Detailed information for compound 162928

Basic information

Technical information
  • TDR Targets ID: 162928
  • Name: (2S)-2-amino-4-[(4-chlorophenyl)methylamino]- 1-(4-fluoropiperidin-1-yl)butan-1-one
  • MW: 327.825 | Formula: C16H23ClFN3O
  • H donors: 2 H acceptors: 1 LogP: 1.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC1CCN(CC1)C(=O)[C@H](CCNCc1ccc(cc1)Cl)N
  • InChi: 1S/C16H23ClFN3O/c17-13-3-1-12(2-4-13)11-20-8-5-15(19)16(22)21-9-6-14(18)7-10-21/h1-4,14-15,20H,5-11,19H2/t15-/m0/s1
  • InChiKey: LFKRQSSJAHOQJD-HNNXBMFYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-(4-fluoro-1-piperidyl)butan-1-one
  • (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-(4-fluoro-1-piperidinyl)-1-butanone
  • (2S)-2-azanyl-4-[(4-chlorophenyl)methylamino]-1-(4-fluoropiperidin-1-yl)butan-1-one
  • (2S)-2-amino-4-[(4-chlorobenzyl)amino]-1-(4-fluoropiperidino)butan-1-one
  • (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-(4-fluoro-1-piperidinyl)butan-1-one
  • (2S)-2-amino-4-[(4-chlorobenzyl)amino]-1-(4-fluoro-1-piperidyl)butan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Echinococcus granulosus Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Schistosoma mansoni family S28 unassigned peptidase (S28 family) Get druggable targets OG5_139351 All targets in OG5_139351
Schistosoma japonicum ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative Get druggable targets OG5_139351 All targets in OG5_139351
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi serine carboxypeptidase S28, putative dipeptidyl-peptidase 7 492 aa 471 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis serotonin receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.4814 0.6978 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2341 0.3371 1
Echinococcus multilocularis glutamate receptor 2 0.005 0.0029 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.2762 0.3985 0.571
Echinococcus granulosus g-protein coupled receptor 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.002 0.002
Loa Loa (eye worm) BEN-1 protein 0.0045 0.002 0.0029
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus multilocularis GPCR, family 2 0.0874 0.123 0.123
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0029 0.0028
Leishmania major heat shock protein, putative 0.0058 0.0039 0.0947
Echinococcus granulosus dro:myosuppressin receptor 0.0349 0.0464 0.0463
Schistosoma mansoni hypothetical protein 0.0349 0.0464 0.0463
Schistosoma mansoni biogenic amine (5HT) receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus 7TM GPCR rhodopsin 0.0349 0.0464 0.0463
Echinococcus multilocularis g protein coupled receptor 0.0349 0.0464 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0051 0.0051
Brugia malayi Dopamine receptor protein 2 0.0349 0.0464 0.0665
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.6886 1 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi beta-tubulin, identical 0.0045 0.002 0.0029
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Loa Loa (eye worm) tubulin beta chain 0.0045 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus beta tubulin 0.0045 0.002 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0349 0.0464 0.0463
Trichomonas vaginalis heat shock protein, putative 0.0086 0.0081 0.212
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.0128 0.0128
Loa Loa (eye worm) tubulin beta-1 chain 0.0045 0.002 0.0029
Schistosoma mansoni glutamate receptor NMDA 0.0281 0.0365 0.0364
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis allatostatin A receptor 0.062 0.086 0.086
Echinococcus multilocularis dna repair protein rad51 1 0.0046 0.0022 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni hypothetical protein 0.0874 0.123 0.123
Trypanosoma cruzi heat shock protein 85, putative 0.0154 0.018 0.7982
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.0046 0.0022 0.0969
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0349 0.0464 0.0463
Schistosoma mansoni biogenic amine receptor 0.0349 0.0464 0.0463
Echinococcus granulosus neuropeptide FF receptor 2 0.0349 0.0464 0.0463
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.0175 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Echinococcus multilocularis g protein coupled receptor 0.0349 0.0464 0.0463
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0038 0.0038
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0349 0.0464 0.0463
Plasmodium falciparum heat shock protein 90 0.0183 0.0222 1
