeptide receptor 0.0076 0.062 0.1177
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0318 0.0873
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.062 0.1802
Onchocerca volvulus 0.0076 0.062 0.2353
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0318 0.0873
Loa Loa (eye worm) fibroinase 0.0053 0.0318 0.0488
Trypanosoma brucei antigen, putative 0.0036 0.0095 0.0498
Echinococcus multilocularis allatostatin A receptor 0.0215 0.2429 0.2404
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.062 0.0589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.062 0.1069
Brugia malayi cathepsin B-like cysteine proteinase 0.0282 0.329 0.6244
Echinococcus granulosus prolyl endopeptidase 0.0127 0.128 0.3829
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.062 0.1802
Loa Loa (eye worm) cathepsin B 0.0098 0.0907 0.162
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0063 0.0092
Brugia malayi follicle stimulating hormone receptor 0.0076 0.062 0.1177
Brugia malayi Dopamine receptor protein 1 0.0076 0.062 0.1177
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.062 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Schistosoma mansoni neuropeptide receptor 0.0076 0.062 0.1177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0053 0.0318 0.0488
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0036
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.01 0.0929 0.0899
Schistosoma mansoni hypothetical protein 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0054 0.0334 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Onchocerca volvulus 0.0053 0.0318 0.1074
Loa Loa (eye worm) hypothetical protein 0.0073 0.0573 0.0978
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.062 0.1177
Schistosoma mansoni amine GPCR 0.0076 0.062 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0124 0.1036
Echinococcus granulosus biogenic amine 5HT receptor 0.0224 0.2534 0.768
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Echinococcus granulosus g-protein coupled receptor 0.0076 0.062 0.1802
Onchocerca volvulus 0.0053 0.0318 0.1074
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0033 0.0063
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0191
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0063 0.012
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0318 0.1074
Brugia malayi calpain family protein 1 0.0096 0.0873 0.1656
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0127 0.128 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0294 0.0558
Schistosoma mansoni amine GPCR 0.0076 0.062 0.1177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.062 0.1069
Echinococcus granulosus calpain A 0.01 0.0929 0.2751
Onchocerca volvulus 0.0076 0.062 0.2353
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.062 0.1177
Onchocerca volvulus 0.0076 0.062 0.2353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0318 0.0873
Onchocerca volvulus 0.0054 0.0334 0.1142
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0085 0.0731 0.1283
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.062 0.1177
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0063 0.003
Echinococcus multilocularis g protein coupled receptor 0.0076 0.062 0.0589
Loa Loa (eye worm) ctsf protein 0.0053 0.0318 0.0488
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.062 0.0589
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.1107 1
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0063 0.0092
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Brugia malayi Cathepsin L-like precursor 0.0038 0.0124 0.0235
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0283 0.2002
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Giardia lamblia Cathepsin B precursor 0.0098 0.0907 0.5
Schistosoma mansoni calpain-7 (C02 family) 0.0036 0.0095 0.0181
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0063 0.003
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0282 0.329 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.062 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.0127 0.128 0.2337
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.062 0.1177
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0095 0.0498
Loa Loa (eye worm) calpain family protein 1 0.0096 0.0873 0.1554
Echinococcus granulosus somatostatin receptor 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.0071 0.0543 0.0922
Loa Loa (eye worm) hypothetical protein 0.0215 0.2429 0.4544
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.062 0.0589
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0063 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0063 0.0092
Echinococcus multilocularis calpain 7 (C02 family) 0.0036 0.0095 0.0062
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.062 0.0589
Onchocerca volvulus 0.0076 0.062 0.2353
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0318 0.1074
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.062 0.1177
Echinococcus granulosus metabotropic glutamate receptor 2 0.005 0.027 0.0726
Onchocerca volvulus 0.0076 0.062 0.2353
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.062 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.0907 0.1721
Onchocerca volvulus 0.0053 0.0318 0.1074
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.0907 0.693
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Onchocerca volvulus 0.0076 0.062 0.2353
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.062 0.1802
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0124 0.1036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.062 0.0589
Plasmodium vivax vivapain-2 0.0053 0.0318 1
Brugia malayi calpain 7 0.0036 0.0095 0.0181
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.062 0.0589
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0191
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0263
Schistosoma mansoni amine GPCR 0.0076 0.062 0.1177
Schistosoma mansoni hypothetical protein 0.0076 0.062 0.1177
Onchocerca volvulus 0.0076 0.062 0.2353
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.128 0.243
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0063 0.0092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0434 0.5269 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.062 0.1177
Echinococcus granulosus neuropeptide s receptor 0.0076 0.062 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.062 0.2353
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0318 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0498
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0076 0.062 0.0589
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.062 0.2353
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0283 0.1805
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Echinococcus multilocularis cathepsin b 0.0282 0.329 0.3267
Loa Loa (eye worm) cysteine protease 0.0053 0.0318 0.0488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Leishmania major cathepsin L-like protease 0.0053 0.0318 0.2089
Loa Loa (eye worm) hypothetical protein 0.0224 0.2534 0.4747
