Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0063 | 0.0127 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0033 | 0.1956 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0043 | 0.003 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1949 | 0.3982 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.0203 | 0.0198 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0077 | 0.0117 | 0.0112 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.0178 | 0.0174 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0077 | 0.0117 | 0.0261 |
Trypanosoma brucei | glucose transporter 2A | 0.0037 | 0.0034 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0029 | 0.0018 | 0.0423 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0043 | 0.0075 |
Echinococcus multilocularis | transcription factor btf3 | 0.0034 | 0.003 | 0.002 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4863 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4863 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Echinococcus granulosus | geminin | 0.0544 | 0.1082 | 0.1074 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0066 | 0.0057 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.003 | 0.1598 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0045 | 0.004 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0043 | 0.0075 |
Plasmodium vivax | hexose transporter | 0.0118 | 0.0203 | 0.0478 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0077 | 0.0117 | 0.5617 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0051 | 0.0063 | 0.0159 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0077 | 0.0117 | 0.5617 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.0178 | 0.0174 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0043 | 0.0107 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0055 | 0.0138 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0054 |
Plasmodium vivax | CDK-related protein kinase 6, putative | 0.0502 | 0.0996 | 0.2475 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0345 | 0.0672 | 0.0663 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.0203 | 0.0198 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0043 | 0.0038 |
Echinococcus granulosus | transcription factor btf3 | 0.0034 | 0.003 | 0.002 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0029 | 0.0018 | 0.0044 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.026 | 0.0496 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0544 | 0.1082 | 0.1078 |
Trichomonas vaginalis | sugar transporter, putative | 0.0037 | 0.0034 | 0.1423 |
Trypanosoma cruzi | hexose transporter, putative | 0.0037 | 0.0034 | 0.0086 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0043 | 0.0038 |
Echinococcus multilocularis | zinc finger protein | 0.0025 | 0.001 | 0.0001 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0018 | 0.0565 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.0178 | 0.0174 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0038 | 0.0063 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.0178 | 0.0174 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0458 | 0.0904 | 0.0896 |
Echinococcus granulosus | dihydrofolate reductase | 0.4863 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1949 | 0.3982 | 1 |
Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0036 | 0.0033 | 0.0051 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1949 | 0.3982 | 1 |
Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0036 | 0.0033 | 0.0051 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1949 | 0.3982 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 0.1365 | 0.1357 |
Onchocerca volvulus | 0.0052 | 0.0066 | 0.1383 | |
Plasmodium falciparum | hexose transporter | 0.0118 | 0.0203 | 0.0478 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0043 | 0.0038 |
Loa Loa (eye worm) | ICD-1 protein | 0.0034 | 0.003 | 0.0024 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.0435 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0018 | 0.0012 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.0245 | 0.0236 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0081 | 0.0072 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0029 | 0.0018 | 0.0011 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4863 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0032 | 0.0027 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0036 | 0.0033 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0035 | 0.0032 | 0.0019 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0018 | 0.0565 |
Echinococcus granulosus | zinc finger protein | 0.0025 | 0.001 | 0.0001 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1949 | 0.3982 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0043 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Trypanosoma cruzi | hexose transporter, putative | 0.0037 | 0.0034 | 0.0086 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0055 | 0.0105 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0055 | 0.0105 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0206 | 0.0383 | 0.0374 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.003 | 0.0075 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.0435 | 0.0423 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0043 | 0.0038 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.0033 | 0.1956 |
Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0035 | 0.0032 | 0.0027 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0036 | 0.0033 | 0.1374 |
Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0041 | 0.0044 | 0.0078 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.0203 | 0.0198 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.0178 | 0.0174 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.0259 | 0.0246 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.004 | 0.003 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0081 | 0.0076 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0345 | 0.0672 | 0.0663 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0051 | 0.0063 | 0.0127 |