Brugia malayi Dopamine receptor protein 1 0.0349 0.0464 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0038 0.0894
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.0046 0.0022 0.0235
Loa Loa (eye worm) hypothetical protein 0.062 0.086 0.1233
Echinococcus granulosus g protein coupled receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis serotonin receptor 0.0349 0.0464 0.0463
Trypanosoma cruzi heat shock protein 85, putative 0.0183 0.0222 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Brugia malayi CXXC zinc finger family protein 0.0031 0 0.0001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.008 1
Echinococcus multilocularis neuropeptide receptor 0.6886 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0349 0.0464 0.0665
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0349 0.0464 0.0463
Brugia malayi Serotonin receptor 0.0349 0.0464 0.0665
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0005 0.022
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0349 0.0464 0.0463
Echinococcus granulosus glutamate NMDA receptor subunit 0.0281 0.0365 0.0364
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Schistosoma mansoni neuropeptide receptor 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.4814 0.6978 1
Schistosoma mansoni heat shock protein 0.0058 0.0039 0.0039
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0038 0.0038
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0073 0.0073
Schistosoma mansoni opsin-like receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0349 0.0464 0.0665
Echinococcus multilocularis neuropeptide s receptor 0.0349 0.0464 0.0463
Brugia malayi latrophilin 2 splice variant baaae 0.1888 0.271 0.3883
Echinococcus granulosus insulin receptor 0.0048 0.0025 0.0025
Echinococcus granulosus biogenic amine 5HT receptor 0.0349 0.0464 0.0463
Trichomonas vaginalis heat shock protein, putative 0.0154 0.018 0.5258
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis neuropeptides capa receptor 0.0349 0.0464 0.0463
Brugia malayi Melatonin receptor type 1A 0.0349 0.0464 0.0665
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0004 0.0003
Brugia malayi larval opioid receptor 0.0349 0.0464 0.0665
Loa Loa (eye worm) latrophilin receptor protein 2 0.0874 0.123 0.1763
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.002 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0349 0.0464 0.0665
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0014 0.0042
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0175 0.0174
Echinococcus multilocularis neuropeptide FF receptor 2 0.0349 0.0464 0.0463
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0004 0.0005
Entamoeba histolytica heat shock protein 90, putative 0.0183 0.0222 1
Schistosoma mansoni histamine h1 receptor 0.0349 0.0464 0.0463
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0349 0.0464 0.0463
Brugia malayi heat shock protein 90 0.0183 0.0222 0.0318
Schistosoma mansoni biogenic amine receptor 0.0349 0.0464 0.0463
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni tyrosine kinase 0.008 0.0072 0.0071
Trypanosoma brucei heat shock protein 84, putative 0.0058 0.0039 0.1772
Echinococcus granulosus alpha 1A adrenergic receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Giardia lamblia Grp94/Hsp90 0.0154 0.018 0.811
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus biogenic amine 5HT receptor 0.0349 0.0464 0.0463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0349 0.0464 0.0463
Schistosoma mansoni alpha-1 adrenergic receptor 0.0349 0.0464 0.0463
Brugia malayi AKH receptor 0.0349 0.0464 0.0665
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0038 0.0038
Trichomonas vaginalis tubulin, putative 0.0045 0.002 0.0185
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.008 0.4406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0201 0.2331
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Toxoplasma gondii beta-1 tubulin, putative 0.0045 0.002 0.0897
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Brugia malayi G-protein coupled receptor 0.0349 0.0464 0.0665
Echinococcus granulosus sex peptide receptor 0.0349 0.0464 0.0463
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0154 0.018 0.0533
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0014 0.0042
Echinococcus multilocularis somatostatin receptor 0.0349 0.0464 0.0463
Schistosoma mansoni amine GPCR 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Schistosoma mansoni tyrosine kinase 0.0081 0.0073 0.0073
Brugia malayi Tachykinin-like peptides receptor 99D 0.0349 0.0464 0.0665