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0124 0.3182
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.062 0.1802
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0054 0.0334 0.0922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Brugia malayi sulfakinin receptor protein 0.0076 0.062 0.1177
Loa Loa (eye worm) peptidase family M1 containing protein 0.0093 0.0831 0.1474
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.01 0.0929 0.2751
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0318 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Onchocerca volvulus 0.0038 0.0124 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma cruzi prolyl endopeptidase 0.0127 0.128 0.3829
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0067 0.05 0.0949
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0033 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.062 0.1802
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.0907 0.2682
Schistosoma mansoni amine GPCR 0.0076 0.062 0.1177
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.062 0.1177
Echinococcus granulosus fmrfamide receptor 0.0076 0.062 0.1802
Onchocerca volvulus 0.0215 0.2429 1
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.062 0.0589
Onchocerca volvulus 0.0053 0.0318 0.1074
Echinococcus granulosus metabotropic glutamate receptor 5 0.0073 0.0573 0.1656
Brugia malayi Cathepsin L-like precursor 0.0038 0.0124 0.0235
Brugia malayi cathepsin L-like precursor 0.0038 0.0124 0.0235
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.062 0.0589
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0096 0.0873 0.1656
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.062 0.1069
Brugia malayi hypothetical protein 0.0034 0.0063 0.012
Plasmodium vivax vivapain-2 0.0053 0.0318 1
Echinococcus multilocularis neuropeptide receptor 0.0076 0.062 0.0589
Onchocerca volvulus 0.0076 0.062 0.2353
Echinococcus multilocularis metabotropic glutamate receptor 2 0.005 0.027 0.0237
Schistosoma mansoni metabotropic glutamate receptor 0.005 0.027 0.0512
Onchocerca volvulus 0.0076 0.062 0.2353
Toxoplasma gondii prolyl endopeptidase 0.0127 0.128 1
Echinococcus multilocularis prolyl endopeptidase 0.0127 0.128 0.1251
Echinococcus granulosus calpain 7 C02 family 0.0036 0.0095 0.0191
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0036 0.0095 0.0191
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0095 0.0498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Schistosoma mansoni myosin xvIII 0.0076 0.062 0.1177
Echinococcus multilocularis neuropeptide receptor 0.0076 0.062 0.0589
Echinococcus multilocularis serotonin receptor 0.0224 0.2534 0.2509
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0318 0.0873
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0063 0.0092
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0095 0.0498
Echinococcus multilocularis inhibitor of apoptosis protein 0.0054 0.0334 0.0301
Echinococcus granulosus neuropeptide receptor 0.0076 0.062 0.1802
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0318 0.0873
Onchocerca volvulus 0.0076 0.062 0.2353
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0063 0.0092
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0318 0.0285
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.062 0.1802
Schistosoma mansoni hypothetical protein 0.0076 0.062 0.1177
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0543 0.0922
Giardia lamblia Cathepsin B precursor 0.0098 0.0907 0.5
Trypanosoma brucei oligopeptidase b 0.0051 0.0283 0.2002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.062 0.1802
Brugia malayi AKH receptor 0.0076 0.062 0.1177
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.062 0.0589
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.062 0.1802
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.01 0.0929 0.1763
Echinococcus granulosus cathepsin b 0.0282 0.329 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.062 0.1177
Brugia malayi GnHR receptor homolog 0.0076 0.062 0.1177
Echinococcus granulosus cathepsin l1 0.0038 0.0124 0.0278
Schistosoma mansoni opsin-like receptor 0.0076 0.062 0.1177
Echinococcus granulosus neuropeptide receptor 0.0076 0.062 0.1802
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Giardia lamblia Cathepsin B precursor 0.0098 0.0907 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0318 0.0488
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.0907 0.7004
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.062 0.0589
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.062 0.1177
Schistosoma mansoni inhibitor of apoptosis protein 0.0054 0.0334 0.0633
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.062 0.0589
Loa Loa (eye worm) hypothetical protein 0.0224 0.2534 0.4747
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0073 0.0573 0.0541
Echinococcus granulosus g protein coupled receptor 0.0076 0.062 0.1802
Schistosoma mansoni biogenic amine receptor 0.0076 0.062 0.1177
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.062 0.1802
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.062 0.0589
Echinococcus granulosus g protein coupled receptor 0.0076 0.062 0.1802
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.062 0.0589
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.062 0.1177
Echinococcus multilocularis fmrfamide receptor 0.0076 0.062 0.0589
Echinococcus granulosus allatostatin A receptor 0.0215 0.2429 0.7357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Onchocerca volvulus 0.0076 0.062 0.2353
Echinococcus granulosus calpain 5 0.0036 0.0095 0.0191
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.062 0.1177
Echinococcus multilocularis cysteine protease 0.0053 0.0318 0.0285
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.062 0.1802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0443
Onchocerca volvulus Deterin homolog 0.0054 0.0334 0.1142
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0063 0.0092
Onchocerca volvulus 0.0076 0.062 0.2353
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0318 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Brugia malayi larval opioid receptor 0.0076 0.062 0.1177
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0215 0.2429 0.461
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Onchocerca volvulus 0.0053 0.0318 0.1074
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0263
Echinococcus granulosus cathepsin l1 0.0053 0.0318 0.0873
Onchocerca volvulus 0.0053 0.0318 0.1074
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0191
Trypanosoma brucei calpain-like protein, putative 0.0036 0.0095 0.0498
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.329 0.6244
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.062 0.1802
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.062 0.1177
Schistosoma mansoni opsin-like receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.062 0.1069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus multilocularis aminopeptidase N 0.0115 0.1115 0.1086
