Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4039 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1334 | 0.0944 | 0.0944 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1939 | 0.2968 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1559 | 0.1695 | 0.5 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1939 | 0.2968 | 0.2234 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4039 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.1939 | 0.2968 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1559 | 0.1695 | 0.5712 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1939 | 0.2968 | 0.2234 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1939 | 0.2968 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1334 | 0.0944 | 0.0944 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1939 | 0.2968 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4039 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Loa Loa (eye worm) | hypothetical protein | 0.4039 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1939 | 0.2968 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1939 | 0.2968 | 0.2234 |
Loa Loa (eye worm) | fibroinase | 0.1939 | 0.2968 | 0.2234 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1334 | 0.0944 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.1334 | 0.0944 | 0.0944 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1334 | 0.0944 | 0.0944 |
Plasmodium vivax | vivapain-2 | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1939 | 0.2968 | 0.2968 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1939 | 0.2968 | 0.2968 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1559 | 0.1695 | 0.1695 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.1559 | 0.1695 | 0.0829 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4039 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.4039 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4039 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1334 | 0.0944 | 0.0944 |
Echinococcus granulosus | cathepsin b | 0.4039 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4039 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1939 | 0.2968 | 0.2234 |
Giardia lamblia | Cathepsin B precursor | 0.1559 | 0.1695 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1939 | 0.2968 | 0.2968 |
Toxoplasma gondii | cathepsin CPL | 0.1939 | 0.2968 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1334 | 0.0944 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1939 | 0.2968 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1939 | 0.2968 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1939 | 0.2968 | 0.2968 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1939 | 0.2968 | 0.2234 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1939 | 0.2968 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1939 | 0.2968 | 0.2968 |
Leishmania major | cysteine peptidase A (CPA) | 0.1939 | 0.2968 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1334 | 0.0944 | 0.0944 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Leishmania major | cathepsin L-like protease | 0.1939 | 0.2968 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4039 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1334 | 0.0944 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Onchocerca volvulus | 0.1939 | 0.2968 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.1939 | 0.2968 | 0.2968 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1939 | 0.2968 | 0.2968 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1559 | 0.1695 | 0.1695 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1939 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1939 | 0.2968 | 1 |
Plasmodium vivax | vivapain-2 | 0.1939 | 0.2968 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1939 | 0.2968 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1559 | 0.1695 | 0.5712 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1334 | 0.0944 | 0.0944 |
Echinococcus granulosus | cathepsin l1 | 0.1939 | 0.2968 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.1939 | 0.2968 | 0.2968 |
Giardia lamblia | Cathepsin B precursor | 0.1559 | 0.1695 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1939 | 0.2968 | 0.2968 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.788 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.493 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.095 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.