Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.1052 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0355 | 0.1813 | 0.3111 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.1052 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0414 | 0.2504 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0414 | 0.2504 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0414 | 0.2504 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0496 | 0.3468 | 0.5951 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0414 | 0.2504 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0496 | 0.3468 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0414 | 0.2504 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0355 | 0.1813 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2504 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0355 | 0.1813 | 0.5229 |
Echinococcus granulosus | acetylcholinesterase | 0.0414 | 0.2504 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0496 | 0.3468 | 0.5951 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0312 | 0.1304 | 0.2238 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0414 | 0.2504 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0697 | 0.5827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2504 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0414 | 0.2504 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0414 | 0.2504 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0414 | 0.2504 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0414 | 0.2504 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of CXCR1/2 in human polymorphonucleate cells assessed as inhibition of CXCL8-induced chemotaxis at 10'-8 M incubated for 15 mins prior to CXCL8-induction measured after 45 mins | ChEMBL. | 24900265 | |
Inhibition (binding) | Inhibition of CXCR2 in human polymorphonucleate cells assessed as inhibition of CXCL1-induced chemotaxis at 10'-8 M incubated for 15 mins prior to CXCL1-induction measured after 45 mins | ChEMBL. | 24900265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.