TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 596.779 | Formula: C29H48N4O7S
H donors: 5 H acceptors: 6 LogP: 2.97 Rotable bonds: 21
Rule of 5 violations (Lipinski): 2
SMILES: C=CCC(C(=O)N[C@H]([C@H]([C@H](CC(C)C)O)O)CCCCCc1ccccc1)NC(=O)CNS(=O)(=O)N1CCOCC1
InChi: 1S/C29H48N4O7S/c1-4-11-25(31-27(35)21-30-41(38,39)33-16-18-40-19-17-33)29(37)32-24(28(36)26(34)20-22(2)3)15-10-6-9-14-23-12-7-5-8-13-23/h4-5,7-8,12-13,22,24-26,28,30,34,36H,1,6,9-11,14-21H2,2-3H3,(H,31,35)(H,32,37)/t24-,25?,26-,28+/m0/s1
InChiKey: VCMCZLRICONYCZ-KXNRUXQSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0045	0.0148	0.0148
Schistosoma mansoni	retinoic acid receptor RXR	0.0084	0.0527	0.0527
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.1081	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0084	0.0527	0.0527
Echinococcus multilocularis	ecdysone induced protein 78C	0.0084	0.0527	0.0527
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0084	0.0527	0.0527
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.004	0.0103	0.0103
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.1081	1	1
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0212	0.1743	0.1743
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0212	0.1743	0.1743
Brugia malayi	ecdysteroid receptor	0.0084	0.0527	0.0527
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.052	0.4671	0.3546
Brugia malayi	nuclear receptor RXR	0.0045	0.0148	0.0148
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0212	0.1743	0.1743
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0212	0.1743	0.1743
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.004	0.0103	0.0103
Schistosoma mansoni	nuclear receptor	0.004	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0084	0.0527	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0084	0.0527	0.0527
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.084	0.7708	0.7224
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0084	0.0527	0.0527
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0212	0.1743	0.1743
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0084	0.0527	0.0527
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0212	0.1743	0.5
Brugia malayi	Proteasome subunit alpha type 7-1	0.0212	0.1743	0.1743
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.052	0.4671	0.3546
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0212	0.1743	0.1743
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0212	0.1743	0.1743
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.084	0.7708	0.7708
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0212	0.1743	0.1743
Leishmania major	proteasome beta 2 subunit, putative	0.052	0.4671	0.3546
Echinococcus granulosus	Proteasome subunit alpha beta	0.0212	0.1743	0.1743
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0103	0.0103
Brugia malayi	20S proteasome alpha5 subunit	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0212	0.1743	0.1743
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.084	0.7708	0.7708
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0084	0.0527	0.2753
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome subunit beta type 1	0.084	0.7708	0.7708
Onchocerca volvulus	Bile acid receptor homolog	0.0084	0.0527	0.2753
Schistosoma mansoni	thyroid hormone receptor	0.0084	0.0527	0.0527
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0084	0.0527	0.0527
Mycobacterium ulcerans	proteasome PrcB	0.1081	1	1
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.052	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0148	0.0148
Echinococcus multilocularis	proteasome subunit beta type 7	0.0212	0.1743	0.1743
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.084	0.7708	0.7224
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0084	0.0527	0.0527
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0084	0.0527	0.0527
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0212	0.1743	0.1743
Brugia malayi	proteasome subunit alpha type 1	0.0212	0.1743	0.1743
Schistosoma mansoni	hypothetical protein	0.0165	0.129	0.129
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0084	0.0527	0.0527
Echinococcus multilocularis	nuclear receptor nhr 48	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.052	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus multilocularis	proteasome subunit beta type 6	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0212	0.1743	0.1743
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0212	0.1743	0.1743
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0212	0.1743	0.1743
Echinococcus multilocularis	proteasome (prosome, macropain)	0.1081	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0084	0.0527	0.0527
Brugia malayi	tailless protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	PAS-3 protein	0.0212	0.1743	0.1743
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0212	0.1743	0.1743
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0084	0.0527	0.0527
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0212	0.1743	0.1743
Brugia malayi	proteasome subunit beta type 2	0.052	0.4671	0.4671
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0084	0.0527	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.1081	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.084	0.7708	0.7708
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.1081	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0084	0.0527	0.0527
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0103	0.0103
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0212	0.1743	0.1743
Brugia malayi	nuclear hormone receptor	0.004	0.0103	0.0103
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0212	0.1743	0.1743
Brugia malayi	nuclear receptor RXR	0.004	0.0103	0.0103
Onchocerca volvulus		0.023	0.1913	1
Plasmodium vivax	proteasome subunit beta type-2, putative	0.052	0.4671	0.4671
Brugia malayi	proteasome subunit alpha type 4	0.0212	0.1743	0.1743
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0148	0.0148
