Detailed information for compound 162987

Basic information

Technical information
  • TDR Targets ID: 162987
  • Name: (2R,3R)-3-(cyclopentylmethyl)-2-[[dimethylsul famoyl(methyl)amino]methyl]-N-hydroxy-4-oxo-4 -piperidin-1-ylbutanamide
  • MW: 432.578 | Formula: C19H36N4O5S
  • H donors: 2 H acceptors: 5 LogP: 1.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@H]([C@H](C(=O)N1CCCCC1)CC1CCCC1)CN(S(=O)(=O)N(C)C)C
  • InChi: 1S/C19H36N4O5S/c1-21(2)29(27,28)22(3)14-17(18(24)20-26)16(13-15-9-5-6-10-15)19(25)23-11-7-4-8-12-23/h15-17,26H,4-14H2,1-3H3,(H,20,24)/t16-,17+/m1/s1
  • InChiKey: YLYMDJMYRSEUOA-SJORKVTESA-N  

Network

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Synonyms

  • (2R,3R)-3-(cyclopentylmethyl)-2-[[dimethylsulfamoyl(methyl)amino]methyl]-4-oxo-4-(1-piperidyl)butanehydroxamic acid
  • (2R,3R)-3-(cyclopentylmethyl)-2-[[dimethylsulfamoyl(methyl)amino]methyl]-N-hydroxy-4-oxo-4-piperidin-1-yl-butanamide
  • (2R,3R)-3-(cyclopentylmethyl)-2-[[dimethylsulfamoyl(methyl)amino]methyl]-4-keto-4-piperidino-butanehydroxamic acid
  • (2R,3R)-3-(cyclopentylmethyl)-2-[(dimethylsulfamoyl-methylamino)methyl]-N-hydroxy-4-oxo-4-piperidin-1-ylbutanamide
  • (2R,3R)-3-(cyclopentylmethyl)-2-[(dimethylsulfamoyl-methyl-amino)methyl]-4-oxo-4-(1-piperidyl)butanehydroxamic acid
  • (2R,3R)-3-(cyclopentylmethyl)-2-[(dimethylsulfamoyl-methylamino)methyl]-4-oxo-4-(1-piperidyl)butanehydroxamic acid
  • (2R,3R)-3-(cyclopentylmethyl)-2-[(dimethylsulfamoyl-methyl-amino)methyl]-4-keto-4-piperidino-butanehydroxamic acid
  • (2R,3R)-3-(cyclopentylmethyl)-2-[(dimethylsulfamoyl-methyl-amino)methyl]-N-hydroxy-4-oxo-4-piperidin-1-yl-butanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 8 (neutrophil collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 8 (neutrophil collagenase) 467 aa 467 aa 33.4 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0044 0.0044
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0098 0.0565 0.0565
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0419 0.0419
Giardia lamblia GTOR 0.0045 0.0207 0.0165
Schistosoma mansoni hypothetical protein 0.0068 0.0363 0.0362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1483 1 1
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0079 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.015 0.015
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0045 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0176 0.0176
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.018 0.018
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.3828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Echinococcus granulosus orexin receptor type 2 0.0076 0.0419 0.0419
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0419 0.0418
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.0075
Echinococcus granulosus peroxidasin 0.0026 0.0079 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0169 0.1053 0.1053
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.0443 0.0443
Echinococcus granulosus lamin b receptor 0.0048 0.0223 0.0223
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0226 0.0226
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0419 0.0419
Echinococcus granulosus transcription factor btf3 0.0035 0.0138 0.0138
Echinococcus multilocularis RUN 0.002 0.0034 0.0034
Brugia malayi CXXC zinc finger family protein 0.0029 0.0096 0.0095
Schistosoma mansoni hypothetical protein 0.0069 0.0366 0.0365
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0029
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0291 0.1884 0.1883
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0419 0.0419
Echinococcus multilocularis ecdysone induced protein 78C 0.0169 0.1053 0.1053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0419 0.0419
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0113
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0714 0.4762 0.4762
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0002 0.0002
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1483 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0207 0.0207
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0291 0.1884 0.1859
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4617 0.4616
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0419 0.0418
Schistosoma mansoni retinoic acid receptor RXR 0.0268 0.1726 0.1726
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Brugia malayi multidrug resistance protein 3 0.0021 0.0044 0.0043
Toxoplasma gondii ABC1 family protein 0.0036 0.0146 0.0138
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0411 0.2696 0.2694
Trypanosoma cruzi polyprenyl synthase, putative 0.0026 0.0076 0.0074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0179
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0103 0.06 0.0594
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Onchocerca volvulus 0.0076 0.0419 0.1454
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0146 0.0138
Schistosoma mansoni multidrug resistance protein 0.0021 0.0044 0.0043
Brugia malayi beta-lactamase family protein 0.0036 0.0146 0.0144
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.018 0.018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0154 0.0947 0.0946
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0176 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0099 0.0099
Echinococcus multilocularis phospholipase d3 0.0019 0.0032 0.0032
Brugia malayi GnHR receptor homolog 0.0076 0.0419 0.0418
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0394 0.0394
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0207 0.0206
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0226 0.0226
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0138 0.0137
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0045 0.0037
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0026 0.0076 0.0075
Brugia malayi Melatonin receptor type 1A 0.0076 0.0419 0.0418
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0419 0.0418
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0291 0.1884 0.1884
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Brugia malayi hypothetical protein 0.0017 0.0012 0.0011
Echinococcus multilocularis 0.0021 0.0045 0.0045
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0094 0.0094
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi Proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0419 0.0419
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0394 0.0393
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Brugia malayi Pre-SET motif family protein 0.021 0.1326 0.1326
Echinococcus granulosus proteasome subunit beta t family 0.0291 0.1884 0.1884
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.018 0.0179
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.0048 0.0226 0.0225
Echinococcus granulosus tm gpcr rhodopsin 0.0596 0.3958 0.3958
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0207 0.0204
Echinococcus granulosus tyrosine protein kinase Lyn 0.0048 0.0226 0.0226
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0411 0.2696 0.2694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0044 0.0044
Brugia malayi Importin beta-1 subunit 0.0029 0.0094 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0105 0.0105
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0034 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0175 0.0174
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.0344
Brugia malayi Proteasome subunit alpha type 7-1 0.0291 0.1884 0.1883
Onchocerca volvulus 0.0041 0.018 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1053 0.1052
Echinococcus granulosus proteasome prosome macropain subunit beta 0.1152 0.7747 0.7747
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0031
Brugia malayi nuclear receptor NHR-67 0.008 0.0443 0.0442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Echinococcus multilocularis geminin 0.017 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.1459 0.9836 0.9836
Trichomonas vaginalis esterase, putative 0.0036 0.0146 0.0146
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0079 0.0078
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0291 0.1884 0.1882
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0026 0.0076 0.0076
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0066 0.0352 0.0349
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0044 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0363 0.0362
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0041 0.018 0.018
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Giardia lamblia Farnesyl diphosphate synthase 0.0103 0.06 0.056
Onchocerca volvulus 0.0066 0.035 0.1194
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0291 0.1884 0.1882
Brugia malayi Matrixin family protein 0.0126 0.076 0.0759
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0207 0.0204
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0066 0.0352 0.0349
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0114 0.0113
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0138
Echinococcus granulosus epidermal growth factor receptor 0.0163 0.1009 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1483 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0419 0.0418
Echinococcus granulosus insulin receptor 0.0098 0.0565 0.0565
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0291 0.1884 0.1859
Echinococcus granulosus phospholipase D 0.0091 0.0521 0.0521
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.0443 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0169 0.1053 0.1052
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.003 0.0029
Brugia malayi Doublecortin family protein 0.002 0.0034 0.0033
Echinococcus granulosus tyrosine kinase 0.0041 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0087 0.049 0.0489
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.003 0.003
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0291 0.1884 0.1884
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0146 0.0146
Schistosoma mansoni loxhd1 0.002 0.0034 0.0033
Schistosoma mansoni nuclear receptor 0.008 0.0443 0.0442
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0044 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0169 0.1053 0.1052
Schistosoma mansoni tyrosine kinase 0.0302 0.1953 0.1952
