Detailed information for compound 1628735

Basic information

Technical information
  • TDR Targets ID: 1628735
  • Name: N-(3-chloro-5-methyl-9H-xanthen-9-yl)-3-[4-(2 -hydroxyethyl)piperazin-1-yl]propanamide
  • MW: 429.94 | Formula: C23H28ClN3O3
  • H donors: 2 H acceptors: 2 LogP: 2.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)CCC(=O)NC1c2ccc(cc2Oc2c1cccc2C)Cl
  • InChi: 1S/C23H28ClN3O3/c1-16-3-2-4-19-22(18-6-5-17(24)15-20(18)30-23(16)19)25-21(29)7-8-26-9-11-27(12-10-26)13-14-28/h2-6,15,22,28H,7-14H2,1H3,(H,25,29)
  • InChiKey: PLXNZYLEZNYLHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chloro-5-methyl-9H-xanthen-9-yl)-3-[4-(2-hydroxyethyl)-1-piperazinyl]propanamide
  • N-(3-chloro-5-methyl-9H-xanthen-9-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propionamide
  • NCI60_019507
  • AIDS-141268
  • AIDS141268
  • N-(3-Chloro-5-methyl-9H-xanthen-9-yl)-3-(4-(2-hydroxyethyl)-1-piperazinyl)propanamide
  • NSC656354

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine threonine protein kinase 0.006 0.3034 0.4527
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.006 0.006
Echinococcus granulosus myotubularin protein 13 0.0009 0.016 0.0238
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0238
Echinococcus multilocularis serine:threonine protein kinase 38 0.006 0.3034 0.4527
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Loa Loa (eye worm) PH domain-containing protein 0.0009 0.016 0.016
Echinococcus granulosus cytohesin 1 0.0009 0.016 0.0238
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0009 0.016 0.016
Echinococcus granulosus serine threonine protein kinase nrc 0.0116 0.6202 0.9257
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Schistosoma mansoni centaurin alpha 0.0009 0.016 0.0238
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.006 0.3034 0.4527
Echinococcus multilocularis oxysterol binding protein 3 0.0009 0.016 0.0238
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0009 0.016 0.01
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Trypanosoma brucei rac serine-threonine kinase, putative 0.0183 1 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.006 0.3034 0.4527
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Schistosoma mansoni rho gtpase activating protein 0.0009 0.016 0.0238
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.001 0.0232 0.0111
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0009 0.016 0.01
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0009 0.016 0.0238
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.006 0.3034 0.4527
Leishmania major protein kinase, putative 0.001 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Plasmodium falciparum oxysterol-binding protein, putative 0.0009 0.016 0.0257
Schistosoma mansoni goodpasture antigen-binding protein 0.0009 0.016 0.0238
Echinococcus granulosus serine:threonine protein kinase N2 0.006 0.3034 0.4527
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.6701 1
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.016 0.016
Echinococcus multilocularis myotubularin protein 13 0.0009 0.016 0.0238
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.1542 0.1491
Brugia malayi Variant SH3 domain containing protein 0.0009 0.016 0.016
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.001 0.0232 0.0074
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.006 0.0089
Onchocerca volvulus 0.0009 0.016 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.006 0.0089
Entamoeba histolytica protein kinase, putative 0.0174 0.9502 0.9494
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Leishmania major protein kinase, putative 0.001 0.0232 1
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Brugia malayi Oxysterol-binding protein 0.0009 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Echinococcus granulosus protein kinase C gamma type 0.006 0.3034 0.4527
Onchocerca volvulus Protein melted homolog 0.0009 0.016 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.001 0.0232 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.001 0.0232 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.1859 0.2775
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Toxoplasma gondii AtPH1 family protein 0.0009 0.016 0.0168
Trichomonas vaginalis AGC family protein kinase 0.0069 0.3532 0.3493
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0245 0.0365
Schistosoma mansoni goodpasture antigen-binding protein 0.0009 0.016 0.0238
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.006 0.0089
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0232 0.0074
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0115 0.613 0.9148
Echinococcus multilocularis oxysterol binding protein 9 0.0009 0.016 0.0238
Echinococcus multilocularis cytohesin 1 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Echinococcus multilocularis Oxysterol binding protein 11 0.0009 0.016 0.0238
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.016 0.0257
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.1675 0.1675
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.006 0.0089
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0238
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0058 0.2961 0.2919
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Schistosoma mansoni vav2 0.0009 0.016 0.0238
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.006 0.006
Schistosoma mansoni atypical protein kinase C 0.006 0.3034 0.4527
Brugia malayi Protein kinase domain containing protein 0.006 0.3034 0.3034
Schistosoma mansoni dynamin 0.0009 0.016 0.0238
Echinococcus granulosus dynamin 1 0.0009 0.016 0.0238
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.006 0.0089
