Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3868 | 0.3123 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Toxoplasma gondii | cathepsin CPL | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1837 | 0.0913 | 0.2198 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1837 | 0.0913 | 0.2198 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Plasmodium vivax | vivapain-2 | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.149 | 0.0536 | 0.1716 |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1265 | 0.029 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1265 | 0.029 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.1837 | 0.0913 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Echinococcus granulosus | cathepsin l1 | 0.1265 | 0.029 | 0.029 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.3868 | 0.3123 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.149 | 0.0536 | 0.1716 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1265 | 0.029 | 0.093 |
Echinococcus multilocularis | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3868 | 0.3123 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1837 | 0.0913 | 0.2924 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 1.019 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1837 | 0.0913 | 0.2924 |
Onchocerca volvulus | Cathepsin L homolog | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1265 | 0.029 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1265 | 0.029 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.149 | 0.0536 | 0.5868 |
Onchocerca volvulus | Cathepsin F homolog | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Echinococcus granulosus | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Loa Loa (eye worm) | hypothetical protein | 0.1837 | 0.0913 | 0.2198 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1265 | 0.029 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1837 | 0.0913 | 0.2198 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.149 | 0.0536 | 0.5868 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1837 | 0.0913 | 0.2198 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1837 | 0.0913 | 0.2198 |
Loa Loa (eye worm) | cathepsin B | 0.149 | 0.0536 | 0.0866 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1837 | 0.0913 | 0.0913 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1837 | 0.0913 | 0.2924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.