Loa Loa (eye worm) tubulin beta-2A chain 0.0045 0.002 0.0029
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.033 0.0472
Toxoplasma gondii beta tubulin 0.0045 0.002 0.0897
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0349 0.0464 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0349 0.0464 0.0463
Chlamydia trachomatis glutamine binding protein 0.0085 0.008 1
Trypanosoma brucei Heat shock protein 83, putative 0.0183 0.0222 1
Echinococcus granulosus heat shock protein 90 0.0183 0.0222 0.0222
Trypanosoma cruzi heat shock protein 85, putative 0.0183 0.0222 1
Schistosoma mansoni neuropeptide F-like receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.002 0.002
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.017 0.0203 0.0202
Schistosoma mansoni cpg binding protein 0.0033 0.0003 0.0003
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0004 0.0003
Schistosoma mansoni amine GPCR 0.0349 0.0464 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0029 0.0028
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0038 0.171
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2341 0.3371 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0874 0.123 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0349 0.0464 0.0463
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0349 0.0464 0.0463
Echinococcus multilocularis neuropeptide receptor A26 0.0349 0.0464 0.0463
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0058 0.0039 0.0453
Echinococcus granulosus tm gpcr rhodopsin 0.0349 0.0464 0.0463
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni hypothetical protein 0.1888 0.271 0.2709
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.008 0.0235
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0004 0.0003
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Leishmania major RAD51/dmc1 protein 0.0046 0.0022 0.0079
Echinococcus multilocularis heat shock protein 0.0183 0.0222 0.0222
Trichomonas vaginalis tubulin epsilon chain, putative 0.0045 0.002 0.0185
Schistosoma mansoni adenoreceptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) beta-tubulin 0.0045 0.002 0.0029
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0025 0.0025
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0349 0.0464 0.0463
Giardia lamblia Heat shock protein HSP 90-alpha 0.0154 0.018 0.811
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus granulosus peptide allatostatin:somatostatin 0.0349 0.0464 0.0463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0349 0.0464 0.0463
Echinococcus granulosus tubulin subunit beta 0.0045 0.002 0.002
Echinococcus multilocularis tubulin beta 1 chain 0.0045 0.002 0.002
Entamoeba histolytica DNA repair protein RAD51, putative 0.0046 0.0022 0.0079
Plasmodium vivax endoplasmin, putative 0.0183 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.06 0.06
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0349 0.0464 0.0665
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.0621 0.0621
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Entamoeba histolytica heat shock protein 90, putative 0.0183 0.0222 1
Loa Loa (eye worm) prolyl oligopeptidase 0.017 0.0203 0.029
Trypanosoma brucei heat shock protein 90, putative 0.0183 0.0222 1
Echinococcus granulosus endoplasmin 0.0154 0.018 0.018
Echinococcus multilocularis heat shock protein 90 0.0183 0.0222 0.0222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0349 0.0464 0.0463
Echinococcus multilocularis NMDA receptor 0.0033 0.0004 0.0003
Echinococcus multilocularis beta tubulin 0.0045 0.002 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0349 0.0464 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Echinococcus multilocularis G protein coupled receptor 139 0.6886 1 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0058 0.0039 0.1758
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.0039 0.0947
Loa Loa (eye worm) tubulin beta-4 chain 0.0045 0.002 0.0029
Trichomonas vaginalis endoplasmin, putative 0.0086 0.0081 0.212
Echinococcus granulosus tubulin beta 4A class IVa 0.0045 0.002 0.002
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0025 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Echinococcus granulosus g protein coupled receptor 0.0349 0.0464 0.0463
Trypanosoma brucei heat shock protein 90, putative 0.0183 0.0222 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Loa Loa (eye worm) hypothetical protein 0.1888 0.271 0.3883
