Detailed information for compound 163066

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 596.779 | Formula: C29H48N4O7S
  • H donors: 5 H acceptors: 6 LogP: 2.97 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCC(C(=O)N[C@H]([C@H]([C@H](CC(C)C)O)O)CCCCCc1ccccc1)NC(=O)CNS(=O)(=O)N1CCOCC1
  • InChi: 1S/C29H48N4O7S/c1-4-11-25(31-27(35)21-30-41(38,39)33-16-18-40-19-17-33)29(37)32-24(28(36)26(34)20-22(2)3)15-10-6-9-14-23-12-7-5-8-13-23/h4-5,7-8,12-13,22,24-26,28,30,34,36H,1,6,9-11,14-21H2,2-3H3,(H,31,35)(H,32,37)/t24-,25?,26-,28+/m0/s1
  • InChiKey: VCMCZLRICONYCZ-KXNRUXQSSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0084 0.0527 0.0527
Loa Loa (eye worm) PAS-3 protein 0.0212 0.1743 0.1743
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0212 0.1743 0.1743
Echinococcus granulosus proteasome subunit alpha type 2 0.0212 0.1743 0.1743
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.052 0.4671 0.4671
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0212 0.1743 0.1743
Plasmodium falciparum proteasome subunit beta type-2, putative 0.052 0.4671 0.3546
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0527 0.0527
Schistosoma mansoni thyroid hormone receptor 0.0084 0.0527 0.0527
Plasmodium falciparum proteasome subunit beta type-1, putative 0.084 0.7708 0.7224
Toxoplasma gondii proteasome subunit alpha1, putative 0.0212 0.1743 0.1743
Echinococcus granulosus Proteasome subunit alpha type 7 0.0212 0.1743 0.1743
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0103 0.0103
Schistosoma mansoni retinoic acid receptor RXR 0.0084 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Brugia malayi proteasome subunit beta type 2 0.052 0.4671 0.4671
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1081 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0103 0.0103
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0103 0.0103
Plasmodium vivax proteasome subunit beta type-1, putative 0.084 0.7708 0.7708
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0084 0.0527 0.0527
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0527 0.0527
Echinococcus granulosus geminin 0.0165 0.129 0.129
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0048 0.0185 0.0185
Toxoplasma gondii proteasome subunit alpha type, putative 0.0212 0.1743 0.1743
Mycobacterium ulcerans proteasome PrcB 0.1081 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0084 0.0527 0.0527
Brugia malayi hypothetical protein 0.0045 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0165 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Echinococcus granulosus subfamily T1A non peptidase ue 0.0212 0.1743 0.1743
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Echinococcus multilocularis proteasome (prosome, macropain) 0.1081 1 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.084 0.7708 0.7708
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0103 0.0103
Schistosoma mansoni RAR-like nuclear receptor 0.0084 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0084 0.0527 0.0527
Plasmodium vivax proteasome subunit beta type-7, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0084 0.0527 0.0527
Brugia malayi proteasome subunit alpha type 1 0.0212 0.1743 0.1743
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0527 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0084 0.0527 0.0527
Brugia malayi proteasome subunit beta type 1 0.084 0.7708 0.7708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0084 0.0527 0.0527
Giardia lamblia Proteasome subunit beta type 1 0.084 0.7708 0.7224
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Toxoplasma gondii proteasome subunit beta type, putative 0.1081 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0148 0.0148
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0212 0.1743 0.1743
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0084 0.0527 0.0527
Brugia malayi nuclear receptor RXR 0.004 0.0103 0.0103
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0212 0.1743 0.1743
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0212 0.1743 0.1743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0084 0.0527 0.0527
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0103 0.0537
Plasmodium vivax proteasome subunit beta type-6, putative 0.0212 0.1743 0.1743
Plasmodium vivax proteasome subunit beta type-4, putative 0.0212 0.1743 0.1743
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0212 0.1743 0.1743
Echinococcus granulosus proteasome prosome macropain 0.1081 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0148 0.0148
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0084 0.0527 0.0527
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor E75 0.004 0.0103 0.0103
Brugia malayi nuclear receptor NHR-88 0.004 0.0103 0.0103
Toxoplasma gondii heat shock protein hslv, putative 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0527 0.0527
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0527 0.0527
Brugia malayi proteasome subunit alpha type 4 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0084 0.0527 0.0527
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0103 0.0103
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0212 0.1743 0.1743
Toxoplasma gondii proteasome subunit 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0084 0.0527 0.0527
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0103 0.0103
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0103 0.0103
Brugia malayi proteasome subunit beta type 3 0.0212 0.1743 0.1743
Toxoplasma gondii proteasome subunit beta type 2, putative 0.052 0.4671 0.4671
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1647 0.1647
Echinococcus granulosus proteasome subunit beta type 6 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0212 0.1743 0.1743
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0527 0.0527