Echinococcus granulosus orexin receptor type 2 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.006 0.0402 0.065
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.062 0.0589
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0063 0.0241
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0318 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.062 0.1802
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0063 0.003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.128 0.243
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0318 0.1074
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0063 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0318 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0054 0.0322 0.0612
Echinococcus granulosus calpain 0.0036 0.0095 0.0191
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Onchocerca volvulus 0.0076 0.062 0.2353
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.062 0.1177
Schistosoma mansoni hypothetical protein 0.0035 0.0082 0.0156
Onchocerca volvulus 0.0076 0.062 0.2353
Echinococcus multilocularis calpain A 0.01 0.0929 0.0899
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.062 0.0589
Echinococcus multilocularis calpain 0.0036 0.0095 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0318 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0033 0.0063
Echinococcus granulosus hypothetical protein 0.0076 0.062 0.1802
Loa Loa (eye worm) hypothetical protein 0.0389 0.4688 0.8884
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.062 0.1177
Echinococcus granulosus inhibitor of apoptosis protein 0.0054 0.0334 0.0922
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0063 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.062 0.1177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.062 0.1177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0283 0.0767
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.062 0.1069
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0283 0.2002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0283 0.0767
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0434 0.5269 1
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.062 0.1802
Onchocerca volvulus 0.0115 0.1115 0.4447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Loa Loa (eye worm) calpain 0.0036 0.0095 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0282 0.329 0.6244
Echinococcus granulosus g protein coupled receptor 0.0076 0.062 0.1802
Echinococcus multilocularis serotonin receptor 0.0224 0.2534 0.2509
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.062 0.1802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Echinococcus granulosus aminopeptidase N 0.0115 0.1115 0.3323
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.062 0.1069
Brugia malayi G-protein coupled receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.062 0.1069
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.062 0.1802
Echinococcus granulosus calpain A 0.0036 0.0095 0.0191
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0063 0.0345
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0063 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.0907 1
Brugia malayi ORL1-like opioid receptor 0.0076 0.062 0.1177
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0318 1
Brugia malayi Peptidase family M1 containing protein 0.0115 0.1115 0.2117
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.062 0.1069
Brugia malayi hypothetical protein 0.0076 0.062 0.1177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Echinococcus multilocularis somatostatin receptor 0.0076 0.062 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.062 0.0589
Echinococcus multilocularis fmrfamide receptor 0.0076 0.062 0.0589
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.062 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0318 0.3255
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0283 0.5
Echinococcus granulosus cathepsin b 0.0282 0.329 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.062 0.1177
Brugia malayi G protein-coupled receptor 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0434 0.5269 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.062 0.1177
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0095 0.0191
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0116
Onchocerca volvulus 0.0076 0.062 0.2353
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0033 0.0063
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0063 0.1059
Brugia malayi Cathepsin L-like precursor 0.0053 0.0318 0.0603
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0318 0.0285
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0191
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0498
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.1069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0294 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0318 0.3255
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0318 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0095 0.0191
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.128 0.243
Trypanosoma cruzi oligopeptidase b 0.0051 0.0283 0.0767
Brugia malayi Serotonin receptor 0.0076 0.062 0.1177
Plasmodium vivax calpain, putative 0.0036 0.0095 0.2184
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.062 0.1802
Schistosoma mansoni calpain (C02 family) 0.0036 0.0095 0.0181
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.062 0.1177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.062 0.1177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0318 0.228
Schistosoma mansoni Mername-AA248 (C02 family) 0.0036 0.0095 0.0181
Echinococcus multilocularis g protein coupled receptor 0.0076 0.062 0.0589
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0124 0.0278
Echinococcus multilocularis hypothetical protein 0.0036 0.0095 0.0062
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.062 0.0589
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.062 0.0589

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 nM [3H]-5-HT reuptake inhibition in Rat brain synaptosomes. ChEMBL. 10737747
IC50 (binding) = 120 nM Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
IC50 (binding) = 120 nM Binding affinity towards 5-hydroxytryptamine 1B receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
IC50 (binding) = 200 nM Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
IC50 (binding) = 200 nM Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
IC50 (binding) > 300 nM Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
IC50 (binding) > 300 nM Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand. ChEMBL. 10737747
pA2 (functional) = 7.7 Inhibition of the contractile responses elicited by sumatriptan in rabbit saphenous vein (RSV) ChEMBL. 10737747
Release (functional) = 121 % Sumatriptan induced inhibition of potassium evoked [3H]-5-HT release from guinea pig cortex slices ChEMBL. 10737747

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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