Detailed information for compound 1628053

Basic information

Technical information
  • TDR Targets ID: 1628053
  • Name: 1-methyl-3-(phenylmethoxy)-4-(2-sulfanylidene 1,3-thiazolidine-3-carbonyl)pyridin-2-one
  • MW: 360.451 | Formula: C17H16N2O3S2
  • H donors: 0 H acceptors: 2 LogP: 2.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1SCCN1C(=O)c1ccn(c(=O)c1OCc1ccccc1)C
  • InChi: 1S/C17H16N2O3S2/c1-18-8-7-13(15(20)19-9-10-24-17(19)23)14(16(18)21)22-11-12-5-3-2-4-6-12/h2-8H,9-11H2,1H3
  • InChiKey: LSCQAXFNKGKCDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-3-(phenylmethoxy)-4-(2-thioxothiazolidine-3-carbonyl)pyridin-2-one
  • 1-methyl-4-[oxo-(2-thioxo-3-thiazolidinyl)methyl]-3-(phenylmethoxy)-2-pyridinone
  • 3-(benzyloxy)-1-methyl-4-(2-thioxothiazolidine-3-carbonyl)-2-pyridone
  • 1-methyl-3-(phenylmethoxy)-4-[(2-sulfanylidene-1,3-thiazolidin-3-yl)carbonyl]pyridin-2-one
  • NSC691699
  • NCI60_032917
  • 3-(Benzyloxy)-1-methyl-4-((2-thioxo-1,3-thiazolidin-3-yl)carbonyl)-2(1H)-pyridinone
  • AIDS-151405
  • AIDS151405