Trypanosoma cruzi | hexose transporter, putative | 0.0037 | 0.0034 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Schistosoma mansoni | protein kinase | 0.0036 | 0.0033 | 0.0028 |
Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0191 | 0.0353 | 0.0857 |
Echinococcus granulosus | General substrate transporter | 0.0102 | 0.0169 | 0.0159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.003 | 0.1185 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0034 | 0.1423 |
Leishmania major | glycosyl hydrolase-like protein | 0.0029 | 0.0018 | 0.0011 |
Brugia malayi | isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.005 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0077 | 0.0117 | 0.5617 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0055 | 0.0105 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0054 |
Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0036 | 0.0033 | 0.0051 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 0.0235 | 0.6167 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0055 | 0.0105 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4863 | 1 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0066 | 0.1383 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0035 | 0.0032 | 0.0019 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0058 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0043 | 0.185 |
Schistosoma mansoni | alpha-glucosidase | 0.0297 | 0.0572 | 0.0567 |
Leishmania major | protein kinase, putative | 0.0036 | 0.0033 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0036 | 0.0033 | 0.0051 |
Echinococcus multilocularis | General substrate transporter | 0.0102 | 0.0169 | 0.0159 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0077 | 0.0117 | 0.5617 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0077 | 0.0117 | 0.5617 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0077 | 0.0117 | 0.0107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0117 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0033 | 0.0028 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0051 | 0.0063 | 0.0054 |
Trichomonas vaginalis | glucose transporter, putative | 0.0037 | 0.0034 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0013 | 0.0008 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.0178 | 0.0174 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 0.1365 | 0.1361 |
Trichomonas vaginalis | glucose transporter, putative | 0.0037 | 0.0034 | 0.1423 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0055 | 0.005 |
Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0036 | 0.0033 | 0.0051 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0681 | 0.1365 | 0.1357 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0018 | 0.0565 |
Leishmania major | glucose transporter, lmgt1 | 0.0037 | 0.0034 | 0.0054 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0206 | 0.0383 | 0.0374 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0037 | 0.0034 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0118 | 0.0113 |
Schistosoma mansoni | glucose transport protein | 0.0118 | 0.0203 | 0.0198 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0036 | 0.0033 | 0.0028 |
Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0026 | 0.0013 | 0.0342 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0052 | 0.0039 |
Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0035 | 0.0032 | 0.1297 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0066 | 0.0057 |
Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0191 | 0.0353 | 0.0857 |
Plasmodium vivax | proline--tRNA ligase, putative | 0.0041 | 0.0044 | 0.0078 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4863 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0043 | 0.003 |
Schistosoma mansoni | transcription factor btf3 | 0.0034 | 0.003 | 0.0024 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0051 | 0.0094 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0077 | 0.0117 | 0.5617 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Echinococcus granulosus | lysyl tRNA synthetase | 0.0026 | 0.0013 | 0.0004 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.0178 | 0.0174 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.0203 | 0.0198 |
Brugia malayi | beta-NAC-like protein | 0.0034 | 0.003 | 0.0017 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0066 | 0.0057 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0055 | 0.0042 |
Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0035 | 0.0032 | 0.0027 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0043 | 0.003 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0345 | 0.0672 | 0.0663 |
Echinococcus multilocularis | calcium dependent protein kinase | 0.0034 | 0.0029 | 0.0019 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0054 |
Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0035 | 0.0032 | 0.0027 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0036 | 0.0033 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0032 | 0.0027 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0062 | 0.0057 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0081 | 0.0072 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0026 | 0.0013 | 0.0008 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0034 | 0.003 | 0.0042 |
Echinococcus granulosus | calcium dependent protein kinase | 0.0034 | 0.0029 | 0.0019 |
Plasmodium falciparum | protein kinase 7 | 0.0334 | 0.0649 | 0.1602 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0026 | 0.0013 | 0.0008 |
Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0035 | 0.0032 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.0203 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0043 | 0.0038 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.004 | 0.003 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0036 | 0.0033 | 0.0051 |
