Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.116 | 0.093 | 0.093 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3546 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3546 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3546 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1366 | 0.1716 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.116 | 0.093 | 0.093 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1684 | 0.2924 | 0.2198 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1684 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1366 | 0.1716 | 0.5868 |
Onchocerca volvulus | Cathepsin F homolog | 0.1684 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1684 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3546 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1684 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1684 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1684 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1684 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.116 | 0.093 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1684 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1684 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.116 | 0.093 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1684 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1684 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1684 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Plasmodium vivax | vivapain-2 | 0.1684 | 0.2924 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.116 | 0.093 | 0.093 |
Toxoplasma gondii | cathepsin CPL | 0.1684 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.116 | 0.093 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1684 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.1366 | 0.1716 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1684 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1684 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | cysteine protease | 0.1684 | 0.2924 | 0.2198 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1684 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1366 | 0.1716 | 0.1716 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1684 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | cathepsin B | 0.1366 | 0.1716 | 0.0866 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.3546 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.116 | 0.093 | 0.093 |
Echinococcus granulosus | cathepsin b | 0.3546 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.3546 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3546 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3546 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1684 | 0.2924 | 0.2198 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1684 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1366 | 0.1716 | 0.1716 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Plasmodium vivax | vivapain-2 | 0.1684 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1684 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1684 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.1366 | 0.1716 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.1684 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.116 | 0.093 | 0.093 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1366 | 0.1716 | 0.5868 |
Entamoeba histolytica | cysteine protease, putative | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.116 | 0.093 | 0.093 |
Leishmania major | cysteine peptidase A (CPA) | 0.1684 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1684 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cathepsin b | 0.3546 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1684 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1684 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1684 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.1684 | 0.2924 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.1684 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1684 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.116 | 0.093 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 29425 after 16 hrs by broth microdilution method | ChEMBL. | 22494615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.