Detailed information for compound 163009

Basic information

Technical information
  • TDR Targets ID: 163009
  • Name: 3-[[benzyl(methyl)amino]methyl]-5-chloro-1,3- benzoxazol-2-one
  • MW: 302.756 | Formula: C16H15ClN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cn1c(=O)oc2c1cc(Cl)cc2)Cc1ccccc1
  • InChi: 1S/C16H15ClN2O2/c1-18(10-12-5-3-2-4-6-12)11-19-14-9-13(17)7-8-15(14)21-16(19)20/h2-9H,10-11H2,1H3
  • InChiKey: MXLGRRCXEGWFFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-3-[[methyl(phenylmethyl)amino]methyl]-1,3-benzoxazol-2-one
  • 5-chloro-3-[(methyl-(phenylmethyl)amino)methyl]-1,3-benzoxazol-2-one
  • 3-[(benzyl-methyl-amino)methyl]-5-chloro-1,3-benzoxazol-2-one
  • ST5432333

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nitric oxide synthase 3 (endothelial cell) Starlite/ChEMBL No references
Homo sapiens nitric oxide synthase 2, inducible Starlite/ChEMBL No references
Homo sapiens nitric oxide synthase 1 (neuronal) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.4003 0.222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus g protein coupled receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni opsin-like receptor 0.0064 0.4003 0.4003
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.4003 0.222
Brugia malayi larval opioid receptor 0.0064 0.4003 0.222
Echinococcus multilocularis serotonin receptor 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide receptor 0.0064 0.4003 0.222
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.4003 0.222
Echinococcus multilocularis fmrfamide receptor 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.4003 0.222
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.4003 0.222
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Schistosoma mansoni amine GPCR 0.0064 0.4003 0.4003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.4003 0.4003
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0091 1 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.4003 0.222
Echinococcus multilocularis allatostatin A receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.4003 0.4003
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.4003 0.222
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.4003 0.222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.4003 0.222
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0091 1 0.5
Schistosoma mansoni cytochrome P450 reductase 0.0091 1 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0091 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.4003 0.4003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.4003 0.222
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.4003 0.4003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptide receptor 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide receptor 0.0064 0.4003 0.222
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.4003 0.4003
Echinococcus granulosus hypothetical protein 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi G-protein coupled receptor 0.0064 0.4003 0.222
Schistosoma mansoni biogenic amine receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis serotonin receptor 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.4003 0.222
Schistosoma mansoni opsin-like receptor 0.0064 0.4003 0.4003
Schistosoma mansoni adenoreceptor 0.0064 0.4003 0.4003
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus granulosus orexin receptor type 2 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Brugia malayi sulfakinin receptor protein 0.0064 0.4003 0.222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0056 0.2291 0.2291
Echinococcus multilocularis g protein coupled receptor 0.0064 0.4003 0.222
Brugia malayi AKH receptor 0.0064 0.4003 0.222
Brugia malayi GnHR receptor homolog 0.0064 0.4003 0.222
Schistosoma mansoni neuropeptide receptor 0.0064 0.4003 0.4003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) FAD binding domain-containing protein 0.0091 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.4003 0.222
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.4003 0.222
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0091 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.4003 0.222
Echinococcus granulosus neuropeptide s receptor 0.0064 0.4003 0.222
Echinococcus granulosus g protein coupled receptor 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis g protein coupled receptor 0.0064 0.4003 0.222
Leishmania major p450 reductase, putative 0.0091 1 1
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis somatostatin receptor 0.0064 0.4003 0.222
Plasmodium falciparum nitric oxide synthase, putative 0.0091 1 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.4003 0.222
Echinococcus granulosus fmrfamide receptor 0.0064 0.4003 0.222
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.4003 0.222
Schistosoma mansoni neuropeptide receptor 0.0064 0.4003 0.4003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.4003 0.4003
Giardia lamblia Hypothetical protein 0.0081 0.7709 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0091 1 0.5
Echinococcus granulosus g protein coupled receptor 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Brugia malayi Dopamine receptor 0.0064 0.4003 0.222
Brugia malayi putative neuropeptide receptor 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.4003 0.222
Trichomonas vaginalis sulfite reductase, putative 0.0091 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.4003 0.222
Echinococcus granulosus somatostatin receptor 0.0064 0.4003 0.222
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0091 1 0.5
Brugia malayi Dopamine receptor protein 1 0.0064 0.4003 0.222
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0091 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.4003 0.4003
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.4003 0.222
Echinococcus granulosus allatostatin A receptor 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.4003 0.222
Echinococcus multilocularis g protein coupled receptor 0.0064 0.4003 0.222
Brugia malayi RE15519p 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.4003 0.222