Schistosoma mansoni | glucose transport protein | 0.0118 | 0.0203 | 0.0198 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0023 | 0.0006 | 0.0001 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0051 | 0.225 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0055 | 0.0042 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0029 | 0.0018 | 0.0044 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0018 | 0.0565 |
Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0026 | 0.0013 | 0.0033 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0043 | 0.0038 |
Brugia malayi | Dihydrofolate reductase | 0.4863 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.4863 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0043 | 0.003 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0077 | 0.0117 | 0.5617 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0066 | 0.0061 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0018 | 0.0565 |
Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0036 | 0.0033 | 0.0051 |
Leishmania major | glucose transporter, lmgt3 | 0.0037 | 0.0034 | 0.0054 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0077 | 0.0117 | 0.0107 |
Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0041 | 0.0044 | 0.0111 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.001 | 0.0004 |
Schistosoma mansoni | zinc finger protein | 0.0025 | 0.001 | 0.0005 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0043 | 0.185 |
Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0041 | 0.0044 | 0.0078 |
Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0036 | 0.0033 | 0.0051 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0043 | 0.0038 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0043 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.003 | 0.1185 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0055 | 0.0105 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.003 | 0.0075 |
Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0026 | 0.0013 | 0.0008 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0043 | 0.003 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0081 | 0.0076 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0081 | 0.0072 |
Trypanosoma brucei | glucose transporter 1E | 0.0037 | 0.0034 | 0.0054 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.0109 | 0.0104 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0118 | 0.0203 | 0.0478 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0058 |
Brugia malayi | Isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0034 | 0.1423 |
Leishmania major | glucose transporter, lmgt2 | 0.0037 | 0.0034 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0544 | 0.1082 | 0.1078 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0022 | 0.0009 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0345 | 0.0672 | 0.0659 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0127 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0066 | 0.0061 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0081 | 0.0072 |
Trichomonas vaginalis | sugar transporter, putative | 0.0037 | 0.0034 | 0.1423 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0063 | 0.0127 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0043 | 0.0038 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0055 | 0.0105 |
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 0.0235 | 0.6167 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0034 | 0.003 | 0.1598 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0235 | 0.023 |
Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0036 | 0.0033 | 0.0051 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Schistosoma mansoni | alpha-glucosidase | 0.0297 | 0.0572 | 0.0567 |
Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0036 | 0.0033 | 0.0028 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.0259 | 0.0249 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0055 | 0.0105 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0043 | 0.003 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0043 | 0.0075 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0043 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0058 | 0.0053 |
Schistosoma mansoni | alpha glucosidase | 0.0077 | 0.0117 | 0.0112 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0127 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0066 | 0.0053 |
Echinococcus granulosus | neuropeptide s receptor | 0.0458 | 0.0904 | 0.0896 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0018 | 0.0565 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0055 | 0.005 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0051 | 0.0063 | 0.0127 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0043 | 0.185 |
Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0041 | 0.0044 | 0.0078 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0051 | 0.0094 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Echinococcus multilocularis | geminin | 0.0544 | 0.1082 | 0.1074 |
Brugia malayi | hypothetical protein | 0.0134 | 0.0235 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0235 | 0.023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0036 | 0.0033 | 0.0028 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0077 | 0.0117 | 0.0104 |
Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0035 | 0.0032 | 0.181 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0043 | 0.003 |
Trichomonas vaginalis | sugar transporter, putative | 0.0037 | 0.0034 | 0.1423 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0043 | 0.0075 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0034 | 0.003 | 0.0042 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0036 | 0.0033 | 0.0051 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0101 | 0.0091 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0077 | 0.0117 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0345 | 0.0672 | 0.0667 |