Echinococcus granulosus phospholipase D1 0.0103 0.0603 0.0603
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0291 0.1884 0.1859
Schistosoma mansoni hypothetical protein 0.002 0.0034 0.0033
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.003 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0509 0.0508
Echinococcus granulosus proteasome prosome macropain 0.1483 1 1
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0419 0.0419
Schistosoma mansoni opsin-like receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0291 0.1884 0.1883
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0268 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Brugia malayi Tyrosine-protein kinase abl-1 0.0019 0.0027 0.0026
Toxoplasma gondii peptidase, T1 family protein 0.0291 0.1884 0.1878
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0026 0.0076 0.0075
Brugia malayi proteasome subunit beta type 2 0.0714 0.4762 0.4761
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0419 0.0419
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0027 0.0026
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0291 0.1884 0.1884
Trichomonas vaginalis abcb9, putative 0.0021 0.0044 0.0044
Echinococcus granulosus GPCR family 2 0.0031 0.0114 0.0114
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0291 0.1884 0.1849
Leishmania major proteasome beta 5 subunit, putative 0.1483 1 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0079 0.0078
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0103 0.06 0.0598
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0098 0.0565 0.0565
Brugia malayi Cytochrome P450 family protein 0.003 0.0104 0.0103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0243 0.1552 0.1552
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0291 0.1884 0.1883
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0103 0.06 0.06
Loa Loa (eye worm) polyprenyl synthetase 0.0026 0.0076 0.0075
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0044 0.0043
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0104 0.0102
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0291 0.1884 0.1878
Onchocerca volvulus Matrilysin homolog 0.028 0.1807 0.6664
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.0419 0.0419
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0291 0.1884 0.1882
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0169 0.1053 0.1052
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0045 0.0037
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0291 0.1884 0.1882
Onchocerca volvulus 0.0036 0.0146 0.0426
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1665 0.1664
Echinococcus granulosus dnaJ subfamily B 0.0411 0.2696 0.2696
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.0322
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0138 0.0136
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1472 0.1466
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0291 0.1884 0.1878
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0169 0.1053 0.1052
Brugia malayi Phospholipase D. Active site motif family protein 0.0036 0.0145 0.0144
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0079 0.0078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0145 0.0145
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0419 0.0418
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0044 0.1879
Onchocerca volvulus 0.0126 0.076 0.2731
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0291 0.1884 0.1859
Echinococcus granulosus proteasome subunit beta type 7 0.0291 0.1884 0.1884
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.003 0.003
Loa Loa (eye worm) cytochrome P450 0.0021 0.0045 0.0044
Entamoeba histolytica hypothetical protein 0.0036 0.0145 0.0115
Onchocerca volvulus Peroxidase homolog 0.0026 0.0079 0.0177
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0146 0.0101
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0473 0.0473
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0291 0.1884 0.1883
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0103 0.06 0.06
Brugia malayi hypothetical protein 0.0089 0.0509 0.0508
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0419 0.0418
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.0419 0.1454
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.003 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0146 0.0138
Leishmania major C-8 sterol isomerase-like protein 0.1459 0.9836 0.9836
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0154 0.0947 0.094
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.0076
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0714 0.4762 0.4746
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0419 0.0419
Brugia malayi nuclear receptor NHR-88 0.008 0.0443 0.0442
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0176 0.0176
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis serotonin receptor 0.0199 0.1252 0.1252
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0207 0.0206
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0291 0.1884 0.1883
Plasmodium falciparum proteasome subunit beta type-4 0.0291 0.1884 0.1878
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0291 0.1884 0.1859
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0104 0.006
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.0419 0.1454
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Loa Loa (eye worm) hypothetical protein 0.0126 0.076 0.0759
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0291 0.1884 0.1882
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0044 0.0036
Schistosoma mansoni hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0163 0.1009 0.1009
Entamoeba histolytica hypothetical protein 0.0036 0.0145 0.0115
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0179
Schistosoma mansoni multidrug resistance protein 0.0021 0.0044 0.0043
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0044 0.0013
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Echinococcus multilocularis epidermal growth factor receptor 0.0163 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Loa Loa (eye worm) hypothetical protein 0.0462 0.3048 0.3048
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 0.0143
Loa Loa (eye worm) proteasome subunit beta type 1 0.1152 0.7747 0.7747
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0002 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0908 0.608 0.608
Loa Loa (eye worm) solute carrier family 6 member 4 0.0243 0.1552 0.1552
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.003 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0146 0.0101
Echinococcus multilocularis phospholipase D1 0.0103 0.0603 0.0603
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0145 0.0145
Toxoplasma gondii proteasome subunit beta type, putative 0.1483 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0107 0.0107
Brugia malayi RE15519p 0.0076 0.0419 0.0418
Onchocerca volvulus 0.0169 0.1053 0.3831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0044 0.0044
Onchocerca volvulus 0.0076 0.0419 0.1454
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni RAR-like nuclear receptor 0.0169 0.1053 0.1052
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0207 0.0177
Echinococcus granulosus somatostatin receptor 0.0076 0.0419 0.0419
Echinococcus granulosus hypothetical protein 0.0769 0.5137 0.5137
Echinococcus granulosus g protein coupled receptor 0.0076 0.0419 0.0419
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0714 0.4762 0.476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.018 0.0179
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1483 1 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0291 0.1884 0.1883
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0103 0.06 0.06
Brugia malayi Peroxidasin 0.0026 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0169 0.1053 0.1052
Plasmodium vivax proteasome subunit beta type-6, putative 0.0291 0.1884 0.1878
Onchocerca volvulus 0.0026 0.0079 0.0177
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0002 0.0002
Loa Loa (eye worm) proteasome subunit beta type 3 0.0291 0.1884 0.1883
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0291 0.1884 0.1884
Onchocerca volvulus 0.0036 0.0146 0.0426
Echinococcus granulosus ecdysone induced protein 78C 0.0169 0.1053 0.1053
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0508
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni sodium-dependent amino acid transporter 0.0041 0.018 0.0179
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0318 0.2068 0.2067
Loa Loa (eye worm) hypothetical protein 0.0243 0.1552 0.1552
Schistosoma mansoni transcription factor btf3 0.0035 0.0138 0.0137
Brugia malayi Polyprenyl synthetase family protein 0.0026 0.0076 0.0075
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0103 0.06 0.0558
Brugia malayi G-protein coupled receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0044
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0291 0.1884 0.1883
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Loa Loa (eye worm) fli-1 protein 0.0221 0.1402 0.1402
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni tyrosine kinase 0.0163 0.1009 0.1009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0419 0.0418
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.0419 0.0418
Schistosoma mansoni axis inhibition protein axin 0.0019 0.003 0.0029
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.003 0.003
Brugia malayi beta-lactamase 0.0036 0.0146 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Schistosoma mansoni biogenic amine receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Brugia malayi nuclear hormone receptor 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi tailless protein 0.008 0.0443 0.0442
Brugia malayi hypothetical protein 0.0019 0.003 0.0029
Leishmania major proteasome alpha 1 subunit, putative 0.0291 0.1884 0.1882
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.0108
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1665 0.1664
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0291 0.1884 0.1859
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0146 0.0146
Schistosoma mansoni amine GPCR 0.0409 0.2684 0.2683