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0212 0.1743 0.1743
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0527 0.0527
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0148 0.0148
Echinococcus multilocularis proteasome subunit alpha type 6 0.0212 0.1743 0.1743
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0084 0.0527 0.0527
Echinococcus multilocularis thyroid hormone receptor alpha 0.0084 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0084 0.0527 0.0527
Echinococcus granulosus ecdysone induced protein 78C 0.0084 0.0527 0.0527
Brugia malayi Proteasome subunit alpha type 1 0.0212 0.1743 0.1743
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.084 0.7708 0.7224
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1081 1 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1081 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0103 0.0103
Onchocerca volvulus Notchless protein homolog 0.0212 0.1743 0.9113
Echinococcus granulosus proteasome subunit beta type 7 0.0212 0.1743 0.1743
Onchocerca volvulus Protein ultraspiracle homolog 0.0084 0.0527 0.2753
Schistosoma mansoni hypothetical protein 0.0165 0.129 0.129
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.052 0.4671 0.3546
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.0527 0.0527
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0103 0.0103
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0148 0.0148
Trypanosoma cruzi 20S proteasome subunit 0.052 0.4671 0.3546
Schistosoma mansoni steroid hormone receptor ad4bp 0.0084 0.0527 0.0527
Entamoeba histolytica proteasome subunit beta type 1, putative 0.084 0.7708 0.7224
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0212 0.1743 0.1743
Brugia malayi nuclear receptor NHR-67 0.004 0.0103 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0084 0.0527 0.0527
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0039
Schistosoma mansoni coup transcription factor 0.0084 0.0527 0.0527
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0084 0.0527 0.0527
Giardia lamblia Proteasome subunit beta type 2 0.052 0.4671 0.3546
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0212 0.1743 0.1743
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0103 0.0103
Brugia malayi Pre-SET motif family protein 0.0202 0.1647 0.1647
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0084 0.0527 0.0527
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0212 0.1743 0.1743
Echinococcus granulosus proteasome subunit beta t family 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Plasmodium vivax proteasome subunit beta type-3, putative 0.0212 0.1743 0.1743
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0148 0.0148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0185 0.0185
Trypanosoma brucei proteasome beta 6 subunit 0.084 0.7708 0.7224
Onchocerca volvulus 0.004 0.0103 0.0537
Echinococcus multilocularis FTZ F1 alpha 0.0084 0.0527 0.0527
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0084 0.0527 0.0527
Brugia malayi nuclear hormone receptor 0.004 0.0103 0.0103
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.084 0.7708 0.7224
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0212 0.1743 0.1743
Brugia malayi Proteasome subunit alpha type 7-1 0.0212 0.1743 0.1743
Echinococcus multilocularis ecdysone induced protein 78C 0.0084 0.0527 0.0527
Echinococcus granulosus proteasome prosome macropain subunit beta 0.052 0.4671 0.4671
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0527 0.0527
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1081 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0103 0.0103
Brugia malayi nuclear receptor NHR-88 0.0084 0.0527 0.0527
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1081 1 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.1081 1 1
Brugia malayi nuclear receptor RXR 0.0045 0.0148 0.0148
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0212 0.1743 0.1743
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Loa Loa (eye worm) steroid hormone receptor 0.0084 0.0527 0.0527
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0103 0.0103
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1081 1 1
Brugia malayi nuclear hormone receptor 0.0084 0.0527 0.0527
Brugia malayi ecdysone receptor 0.004 0.0103 0.0103
Echinococcus granulosus proteasome prosome macropain subunit beta 0.084 0.7708 0.7708
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0212 0.1743 0.1743
Echinococcus multilocularis proteasome subunit beta type 7 0.0212 0.1743 0.1743
Brugia malayi proteasome subunit alpha type 3 0.0212 0.1743 0.1743
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0103 0.0103
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0212 0.1743 0.1743
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0103 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0084 0.0527 0.0527
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.084 0.7708 0.7224
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.084 0.7708 0.7224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0527 0.0527
Toxoplasma gondii proteasome beta subunit 0.0212 0.1743 0.1743
Schistosoma mansoni thyroid hormone receptor 0.0084 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome subunit beta type 3 0.0212 0.1743 0.1743
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0527 0.0527
Trichomonas vaginalis set domain proteins, putative 0.023 0.1913 0.0205
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0212 0.1743 0.1743
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0103 0.0537
Brugia malayi tailless protein 0.004 0.0103 0.0103
Trypanosoma brucei proteasome subunit beta type-2, putative 0.052 0.4671 0.3546
Toxoplasma gondii peptidase, T1 family protein 0.0212 0.1743 0.1743
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0084 0.0527 0.0527