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.4877 0.3797 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0448 0.0332 0.0533
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0008 0.0007
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1735 0.1339 0.2162
Echinococcus multilocularis Biotin lipoyl attachment 0.0448 0.0332 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.004 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0008 0.0006
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0448 0.0332 0.0332
Brugia malayi Bromodomain containing protein 0.0045 0.0016 0.0014
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.2183 0.169 0.5
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0035 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.0188 0.0186
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.4877 0.3797 1
Schistosoma mansoni hypothetical protein 0.0035 0.0008 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.0689 0.0688
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0198 0.0136 0.0138
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.4877 0.3797 1
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.4877 0.3797 0.3796
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.1735 0.1339 0.2905
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0448 0.0332 0.0533
Brugia malayi Carboxyl transferase domain containing protein 1.2355 0.9649 1
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.1735 0.1339 0.1339
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0067 0.0067
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4877 0.3797 0.3797
Toxoplasma gondii carbamoylphosphate synthetase 0.1102 0.0844 0.0841
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0448 0.0332 0.0533
Toxoplasma gondii acetyl-coA carboxylase ACC2 1.2803 1 1
Schistosoma mansoni bromodomain containing protein 0.0074 0.0039 0.0039
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0448 0.0332 0.033
Schistosoma mansoni survival motor neuron protein 0.0054 0.0023 0.0023
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0448 0.0332 0.033
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.1735 0.1339 0.1337
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0448 0.0332 0.033
Schistosoma mansoni hypothetical protein 0.0075 0.004 0.004
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0448 0.0332 0.033
Loa Loa (eye worm) hypothetical protein 0.0082 0.0046 0.0047
Loa Loa (eye worm) hypothetical protein 0.0198 0.0136 0.0141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0014 0.0012
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.1735 0.1339 0.2905
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1735 0.1339 0.1337
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0002 0.0002
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0448 0.0332 0.033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0045 0.0044
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.1735 0.1339 0.2162
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1735 0.1339 0.2162
Trichomonas vaginalis conserved hypothetical protein 0.0192 0.0132 0.5
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0448 0.0332 0.033
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0082 0.0085
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.4877 0.3797 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0448 0.0332 0.0342
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.1102 0.0844 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0448 0.0332 0.0344
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0448 0.0332 0.033
Schistosoma mansoni pyruvate carboxylase 0.4877 0.3797 0.3797
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0448 0.0332 0.0533
Schistosoma mansoni carbamoyl-phosphate synthetase 0.1102 0.0844 0.0844
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.1735 0.1339 0.2905
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0008 0.0006
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0448 0.0332 0.0342
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0035 0.0036
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0448 0.0332 0.033
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.1735 0.1339 0.2905
Loa Loa (eye worm) hypothetical protein 0.0075 0.004 0.0041
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4877 0.3797 0.3796
Echinococcus granulosus microtubule associated protein 2 0.0743 0.0563 0.0561
Echinococcus granulosus Biotin lipoyl attachment 0.0448 0.0332 0.033
Schistosoma mansoni hypothetical protein 0.0054 0.0023 0.0023
Toxoplasma gondii acetyl-CoA carboxylase ACC1 1.2803 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0003
Loa Loa (eye worm) carboxyl transferase domain-containing protein 1.2355 0.9649 1
Schistosoma mansoni microtubule-associated protein tau 0.0743 0.0563 0.0563
Leishmania major propionyl-coa carboxylase beta chain, putative 0.1735 0.1339 0.1337
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.4877 0.3797 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0082 0.0085
Echinococcus multilocularis microtubule associated protein 2 0.0743 0.0563 0.0561
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0008 0.0009
Chlamydia trachomatis biotin carboxylase 0.4428 0.3446 1
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.1735 0.1339 0.2905
Trypanosoma cruzi acetyl-CoA carboxylase 0.7927 0.6184 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0035 0.0035
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0448 0.0332 0.033
Brugia malayi Bromodomain containing protein 0.0087 0.0049 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0014 0.0012
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.1735 0.1339 0.1337
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.1102 0.0844 0.1476
Loa Loa (eye worm) RNA binding protein 0.0068 0.0035 0.0036
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.1735 0.1339 0.2905
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.1735 0.1339 0.2905
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.1102 0.0844 0.1476
Loa Loa (eye worm) hypothetical protein 0.0045 0.0016 0.0017
Echinococcus granulosus tar DNA binding protein 0.0068 0.0035 0.0033
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.1735 0.1339 0.2905
Schistosoma mansoni hypothetical protein 0.0035 0.0008 0.0008
Brugia malayi RNA binding protein 0.0068 0.0035 0.0033
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.1735 0.1339 0.1337
Mycobacterium ulcerans pyruvate carboxylase 0.4877 0.3797 1
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0448 0.0332 0.0456
Toxoplasma gondii pyruvate carboxylase 0.4877 0.3797 0.3796
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4877 0.3797 0.3796
Schistosoma mansoni carbamoyl-phosphate synthetase 0.1102 0.0844 0.0844
Schistosoma mansoni acetyl-CoA carboxylase 1.2803 1 1
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0448 0.0332 0.033
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0448 0.0332 0.033
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0448 0.0332 0.033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0035 0.0036
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4877 0.3797 0.3797
Echinococcus multilocularis GPCR, family 2 0.0035 0.0008 0.0007
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4877 0.3797 0.6139
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0045 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0036 0.0034
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0448 0.0332 0.0533
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0448 0.0332 0.0533
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0019
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0448 0.0332 0.0533
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.0188 0.0186
Trypanosoma brucei acetyl-CoA carboxylase 1.2803 1 1
Echinococcus granulosus GPCR family 2 0.0035 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0067 0.0069
Schistosoma mansoni hypothetical protein 0.0082 0.0045 0.0045
Brugia malayi hypothetical protein 0.0264 0.0188 0.0192
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 1.2803 1 1
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.1735 0.1339 0.2905
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0448 0.0332 0.033
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.1735 0.1339 0.3233
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0448 0.0332 0.033
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.4877 0.3797 1
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.9265 0.7231 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0067 0.0069
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.1102 0.0844 0.0841
Loa Loa (eye worm) hypothetical protein 0.005 0.002 0.0021
Treponema pallidum pyruvate carboxylase subunit B 0.0448 0.0332 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0067 0.0067
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.1735 0.1339 0.2905
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0036 0.0034
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0448 0.0332 0.0456
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.4877 0.3797 0.3796
Leishmania major acetyl-CoA carboxylase, putative 1.2803 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0008 0.0008
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0448 0.0332 0.033
Schistosoma mansoni hypothetical protein 0.0035 0.0008 0.0008
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.4877 0.3797 0.3796
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.1735 0.1339 0.2905
Loa Loa (eye worm) hypothetical protein 0.0448 0.0332 0.0344
Loa Loa (eye worm) hypothetical protein 0.0264 0.0188 0.0194
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1735 0.1339 0.1337
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0448 0.0332 0.0456
Brugia malayi PHD-finger family protein 0.0029 0.0004 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0035 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0045 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0008 0.0007
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0448 0.0332 0.0332
Entamoeba histolytica acetyl-coA carboxylase, putative 0.2183 0.169 1
Schistosoma mansoni aspartate carbamoyltransferase 0.1102 0.0844 0.0844
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0008 0.0007
Leishmania major carboxylase, putative 0.4877 0.3797 0.3796
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0035 0.0033
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0448 0.0332 0.0342
Brugia malayi TAR-binding protein 0.0068 0.0035 0.0033
Brugia malayi hypothetical protein 0.0082 0.0045 0.0044
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0448 0.0332 0.0332
Plasmodium falciparum carbamoyl phosphate synthetase 0.1102 0.0844 0.1164
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4877 0.3797 0.6139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0023 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0008 0.0007
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0448 0.0332 0.0456
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0448 0.0332 0.0332
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0448 0.0332 0.0456
Loa Loa (eye worm) hypothetical protein 0.0448 0.0332 0.0344
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0448 0.0332 0.033
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0448 0.0332 0.033
Leishmania major carbamoyl-phosphate synthase, putative 0.1102 0.0844 0.0841
Trypanosoma brucei unspecified product 0.3206 0.249 0.2488
Brugia malayi MH2 domain containing protein 0.0129 0.0082 0.0082
Onchocerca volvulus 0.0054 0.0023 0.5
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.1102 0.0844 0.1361
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.1735 0.1339 0.2905
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.9265 0.7231 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.4877 0.3797 1
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.1102 0.0844 0.1164

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.261 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.169 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.102 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.057 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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