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0212	0.1743	0.1743
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0084	0.0527	0.0527
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0084	0.0527	0.0527
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0084	0.0527	0.0527
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0212	0.1743	0.1743
Plasmodium vivax	proteasome subunit beta type-5, putative	0.1081	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.004	0.0103	0.0103
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Giardia lamblia	Proteasome subunit beta type 1	0.084	0.7708	0.7224
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0212	0.1743	0.1743
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.084	0.7708	0.7224
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.1081	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0084	0.0527	0.0527
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor-like 1	0.0084	0.0527	0.0527
Loa Loa (eye worm)	steroid hormone receptor	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0039	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0084	0.0527	0.0527
Toxoplasma gondii	proteasome subunit	0.0212	0.1743	0.1743
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0084	0.0527	0.0527
Schistosoma mansoni	thyroid hormone receptor	0.0084	0.0527	0.0527
Echinococcus granulosus	geminin	0.0165	0.129	0.129
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0212	0.1743	0.1743
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0185	0.0185
Echinococcus granulosus	FTZ F1 alpha	0.0084	0.0527	0.0527
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0084	0.0527	0.0527
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0212	0.1743	0.1743
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.004	0.0103	0.0103
Onchocerca volvulus		0.0084	0.0527	0.2753
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0212	0.1743	0.1743
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0148	0.0148
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.004	0.0103	0.0103
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.052	0.4671	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0148	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0084	0.0527	0.0527
Brugia malayi	Pre-SET motif family protein	0.0202	0.1647	0.1647
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.052	0.4671	0.4671
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.004	0.0103	0.0103
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0212	0.1743	0.1743
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0045	0.0148	0.0148
Brugia malayi	nuclear hormone receptor family member nhr-6	0.004	0.0103	0.0103
Brugia malayi	conserved hypotetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus granulosus	proteasome subunit beta type 7	0.0212	0.1743	0.1743
Toxoplasma gondii	peptidase, T1 family protein	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0212	0.1743	0.1743
Schistosoma mansoni	hypothetical protein	0.0033	0.0039	0.0039
Brugia malayi	Proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0212	0.1743	0.1743
Brugia malayi	nuclear receptor NHR-88	0.0084	0.0527	0.0527
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0185	0.0185
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0148	0.0148
Echinococcus granulosus	proteasome subunit alpha type 2	0.0212	0.1743	0.1743
Brugia malayi	photoreceptor-specific nuclear receptor	0.0084	0.0527	0.0527
Trypanosoma brucei	proteasome beta 6 subunit	0.084	0.7708	0.7224
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0148	0.0148
Toxoplasma gondii	proteasome beta subunit	0.0212	0.1743	0.1743
Schistosoma mansoni	coup transcription factor	0.0084	0.0527	0.0527
Loa Loa (eye worm)	DR-78	0.004	0.0103	0.0103
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0103	0.0103
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0212	0.1743	0.1743
Brugia malayi	Proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome subunit beta type 2	0.052	0.4671	0.4671
Trichomonas vaginalis	set domain proteins, putative	0.023	0.1913	0.0205
Onchocerca volvulus	Notchless protein homolog	0.0212	0.1743	0.9113
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0103	0.0537
Schistosoma mansoni	zinc finger protein	0.004	0.0103	0.0103
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.052	0.4671	0.4671
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0084	0.0527	0.0527
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.1081	1	1
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.1081	1	1
Brugia malayi	steroid hormone receptor	0.0084	0.0527	0.0527
Echinococcus granulosus	proteasome subunit beta type 6	0.0212	0.1743	0.1743
Brugia malayi	nuclear receptor NHR-67	0.004	0.0103	0.0103
Brugia malayi	ecdysone receptor	0.004	0.0103	0.0103
Brugia malayi	nuclear hormone receptor	0.0084	0.0527	0.0527
Plasmodium vivax	proteasome subunit beta type-1, putative	0.084	0.7708	0.7708
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0212	0.1743	0.1743
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0212	0.1743	0.1743
Toxoplasma gondii	proteasome subunit beta type, putative	0.1081	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0084	0.0527	0.0527
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0103	0.0103
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.052	0.4671	0.3546
Brugia malayi	proteasome subunit alpha type 2	0.0212	0.1743	0.1743
Plasmodium falciparum	proteasome subunit beta type-5	0.1081	1	1
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0103	0.0103
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.1647	0.1647
Loa Loa (eye worm)	nuclear receptor NHR-67	0.004	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0084	0.0527	0.0527
Schistosoma mansoni	nuclear receptor nhr-48	0.004	0.0103	0.0103
Brugia malayi	proteasome subunit alpha type 3	0.0212	0.1743	0.1743
Brugia malayi	hypothetical protein	0.0045	0.0148	0.0148
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.1081	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus granulosus	proteasome prosome macropain	0.1081	1	1