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0103 0.06 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0169 0.1053 0.1052
Plasmodium vivax amine transporter, putative 0.0041 0.018 0.0173
Brugia malayi cytochrome P450 0.0021 0.0045 0.0044
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.015 0.015
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0103 0.06 0.0599
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0044 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1053 0.1052
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0352 0.0352
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0419 0.0419
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.0509 0.0508
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0291 0.1884 0.1878
Schistosoma mansoni neuropeptide receptor 0.0076 0.0419 0.0418
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0033
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni tyrosine kinase 0.0019 0.0027 0.0026
Brugia malayi Ets-domain containing protein 0.0073 0.0394 0.0393
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0419 0.0418
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0291 0.1884 0.1883
Brugia malayi Protein kinase domain containing protein 0.0098 0.0565 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Echinococcus granulosus neuropeptide s receptor 0.0538 0.3564 0.3564
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Echinococcus granulosus geminin 0.017 0.1058 0.1058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0169 0.1053 0.1053
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0146 0.0101
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0083 0.0083
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0291 0.1884 0.1859
Leishmania major proteasome alpha 3 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0096 0.0095
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1326 0.1326
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.003 0.0029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0419 0.0418
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0094 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.018 0.0179
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Toxoplasma gondii heat shock protein hslv, putative 0.0291 0.1884 0.1878
Schistosoma mansoni hypothetical protein 0.0305 0.1979 0.1978
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0033
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0144 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.0029
Onchocerca volvulus 0.0238 0.1523 0.5597
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.018 0.0179
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0103 0.06 0.0594
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0093
Toxoplasma gondii proteasome subunit 0.0291 0.1884 0.1878
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Onchocerca volvulus 0.002 0.0034 0.0008
Brugia malayi Cytochrome P450 family protein 0.0021 0.0045 0.0044
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0169 0.1053 0.1053
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.0443 0.0442
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0146 0.0138
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0226 0.0226
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1913 0.1912
Schistosoma mansoni neuropeptide receptor 0.0076 0.0419 0.0418
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0146 0.0143
Onchocerca volvulus Peroxidase homolog 0.0026 0.0079 0.0177
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0144 0.0142
Echinococcus granulosus proteasome subunit alpha type 2 0.0291 0.1884 0.1884
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0207 0.0204
Echinococcus granulosus sex peptide receptor 0.0076 0.0419 0.0419
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0207 0.0207
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0045 0.0037
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0223 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0045 0.0037
Schistosoma mansoni trans-prenyltransferase 0.0026 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi Matrixin family protein 0.0126 0.076 0.0759
Leishmania major cytochrome p450-like protein 0.0021 0.0045 0.0042
Schistosoma mansoni sodium/chloride dependent transporter 0.0243 0.1552 0.1552
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0146 0.0143
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.0057
Brugia malayi hypothetical protein 0.0066 0.035 0.0349
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4617 0.4617
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi beta-NAC-like protein 0.0035 0.0138 0.0137
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1483 1 1
Loa Loa (eye worm) PAS-3 protein 0.0291 0.1884 0.1883
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0026 0.0076 0.0069
Brugia malayi Matrixin family protein 0.0126 0.076 0.0759
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0291 0.1884 0.1883
Schistosoma mansoni ran 0.0021 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.003 0.003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0146 0.0146
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0443 0.0443
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Plasmodium vivax proteasome subunit beta type-3, putative 0.0291 0.1884 0.1878
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0352 0.0349
Onchocerca volvulus 0.0031 0.0108 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.112 0.112
Echinococcus granulosus allatostatin A receptor 0.0076 0.0419 0.0419
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0044 0.0044
Brugia malayi Fli-1 protein 0.0221 0.1402 0.1402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1053 0.1052
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0419 0.0419
Echinococcus granulosus proteasome subunit alpha type 6 0.0291 0.1884 0.1884
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0352 0.0349
Trypanosoma cruzi cardiolipin synthetase, putative 0.0036 0.0145 0.0142
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0079 0.0078
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0291 0.1884 0.1878
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1884 0.1884
Schistosoma mansoni nuclear hormone receptor 0.008 0.0443 0.0442
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0079 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0044 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0419 0.0418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1053 0.1053
Onchocerca volvulus 0.0411 0.2696 1
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0103 0.06 0.0598
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0017 0.0012 0.0011
Brugia malayi PXA domain containing protein 0.0024 0.0061 0.006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0169 0.1053 0.1053
Trichomonas vaginalis ran, putative 0.0021 0.0043 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) serotonin transporter b 0.0243 0.1552 0.1552
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0026 0.0076 0.0076
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.0443 0.0443
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0079 0.0177
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0007
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0419 0.0418
Brugia malayi hypothetical protein 0.002 0.0034 0.0033
Schistosoma mansoni amine GPCR 0.0076 0.0419 0.0418
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1913 0.1913
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0352 0.0345
Plasmodium vivax proteasome subunit beta type-4, putative 0.0291 0.1884 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0169 0.1053 0.1052
Loa Loa (eye worm) proteasome subunit beta type 2 0.0714 0.4762 0.4761
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0419 0.0419
Mycobacterium ulcerans beta-lactamase 0.0036 0.0146 0.0101
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0045 0.0037
Plasmodium falciparum proteasome subunit beta type-5 0.1483 1 1
Echinococcus granulosus FTZ F1 alpha 0.0169 0.1053 0.1053
Echinococcus granulosus fmrfamide receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0033
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0714 0.4762 0.4762
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.0443 0.0443
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0006
Onchocerca volvulus 0.0076 0.0419 0.1454
Onchocerca volvulus 0.0036 0.0146 0.0426
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0146 0.0146
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0419 0.0418
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0019 0.0032 0.003
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0195 0.1225 0.1224
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0027 0.0027
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0291 0.1884 0.1882
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Brugia malayi Proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0291 0.1884 0.1859
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0113
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0076 0.0419 0.0418
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0138
Echinococcus granulosus snurportin 1 0.0305 0.1979 0.1979
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0175 0.0174
Schistosoma mansoni zinc finger protein 0.008 0.0443 0.0442
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0291 0.1884 0.1859
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0042 0.0042
Giardia lamblia Proteasome subunit beta type 2 0.0714 0.4762 0.4739
Schistosoma mansoni tyrosine kinase 0.0163 0.1009 0.1009
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0044 0.0036
Echinococcus multilocularis proteasome subunit beta type 6 0.0291 0.1884 0.1884
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0714 0.4762 0.4762
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0035
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0291 0.1884 0.1878
Giardia lamblia 20S proteasome alpha subunit 2 0.0291 0.1884 0.1849
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0199 0.1252 0.1251
Leishmania major GTP-binding protein, putative 0.0021 0.0043 0.004
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0419 0.0418
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0103 0.06 0.0598