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0004 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Mycobacterium ulcerans heat shock protein 90 0.0154 0.018 0.0533
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.008 0.0235
Trypanosoma cruzi beta tubulin, putative 0.0045 0.002 0.028
Schistosoma mansoni hypothetical protein 0.0349 0.0464 0.0463
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.008 0.4406
Giardia lamblia Beta tubulin 0.0045 0.002 0.0897
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0004 0.0005
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.0128 0.0128
Schistosoma mansoni endoplasmin 0.0183 0.0222 0.0222
Trypanosoma brucei unspecified product 0.0034 0.0005 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Schistosoma mansoni tyrosine kinase 0.008 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Giardia lamblia Beta tubulin 0.0045 0.002 0.0897
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Schistosoma mansoni hypothetical protein 0.0874 0.123 0.123
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0014 0.065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2762 0.3985 0.571
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0073 0.0073
Trichomonas vaginalis heat shock protein, putative 0.0154 0.018 0.5258
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Echinococcus granulosus neuropeptide Y receptor 0.0349 0.0464 0.0463
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0004 0.0003
Schistosoma mansoni neuropeptide receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0038 0.1724
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni biogenic amine (5HT) receptor 0.0349 0.0464 0.0463
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0349 0.0464 0.0665
Toxoplasma gondii heat shock protein 75, putative 0.0058 0.0039 0.1758
Echinococcus granulosus serotonin receptor 0.0349 0.0464 0.0463
Brugia malayi neuropeptide F receptor 0.0349 0.0464 0.0665
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0004 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.0349 0.0464 0.0463
Schistosoma mansoni opsin-like receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0349 0.0464 0.0463
Loa Loa (eye worm) TYRA-2 protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0038 0.0055
Schistosoma mansoni amine GPCR 0.0349 0.0464 0.0463
Echinococcus granulosus 7tm_1 domain containing protein 0.0349 0.0464 0.0463
Echinococcus multilocularis tubulin subunit beta 0.0045 0.002 0.002
Echinococcus multilocularis sex peptide receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.002 0.002
Echinococcus multilocularis fmrfamide receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis orexin receptor type 2 0.0349 0.0464 0.0463
Brugia malayi Dopamine receptor 0.0349 0.0464 0.0665
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Trypanosoma cruzi heat shock protein 90, putative 0.0125 0.0138 0.594
Trypanosoma cruzi heat shock protein 90, putative 0.0183 0.0222 1
Schistosoma mansoni hypothetical protein 0.0874 0.123 0.123
Echinococcus multilocularis fmrfamide receptor 0.0349 0.0464 0.0463
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.0128 0.0128
Trypanosoma cruzi heat shock protein, putative 0.0058 0.0039 0.12
Brugia malayi sulfakinin receptor protein 0.0349 0.0464 0.0665
Schistosoma mansoni hypothetical protein 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Schistosoma mansoni neuropeptide receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) heat shock protein 75 0.0058 0.0039 0.0056
Echinococcus granulosus glutamate receptor 2 0.005 0.0029 0.0028
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0349 0.0464 0.0463
Schistosoma mansoni amine GPCR 0.0349 0.0464 0.0463
Echinococcus multilocularis neuropeptides capa receptor 0.0349 0.0464 0.0463
Echinococcus granulosus cpg binding protein 0.0033 0.0003 0.0003
Echinococcus multilocularis G-protein coupled receptor, putative 0.0349 0.0464 0.0463
Loa Loa (eye worm) endoplasmin 0.0183 0.0222 0.0318
Loa Loa (eye worm) hypothetical protein 0.0874 0.123 0.1763
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0349 0.0464 0.0665
Echinococcus granulosus heat shock protein 0.0183 0.0222 0.0222
Brugia malayi G-protein coupled receptor 0.0349 0.0464 0.0665
Giardia lamblia Heat shock protein HSP 90-alpha 0.0183 0.0222 1
Echinococcus granulosus neuropeptide s receptor 0.0349 0.0464 0.0463
Brugia malayi follicle stimulating hormone receptor 0.0349 0.0464 0.0665
Echinococcus granulosus fmrfamide receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Echinococcus granulosus allatostatin A receptor 0.062 0.086 0.086
