Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.063 | 0.3546 | 0.3546 |
Mycobacterium ulcerans | proteasome PrcB | 0.1308 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.1016 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1308 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.1016 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.063 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.063 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1308 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0257 | 0 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.1016 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.1016 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1308 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1308 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.1308 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.063 | 0.3546 | 0.3546 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.063 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1308 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.1016 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1308 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.1016 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.1016 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1016 | 0.7224 | 0.7224 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.063 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1308 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.1016 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.063 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1308 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1308 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.063 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.063 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.063 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0257 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0465 | 0.1977 | 0.1977 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1308 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1308 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LED (functional) | = 0.1 mgP kg-1 | Bone resorption activity in rats. | ChEMBL. | 12086477 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.