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0419 0.0418
Echinococcus granulosus Proteasome subunit alpha beta 0.0291 0.1884 0.1884
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0577 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0291 0.1884 0.1883
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0419 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Brugia malayi Hemopexin family protein 0.0179 0.1119 0.1118
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0154 0.0947 0.0946
Echinococcus multilocularis serotonin transporter 0.0243 0.1552 0.1552
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0057 0.0057
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1483 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0034 0.0034
Brugia malayi AKH receptor 0.0076 0.0419 0.0418
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0045 0.0037
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0195 0.1225 0.1225
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0207 0.0206
Brugia malayi Serotonin receptor 0.0538 0.3564 0.3564
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0279 0.0272
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.003 0.0029
Schistosoma mansoni myosin xvIII 0.0076 0.0419 0.0418
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.003 0.003
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1459 0.9836 0.9836
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0419 0.0418
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0291 0.1884 0.1878
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0057 0.0055
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1459 0.9836 0.9836
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0044 0.0044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0108 0.0108
Giardia lamblia 20S proteasome alpha subunit 7 0.0291 0.1884 0.1849
Brugia malayi 20S proteasome alpha5 subunit 0.0291 0.1884 0.1883
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0291 0.1884 0.1884
Schistosoma mansoni importin beta-1 0.0029 0.0094 0.0093
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0033 0.0125 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0083 0.0083
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0041 0.018 0.018
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.024 0.0239
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0291 0.1884 0.1878
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0419 0.0418
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0068 0.0363 0.0362
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0291 0.1884 0.1878
Trichomonas vaginalis abcb9, putative 0.0021 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0126 0.076 0.0759
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0419 0.0419
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0043 0.0035
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.076 0.076
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0103 0.06 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0067 0.0357 0.0356
Onchocerca volvulus 0.0076 0.0419 0.1454
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0443 0.0443
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0152 0.0152
Echinococcus granulosus g protein coupled receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0169 0.1053 0.1052
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0291 0.1884 0.1878
Leishmania major proteasome beta-1 subunit, putative 0.0291 0.1884 0.1882
Brugia malayi proteasome subunit alpha type 6 0.0291 0.1884 0.1883
Echinococcus multilocularis proteasome (prosome, macropain) 0.1483 1 1
Brugia malayi hypothetical protein 0.0026 0.0079 0.0078
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0419 0.0418
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.0509 0.0509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Leishmania major proteasome alpha 2 subunit, putative 0.0291 0.1884 0.1882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0443 0.0443
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0138 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0419 0.0418
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1483 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0226 0.0226
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0044 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0146
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0291 0.1884 0.1882
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0291 0.1884 0.1884
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0041 0.018 0.018
Schistosoma mansoni peroxidasin 0.0026 0.0079 0.0078
Echinococcus granulosus RUN 0.002 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Toxoplasma gondii proteasome subunit alpha1, putative 0.0291 0.1884 0.1878
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0714 0.4762 0.4761
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0146 0.0144
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0419 0.0419
Schistosoma mansoni neuropeptide receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0036 0.0146 0.0143
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0029
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0026 0.0076 0.0069
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0044 0.0044
Schistosoma mansoni cytochrome P450 0.0021 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0352 0.0352
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0419 0.0418
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Giardia lamblia 20S proteasome alpha subunit 1 0.0291 0.1884 0.1849
Schistosoma mansoni peroxidasin 0.0026 0.0079 0.0078
Leishmania major proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0002 0.0001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0352 0.0345
Brugia malayi Phospholipase D. Active site motif family protein 0.0019 0.0032 0.0031
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0179 0.1117 0.1117
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0419 0.0418
Trypanosoma cruzi cardiolipin synthetase, putative 0.0036 0.0145 0.0142
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0045 0.0037
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Leishmania major importin beta-1 subunit, putative 0.0023 0.0057 0.0055
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1884 0.1884
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Echinococcus granulosus serotonin transporter 0.0243 0.1552 0.1552
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0146 0.0144
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0291 0.1884 0.1882
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0045 0.0037
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.003 0.0029
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0026 0.0076 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0419 0.0418
Brugia malayi neuropeptide F receptor 0.0076 0.0419 0.0418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0577 0.0576
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Entamoeba histolytica Ran family GTPase 0.0021 0.0043 0.0012
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0126 0.076 0.0759
Loa Loa (eye worm) matrixin family protein 0.0305 0.1979 0.1978
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0007
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1483 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.0443 0.0442
Echinococcus multilocularis GPCR, family 2 0.0031 0.0114 0.0114
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0045 0.0037
Schistosoma mansoni opsin-like receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0079 0.0078
Onchocerca volvulus 0.0021 0.0044 0.0043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Brugia malayi Matrixin family protein 0.0305 0.1979 0.1978
Loa Loa (eye worm) TK/INSR protein kinase 0.0098 0.0565 0.0564
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0226 0.0226
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.0746 0.4978 0.4978
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0104 0.0103
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.018 0.0179
Brugia malayi beta-lactamase family protein 0.0036 0.0146 0.0144
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0045 0.0037
Brugia malayi Dopamine receptor protein 2 0.0076 0.0419 0.0418
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.0443 0.0442
Schistosoma mansoni tyrosine kinase 0.0159 0.0983 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0144 0.0144
Onchocerca volvulus 0.0041 0.018 0.0555
Brugia malayi proteasome subunit alpha type 4 0.0291 0.1884 0.1883
Brugia malayi Phospholipase d protein 1 0.0103 0.0603 0.0602
Echinococcus multilocularis neuropeptide s receptor 0.0538 0.3564 0.3564
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.018 0.0179
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Brugia malayi putative neuropeptide receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) TK protein kinase 0.0033 0.0125 0.0124
Leishmania major proteasome beta 2 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0169 0.1053 0.1052
Plasmodium vivax proteasome subunit beta type-2, putative 0.0714 0.4762 0.4758
Onchocerca volvulus 0.0026 0.0079 0.0177
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0114 0.0113
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0291 0.1884 0.1884
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0419 0.0419
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.003 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0169 0.1053 0.1053
Brugia malayi Polyprenyl synthetase family protein 0.0103 0.06 0.0599
Plasmodium vivax cardiolipin synthetase, putative 0.0017 0.0012 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0169 0.1053 0.1053
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0026 0.0076 0.0046
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0103 0.06 0.0594
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.018 0.018
Brugia malayi sulfakinin receptor protein 0.0076 0.0419 0.0418
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Brugia malayi Ets-domain containing protein 0.0073 0.0394 0.0393
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0291 0.1884 0.1882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0144 0.0144