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0116 0.6202 1
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0009 0.016 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Trichomonas vaginalis protein transport protein sec7, putative 0.0009 0.016 0.01
Entamoeba histolytica protein kinase, putative 0.001 0.0232 0.0074
Brugia malayi hypothetical protein 0.0009 0.016 0.016
Entamoeba histolytica protein kinase, putative 0.006 0.3034 0.2921
Schistosoma mansoni zinc finger protein 0.0009 0.016 0.0238
Brugia malayi protein kinase C II. 0.006 0.3034 0.3034
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0009 0.016 0.0238
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0116 0.6202 0.9257
Brugia malayi TBC domain containing protein 0.0009 0.016 0.016
Plasmodium falciparum calcium-dependent protein kinase 7 0.001 0.0232 0.0375
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Echinococcus granulosus nervana 2 0.0115 0.613 0.9148
Entamoeba histolytica protein kinase, putative 0.001 0.0232 0.0074
Echinococcus granulosus nervana 2 0.0115 0.613 0.9148
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.001 0.0232 0.0174
Loa Loa (eye worm) cytohesin 3 0.0009 0.016 0.016
Echinococcus multilocularis pleckstrin y domain containing family A 0.0009 0.016 0.0238
Trichomonas vaginalis centaurin/arf, putative 0.0009 0.016 0.01
Echinococcus granulosus protein kinase c iota type 0.006 0.3034 0.4527
Brugia malayi Uncoordinated protein 104 0.0009 0.016 0.016
Echinococcus granulosus calcium dependent secretion activator 1 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Onchocerca volvulus 0.0009 0.016 0.5
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.006 0.3034 0.3034
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.006 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Trichomonas vaginalis protein transport protein sec7, putative 0.0009 0.016 0.01
Entamoeba histolytica protein kinase, putative 0.0183 1 1
Onchocerca volvulus Putative zinc finger protein 0.0009 0.016 0.5
Trypanosoma cruzi NIMA-related kinase, putative 0.001 0.0232 0.0111
Onchocerca volvulus 0.0009 0.016 0.5
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Onchocerca volvulus 0.0009 0.016 0.5
Echinococcus granulosus Rho GTPase activating protein 24 0.0009 0.016 0.0238
Brugia malayi p70 ribosomal S6 kinase beta 0.0174 0.9502 0.9502
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0009 0.016 0.5
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0009 0.016 0.0238
Echinococcus multilocularis beta 1 syntrophin 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.006 0.3034 0.4527
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.001 0.0232 0.012
Onchocerca volvulus 0.0009 0.016 0.5
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.006 0.3034 0.4527
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trypanosoma brucei protein kinase, putative 0.001 0.0232 0.0074
Echinococcus multilocularis rac serine:threonine kinase 0.0125 0.6701 1
Echinococcus multilocularis Pleckstrin y 0.0009 0.016 0.0238
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0245 0.0365
Loa Loa (eye worm) AGC/PKN protein kinase 0.006 0.3034 0.3034
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0009 0.016 0.01
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0116 0.6202 0.9238
Loa Loa (eye worm) AGC/AKT protein kinase 0.0183 1 1
Leishmania major serine/threonine-protein kinase a, putative 0.001 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.1542 0.1491
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Plasmodium falciparum PH domain-containing protein, putative 0.0009 0.016 0.0257
Echinococcus multilocularis Pleckstrin y 0.0009 0.016 0.0238
Loa Loa (eye worm) Plekhf2 protein 0.0009 0.016 0.016
Leishmania major hypothetical protein, conserved 0.0009 0.016 0.6869
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0009 0.016 0.0238
Echinococcus granulosus voltage gated potassium channel 0.001 0.0245 0.0365
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0232 0.0074
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0116 0.6202 1
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.001 0.0232 0.0111
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.6701 0.6647
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0009 0.016 0.01
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Toxoplasma gondii hypothetical protein 0.0009 0.016 0.0168
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.006 0.006
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0125 0.6701 1
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0009 0.016 0.0238
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0009 0.016 0.0238
Echinococcus granulosus Pleckstrin y 0.0009 0.016 0.0238
Entamoeba histolytica protein kinase, putative 0.001 0.0232 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Brugia malayi Dynamin 0.0009 0.016 0.016
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.001 0.0232 0.0111
Toxoplasma gondii protein kinase domain-containing protein 0.001 0.0232 0.0244
Brugia malayi Syntrophin-1 0.0009 0.016 0.016
Schistosoma mansoni myotubularin-related protein 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Echinococcus multilocularis Glutaredoxin protein 5 0.0115 0.613 0.9148
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0009 0.016 0.0238
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0238
Trichomonas vaginalis hypothetical protein 0.0009 0.016 0.01
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0009 0.016 0.0238
Loa Loa (eye worm) uncoordinated protein 104 0.0009 0.016 0.016
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0116 0.6202 0.9257
