Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Protein kinase B | 0.1576 | 0.6622 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.078 | 0.3094 | 0.4372 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.078 | 0.3094 | 0.2841 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.078 | 0.3094 | 0.4372 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0763 | 0.3019 | 0.3019 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1495 | 0.6264 | 0.9428 |
Entamoeba histolytica | protein kinase, putative | 0.2275 | 0.9716 | 0.9716 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1512 | 0.6338 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.078 | 0.3094 | 0.4372 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.2275 | 0.9716 | 0.9706 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1512 | 0.6338 | 0.9571 |
Trichomonas vaginalis | AGC family protein kinase | 0.0844 | 0.3378 | 0.3378 |
Echinococcus granulosus | protein kinase c epsilon type | 0.078 | 0.3094 | 0.4372 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.078 | 0.3094 | 0.4372 |
Trichomonas vaginalis | AGC family protein kinase | 0.078 | 0.3094 | 0.3094 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1495 | 0.6264 | 0.9428 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1576 | 0.6622 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1512 | 0.6338 | 0.9547 |
Brugia malayi | protein kinase C II. | 0.078 | 0.3094 | 0.2841 |
Brugia malayi | Protein kinase domain containing protein | 0.078 | 0.3094 | 0.2841 |
Entamoeba histolytica | protein kinase 2, putative | 0.1512 | 0.6338 | 0.6338 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.078 | 0.3094 | 0.4372 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.078 | 0.3094 | 0.4372 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1512 | 0.6338 | 0.9547 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.2339 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1495 | 0.6264 | 0.9428 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.078 | 0.3094 | 0.4372 |
Loa Loa (eye worm) | hypothetical protein | 0.078 | 0.3094 | 0.2841 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.078 | 0.3094 | 0.2841 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1576 | 0.6622 | 0.6622 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0081 | 0 | 0.5 |
Brugia malayi | Hr1 repeat family protein | 0.078 | 0.3094 | 0.2841 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1512 | 0.6338 | 0.9547 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.2275 | 0.9716 | 0.9706 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0081 | 0 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.2275 | 0.9716 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.078 | 0.3094 | 0.4372 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1495 | 0.6264 | 0.9428 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.078 | 0.3094 | 0.4372 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.078 | 0.3094 | 0.4372 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.078 | 0.3094 | 0.4372 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.078 | 0.3094 | 0.4372 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.078 | 0.3094 | 0.2841 |
Echinococcus multilocularis | serine threonine protein kinase | 0.078 | 0.3094 | 0.4372 |
Leishmania major | folate/biopterin transporter, putative | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.078 | 0.3094 | 0.4372 |
Giardia lamblia | Kinase, AGC PKA | 0.1512 | 0.6338 | 0.5 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1512 | 0.6338 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.2339 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.078 | 0.3094 | 0.3094 |
Echinococcus multilocularis | nervana 2 | 0.1495 | 0.6264 | 0.9428 |
Echinococcus granulosus | nervana 2 | 0.1495 | 0.6264 | 0.9428 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.078 | 0.3094 | 0.2841 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1576 | 0.6622 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1576 | 0.6622 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1576 | 0.6622 | 0.6622 |
Echinococcus granulosus | NDR protein kinase | 0.078 | 0.3094 | 0.4372 |
Entamoeba histolytica | protein kinase, putative | 0.078 | 0.3094 | 0.3094 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1576 | 0.6622 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.078 | 0.3094 | 0.2841 |
Trichomonas vaginalis | AGC family protein kinase | 0.078 | 0.3094 | 0.3094 |
Leishmania major | protein kinase, putative | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.078 | 0.3094 | 0.4372 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.078 | 0.3094 | 0.4372 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.078 | 0.3094 | 0.2841 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1495 | 0.6264 | 0.9428 |
Leishmania major | protein kinase, putative | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.2339 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.2339 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2339 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.078 | 0.3094 | 0.2841 |
Echinococcus granulosus | protein kinase c iota type | 0.078 | 0.3094 | 0.4372 |
Echinococcus multilocularis | nervana 2 | 0.1495 | 0.6264 | 0.9428 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1576 | 0.6622 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.172 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.365 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.29 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.15 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.112 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.065 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.