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0135 0.0135
Loa Loa (eye worm) beta-lactamase 0.0036 0.0146 0.0144
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0419 0.0419
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0291 0.1884 0.1878
Schistosoma mansoni cpg binding protein 0.003 0.0107 0.0106
Echinococcus granulosus proteasome subunit beta type 6 0.0291 0.1884 0.1884
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1884 0.1884
Plasmodium vivax proteasome subunit beta type-5, putative 0.1483 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1152 0.7747 0.7746
Loa Loa (eye worm) matrixin family protein 0.028 0.1807 0.1806
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0108 0.0107
Brugia malayi Matrixin family protein 0.0126 0.076 0.0759
Onchocerca volvulus 0.0076 0.0419 0.1454
Schistosoma mansoni amine GPCR 0.0076 0.0419 0.0418
Leishmania major hypothetical protein, conserved 0.0411 0.2696 0.2694
Brugia malayi Proteasome subunit alpha type 1 0.0291 0.1884 0.1883
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0017 0.0012 0.001
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0291 0.1884 0.1859
Trypanosoma cruzi Emopamil binding protein, putative 0.0411 0.2696 0.2694
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.003 0.0029
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0044 0.0044
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1053 0.1052
Brugia malayi ecdysone receptor 0.008 0.0443 0.0442
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0305 0.0304
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0087 0.049 0.0461
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1053 0.1053
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0169 0.1053 0.1052
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0045 0.0037
Schistosoma mansoni axis inhibition protein axin 0.0019 0.003 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0169 0.1053 0.1053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0107
Toxoplasma gondii proteasome subunit beta type 1, putative 0.1152 0.7747 0.7745
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0291 0.1884 0.1878
Onchocerca volvulus 0.008 0.0443 0.1544
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.112 0.112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0419 0.0419
Schistosoma mansoni cpg binding protein 0.0029 0.0096 0.0095
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0291 0.1884 0.1883
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Mycobacterium leprae Probable lipase LipE 0.0036 0.0146 0.0101
Treponema pallidum sodium- and chloride- dependent transporter 0.0243 0.1552 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0243 0.1552 0.1552
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.003 0.003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0045 0.0042
Leishmania major polyprenyl synthase, putative 0.0026 0.0076 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Onchocerca volvulus Notchless protein homolog 0.0291 0.1884 0.6953
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0045 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0146
Brugia malayi Proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4617 0.4617
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0291 0.1884 0.1859
Brugia malayi SRC-1 0.0048 0.0226 0.0225
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.003 0.003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.004
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Brugia malayi Blistered cuticle protein 3 0.0026 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0492 0.325 0.3249
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0041 0.018 0.0179
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0044 0.0044
Echinococcus multilocularis proteasome subunit beta type 7 0.0291 0.1884 0.1884
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.003 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0169 0.1053 0.1052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0045 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0169 0.1053 0.1052
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0291 0.1884 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0169 0.1053 0.1052
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0226 0.0226
Echinococcus granulosus neuropeptide receptor 0.0076 0.0419 0.0419
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0179
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.0126 0.076 0.0759
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0291 0.1884 0.1859
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0034 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0169 0.1053 0.1053
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0459 0.3027 0.3027
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Schistosoma mansoni polycystin 1-related 0.002 0.0034 0.0033
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0044 0.0044
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0419 0.0418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0107
Giardia lamblia 20S proteasome alpha subunit 5 0.0291 0.1884 0.1849
Onchocerca volvulus 0.0243 0.1552 0.5708
Schistosoma mansoni phospholipase D 0.0103 0.0603 0.0602
Echinococcus granulosus g protein coupled receptor 0.0076 0.0419 0.0419
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0169 0.1053 0.1052
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0045 0.0042
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.018 0.018
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0079 0.0078
Schistosoma mansoni multidrug resistance protein 0.0021 0.0044 0.0043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0076 0.0419 0.1454
Echinococcus granulosus axis inhibition protein axin 0.0019 0.003 0.003
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Brugia malayi hypothetical protein 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.0492 0.325 0.3249
Brugia malayi ABC transporter family protein 0.0021 0.0044 0.0043
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0419 0.0419
Schistosoma mansoni biogenic amine receptor 0.0076 0.0419 0.0418
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0714 0.4762 0.4758
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0044 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Echinococcus multilocularis neuropeptide receptor A26 0.0538 0.3564 0.3564
Leishmania major farnesyl pyrophosphate synthase 0.0103 0.06 0.0598
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.0138
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Leishmania major cytochrome p450-like protein 0.0021 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0169 0.1053 0.1052
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0291 0.1884 0.1882
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0443 0.1544
Echinococcus multilocularis 0.0093 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0419 0.0419
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.0005
Echinococcus granulosus axis inhibition protein axin 0.0019 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0114 0.0113
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.018 0.0179
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0026 0.0076 0.0032
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) hypothetical protein 0.0067 0.0357 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0144 0.0144
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0291 0.1884 0.1882
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.003 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0291 0.1884 0.1878
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0419 0.0418
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.018 0.0179
Trypanosoma brucei Emopamil binding protein, putative 0.0411 0.2696 0.2694
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0419 0.0419
Trichomonas vaginalis abcb9, putative 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0508
Loa Loa (eye worm) hypothetical protein 0.0199 0.1252 0.1251
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0291 0.1884 0.1883
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0043 0.0043
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0079 0.0177
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0291 0.1884 0.1884
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0017 0.0012 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0419 0.0418
Schistosoma mansoni tyrosine kinase 0.0048 0.0226 0.0225
Schistosoma mansoni tyrosine kinase 0.0098 0.0565 0.0564
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0026 0.0076 0.0046
Leishmania major proteasome alpha 1 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0103 0.06 0.0594
Schistosoma mansoni biogenic amine (5HT) receptor 0.0199 0.1252 0.1251
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1152 0.7747 0.7746
Schistosoma mansoni nuclear hormone receptor 0.008 0.0443 0.0442
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0291 0.1884 0.1882
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0146 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0117
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0044 0.0044
Schistosoma mansoni tyrosine kinase 0.0159 0.0983 0.0982
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1483 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1523 0.1523
Brugia malayi G protein-coupled receptor 0.0076 0.0419 0.0418
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0706 0.0706
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0146 0.0138
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0125 0.0125
Onchocerca volvulus 0.0076 0.0419 0.1454
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0138 0.0136
Toxoplasma gondii hypothetical protein 0.0041 0.018 0.0173
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0001 0.0001
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0419 0.0418
Leishmania major C-14 sterol reductase, putative 0.0048 0.0223 0.0221
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0226 0.0226
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0419 0.0419
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0207 0.0177
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0034 0.0027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1979 0.1978