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.0621 0.0621
Echinococcus multilocularis g protein coupled receptor 0.0349 0.0464 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Echinococcus granulosus neuropeptide receptor A26 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0038 0.1724
Brugia malayi Protein kinase domain containing protein 0.0048 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis dro:myosuppressin receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) G-protein coupled receptor 0.0349 0.0464 0.0665
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0029 0.0028
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Trichomonas vaginalis heat shock protein, putative 0.0183 0.0222 0.6587
Echinococcus granulosus G protein coupled receptor 139 0.0349 0.0464 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Brugia malayi hypothetical protein 0.0044 0.0019 0.0027
Brugia malayi Tubulin beta-1 chain 0.0045 0.002 0.0029
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.002 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0029 0.0028
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0038 0.1149
Schistosoma mansoni growth hormone secretagogue receptor 0.0349 0.0464 0.0463
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0349 0.0464 0.0463
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0349 0.0464 0.0665
Schistosoma mansoni hypothetical protein 0.0874 0.123 0.123
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0349 0.0464 0.0463
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.0175 0.025
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0046 0.0022 0.0357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0029 0.0028
Schistosoma mansoni tyrosine kinase 0.0081 0.0073 0.0073
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0004 0.0003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0349 0.0464 0.0463
Toxoplasma gondii beta-tubulin, putative 0.0045 0.002 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Echinococcus granulosus GPCR family 2 0.0874 0.123 0.123
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0154 0.018 0.018
Brugia malayi Serotonin receptor 0.0349 0.0464 0.0665
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0004 0.0003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0029 0.0028
Trypanosoma brucei beta tubulin 0.0045 0.002 0.0912
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0349 0.0464 0.0463
Schistosoma mansoni tyrosine kinase 0.0048 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Toxoplasma gondii heat shock protein HSP90 0.0183 0.0222 1
Echinococcus granulosus heat shock protein 90 0.0154 0.018 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.002 0.002
Brugia malayi Latrophilin receptor protein 2 0.0874 0.123 0.1763
Schistosoma mansoni DNA repair protein RAD51 0.0046 0.0022 0.0021
Trichomonas vaginalis tubulin alpha chain, putative 0.0045 0.002 0.0185
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Echinococcus granulosus hypothetical protein 0.0349 0.0464 0.0463
Schistosoma mansoni cpg binding protein 0.0033 0.0003 0.0003
Trichomonas vaginalis tubulin epsilon chain, putative 0.0045 0.002 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Loa Loa (eye worm) neuropeptide F receptor 0.0349 0.0464 0.0665
Schistosoma mansoni tyrosine kinase 0.0151 0.0175 0.0174
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi G protein-coupled receptor 0.0349 0.0464 0.0665
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0154 0.018 0.7924
Onchocerca volvulus 0.0349 0.0464 0.539
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Schistosoma mansoni excision repair cross-complementing 1 ercc1 0.0031 0 0.00000022714
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.017 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni heat shock protein 0.0183 0.0222 0.0222
Schistosoma mansoni opsin-like receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trichomonas vaginalis tubulin gamma chain, putative 0.0045 0.002 0.0185
Echinococcus multilocularis beta tubulin 0.0045 0.002 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.2926 0.4223 0.4223
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0058 0.0039 0.0039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0349 0.0464 0.0665
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.002 0.002
Plasmodium falciparum endoplasmin, putative 0.0086 0.0081 0.3023
Schistosoma mansoni neuropeptide F-like receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis heat shock protein 90 0.0154 0.018 0.018