Brugia malayi G-protein coupled receptor 0.0064 0.4003 0.222
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0091 1 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.4003 0.222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.4003 0.222
Schistosoma mansoni biogenic amine receptor 0.0064 0.4003 0.4003
Schistosoma mansoni amine GPCR 0.0064 0.4003 0.4003
Onchocerca volvulus 0.0064 0.4003 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni hypothetical protein 0.0064 0.4003 0.4003
Schistosoma mansoni amine GPCR 0.0064 0.4003 0.4003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.4003 0.4003
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0091 1 1
Schistosoma mansoni hypothetical protein 0.0064 0.4003 0.4003
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis sex peptide receptor 0.0064 0.4003 0.222
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.4003 0.4003
Schistosoma mansoni hypothetical protein 0.0064 0.4003 0.4003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.4003 0.4003
Brugia malayi neuropeptide F receptor 0.0064 0.4003 0.222
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.4003 0.222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.4003 0.222
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.4003 0.222
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.4003 0.222
Echinococcus granulosus sex peptide receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.4003 0.222
Schistosoma mansoni histamine h1 receptor 0.0064 0.4003 0.4003
Schistosoma mansoni hypothetical protein 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.4003 0.222
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.4003 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Schistosoma mansoni neuropeptide receptor 0.0064 0.4003 0.4003
Brugia malayi Serotonin receptor 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.4003 0.222
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.4003 0.222
Brugia malayi G protein-coupled receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.4003 0.222
Echinococcus granulosus serotonin receptor 0.0064 0.4003 0.222
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0091 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0091 1 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0091 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi ORL1-like opioid receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni amine GPCR 0.0064 0.4003 0.4003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.4003 0.222
Giardia lamblia Nitric oxide synthase, inducible 0.0081 0.7709 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.4003 0.4003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Onchocerca volvulus 0.0064 0.4003 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.4003 0.222
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni opsin-like receptor 0.0064 0.4003 0.4003
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.4003 0.222
Chlamydia trachomatis sulfite reductase 0.0056 0.2291 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Schistosoma mansoni myosin xvIII 0.0064 0.4003 0.4003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis fmrfamide receptor 0.0064 0.4003 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.4003 0.222
Brugia malayi FAD binding domain containing protein 0.0091 1 1
Schistosoma mansoni biogenic amine receptor 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.4003 0.222
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.4003 0.4003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) hypothetical protein 0.0091 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi follicle stimulating hormone receptor 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.4003 0.4003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.4003 0.222
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.4003 0.5
Brugia malayi neuropeptide F receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus multilocularis neuropeptide receptor 0.0064 0.4003 0.222
Schistosoma mansoni amine GPCR 0.0064 0.4003 0.4003
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.4003 0.222
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.4003 0.222
Echinococcus granulosus g-protein coupled receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.4003 0.4003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.4003 0.4003
Echinococcus multilocularis orexin receptor type 2 0.0064 0.4003 0.222
Brugia malayi hypothetical protein 0.0064 0.4003 0.222
Schistosoma mansoni neuropeptide receptor 0.0064 0.4003 0.4003
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.4003 0.222
Onchocerca volvulus 0.0064 0.4003 0.5
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0091 1 0.5
Brugia malayi Melatonin receptor type 1A 0.0064 0.4003 0.222
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.4003 0.222
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.4003 0.222
Brugia malayi Serotonin receptor 0.0064 0.4003 0.222
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.4003 0.222
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Brugia malayi Dopamine receptor protein 2 0.0064 0.4003 0.222
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0091 1 1
Trypanosoma cruzi p450 reductase, putative 0.0091 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.4003 0.222
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.4003 0.222

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11.5 uM Inhibitory activity against Neuronal nitric oxide synthase ChEMBL. No reference
IC50 (binding) = 11.5 uM Inhibitory activity against Neuronal nitric oxide synthase ChEMBL. No reference
IC50 (binding) = 13.4 uM Inhibitory activity against Inducible nitric oxide synthase ChEMBL. No reference
IC50 (binding) = 13.4 uM Inhibitory activity against Inducible nitric oxide synthase ChEMBL. No reference
IC50 (binding) = 13.6 uM Inhibitory activity against Endothelial nitric oxide synthase ChEMBL. No reference
IC50 (binding) = 13.6 uM Inhibitory activity against Endothelial nitric oxide synthase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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