Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0067 | 0.4379 | 0.4024 |
Echinococcus multilocularis | muscleblind protein | 0.0133 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.1606 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4056 | 0.4056 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.002 | 0.0415 | 0.0535 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.002 | 0.0415 | 0.0415 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0056 | 0.3493 | 0.4501 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.179 | 0.179 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0133 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0017 | 0.0191 | 0.0191 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0107 | 0.7762 | 0.7762 |
Schistosoma mansoni | neuropeptide receptor | 0.0107 | 0.7762 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0107 | 0.7762 | 0.7762 |
Echinococcus granulosus | neuropeptide receptor | 0.0107 | 0.7762 | 0.7762 |
Echinococcus granulosus | muscleblind protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0017 | 0.0191 | 0.0191 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0054 | 0.33 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0053 | 0.3223 | 0.3223 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.002 | 0.0415 | 0.0415 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0032 | 0.1427 | 0.1427 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0271 | 0.0349 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0053 | 0.3223 | 0.3223 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0054 | 0.33 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0016 | 0.0046 | 0.0046 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0191 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1611 | 0.1611 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0032 | 0.1427 | 0.1427 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0054 | 0.33 | 0.33 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.4252 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0018 | 0.0271 | 0.0271 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0054 | 0.33 | 0.4252 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0054 | 0.33 | 0.33 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1934 | 0.1934 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.301 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.119 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.