Echinococcus granulosus beta tubulin 0.0045 0.002 0.002
Schistosoma mansoni serine-type protease inhibitor 0.6041 0.8768 0.8768
Giardia lamblia Beta tubulin 0.0045 0.002 0.0897
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis insulin receptor 0.0048 0.0025 0.0025
Brugia malayi ORL1-like opioid receptor 0.0349 0.0464 0.0665
Schistosoma mansoni peptide (allatostatin)-like receptor 0.062 0.086 0.086
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0046 0.0022 0.0357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0029 0.0028
Schistosoma mansoni myosin xvIII 0.0349 0.0464 0.0463
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0046 0.0022 0.0357
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0154 0.018 0.0533
Onchocerca volvulus Neuropeptide F receptor homolog 0.0349 0.0464 0.539
Trypanosoma brucei beta tubulin 0.0045 0.002 0.0912
Onchocerca volvulus 0.0349 0.0464 0.539
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma brucei beta tubulin 0.0045 0.002 0.0912
Brugia malayi putative neuropeptide receptor NPR1 0.0349 0.0464 0.0665
Plasmodium vivax heat shock protein, putative 0.0058 0.0039 0.0947
Trypanosoma brucei beta tubulin 0.0045 0.002 0.0912
Echinococcus granulosus neuropeptide receptor 0.0349 0.0464 0.0463
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0041 0.1829
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.0621 0.0621
Treponema pallidum heat shock protein 90 0.0154 0.018 1
Echinococcus multilocularis neuropeptide Y receptor 0.0349 0.0464 0.0463
Schistosoma mansoni hypothetical protein 0.0442 0.06 0.06
Schistosoma mansoni amine GPCR 0.0349 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0014 0.065
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0004 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0214 0.6333
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus granulosus dna polymerase kappa 0.0041 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0214 0.6333
Echinococcus granulosus orexin receptor type 2 0.0349 0.0464 0.0463
Plasmodium vivax heat shock protein 90, putative 0.0058 0.0039 0.0947
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0349 0.0464 0.0463
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0874 0.123 0.123
Onchocerca volvulus 0.062 0.086 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0349 0.0464 0.0463
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0349 0.0464 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Schistosoma mansoni tyrosine kinase 0.0048 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0045 0.002 0.002
Brugia malayi G protein-coupled receptor F59B2.13 0.0349 0.0464 0.0665
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0349 0.0464 0.0665
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0349 0.0464 0.0463
Trichomonas vaginalis heat shock protein, putative 0.0154 0.018 0.5258
Schistosoma mansoni hypothetical protein 0.0033 0.0004 0.0003
Plasmodium vivax heat shock protein 86, putative 0.0183 0.0222 1
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.002 0.002
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0349 0.0464 0.0463
Loa Loa (eye worm) melatonin receptor type 1A 0.0349 0.0464 0.0665
Schistosoma mansoni serine-type protease inhibitor 0.6041 0.8768 0.8768
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.033 1
Brugia malayi prolyl oligopeptidase family protein 0.017 0.0203 0.029
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0004 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0349 0.0464 0.0463
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0 0.0001
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0004 0.0005
Schistosoma mansoni endoplasmin 0.0183 0.0222 0.0222
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0281 0.0365 0.0364
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0038 0.1149
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Brugia malayi RE15519p 0.0349 0.0464 0.0665
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0154 0.018 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.017 0.0203 0.2352
Toxoplasma gondii heat shock protein 90, putative 0.0183 0.0222 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Schistosoma mansoni hypothetical protein 0.0349 0.0464 0.0463
Echinococcus multilocularis neuropeptide receptor 0.0349 0.0464 0.0463
Trypanosoma cruzi heat shock protein 85, putative 0.0183 0.0222 1
Brugia malayi neuropeptide F receptor 0.0349 0.0464 0.0665