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0104 0.0103
Echinococcus granulosus phospholipase d3 0.0019 0.0032 0.0032
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0714 0.4762 0.4761
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0173
Leishmania major proteasome beta 7 subunit, putative 0.0291 0.1884 0.1882
Plasmodium falciparum amino acid transporter, putative 0.0041 0.018 0.0173
Leishmania major proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Onchocerca volvulus 0.0076 0.0419 0.1454
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0006
Plasmodium falciparum transporter, putative 0.0041 0.018 0.0173
Schistosoma mansoni tyrosine kinase 0.0159 0.0983 0.0982
Brugia malayi Cytochrome P450 family protein 0.003 0.0104 0.0103
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.1053 0.1052
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1913 0.1912
Echinococcus multilocularis somatostatin receptor 0.0076 0.0419 0.0419
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0138 0.0131
Schistosoma mansoni lipoxygenase 0.0118 0.0706 0.0705
Onchocerca volvulus 0.0076 0.0419 0.1454
Brugia malayi hypothetical protein 0.0036 0.0145 0.0144
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0419 0.0419
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0138 0.0108
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0146 0.0138
Onchocerca volvulus 0.0076 0.0419 0.1454
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0045 0.0042
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0291 0.1884 0.1882
Echinococcus granulosus importin subunit beta 1 0.0029 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Loa Loa (eye worm) PDE1B protein 0.0195 0.1225 0.1224
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Onchocerca volvulus Matrix metalloproteinase homolog 0.028 0.1807 0.6664
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0459 0.3027 0.3027
Entamoeba histolytica proteasome subunit beta type 1, putative 0.1152 0.7747 0.774
Echinococcus granulosus neuropeptide receptor A26 0.0538 0.3564 0.3564
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0169 0.1053 0.1052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.0509 0.0508
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0291 0.1884 0.1883
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0135 0.0135
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Trichomonas vaginalis taga, putative 0.0021 0.0044 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.0419 0.0419
Giardia lamblia Proteasome subunit beta type 3 0.0291 0.1884 0.1849
Plasmodium vivax hypothetical protein, conserved 0.0041 0.018 0.0173
Giardia lamblia 20S proteasome alpha subunit 6 0.0291 0.1884 0.1849
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.0443 0.0443
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0026 0.0076 0.0046
Schistosoma mansoni biogenic amine receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) matrix metalloproteinase 0.0126 0.076 0.0759
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0044 0.0013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1665 0.1665
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0079 0.0177
Schistosoma mansoni cpg binding protein 0.003 0.0107 0.0106
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0026 0.0076 0.0074
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0173
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0043 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0419 0.0419
Schistosoma mansoni lipoxygenase 0.0083 0.0463 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Brugia malayi Nuclear hormone receptor E75 0.008 0.0443 0.0442
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) polyprenyl synthetase 0.0103 0.06 0.0599
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.003 0.003
Mycobacterium ulcerans hydrolase 0.0154 0.0947 0.0907
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0291 0.1884 0.1882
Brugia malayi G-protein coupled receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Trypanosoma brucei cardiolipin synthetase 0.0036 0.0145 0.0142
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0419 0.0419
Schistosoma mansoni amine GPCR 0.0076 0.0419 0.0418
Brugia malayi proteasome subunit beta type 1 0.1152 0.7747 0.7747
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0044 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1053 0.1053
Echinococcus multilocularis expressed protein 0.0375 0.2451 0.2451
Echinococcus granulosus subfamily T1A non peptidase ue 0.0291 0.1884 0.1884
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0291 0.1884 0.1849
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0411 0.2696 0.2694
Brugia malayi PXA domain containing protein 0.0024 0.0061 0.006
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0291 0.1884 0.1849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0002
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0023 0.0057 0.0027
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0419 0.0418
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0291 0.1884 0.1848
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0044 0.0036
Brugia malayi nuclear receptor NHR-88 0.0169 0.1053 0.1052
Schistosoma mansoni jun-related protein 0.0069 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.0099 0.0577 0.0576
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0044 0.0013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0044 0.0044
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.0419 0.0419
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0419 0.0419
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0044 0.0036
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0291 0.1884 0.1882
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0108 0.0108
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0195 0.1225 0.1225
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0419 0.0418
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0291 0.1884 0.1882
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0419 0.0418
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0138 0.0131
Trypanosoma cruzi Emopamil binding protein, putative 0.0411 0.2696 0.2694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0207 0.0207
Schistosoma mansoni opsin-like receptor 0.0076 0.0419 0.0418
Brugia malayi ORL1-like opioid receptor 0.0076 0.0419 0.0418
Plasmodium vivax importin-beta 2, putative 0.0029 0.0094 0.0087
Brugia malayi Furin-like cysteine rich region family protein 0.0302 0.1953 0.1952
Brugia malayi Nuclear hormone receptor E75 0.008 0.0443 0.0442
Giardia lamblia Proteasome subunit beta type 1 0.1152 0.7747 0.7737
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0352 0.0345
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni nuclear receptor 0.008 0.0443 0.0442
Brugia malayi hypothetical protein 0.0089 0.0509 0.0508
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0026 0.0076 0.0076
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0508
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0169 0.1053 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni hypothetical protein 0.0179 0.1119 0.1118
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0291 0.1884 0.1859
Loa Loa (eye worm) phospholipase D 0.0019 0.0032 0.0031
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.1152 0.7747 0.7747
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0045 0.0037
Onchocerca volvulus 0.0076 0.0419 0.1454
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Onchocerca volvulus Matrilysin homolog 0.0126 0.076 0.2731
Brugia malayi nuclear receptor RXR 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0508
Echinococcus granulosus neuropeptide receptor 0.0076 0.0419 0.0419
Trypanosoma cruzi 20S proteasome subunit 0.0714 0.4762 0.476
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0006
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0026 0.0076 0.0076
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0044 0.0044
Brugia malayi RNA, U transporter 1 0.0081 0.0453 0.0452
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0443 0.0443
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0041 0.018 0.018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.003 0.0029
Trypanosoma brucei proteasome alpha 7 subunit 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0419 0.0419
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0207 0.0204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0146 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0138 0.0138
Brugia malayi Dopamine receptor protein 1 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Schistosoma mansoni hypothetical protein 0.0411 0.2696 0.2695
Trypanosoma brucei proteasome beta 6 subunit 0.1152 0.7747 0.7746
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0291 0.1884 0.1882
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0045 0.0037
Echinococcus granulosus biogenic amine 5HT receptor 0.0199 0.1252 0.1252
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0026 0.0076 0.0032
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0419 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0146 0.0144
Schistosoma mansoni tyrosine kinase 0.0098 0.0565 0.0564
Echinococcus multilocularis lamin b receptor 0.0048 0.0223 0.0223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0596 0.3958 0.3958
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0145 0.0144
Onchocerca volvulus 0.0076 0.0419 0.1454
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0044 0.0044
Schistosoma mansoni neuropeptide receptor 0.0076 0.0419 0.0418
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0291 0.1884 0.1882
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.004
Mycobacterium ulcerans proteasome PrcA 0.0291 0.1884 0.1848
Trypanosoma cruzi polyprenyl synthase, putative 0.0026 0.0076 0.0074
Brugia malayi larval opioid receptor 0.0076 0.0419 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1053 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0065
Onchocerca volvulus 0.0076 0.0419 0.1454
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0179
Schistosoma mansoni hypothetical protein 0.017 0.1058 0.1057
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0419 0.0419
