Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0226 | 0.425 | 0.5 |
Echinococcus granulosus | fibropellin Ia | 0.0149 | 0.2391 | 0.2391 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0226 | 0.425 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0361 | 0.0361 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0463 | 1 | 1 | |
Schistosoma mansoni | polycystin 1-related | 0.0066 | 0.0361 | 0.0361 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.021 | 0.3859 | 0.3859 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0066 | 0.0361 | 0.031 | |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Animal haem peroxidase family protein | 0.0463 | 1 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.0232 | 0.0232 |
Schistosoma mansoni | lipoxygenase | 0.0135 | 0.2043 | 0.2043 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0361 | 0.0361 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.0053 | 0.0053 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.0232 | 0.0232 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | notch protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | RUN | 0.0066 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0149 | 0.2391 | 0.5 |
Echinococcus granulosus | protein jagged 1 | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.1998 | 0.1998 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | hypothetical protein | 0.0226 | 0.425 | 0.425 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0463 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0232 | 0.0232 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | peroxidasin | 0.0463 | 1 | 1 |
Onchocerca volvulus | 0.0066 | 0.0361 | 0.031 | |
Echinococcus multilocularis | fibropellin Ia | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0066 | 0.0361 | 0.0361 |
Onchocerca volvulus | 0.0149 | 0.2391 | 0.235 | |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.425 | 0.5 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0226 | 0.425 | 0.5 |
Brugia malayi | Muscle positioning protein 4 | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | slit 2 protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0463 | 1 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus multilocularis | notch | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0463 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0226 | 0.425 | 0.425 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | doublecortin family protein | 0.0066 | 0.0361 | 0.0361 |
Schistosoma mansoni | septate junction protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.0232 | 0.0232 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0149 | 0.2391 | 0.235 | |
Echinococcus granulosus | notch | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | Peroxidasin homolog | 0.0463 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | RUN | 0.0066 | 0.0361 | 0.0361 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Animal haem peroxidase family protein | 0.0463 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0066 | 0.0361 | 0.0361 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0226 | 0.425 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | protein jagged 1 | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | lipoxygenase | 0.013 | 0.192 | 0.192 |
Echinococcus granulosus | delta-like protein 1 | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0149 | 0.2391 | 0.235 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.0053 | 0.0053 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Animal haem peroxidase family protein | 0.0463 | 1 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0226 | 0.425 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0463 | 1 | 1 |
Echinococcus granulosus | neural cadherin | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | neural cadherin | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0066 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | Notch2 | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0463 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0463 | 1 | 1 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0066 | 0.0361 | 0.0361 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | notch | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.1998 | 0.1998 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus granulosus | peroxidasin | 0.0463 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0066 | 0.0361 | 0.0361 |
Onchocerca volvulus | 0.0149 | 0.2391 | 0.235 | |
Onchocerca volvulus | Peroxidase homolog | 0.0463 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0463 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | protein jagged 2 | 0.0149 | 0.2391 | 0.2391 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | cell polarity protein | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | 0.0149 | 0.2391 | 0.235 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0463 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | Animal haem peroxidase family protein | 0.0463 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0463 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | Peroxidasin homolog | 0.0463 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0463 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0463 | 1 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | Slit protein homolog | 0.0149 | 0.2391 | 0.235 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0226 | 0.425 | 0.425 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0066 | 0.0361 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0463 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.021 | 0.3859 | 0.3859 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0226 | 0.425 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0226 | 0.425 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Brugia malayi | Doublecortin family protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.0053 | 0.0053 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0226 | 0.425 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 0.192 | 0.192 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0149 | 0.2391 | 0.2391 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0361 | 0.0361 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.013 | 0.192 | 0.192 |
Echinococcus granulosus | protein jagged 2 | 0.0149 | 0.2391 | 0.2391 |
Giardia lamblia | Rrm3p helicase | 0.0226 | 0.425 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0324 | 0.6626 | 0.6626 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0463 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.1998 | 0.1998 |
Onchocerca volvulus | Putative cubilin | 0.0149 | 0.2391 | 0.235 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.0053 | 0.0053 |
Schistosoma mansoni | rab6-interacting | 0.0066 | 0.0361 | 0.0361 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0226 | 0.425 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.2391 | 0.235 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0066 | 0.0361 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2391 | 0.2391 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0149 | 0.2391 | 0.2391 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0149 | 0.2391 | 0.235 |
Schistosoma mansoni | slit | 0.0149 | 0.2391 | 0.2391 |
Schistosoma mansoni | loxhd1 | 0.0066 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0463 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.