Schistosoma mansoni | protein kinase | 0.0036 | 0.0033 | 0.0028 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0029 | 0.0018 | 0.0565 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0081 | 0.0068 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0055 | 0.0045 |
Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0041 | 0.0044 | 0.0111 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0043 | 0.185 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0055 | 0.005 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0043 | 0.0038 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0043 | 0.003 |
Brugia malayi | Cam kinase protein 1 | 0.0036 | 0.0033 | 0.002 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0043 | 0.0038 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0077 | 0.0117 | 0.5617 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0101 | 0.0091 |
Trypanosoma cruzi | hexose transporter | 0.0037 | 0.0034 | 0.0086 |
Toxoplasma gondii | NAC domain-containing protein | 0.0034 | 0.003 | 0.0042 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0051 | 0.0094 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0051 | 0.0063 | 0.0058 |
Onchocerca volvulus | 0.0041 | 0.0043 | 0.0714 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0117 | 0.0293 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0063 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.0614 | 0.0609 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0038 | 1 |
Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0191 | 0.0353 | 0.0857 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0066 | 0.0061 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4863 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0118 | 0.0203 | 0.0198 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0043 | 0.0107 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0066 | 0.0057 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0051 | 0.0041 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0203 | 0.0198 |
Onchocerca volvulus | 0.02 | 0.0371 | 1 | |
Trypanosoma brucei | glucosidase, putative | 0.0077 | 0.0117 | 0.0261 |
Schistosoma mansoni | protein kinase | 0.0036 | 0.0033 | 0.0028 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0066 | 0.0061 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0034 | 0.003 | 0.0042 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0458 | 0.0904 | 0.0896 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0036 | 0.0033 | 0.0051 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0018 | 0.0565 |
Onchocerca volvulus | 0.0041 | 0.0043 | 0.0714 | |
Leishmania major | alpha glucosidase II subunit, putative | 0.0077 | 0.0117 | 0.0261 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0118 | 0.0203 | 0.0194 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0077 | 0.0117 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0043 | 0.0038 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0051 | 0.225 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0043 | 0.0038 |
Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0036 | 0.0033 | 0.0051 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0043 | 0.185 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0018 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.003 | 0.1185 |
Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0035 | 0.0032 | 0.0022 |
Plasmodium falciparum | protein kinase 6 | 0.0502 | 0.0996 | 0.2475 |
Giardia lamblia | Prolyl-tRNA synthetase | 0.0035 | 0.0032 | 0.7528 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0036 | 0.0033 | 0.002 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0063 | 0.0159 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0029 | 0.0018 | 0.0004 |
Onchocerca volvulus | 0.0041 | 0.0043 | 0.0714 | |
Plasmodium falciparum | proline--tRNA ligase | 0.0041 | 0.0044 | 0.0078 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0051 | 0.0063 | 0.0127 |
Toxoplasma gondii | protein kinase, putative | 0.0334 | 0.0649 | 0.1602 |
Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0041 | 0.0044 | 0.0078 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.0259 | 0.0254 |
Trypanosoma brucei | glucose transporter, putative | 0.0037 | 0.0034 | 0.0054 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0055 | 0.0045 |
Loa Loa (eye worm) | sugar transporter | 0.0118 | 0.0203 | 0.0198 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.0135 | 0.0122 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0066 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0043 | 0.0038 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0066 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0081 | 0.0076 |
Echinococcus multilocularis | lysyl tRNA synthetase | 0.0026 | 0.0013 | 0.0004 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0038 | 0.2404 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0036 | 0.0033 | 0.0024 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0043 | 0.0038 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1949 | 0.3982 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0043 | 0.0038 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0043 | 0.185 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0458 | 0.0904 | 0.0896 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0077 | 0.0117 | 0.5617 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0043 | 0.0033 |
Leishmania major | basic transcription factor 3a, putative | 0.0034 | 0.003 | 0.0042 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.0259 | 0.0254 |
Brugia malayi | Sugar transporter family protein | 0.0118 | 0.0203 | 0.019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 13 mg kg-1 | Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice | ChEMBL. | 6471069 |
IC50 (functional) | = 0.78 uM | In vitro inhibition of 5-HT uptake in rat brain synaptosomes using [3H]- 5-hydroxytryptamine | ChEMBL. | 6471069 |
IC50 (functional) | = 1.1 uM | In vitro inhibition of norepinephrine uptake in rat brain synaptosomes using [3H]-NE | ChEMBL. | 6471069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.