Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0046 | 0.0025 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0037 | 0.0493 |
Trypanosoma cruzi | hypothetical protein | 0.0101 | 0.0673 | 0.1683 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0101 | 0.0673 | 0.5567 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0369 | 0.3863 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0107 | 0.0754 | 0.1953 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.119 | 0.308 |
Echinococcus multilocularis | protein patched | 0.0046 | 0.0025 | 0.0025 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0369 | 0.3863 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0369 | 0.3863 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0369 | 0.3862 | 0.3862 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0369 | 0.3863 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0369 | 0.3863 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0101 | 0.0673 | 0.5567 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0046 | 0.0025 | 0.0025 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.119 | 0.308 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.033 | 0.3396 | 0.8782 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0005 | 0.0014 |
Echinococcus multilocularis | protein dispatched 1 | 0.0053 | 0.0102 | 0.0102 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0189 | 0.1728 | 0.4476 |
Echinococcus multilocularis | expressed conserved protein | 0.0147 | 0.1226 | 0.1226 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0369 | 0.3863 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0005 | 0.0014 |
Brugia malayi | CHE-14 protein | 0.0046 | 0.0025 | 0.0065 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0107 | 0.0754 | 0.0768 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.033 | 0.3396 | 0.8782 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.119 | 0.119 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.0189 | 0.1728 | 0.1728 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.033 | 0.3396 | 0.8782 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0119 | 0.1571 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0148 | 0.1967 |
Leishmania major | dihydroorotate dehydrogenase | 0.0369 | 0.3863 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.0037 | 0.0493 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0369 | 0.3863 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0154 | 0.1303 | 0.3373 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0369 | 0.3863 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0101 | 0.0673 | 0.1744 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0144 | 0.119 | 0.3079 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.119 | 0.4892 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0369 | 0.3863 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0046 | 0.0025 | 0.0065 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0119 | 0.0307 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0156 | 0.1332 | 0.3399 |
Echinococcus granulosus | tumor protein p63 | 0.0369 | 0.3862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0025 | 0.0331 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0369 | 0.3863 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0101 | 0.0677 | 0.0677 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0101 | 0.0673 | 0.1743 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0109 | 0.0774 | 0.2004 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0101 | 0.0673 | 0.5567 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0369 | 0.3863 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0005 | 0.0014 |
Onchocerca volvulus | 0.0054 | 0.0119 | 1 | |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0369 | 0.3863 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.119 | 0.119 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0101 | 0.0673 | 0.0673 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0189 | 0.1728 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0754 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0107 | 0.0754 | 0.0754 |
Schistosoma mansoni | patched 1 | 0.0046 | 0.0025 | 0.0065 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0369 | 0.3863 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0147 | 0.1226 | 0.3175 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.0148 | 0.0314 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0369 | 0.3863 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 0.3029 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.1332 | 0.3399 |
Echinococcus granulosus | expressed conserved protein | 0.0101 | 0.0677 | 0.1753 |
Leishmania major | mitochondrial DNA polymerase beta | 0.033 | 0.3396 | 0.8155 |
Loa Loa (eye worm) | Ulp1 protease | 0.0101 | 0.0673 | 0.8926 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0046 | 0.0025 | 0.0065 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0101 | 0.0673 | 0.5567 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.119 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0154 | 0.1303 | 0.1303 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0101 | 0.0673 | 0.1743 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0005 | 0.0014 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.0037 | 0.0096 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0189 | 0.1728 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.0037 | 0.0096 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0107 | 0.0754 | 0.1953 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.421 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.833 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.54 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.526 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.434 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.109 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.102 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.012 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.942 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.