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.001 0.0232 0.0111
Brugia malayi Dynamin 0.0009 0.016 0.016
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.006 0.0089
Trichomonas vaginalis AGC family protein kinase 0.006 0.3034 0.2992
Brugia malayi Protein kinase domain containing protein 0.006 0.3034 0.3034
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Toxoplasma gondii phosphatidylinositol transfer protein 0.0009 0.016 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Schistosoma mansoni oxysterol-binding protein 1 0.0009 0.016 0.0238
Brugia malayi Pleckstrin Homology Domain 0.0009 0.016 0.016
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.001 0.0232 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trichomonas vaginalis centaurin beta, putative 0.0009 0.016 0.01
Echinococcus granulosus oxysterol binding protein 1 0.0009 0.016 0.0238
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0009 0.016 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Giardia lamblia Kinase, AGC PKA 0.0116 0.6202 0.5
Echinococcus granulosus Glutaredoxin protein 5 0.0115 0.613 0.9148
Brugia malayi Hr1 repeat family protein 0.006 0.3034 0.3034
Trichomonas vaginalis kinesin light chain, putative 0.0009 0.016 0.01
Brugia malayi Plekhf2 protein 0.0009 0.016 0.016
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0009 0.016 0.016
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.6701 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0232 0.0074
Brugia malayi MAX-1A 0.0009 0.016 0.016
Entamoeba histolytica p21-activated kinase 0.001 0.0232 0.0074
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0174 0.9502 0.9502
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0009 0.016 0.5
Entamoeba histolytica protein kinase, putative 0.001 0.0232 0.0074
Echinococcus multilocularis GRB2 associated binding protein 3 0.0009 0.016 0.0238
Entamoeba histolytica protein kinase, putative 0.0183 1 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.006 0.3034 0.3034
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.1675 0.2499
Echinococcus multilocularis calcium dependent secretion activator 1 0.0009 0.016 0.0238
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.006 0.0089
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.006 0.0089
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0009 0.016 0.0238
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.006 0.0089
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.6701 0.6647
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0238
Schistosoma mansoni zinc finger protein 0.0009 0.016 0.0238
Echinococcus multilocularis serine:threonine protein kinase N2 0.006 0.3034 0.4527
Loa Loa (eye worm) AGC/NDR protein kinase 0.006 0.3034 0.3034
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.006 0.0089
Echinococcus multilocularis protein kinase c epsilon type 0.006 0.3034 0.4527
Onchocerca volvulus 0.0009 0.016 0.5
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.001 0.0232 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Toxoplasma gondii hypothetical protein 0.0009 0.016 0.0168
Brugia malayi Cadps2 protein 0.0009 0.016 0.016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.1675 0.1675
Loa Loa (eye worm) hypothetical protein 0.0007 0.006 0.006
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.001 0.0232 0.0174
Loa Loa (eye worm) rho-GTPase-activating 0.0009 0.016 0.016
Entamoeba histolytica hypothetical protein 0.001 0.0232 0.0074
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.001 0.0232 0.0244
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0009 0.016 0.01
Loa Loa (eye worm) oxysterol binding protein 0.0009 0.016 0.016
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0245 0.0365
Echinococcus multilocularis Protein kinase C, brain isozyme 0.006 0.3034 0.4527
Schistosoma mansoni serine/threonine kinase 0.006 0.3034 0.4527
Onchocerca volvulus 0.0009 0.016 0.5
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0232 0.0074
Echinococcus multilocularis protein kinase c iota type 0.006 0.3034 0.4527
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.016 0.0257
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0238
Brugia malayi Variant SH3 domain containing protein 0.0009 0.016 0.016
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Trichomonas vaginalis AGC family protein kinase 0.006 0.3034 0.2992
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trichomonas vaginalis AGC family protein kinase 0.006 0.3034 0.2992
Echinococcus multilocularis dynamin 1 0.0009 0.016 0.0238
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.006 0.3034 0.4527
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.006 0.0089
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.006 0.0089
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.016 0.0238
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0009 0.016 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Trypanosoma cruzi NIMA-related kinase, putative 0.001 0.0232 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Leishmania major hypothetical protein, conserved 0.0009 0.016 0.6869
Loa Loa (eye worm) hypothetical protein 0.0031 0.1409 0.1409
Echinococcus granulosus oxysterol binding protein 3 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.001 0.0232 1
Trypanosoma cruzi serine/threonine protein kinase, putative 0.001 0.0232 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Echinococcus multilocularis Ras associated and pleckstrin y 0.0009 0.016 0.0238
Echinococcus granulosus GRB2 associated binding protein 3 0.0009 0.016 0.0238
Echinococcus granulosus NDR protein kinase 0.006 0.3034 0.4527
