Detailed information for compound 1630395

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 3295.79 | Formula: C133H244N58O38S
  • H donors: 55 H acceptors: 38 LogP: -28.73 Rotable bonds: 160
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N)CSCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(=O)O)CCCCN)CCC(=O)O)CCC(=O)O)CCC(=O)O)CCC(=O)N)CC(=O)N)CCCCN)CO)CCCCN)CCCCN
  • InChi: 1S/C133H244N58O38S/c1-7-68(4)101(191-120(224)77(30-12-17-51-138)182-123(227)90(62-100(204)205)189-121(225)88(60-67(2)3)169-70(6)193)125(229)187-87(42-46-99(202)203)118(222)186-86(41-45-98(200)201)117(221)185-85(40-44-97(198)199)116(220)184-84(39-43-93(139)194)119(223)188-89(61-94(140)195)122(226)181-76(29-11-16-50-137)115(219)190-91(64-192)124(228)183-75(28-10-15-49-136)109(213)174-74(27-9-14-48-135)108(212)173-73(26-8-13-47-134)105(209)168-69(5)104(208)167-63-95(196)171-92(103(142)207)65-230-66-96(197)170-72(32-19-53-160-127(145)146)106(210)175-79(34-21-55-162-129(149)150)110(214)177-81(36-23-57-164-131(153)154)112(216)179-83(38-25-59-166-133(157)158)114(218)180-82(37-24-58-165-132(155)156)113(217)178-80(35-22-56-163-130(151)152)111(215)176-78(33-20-54-161-128(147)148)107(211)172-71(102(141)206)31-18-52-159-126(143)144/h67-69,71-92,101,192H,7-66,134-138H2,1-6H3,(H2,139,194)(H2,140,195)(H2,141,206)(H2,142,207)(H,167,208)(H,168,209)(H,169,193)(H,170,197)(H,171,196)(H,172,211)(H,173,212)(H,174,213)(H,175,210)(H,176,215)(H,177,214)(H,178,217)(H,179,216)(H,180,218)(H,181,226)(H,182,227)(H,183,228)(H,184,220)(H,185,221)(H,186,222)(H,187,229)(H,188,223)(H,189,225)(H,190,219)(H,191,224)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H4,143,144,159)(H4,145,146,160)(H4,147,148,161)(H4,149,150,162)(H4,151,152,163)(H4,153,154,164)(H4,155,156,165)(H4,157,158,166)/t68-,69-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,101-/m0/s1
  • InChiKey: IEENIRMBTZYNFR-UZYVFRPUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni microtubule-associated protein tau 0.0743 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0178 0.0022
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0048 0.0156 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1365 0.3464
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1365 0.4054
Mycobacterium ulcerans glutaminase 0.0294 0.3648 0.5
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0048 0.0156 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Plasmodium vivax vivapain-1 0.0133 0.1365 0.4054
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0156 0.0427
Plasmodium falciparum cysteine proteinase falcipain 1 0.0133 0.1365 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0156 0.0427
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.314 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.069 0.1892
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0258 0.314 0.8607
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0258 0.314 0.3031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0258 0.314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0173 0.193 0.5291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0048 0.0156 0.0156
Plasmodium vivax vivapain-3 0.0133 0.1365 0.4054
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Plasmodium vivax unspecified product 0.0133 0.1365 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Schistosoma mansoni cathepsin B (C01 family) 0.0048 0.0156 0.0156
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0156 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.024 0.0659
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0156 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0258 0.314 0.314
Echinococcus granulosus cathepsin L cysteine proteinase 0.0258 0.314 0.3031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Echinococcus multilocularis cathepsin L cysteine protease 0.0258 0.314 0.3031
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1365 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0156 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0173 0.193 0.5291
Schistosoma mansoni cathepsin C 0.0048 0.0156 0.0156
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1365 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0178 0.0487
Toxoplasma gondii cathepsin CPL 0.0258 0.314 1
Brugia malayi cathepsin L precursor 0.0048 0.0156 0.0427
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Entamoeba histolytica cysteine proteinase, putative 0.0173 0.193 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Echinococcus multilocularis microtubule associated protein 2 0.0743 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0048 0.0156 0.0427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0178 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.069 0.1892
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0133 0.1365 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Brugia malayi Cathepsin L-like precursor 0.0173 0.193 0.5291
Brugia malayi cathepsin F-like cysteine proteinase 0.0048 0.0156 0.0427
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Giardia lamblia Cysteine protease 0.0048 0.0156 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1365 0.1365
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Loa Loa (eye worm) hypothetical protein 0.0085 0.069 0.1892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0178 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Brugia malayi Papain family cysteine protease containing protein 0.0258 0.314 0.8607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Onchocerca volvulus 0.0173 0.193 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.193 0.5081
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Loa Loa (eye worm) hypothetical protein 0.0085 0.069 0.1892
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Trypanosoma cruzi cysteine protease, putative 0.0133 0.1365 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0258 0.314 1
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Schistosoma mansoni cathepsin F (C01 family) 0.0173 0.193 0.193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Entamoeba histolytica cysteine proteinase, putative 0.0258 0.314 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Giardia lamblia Cysteine protease 0.0048 0.0156 0.5
Giardia lamblia Encystation-specific protease 0.0048 0.0156 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.024 0.0659
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0156 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.0173 0.193 0.5291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0178 0.0178
Brugia malayi glutaminase DH11.1 0.0294 0.3648 1
Giardia lamblia Hypothetical protein 0.0048 0.0156 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.1365 0.4054
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Onchocerca volvulus 0.0258 0.314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1365 0.3464
