Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Brugia malayi | fibroinase precursor | 0.0113 | 0.1126 | 0.1126 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.4054 |
Echinococcus granulosus | cathepsin b | 0.0788 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0278 | 0.3296 | 0.2445 |
Onchocerca volvulus | Cathepsin F homolog | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.052 | 0.6478 | 0.6031 |
Plasmodium vivax | vivapain-3 | 0.0278 | 0.3296 | 0.4054 |
Plasmodium vivax | unspecified product | 0.0278 | 0.3296 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.4309 | 0.4309 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.052 | 0.6478 | 0.6031 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.052 | 0.6478 | 0.6031 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0165 | 0.181 | 0.0771 |
Echinococcus multilocularis | cysteine protease | 0.052 | 0.6478 | 0.6031 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.052 | 0.6478 | 0.6031 |
Echinococcus granulosus | cathepsin l1 | 0.0355 | 0.4309 | 0.3586 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.181 | 0.181 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0355 | 0.4309 | 0.5946 |
Echinococcus multilocularis | cathepsin b | 0.0788 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0278 | 0.3296 | 0.4054 |
Loa Loa (eye worm) | ctsf protein | 0.052 | 0.6478 | 0.6478 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0165 | 0.181 | 0.181 |
Echinococcus multilocularis | cysteine protease | 0.052 | 0.6478 | 0.6031 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0355 | 0.4309 | 0.3586 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0278 | 0.3296 | 0.2445 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.4309 | 0.4309 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.181 | 0.181 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0278 | 0.3296 | 0.2445 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Echinococcus multilocularis | cathepsin L | 0.0278 | 0.3296 | 0.2445 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.052 | 0.6478 | 0.6031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0322 | 0.3871 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.6478 | 0.6478 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0113 | 0.1126 | 0.1126 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.2445 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0113 | 0.1126 | 0.1126 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0278 | 0.3296 | 0.3296 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Loa Loa (eye worm) | cathepsin B | 0.0322 | 0.3871 | 0.3871 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0278 | 0.3296 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0165 | 0.181 | 0.181 |
Echinococcus granulosus | cysteine protease | 0.0278 | 0.3296 | 0.2445 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0113 | 0.1126 | 0.1126 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0278 | 0.3296 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0322 | 0.3871 | 0.1806 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.052 | 0.6478 | 1 |
Echinococcus granulosus | cathepsin L | 0.0278 | 0.3296 | 0.2445 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0113 | 0.1126 | 0.1126 |
Onchocerca volvulus | Cathepsin L homolog | 0.052 | 0.6478 | 1 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0355 | 0.4309 | 0.4309 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0113 | 0.1126 | 0.1126 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0113 | 0.1126 | 0.1126 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.181 | 0.0771 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0355 | 0.4309 | 0.5946 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0278 | 0.3296 | 0.2445 |
Leishmania major | cysteine peptidase A (CPA) | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0788 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0113 | 0.1126 | 0.1126 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.052 | 0.6478 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.181 | 0.181 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0278 | 0.3296 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.052 | 0.6478 | 0.6478 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.052 | 0.6478 | 0.6031 |
Echinococcus granulosus | cathepsin l1 | 0.052 | 0.6478 | 0.6031 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.052 | 0.6478 | 0.6031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.052 | 0.6478 | 0.6478 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0355 | 0.4309 | 0.5946 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0278 | 0.3296 | 0.4054 |
Trypanosoma cruzi | cysteine protease, putative | 0.0278 | 0.3296 | 0.2445 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Plasmodium vivax | vivapain-2 | 0.052 | 0.6478 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0322 | 0.3871 | 0.3093 |
Giardia lamblia | Cathepsin B precursor | 0.0322 | 0.3871 | 1 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Plasmodium vivax | unspecified product | 0.0165 | 0.181 | 0.1278 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.2445 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin L precursor | 0.0113 | 0.1126 | 0.1126 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.4054 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0355 | 0.4309 | 0.4309 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.052 | 0.6478 | 1 |
Onchocerca volvulus | 0.0355 | 0.4309 | 0.5946 | |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0355 | 0.4309 | 0.4309 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0113 | 0.1126 | 0.1126 |
Plasmodium vivax | vivapain-1 | 0.0278 | 0.3296 | 0.4054 |
Toxoplasma gondii | cathepsin B | 0.0322 | 0.3871 | 0.5128 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0788 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0788 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0788 | 1 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0113 | 0.1126 | 0.1126 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.052 | 0.6478 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.181 | 0.181 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0278 | 0.3296 | 0.2445 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.052 | 0.6478 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.052 | 0.6478 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.052 | 0.6478 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0113 | 0.1126 | 0.1126 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.052 | 0.6478 | 0.6031 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0355 | 0.4309 | 0.3586 |
Loa Loa (eye worm) | fibroinase | 0.052 | 0.6478 | 0.6478 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0113 | 0.1126 | 0.1126 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Schistosoma mansoni | cathepsin s | 0.0165 | 0.181 | 0.0771 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.052 | 0.6478 | 0.6478 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0278 | 0.3296 | 0.4054 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.052 | 0.6478 | 0.6031 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0278 | 0.3296 | 0.2445 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.052 | 0.6478 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.052 | 0.6478 | 0.6031 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.052 | 0.6478 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0165 | 0.181 | 0.181 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1126 | 0.1126 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0788 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0322 | 0.3871 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0278 | 0.3296 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0322 | 0.3871 | 0.5128 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0322 | 0.3871 | 0.3093 |
Brugia malayi | Cathepsin L-like precursor | 0.0355 | 0.4309 | 0.4309 |
Onchocerca volvulus | 0.052 | 0.6478 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.052 | 0.6478 | 0.6478 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.052 | 0.6478 | 0.6031 |
Entamoeba histolytica | cysteine protease, putative | 0.0278 | 0.3296 | 0.4054 |
Echinococcus granulosus | cathepsin b | 0.0788 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0788 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.052 | 0.6478 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.052 | 0.6478 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.052 | 0.6478 | 0.6478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.