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.001 0.0232 0.0074
Echinococcus granulosus serine/threonine protein kinase 0.0125 0.6701 1
Trichomonas vaginalis AGC family protein kinase 0.0183 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.006 0.3034 0.3034
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0009 0.016 0.0238
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0245 0.0365
Toxoplasma gondii AGC kinase 0.0174 0.9502 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0009 0.016 0.0238
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0009 0.016 0.0257
Echinococcus granulosus Pleckstrin y 0.0009 0.016 0.0238
Echinococcus multilocularis Rho GTPase activating protein 24 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.3034 0.3034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.006 0.0089
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0245 0.0365
Brugia malayi Cytohesin 3 0.0009 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Echinococcus granulosus Protein kinase C brain isozyme 0.006 0.3034 0.4527
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0009 0.016 0.016
Trypanosoma cruzi Protein kinase B 0.0125 0.6701 1
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Leishmania major folate/biopterin transporter, putative 0.001 0.0232 1
Echinococcus granulosus Oxysterol binding protein 11 0.0009 0.016 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.1859 0.2775
Toxoplasma gondii Oxysterol-binding protein 0.0009 0.016 0.0168
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0009 0.016 0.0238
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0009 0.016 0.0238
Schistosoma mansoni serine/threonine protein kinase 0.006 0.3034 0.4527
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0009 0.016 0.016
Entamoeba histolytica protein kinase 2, putative 0.0116 0.6202 0.6141
Entamoeba histolytica hypothetical protein 0.001 0.0232 0.0074
Echinococcus multilocularis Pleckstrin y 0.0009 0.016 0.0238
Trichomonas vaginalis centaurin gamma, putative 0.0009 0.016 0.01
Echinococcus granulosus pleckstrin y domain containing family A 0.0009 0.016 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.006 0.0089
Onchocerca volvulus outspread protein homolog 0.0009 0.016 0.5
Echinococcus multilocularis nervana 2 0.0115 0.613 0.9148
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0009 0.016 0.01
Brugia malayi PH domain containing protein 0.0009 0.016 0.016
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0009 0.016 0.016
Schistosoma mansoni syntrophin 0.0009 0.016 0.0238
Schistosoma mansoni dynamin 0.0009 0.016 0.0238
Echinococcus granulosus pdz domain containing protein 0.0009 0.016 0.0238
Schistosoma mansoni oxysterol-binding protein 1 0.0009 0.016 0.0238
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.016
Echinococcus granulosus DCC interacting protein 13 beta 0.0009 0.016 0.0238
Loa Loa (eye worm) hypothetical protein 0.001 0.0245 0.0245
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0115 0.613 0.9148
Trichomonas vaginalis alpha chimerin, putative 0.0009 0.016 0.01
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trichomonas vaginalis centaurin/arf, putative 0.0009 0.016 0.01
Echinococcus multilocularis pdz domain containing protein 0.0009 0.016 0.0238
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0009 0.016 0.0238
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.006 0.0089
Echinococcus multilocularis nervana 2 0.0115 0.613 0.9148
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.006 0.3034 0.3034
Echinococcus multilocularis oxysterol binding protein 1 0.0009 0.016 0.0238
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Brugia malayi Oxysterol binding protein 0.0009 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.016 0.01
Echinococcus granulosus Pleckstrin y 0.0009 0.016 0.0238
Echinococcus granulosus beta 1 syntrophin 0.0009 0.016 0.0238
Echinococcus granulosus oxysterol binding protein 9 0.0009 0.016 0.0238
Echinococcus granulosus protein kinase c epsilon type 0.006 0.3034 0.4527
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.1675 0.2499
Trichomonas vaginalis AGC family protein kinase 0.001 0.0232 0.0174
Echinococcus multilocularis DCC interacting protein 13 beta 0.0009 0.016 0.0238
Brugia malayi probable spectrin beta chain 0.0009 0.016 0.016
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0245 0.0245
Trypanosoma cruzi rac serine-threonine kinase, putative 0.001 0.0232 0.0111
Loa Loa (eye worm) syntrophin-1 0.0009 0.016 0.016
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0009 0.016 0.0238
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.006 0.3034 0.4527
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0009 0.016 0.0238
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.006 0.0089
Echinococcus multilocularis actin binding protein anillin 0.0009 0.016 0.0238
Trichomonas vaginalis centaurin alpha, putative 0.0009 0.016 0.01
Entamoeba histolytica protein kinase, putative 0.001 0.0232 0.0074
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.001 0.0232 0.0074

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.372 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.024 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.971 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.893 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.883 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.853 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.825 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.637 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.566 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.