Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ctsf protein | 0.2123 | 0.3087 | 0.2334 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.146 | 0.0982 | 0.3182 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1667 | 0.1639 | 0.531 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2123 | 0.3087 | 0.3087 |
Echinococcus multilocularis | cathepsin b | 0.4301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.2123 | 0.3087 | 1 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.1667 | 0.1639 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1667 | 0.1639 | 0.1639 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2123 | 0.3087 | 0.3087 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2123 | 0.3087 | 0.2334 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.146 | 0.0982 | 0.0982 |
Loa Loa (eye worm) | hypothetical protein | 0.4301 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Brugia malayi | cathepsin L-like precursor | 0.146 | 0.0982 | 0.0982 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4301 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1667 | 0.1639 | 0.531 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2123 | 0.3087 | 0.3087 |
Giardia lamblia | Cathepsin B precursor | 0.1667 | 0.1639 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2123 | 0.3087 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2123 | 0.3087 | 0.3087 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4301 | 1 | 1 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Plasmodium vivax | vivapain-2 | 0.2123 | 0.3087 | 1 |
Echinococcus granulosus | cathepsin b | 0.4301 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1667 | 0.1639 | 0.5 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.146 | 0.0982 | 0.0982 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Echinococcus multilocularis | cysteine protease | 0.2123 | 0.3087 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.2123 | 0.3087 | 0.2334 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.2123 | 0.3087 | 0.2334 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2123 | 0.3087 | 0.3087 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.2123 | 0.3087 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.146 | 0.0982 | 0.0982 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.2123 | 0.3087 | 0.3087 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2123 | 0.3087 | 0.3087 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2123 | 0.3087 | 0.3087 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Loa Loa (eye worm) | fibroinase | 0.2123 | 0.3087 | 0.2334 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2123 | 0.3087 | 0.3087 |
Loa Loa (eye worm) | cathepsin B | 0.1667 | 0.1639 | 0.0728 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.146 | 0.0982 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4301 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2123 | 0.3087 | 0.3087 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2123 | 0.3087 | 1 |
Echinococcus granulosus | cathepsin b | 0.4301 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2123 | 0.3087 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.146 | 0.0982 | 0.3182 |
Onchocerca volvulus | 0.2123 | 0.3087 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2123 | 0.3087 | 0.3087 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2123 | 0.3087 | 0.3087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Plasmodium vivax | vivapain-2 | 0.2123 | 0.3087 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.146 | 0.0982 | 0.0982 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2123 | 0.3087 | 0.2334 |
Brugia malayi | Cathepsin L-like precursor | 0.146 | 0.0982 | 0.0982 |
Echinococcus multilocularis | cysteine protease | 0.2123 | 0.3087 | 0.3087 |
Leishmania major | cysteine peptidase A (CPA) | 0.2123 | 0.3087 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4301 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.2123 | 0.3087 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.146 | 0.0982 | 0.0982 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2123 | 0.3087 | 1 |
Leishmania major | cathepsin L-like protease | 0.2123 | 0.3087 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2123 | 0.3087 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1667 | 0.1639 | 0.1639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.813 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.694 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.675 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.663 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.66 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.628 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.624 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.544 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.541 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.369 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.