Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cathepsin B | 0.1564 | 0.1653 | 0.0754 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4038 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1979 | 0.3056 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1979 | 0.3056 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1362 | 0.0973 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1979 | 0.3056 | 0.3056 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1362 | 0.0973 | 0.0973 |
Giardia lamblia | Cathepsin B precursor | 0.1564 | 0.1653 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.1979 | 0.3056 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1362 | 0.0973 | 0.0973 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1979 | 0.3056 | 0.2308 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1979 | 0.3056 | 0.3056 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1979 | 0.3056 | 0.3056 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1564 | 0.1653 | 0.1653 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.4038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4038 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1979 | 0.3056 | 0.3056 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1979 | 0.3056 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1979 | 0.3056 | 0.2308 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Echinococcus granulosus | cathepsin b | 0.4038 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1564 | 0.1653 | 0.5409 |
Loa Loa (eye worm) | ctsf protein | 0.1979 | 0.3056 | 0.2308 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4038 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1979 | 0.3056 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1979 | 0.3056 | 0.2308 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4038 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1979 | 0.3056 | 1 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1564 | 0.1653 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1979 | 0.3056 | 0.3056 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1979 | 0.3056 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Plasmodium vivax | vivapain-2 | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1979 | 0.3056 | 0.3056 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1564 | 0.1653 | 0.5409 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1362 | 0.0973 | 0.0973 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1979 | 0.3056 | 0.3056 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1362 | 0.0973 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Leishmania major | cysteine peptidase A (CPA) | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1362 | 0.0973 | 0.0973 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1564 | 0.1653 | 0.5 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.1362 | 0.0973 | 0.0973 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1979 | 0.3056 | 0.3056 |
Echinococcus granulosus | cathepsin l1 | 0.1979 | 0.3056 | 0.3056 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1362 | 0.0973 | 0.0973 |
Echinococcus multilocularis | cathepsin b | 0.4038 | 1 | 1 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.1979 | 0.3056 | 0.2308 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1979 | 0.3056 | 0.2308 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Onchocerca volvulus | 0.1979 | 0.3056 | 1 | |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1979 | 0.3056 | 0.3056 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1979 | 0.3056 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1979 | 0.3056 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Brugia malayi | Cathepsin L-like precursor | 0.1979 | 0.3056 | 0.3056 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1362 | 0.0973 | 0.0973 |
Plasmodium vivax | vivapain-2 | 0.1979 | 0.3056 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1979 | 0.3056 | 0.3056 |
Onchocerca volvulus | Cathepsin F homolog | 0.1979 | 0.3056 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4038 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4038 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1564 | 0.1653 | 0.1653 |
Echinococcus granulosus | cathepsin b | 0.4038 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1979 | 0.3056 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1979 | 0.3056 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1362 | 0.0973 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1979 | 0.3056 | 0.3056 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1979 | 0.3056 | 1 |
Leishmania major | cathepsin L-like protease | 0.1979 | 0.3056 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.