Brugia malayi hypothetical protein 0.0019 0.003 0.0029
Brugia malayi nuclear hormone receptor 0.0169 0.1053 0.1052
Leishmania major p-glycoprotein 0.0021 0.0044 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis transcription factor btf3 0.0035 0.0138 0.0138
Loa Loa (eye worm) TK protein kinase 0.0041 0.0176 0.0175
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Mycobacterium leprae PROBABLE HYDROLASE 0.0154 0.0947 0.0907
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0108 0.01
Mycobacterium ulcerans proteasome PrcB 0.1483 1 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1884 0.1884
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.2696 0.2696
Echinococcus multilocularis snurportin 1 0.0305 0.1979 0.1979
Echinococcus multilocularis conserved hypothetical protein 0.0693 0.4617 0.4617
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0176 0.0176
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.018 0.0179
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Echinococcus multilocularis jun protein 0.0084 0.0473 0.0473
Trypanosoma brucei C-8 sterol isomerase, putative 0.1459 0.9836 0.9836
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Brugia malayi protein-tyrosine kinase 0.0041 0.0176 0.0175
Brugia malayi Protein K4 0.0017 0.0012 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0094 0.0092
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0042
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0714 0.4762 0.4758
Onchocerca volvulus 0.0041 0.018 0.0555
Trypanosoma brucei cardiolipin synthetase, putative 0.0036 0.0145 0.0142
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0026 0.0076 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0169 0.1053 0.3831
Echinococcus granulosus NCK adaptor protein 0.0015 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0152 0.0152
Brugia malayi hypothetical protein 0.002 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.1152 0.7747 0.7746
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0045 0.0037
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0026 0.0076 0.0069
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1152 0.7747 0.7747
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0419 0.0418
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0419 0.0418
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0045 0.0037
Trypanosoma cruzi C-14 sterol reductase, putative 0.0048 0.0223 0.0221
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.003
Leishmania major basic transcription factor 3a, putative 0.0035 0.0138 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0144 0.0144
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0146 0.0138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0043
Trypanosoma cruzi C-14 sterol reductase, putative 0.0048 0.0223 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0291 0.1884 0.1884
Schistosoma mansoni Lamin B receptor (ERG24) 0.0048 0.0223 0.0222
Brugia malayi photoreceptor-specific nuclear receptor 0.0169 0.1053 0.1052
Schistosoma mansoni hypothetical protein 0.0036 0.0145 0.0144
Plasmodium vivax SET domain protein, putative 0.0031 0.0108 0.01
Onchocerca volvulus 0.0026 0.0079 0.0177
Brugia malayi ecdysteroid receptor 0.0169 0.1053 0.1052
Trypanosoma brucei cytochrome P450, putative 0.003 0.0104 0.0102
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.003 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0076 0.0419 0.0418
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0044 0.0044
Schistosoma mansoni smdr2 0.0021 0.0044 0.0043
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0033
Entamoeba histolytica phospholipase D, putative 0.0103 0.0603 0.0574
Echinococcus multilocularis sex peptide receptor 0.0076 0.0419 0.0419
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0291 0.1884 0.1882
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0323 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0419 0.0419
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0243 0.1552 0.1552
Schistosoma mansoni steroid hormone receptor ad4bp 0.0169 0.1053 0.1052
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Brugia malayi steroid hormone receptor 0.0169 0.1053 0.1052
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.0443 0.0442
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0419 0.0419
Onchocerca volvulus 0.002 0.0034 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0138 0.0138
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0169 0.1053 0.1052
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0291 0.1884 0.1878
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0045 0.0037
Toxoplasma gondii proteasome beta subunit 0.0291 0.1884 0.1878
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0026 0.0076 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0173
Echinococcus multilocularis serotonin receptor 0.0199 0.1252 0.1252
Toxoplasma gondii hypothetical protein 0.0041 0.018 0.0173
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0045 0.0045
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0291 0.1884 0.1859
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0291 0.1884 0.1883
Mycobacterium ulcerans hypothetical protein 0.0036 0.0146 0.0101
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0044 0.0044
Echinococcus granulosus jun protein 0.0084 0.0473 0.0473
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.0443 0.0442
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Echinococcus granulosus expressed protein 0.0375 0.2451 0.2451
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0291 0.1884 0.1878
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0291 0.1884 0.1884
Echinococcus multilocularis insulin receptor 0.0098 0.0565 0.0565
Schistosoma mansoni hypothetical protein 0.017 0.1058 0.1057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0027 0.0025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.0443 0.0442
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0443 0.0443
Leishmania major cardiolipin synthetase, putative 0.0017 0.0012 0.001
Schistosoma mansoni histamine h1 receptor 0.0076 0.0419 0.0418
Echinococcus multilocularis tyrosine protein kinase Abl 0.0019 0.0027 0.0027
Echinococcus multilocularis phospholipase D 0.0091 0.0521 0.0521
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0419 0.0419
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0714 0.4762 0.476
Brugia malayi Steroid receptor seven-up type 2 0.0169 0.1053 0.1052
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0113
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0207 0.0204
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0026 0.0076 0.0344
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) hypothetical protein 0.0089 0.0509 0.0508
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0079 0.0078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0108 0.0108
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0026 0.0076 0.0074
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0291 0.1884 0.1883
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0146 0.0146
Schistosoma mansoni ran 0.0021 0.0043 0.0042
Plasmodium vivax proteasome subunit beta type-7, putative 0.0291 0.1884 0.1878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0419 0.0419
Brugia malayi bZIP transcription factor family protein 0.0084 0.0473 0.0472
Brugia malayi Pre-SET motif family protein 0.0031 0.0108 0.0107
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.1152 0.7747 0.7747
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1053 0.1052
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0138 0.0131
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.0443 0.0442
Brugia malayi hypothetical protein 0.0122 0.0732 0.0731
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0291 0.1884 0.1878
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.003 0.0029
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0041 0.018 0.018
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0291 0.1884 0.1859
Echinococcus multilocularis cpg binding protein 0.003 0.0107 0.0107
Brugia malayi Serotonin receptor 0.0076 0.0419 0.0418
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.018 0.0179
Loa Loa (eye worm) DR-78 0.008 0.0443 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0146 0.0138
Loa Loa (eye worm) RGS-3 protein 0.0019 0.003 0.0029
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0043 0.0035
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0419 0.0418
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.004
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0226 0.0226
Loa Loa (eye worm) norepinephrine transporter 0.0243 0.1552 0.1552
Onchocerca volvulus 0.0179 0.1119 0.4081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0419 0.0419
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0082 0.0458 0.0457
Entamoeba histolytica phospholipase D, putative 0.0103 0.0603 0.0574
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0419 0.0419
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.1058 0.3851
Onchocerca volvulus 0.0076 0.0419 0.1454
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0094 0.0087
Giardia lamblia 20S proteasome alpha subunit 4 0.0291 0.1884 0.1849
Schistosoma mansoni ets-related 0.0221 0.1402 0.1402
Echinococcus multilocularis proteasome subunit alpha type 6 0.0291 0.1884 0.1884
Leishmania major cytochrome p450-like protein 0.003 0.0104 0.0102
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.0443 0.0443
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1483 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0083 0.0083
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0443 0.1544
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni nuclear hormone receptor 0.0169 0.1053 0.1052
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0042 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.0057
Echinococcus multilocularis epidermal growth factor receptor 0.0302 0.1953 0.1953
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0291 0.1884 0.1882
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0128 0.0128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.018 0.018
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0291 0.1884 0.1882