Echinococcus multilocularis g-protein coupled receptor 0.0349 0.0464 0.0463
Echinococcus granulosus tm gpcr rhodopsin 0.0349 0.0464 0.0463
Schistosoma mansoni tyrosine kinase 0.008 0.0072 0.0071
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus g protein coupled receptor 0.0349 0.0464 0.0463
Echinococcus multilocularis cpg binding protein 0.0033 0.0003 0.0003
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Echinococcus granulosus dna repair protein rad51 1 0.0046 0.0022 0.0021
Brugia malayi Endoplasmin precursor 0.0183 0.0222 0.0318
Brugia malayi GnHR receptor homolog 0.0349 0.0464 0.0665
Loa Loa (eye worm) G-protein coupled receptor 0.0349 0.0464 0.0665
Loa Loa (eye worm) BEN-1 protein 0.0045 0.002 0.0029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0349 0.0464 0.539
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0073 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0349 0.0464 0.0463
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Schistosoma mansoni neuropeptide f receptor 76f 0.0349 0.0464 0.0463
Schistosoma mansoni tubulin subunit beta 0.0045 0.002 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0874 0.123 0.1763
Brugia malayi putative neuropeptide receptor 0.0349 0.0464 0.0665
Echinococcus multilocularis endoplasmin 0.0154 0.018 0.018
Schistosoma mansoni heat shock protein 0.0183 0.0222 0.0222
Loa Loa (eye worm) heat shock protein 90 0.0183 0.0222 0.0318
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Echinococcus granulosus dnaJ subfamily B 0.0442 0.06 0.06
Echinococcus multilocularis 0.0047 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0058 0.0039 0.0039
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2341 0.3371 1
Echinococcus granulosus tm gpcr rhodopsin 0.0349 0.0464 0.0463
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.033 0.0472
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0004 0.0003
Loa Loa (eye worm) rad51 0.0046 0.0022 0.0031
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Schistosoma mansoni biogenic amine receptor 0.0349 0.0464 0.0463
Brugia malayi hypothetical protein 0.0349 0.0464 0.0665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0349 0.0464 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0201 0.5914
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0349 0.0464 0.0665
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0349 0.0464 0.0463
Echinococcus granulosus neuropeptide Y receptor 0.0349 0.0464 0.0463
Onchocerca volvulus 0.0349 0.0464 0.539
Brugia malayi Hsp90 protein 0.0058 0.0039 0.0056
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0046 0.0022 0.0357
Trypanosoma cruzi Heat shock protein 83, putative 0.0183 0.0222 1
Echinococcus granulosus tubulin beta 1 chain 0.0045 0.002 0.002
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Onchocerca volvulus 0.0349 0.0464 0.539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.2926 0.4223 0.4223
Trypanosoma brucei heat shock protein, putative 0.0183 0.0222 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0349 0.0464 0.0463
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.017 0.0203 0.0202
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0058 0.0039 0.0947
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0349 0.0464 0.0463
Echinococcus granulosus somatostatin receptor 0.0349 0.0464 0.0463
Leishmania major heat shock protein 83-1 0.0183 0.0222 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0349 0.0464 0.0463
Trypanosoma cruzi heat shock protein 90, putative 0.0154 0.018 0.7982
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0004 0.0003
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.0039 0.0947
Loa Loa (eye worm) hypothetical protein 0.0349 0.0464 0.0665
Trichomonas vaginalis tubulin beta chain, putative 0.0045 0.002 0.0185
Brugia malayi DNA repair protein RAD51 homolog 1 0.0046 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0039 0.0791

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.39 nM Inhibition of human Dipeptidyl-peptidase II (DPP II) ChEMBL. 15139769
IC50 (binding) = 0.39 nM Inhibition of human Dipeptidyl-peptidase II (DPP II) ChEMBL. 15139769
IC50 (binding) = 70 uM Inhibition of human Dipeptidyl-peptidase IV (DPP IV) ChEMBL. 15139769
IC50 (binding) = 70 uM Inhibition of human Dipeptidyl-peptidase IV (DPP IV) ChEMBL. 15139769
SI (binding) = 180000 Ratio of IC50 for DPP IV to that of IC50 for DPP II ChEMBL. 15139769

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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