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0212	0.1743	0.1743
Echinococcus granulosus	thyroid hormone receptor alpha	0.004	0.0103	0.0103
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.084	0.7708	0.7224
Echinococcus granulosus	proteasome subunit alpha type 6	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0084	0.0527	0.0527
Leishmania major	proteasome beta 5 subunit, putative	0.1081	1	1
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0212	0.1743	0.1743
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.052	0.4671	0.3546
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0084	0.0527	0.0527
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0185	0.0185
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.004	0.0103	0.0103
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0212	0.1743	0.1743
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0084	0.0527	0.0527
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0212	0.1743	0.1743
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0212	0.1743	0.1743
Onchocerca volvulus		0.004	0.0103	0.0537
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0212	0.1743	0.1743
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.084	0.7708	0.7224
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0084	0.0527	0.0527
Onchocerca volvulus	Protein ultraspiracle homolog	0.0084	0.0527	0.2753
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.052	0.4671	0.4671
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0084	0.0527	0.0527
Brugia malayi	hypothetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0103	0.0103
Brugia malayi	proteasome subunit alpha type 6	0.0212	0.1743	0.1743
Brugia malayi	Steroid receptor seven-up type 2	0.0084	0.0527	0.0527
Brugia malayi	nuclear receptor NHR-88	0.004	0.0103	0.0103
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0212	0.1743	0.1743
Giardia lamblia	Proteasome subunit beta type 2	0.052	0.4671	0.3546
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus granulosus	ecdysone induced protein 78C	0.0084	0.0527	0.0527
Brugia malayi	Proteasome subunit alpha type 1	0.0212	0.1743	0.1743
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0212	0.1743	0.1743
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.084	0.7708	0.7708
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0084	0.0527	0.0527
Brugia malayi	nuclear hormone receptor family member odr-7	0.004	0.0103	0.0103
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0103	0.0103
Echinococcus multilocularis	FTZ F1 alpha	0.0084	0.0527	0.0527
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0045	0.0148	0.0148
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0103	0.0103
Schistosoma mansoni	nuclear receptor	0.004	0.0103	0.0103
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0039	0.0039
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0527	0.0527
Schistosoma mansoni	hypothetical protein	0.0165	0.129	0.129
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0084	0.0527	0.0527
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0103	0.0537
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.084	0.7708	0.7224
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0084	0.0527	0.0527
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0084	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0148	0.0148
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0084	0.0527	0.0527
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.004	0.0103	0.0103
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0212	0.1743	0.1743
Brugia malayi	hypothetical protein	0.0045	0.0148	0.0148
Echinococcus multilocularis	geminin	0.0165	0.129	0.129
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0084	0.0527	0.0527
Brugia malayi	hypothetical protein	0.004	0.0103	0.0103
Schistosoma mansoni	RAR-like nuclear receptor	0.0084	0.0527	0.0527
Echinococcus granulosus	proteasome subunit beta t family	0.0212	0.1743	0.1743
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0084	0.0527	0.0527
Toxoplasma gondii	heat shock protein hslv, putative	0.0212	0.1743	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0148	0.0148
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Trypanosoma cruzi	20S proteasome subunit	0.052	0.4671	0.3546
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0212	0.1743	0.1743
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.052	0.4671	0.3546
Brugia malayi	orphan nuclear receptor NR2E1	0.004	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0084	0.0527	0.0527
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0212	0.1743	0.1743
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0212	0.1743	0.1743
Brugia malayi	Proteasome A-type and B-type family protein	0.0212	0.1743	0.1743
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0212	0.1743	0.1743
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0212	0.1743	0.1743
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0212	0.1743	0.1743
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0045	0.0148	0.0148
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.1081	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.004	0.0103	0.0103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0084	0.0527	0.0527
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.1081	1	1
Brugia malayi	proteasome subunit beta type 3	0.0212	0.1743	0.1743
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0084	0.0527	0.0527
Brugia malayi	proteasome subunit beta type 1	0.084	0.7708	0.7708
Loa Loa (eye worm)	hypothetical protein	0.004	0.0103	0.0103
Onchocerca volvulus		0.004	0.0103	0.0537
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0212	0.1743	0.1743

Activities

Activity type	Activity value	Assay description	Source	Reference
Affinity (binding)	= 479 nM	Binding affinity against human renin enzyme	ChEMBL.	7636850
Affinity (binding)	= 479 nM	Binding affinity against human renin enzyme	ChEMBL.	7636850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 163066