Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein kinase c iota type | 0.0352 | 0.2769 | 0.4166 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | protein kinase, putative | 0.1027 | 0.9342 | 0.9342 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0352 | 0.2769 | 0.2769 |
Echinococcus granulosus | nervana 2 | 0.0675 | 0.5915 | 0.8899 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0075 | 0.0074 | 0.0111 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0075 | 0.0074 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1374 | 0.1374 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Brugia malayi | GTP-ase activating protein for Arf containing protein | 0.0068 | 0.000000012206 | 0.000000012206 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma cruzi | serine/threonine-protein kinase NRKB, putative | 0.0075 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0682 | 0.5989 | 0.901 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0692 | 0.6079 | 0.9145 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine kinase | 0.0352 | 0.2769 | 0.4166 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0675 | 0.5915 | 0.8899 |
Leishmania major | protein kinase, putative | 0.0075 | 0.0074 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0352 | 0.2769 | 0.2769 |
Entamoeba histolytica | protein kinase, putative | 0.0352 | 0.2769 | 0.2769 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0352 | 0.2769 | 0.2769 |
Brugia malayi | Hr1 repeat family protein | 0.0352 | 0.2769 | 0.2769 |
Echinococcus granulosus | protein kinase C gamma type | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Trichomonas vaginalis | centaurin/arf, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.1094 | 1 | 1 |
Trichomonas vaginalis | ankyrin 2,3/unc44, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Echinococcus multilocularis | arf GAP with coiled coil, ANK repeat and PH | 0.0068 | 0.000000012206 | 0.000000018364 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0675 | 0.5915 | 0.8899 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.2769 | 0.2769 |
Giardia lamblia | Kinase, AGC PKA | 0.0682 | 0.5989 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0075 | 0.0074 | 0.0111 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.075 | 0.6647 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0682 | 0.5989 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0682 | 0.5989 | 0.901 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0352 | 0.2769 | 0.2769 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0075 | 0.0074 | 0.0111 |
Trypanosoma brucei | NEK family Serine/threonine-protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | protein kinase, putative | 0.1094 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0675 | 0.5915 | 0.8899 |
Onchocerca volvulus | 0.0237 | 0.1654 | 1 | |
Echinococcus multilocularis | serine threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0692 | 0.6079 | 0.9145 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.075 | 0.6647 | 0.6647 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK21, putative | 0.0075 | 0.0074 | 0.0074 |
Brugia malayi | Protein kinase domain containing protein | 0.0352 | 0.2769 | 0.2769 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0352 | 0.2769 | 0.4166 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0352 | 0.2769 | 0.4166 |
Echinococcus granulosus | serine/threonine protein kinase | 0.075 | 0.6647 | 1 |
Leishmania major | folate/biopterin transporter, putative | 0.0075 | 0.0074 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0682 | 0.5989 | 1 |
Trypanosoma brucei | serine/threonine-protein kinase NRKB, putative | 0.0075 | 0.0074 | 0.0074 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0075 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0419 | 0.3427 | 0.3427 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0075 | 0.0074 | 0.0123 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0075 | 0.0074 | 0.0123 |
Echinococcus granulosus | NDR protein kinase | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0075 | 0.0074 | 0.0111 |
Echinococcus multilocularis | nervana 2 | 0.0675 | 0.5915 | 0.8899 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | protein kinase, putative | 0.1094 | 1 | 1 |
Trypanosoma brucei | serine/threonine-protein kinase NrkA | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | ankyrin repeat-containing protein, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0344 | 0.2695 | 0.2695 |
Echinococcus granulosus | arf GAP with coiled coil ANK repeat and PH | 0.0068 | 0.000000012206 | 0.000000018364 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0352 | 0.2769 | 0.4166 |
Echinococcus granulosus | nervana 2 | 0.0675 | 0.5915 | 0.8899 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | ARF GTPase activating protein, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Entamoeba histolytica | protein kinase 2, putative | 0.0682 | 0.5989 | 0.5989 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0352 | 0.2769 | 0.2769 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1027 | 0.9342 | 0.9342 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0075 | 0.0074 | 0.0111 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0682 | 0.5989 | 0.901 |
Brugia malayi | Protein kinase domain containing protein | 0.0352 | 0.2769 | 0.2769 |
Trypanosoma brucei | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Echinococcus granulosus | protein kinase c iota type | 0.0352 | 0.2769 | 0.4166 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0352 | 0.2769 | 0.2769 |
Trichomonas vaginalis | centaurin gamma, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0075 | 0.0074 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0352 | 0.2769 | 0.4166 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.075 | 0.6647 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.075 | 0.6647 | 0.6647 |
Trichomonas vaginalis | ankyrin repeat-containing protein, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0352 | 0.2769 | 0.4166 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0352 | 0.2769 | 0.2769 |
Trichomonas vaginalis | 3-phosphoinositide dependent protein kinase-1, putative | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | ankyrin repeat and FYVE domain containing protein, putative | 0.0068 | 0.000000012206 | 0.000000012206 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0352 | 0.2769 | 0.2769 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0075 | 0.0074 | 0.0079 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0352 | 0.2769 | 0.4166 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | ribosomal protein S6 kinase, 90kD, polypeptide, putative | 0.0075 | 0.0074 | 0.0074 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1374 | 0.1374 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0352 | 0.2769 | 0.4166 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.075 | 0.6647 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.075 | 0.6647 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0352 | 0.2769 | 0.4166 |
Leishmania major | protein kinase, putative | 0.0075 | 0.0074 | 1 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0075 | 0.0074 | 1 |
Toxoplasma gondii | AGC kinase | 0.1027 | 0.9342 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0675 | 0.5915 | 0.8899 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0692 | 0.6079 | 0.9145 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0682 | 0.5989 | 0.901 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1027 | 0.9342 | 0.9342 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.1654 | 0.1654 |
Echinococcus multilocularis | nervana 2 | 0.0675 | 0.5915 | 0.8899 |
Brugia malayi | protein kinase C II. | 0.0352 | 0.2769 | 0.2769 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0352 | 0.2769 | 0.4166 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0074 | 0.0074 |
Entamoeba histolytica | p21-activated kinase | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0352 | 0.2769 | 0.2769 |
Entamoeba histolytica | protein kinase, putative | 0.0075 | 0.0074 | 0.0074 |
Trypanosoma cruzi | Protein kinase B | 0.075 | 0.6647 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0075 | 0.0074 | 0.0079 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0075 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.1094 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0075 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 0.0074 | 0.0074 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0352 | 0.2769 | 0.4166 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0075 | 0.0074 | 0.0111 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.1094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.819 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.814 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.759 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.729 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.72 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.643 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.616 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.609 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.552 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.537 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.432 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.