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Brugia malayi Dopamine receptor 0.0076 0.0419 0.0418
Leishmania major solanesyl-diphosphate synthase, putative 0.0026 0.0076 0.0074
Schistosoma mansoni amine GPCR 0.0076 0.0419 0.0418
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0291 0.1884 0.1878
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0419 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0169 0.1053 0.1052
Plasmodium falciparum proteasome subunit beta type-1, putative 0.1152 0.7747 0.7745
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0419 0.0419
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0103 0.06 0.0558
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.076 0.076
Schistosoma mansoni adenoreceptor 0.0076 0.0419 0.0418
Echinococcus granulosus Proteasome subunit alpha type 7 0.0291 0.1884 0.1884
Brugia malayi nuclear receptor RXR 0.0089 0.0509 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0002
Plasmodium vivax proteasome subunit beta type-1, putative 0.1152 0.7747 0.7745
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0291 0.1884 0.1884
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0114 0.0113
Schistosoma mansoni coup transcription factor 0.0169 0.1053 0.1052
Loa Loa (eye worm) hypothetical protein 0.0243 0.1552 0.1552
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0144
Toxoplasma gondii proteasome subunit alpha type, putative 0.0291 0.1884 0.1878
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0144 0.0142
Brugia malayi Cytochrome P450 family protein 0.006 0.0305 0.0304
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0152 0.0151
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0714 0.4762 0.4762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0011
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0291 0.1884 0.1882
Onchocerca volvulus 0.008 0.0443 0.1544
Onchocerca volvulus Protein ultraspiracle homolog 0.0169 0.1053 0.3831
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0291 0.1884 0.1878
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0169 0.1053 0.1053
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0125 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.003 0.003
Brugia malayi proteasome subunit alpha type 2 0.0291 0.1884 0.1883
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0223 0.0221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0473 0.0473
Leishmania major proteasome beta 3 subunit, putative 0.0291 0.1884 0.1882
Schistosoma mansoni gabp alpha 0.0073 0.0394 0.0393
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.003 0.003
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0044 0.0013
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0017 0.0012 0.0005
Loa Loa (eye worm) PXA domain-containing protein 0.0024 0.0061 0.006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0226 0.0226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0443 0.0443
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0291 0.1884 0.1884
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.018 0.018
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0041 0.018 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0419 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0169 0.1053 0.1052
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0509 0.0508
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0419 0.0419
Schistosoma mansoni tyrosine kinase 0.0019 0.0027 0.0026
Brugia malayi proteasome subunit alpha type 1 0.0291 0.1884 0.1883
Schistosoma mansoni hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Loa Loa (eye worm) doublecortin family protein 0.002 0.0034 0.0033
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0113
Brugia malayi proteasome subunit alpha type 3 0.0291 0.1884 0.1883
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0291 0.1884 0.1884
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0419 0.0418
Loa Loa (eye worm) SRC-1 0.0048 0.0226 0.0225
Brugia malayi hypothetical protein 0.0076 0.0419 0.0418
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0179
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.018 0.0179
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0195 0.1225 0.1224
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0291 0.1884 0.1883
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0128 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0419 0.0419
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0036 0.0145 0.0137
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0291 0.1884 0.1882
Loa Loa (eye worm) TK/EGFR protein kinase 0.0302 0.1953 0.1952
Loa Loa (eye worm) CYP4Cod1 0.003 0.0104 0.0103
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.0443 0.0442
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0291 0.1884 0.1882
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0169 0.1053 0.1052
Brugia malayi neuropeptide F receptor 0.0076 0.0419 0.0418
Entamoeba histolytica hypothetical protein 0.0036 0.0145 0.0115
Brugia malayi hypothetical protein 0.008 0.0443 0.0442
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0027 0.0027
Onchocerca volvulus 0.0076 0.0419 0.1454
Brugia malayi conserved hypotetical protein 0.008 0.0443 0.0442
Echinococcus multilocularis peroxidasin 0.0026 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.0036 0.0145 0.0115
Onchocerca volvulus Bile acid receptor homolog 0.0169 0.1053 0.3831
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0079 0.0078
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0419 0.0419
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0026 0.0076 0.0074
Trypanosoma brucei C-14 sterol reductase, putative 0.0048 0.0223 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1058 0.1058
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0291 0.1884 0.1883
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0291 0.1884 0.1878
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0029
Echinococcus granulosus serotonin receptor 0.0076 0.0419 0.0419
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0226 0.0226
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0394 0.0394
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0509 0.0508
Loa Loa (eye worm) hypothetical protein 0.0126 0.076 0.0759
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0419 0.0419
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0291 0.1884 0.1859
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0291 0.1884 0.1882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0207 0.0207
Echinococcus multilocularis proteasome subunit alpha type 2 0.0291 0.1884 0.1884
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0026 0.0076 0.0069
Giardia lamblia 20S proteasome alpha subunit 3 0.0291 0.1884 0.1849
Schistosoma mansoni glutathione synthetase 0.0026 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0078
Plasmodium falciparum importin beta, putative 0.0029 0.0094 0.0087
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0291 0.1884 0.1882
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0017 0.0012 0.0005
Onchocerca volvulus 0.0029 0.0096 0.0239
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0418
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0419 0.0419
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0044 0.0044
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0291 0.1884 1
Onchocerca volvulus 0.0076 0.0419 0.1454
Loa Loa (eye worm) hypothetical protein 0.0087 0.049 0.0489
Leishmania major proteasome beta 2 subunit, putative 0.0714 0.4762 0.476
Mycobacterium ulcerans lipase LipD 0.0036 0.0146 0.0101
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0706 0.0706
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0291 0.1884 0.1883
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0291 0.1884 0.1878
Echinococcus granulosus epidermal growth factor receptor 0.0302 0.1953 0.1953
Echinococcus granulosus tm gpcr rhodopsin 0.0908 0.608 0.608
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0207 0.0204
Leishmania major sterol C-24 reductase, putative 0.0048 0.0223 0.0221
Brugia malayi proteasome subunit beta type 3 0.0291 0.1884 0.1883
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0442
Brugia malayi hypothetical protein 0.0041 0.018 0.0179
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0419 0.0418
Onchocerca volvulus 0.0076 0.0419 0.1454
Trypanosoma brucei proteasome beta 7 subunit 0.0291 0.1884 0.1882
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0026 0.0076 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0169 0.1053 0.1052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0577 0.0576

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 904 ng ml-1 hr-1 The compound was evaluated for oral bioavailability data in the rat ChEMBL. 10522712
Cmax (ADMET) = 47.55 ng ml-1 The compound was evaluated for oral bioavailability data in the rat at 6 hr ChEMBL. 10522712
IC50 (binding) = 6.4 Inhibition of MMP3 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 6.52 Inhibition of MMP2 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 7.4 Inhibition of MMP13 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 8 Inhibition of MMP8 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 6 nM Inhibition of HFC MMP-1 ChEMBL. 10522712
IC50 (binding) = 6 nM Inhibition of HFC MMP-1 ChEMBL. 10522712
IC50 (binding) = 10 nM Inhibition of HNC MMP-8 ChEMBL. 10522712
IC50 (binding) = 10 nM Inhibition of HNC MMP-8 ChEMBL. 10522712
IC50 (binding) = 40 nM Inhibition of Coll-3 MMP-13 ChEMBL. 10522712
IC50 (binding) = 40 nM Inhibition of Coll-3 MMP-13 ChEMBL. 10522712
IC50 (binding) = 300 nM Inhibition of Gel-A MMP-2 ChEMBL. 10522712
IC50 (binding) = 300 nM Inhibition of Gel-A MMP-2 ChEMBL. 10522712
IC50 (binding) = 400 nM Inhibition of Strom-1 MMP-3 ChEMBL. 10522712
IC50 (binding) = 400 nM Inhibition of Strom-1 MMP-3 ChEMBL. 10522712
log(1/IC50) (binding) = 6.4 Inhibition of MMP3 (unknown origin) ChEMBL. 17275314
log(1/IC50) (binding) = 6.52 Inhibition of MMP2 (unknown origin) ChEMBL. 17275314
log(1/IC50) (binding) = 7.4 Inhibition of MMP13 (unknown origin) ChEMBL. 17275314
log(1/IC50) (binding) = 8 Inhibition of MMP8 (unknown origin) ChEMBL. 17275314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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