Loa Loa (eye worm) fibroinase 0.0258 0.314 0.8607
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0048 0.0156 0.0427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Plasmodium vivax unspecified product 0.0085 0.069 0.1791
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1365 0.4054
Giardia lamblia Cathepsin L precursor 0.0048 0.0156 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Entamoeba histolytica cysteine proteinase 1, putative 0.0133 0.1365 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0156 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0178 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Entamoeba histolytica cysteine protease, putative 0.0258 0.314 1
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Giardia lamblia Cathepsin L-like protease 0.0048 0.0156 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1365 0.4054
Giardia lamblia Cysteine protease 0.0048 0.0156 0.5
Loa Loa (eye worm) glutaminase 2 0.0294 0.3648 1
Brugia malayi fibroinase precursor 0.0048 0.0156 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Brugia malayi Cathepsin L-like precursor 0.0085 0.069 0.1892
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.193 0.5946
Echinococcus granulosus cathepsin L cysteine protease 0.0133 0.1365 0.1229
Onchocerca volvulus 0.0258 0.314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.193 0.5081
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0258 0.314 1
Giardia lamblia Cysteine protease 0.0048 0.0156 0.5
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Schistosoma mansoni cathepsin S (C01 family) 0.0048 0.0156 0.0156
Onchocerca volvulus 0.0258 0.314 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0085 0.069 0.1892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1365 0.4054
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Echinococcus multilocularis cysteine protease 0.0258 0.314 0.3031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Leishmania major cysteine peptidase A (CPA) 0.0258 0.314 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0258 0.314 0.8545
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.024 0.0659
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Loa Loa (eye worm) hypothetical protein 0.0173 0.193 0.5291
Echinococcus granulosus cysteine protease 0.0133 0.1365 0.1229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Trypanosoma cruzi cruzipain precursor, putative 0.0085 0.069 0.1791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1365 0.3743
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Loa Loa (eye worm) glutaminase 0.0294 0.3648 1
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1365 0.3743
Echinococcus multilocularis cysteine protease 0.0258 0.314 0.3031
Plasmodium falciparum cysteine proteinase falcipain 3 0.0258 0.314 1
Loa Loa (eye worm) ctsf protein 0.0258 0.314 0.8607
Echinococcus granulosus cathepsin l1 0.0258 0.314 0.3031
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.314 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0048 0.0156 0.5
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1365 0.4054
Loa Loa (eye worm) hypothetical protein 0.0054 0.024 0.0659
Entamoeba histolytica cysteine proteinase, putative 0.0258 0.314 1
Brugia malayi Cathepsin L-like precursor 0.0173 0.193 0.5291
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0258 0.314 0.8607
Schistosoma mansoni cathepsin F (C01 family) 0.0258 0.314 0.314
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0156 0.0156
Loa Loa (eye worm) cathepsin B 0.0048 0.0156 0.0427
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0156 0.0427
Schistosoma mansoni glutaminase 0.0294 0.3648 0.3648
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0156 0.0156
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0085 0.069 0.1892
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.314 1
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Trichomonas vaginalis glutaminase, putative 0.0294 0.3648 1
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Plasmodium vivax vivapain-2 0.0258 0.314 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0178 0.0022
Onchocerca volvulus 0.0258 0.314 1
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.314 1
Giardia lamblia Hypothetical protein 0.0048 0.0156 0.5
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0258 0.314 0.3031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Giardia lamblia Cathepsin L-like protease 0.0048 0.0156 0.5
Loa Loa (eye worm) hypothetical protein 0.0258 0.314 0.8607
Echinococcus granulosus cathepsin L 0.0133 0.1365 0.1229
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0156 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.314 0.8545
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.069 0.1791
Echinococcus multilocularis cathepsin L 0.0133 0.1365 0.1229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Onchocerca volvulus 0.0258 0.314 1
Schistosoma mansoni cathepsin s 0.0085 0.069 0.069
Brugia malayi Cathepsin L-like precursor 0.0258 0.314 0.8607
Brugia malayi cathepsin B-like cysteine proteinase 0.0048 0.0156 0.0427
Onchocerca volvulus Cathepsin L homolog 0.0258 0.314 1
Onchocerca volvulus 0.0258 0.314 1
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1365 0.4054
Echinococcus granulosus cathepsin l cysteine peptidase 0.0258 0.314 0.3031
Brugia malayi cathepsin L-like precursor 0.0173 0.193 0.5291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Entamoeba histolytica cysteine protease, putative 0.0133 0.1365 0.4054
Onchocerca volvulus 0.0258 0.314 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0258 0.314 0.3031
Leishmania major cathepsin L-like protease 0.0258 0.314 1
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1365 0.1365
Loa Loa (eye worm) cysteine protease 0.0258 0.314 0.8607
Trypanosoma cruzi cruzipain precursor, putative 0.0258 0.314 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.314 0.8545
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0156 0.0427
Plasmodium vivax vivapain-2 0.0258 0.314 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.314 1
Entamoeba histolytica cysteine proteinase 2 0.0133 0.1365 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0156 0.0427
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0048 0.0156 0.0156
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1365 0.1365
Onchocerca volvulus Cathepsin F homolog 0.0258 0.314 1
Echinococcus granulosus cathepsin l1 0.0173 0.193 0.1802
Giardia lamblia Cathepsin B precursor 0.0048 0.0156 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0258 0.314 0.8545

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 50 uM Cytotoxicity against human MT4 cells after 5 days by MTT assay ChEMBL. 22277590

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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