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0039 0.0039
Echinococcus multilocularis geminin 0.0165 0.129 0.129
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.052 0.4671 0.4671
Loa Loa (eye worm) DR-78 0.004 0.0103 0.0103
Onchocerca volvulus Bile acid receptor homolog 0.0084 0.0527 0.2753
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Onchocerca volvulus 0.023 0.1913 1
Schistosoma mansoni zinc finger protein 0.004 0.0103 0.0103
Echinococcus granulosus Proteasome subunit alpha beta 0.0212 0.1743 0.1743
Brugia malayi hypothetical protein 0.004 0.0103 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0084 0.0527 0.0527
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome subunit beta type 1 0.084 0.7708 0.7708
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Brugia malayi Nuclear hormone receptor E75 0.004 0.0103 0.0103
Brugia malayi proteasome subunit alpha type 2 0.0212 0.1743 0.1743
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.052 0.4671 0.3546
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0084 0.0527 0.0527
Echinococcus granulosus FTZ F1 alpha 0.0084 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Brugia malayi ecdysteroid receptor 0.0084 0.0527 0.0527
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Leishmania major proteasome beta 2 subunit, putative 0.052 0.4671 0.3546
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0084 0.0527 0.0527
Onchocerca volvulus 0.004 0.0103 0.0537
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0084 0.0527 0.0527
Brugia malayi steroid hormone receptor 0.0084 0.0527 0.0527
Schistosoma mansoni nuclear receptor 0.004 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0212 0.1743 0.1743
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0212 0.1743 0.1743
Brugia malayi Proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0212 0.1743 0.1743
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.052 0.4671 0.3546
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0084 0.0527 0.2753
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0212 0.1743 0.1743
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0103 0.0103
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0212 0.1743 0.1743
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0212 0.1743 0.1743
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0527 0.0527
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0212 0.1743 0.1743
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0212 0.1743 0.1743
Echinococcus multilocularis proteasome subunit beta type 6 0.0212 0.1743 0.1743
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0527 0.0527
Loa Loa (eye worm) proteasome subunit beta type 2 0.052 0.4671 0.4671
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0103 0.0103
Brugia malayi hypothetical protein 0.0045 0.0148 0.0148
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0212 0.1743 0.1743
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.052 0.4671 0.3546
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0103 0.0103
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1081 1 1
Schistosoma mansoni nuclear hormone receptor 0.004 0.0103 0.0103
Plasmodium falciparum proteasome subunit beta type-5 0.1081 1 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0103 0.0103
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.052 0.4671 0.4671
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0084 0.0527 0.0527
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1081 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0084 0.0527 0.0527
Echinococcus multilocularis proteasome subunit alpha type 2 0.0212 0.1743 0.1743
Brugia malayi hypothetical protein 0.004 0.0103 0.0103
Onchocerca volvulus 0.0084 0.0527 0.2753
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Brugia malayi Steroid receptor seven-up type 2 0.0084 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0084 0.0527 0.0527
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.084 0.7708 0.7708
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0212 0.1743 0.1743
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0103 0.0103
Schistosoma mansoni nuclear hormone receptor 0.004 0.0103 0.0103
Brugia malayi proteasome subunit alpha type 6 0.0212 0.1743 0.1743
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0185 0.0185
Plasmodium vivax proteasome subunit beta type-2, putative 0.052 0.4671 0.4671
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0103 0.0103
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0212 0.1743 0.1743
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0212 0.1743 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0103 0.0103
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Brugia malayi conserved hypotetical protein 0.004 0.0103 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0084 0.0527 0.0527
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0212 0.1743 0.1743
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1081 1 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.084 0.7708 0.7708
Leishmania major proteasome beta 5 subunit, putative 0.1081 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0212 0.1743 0.1743
Brugia malayi Proteasome A-type and B-type family protein 0.0212 0.1743 0.1743
Echinococcus granulosus proteasome subunit alpha type 6 0.0212 0.1743 0.1743
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0084 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0212 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0045 0.0148 0.0148
Brugia malayi 20S proteasome alpha5 subunit 0.0212 0.1743 0.1743
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1081 1 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0103
Schistosoma mansoni nuclear receptor 0.004 0.0103 0.0103

Activities

Activity type Activity value Assay description Source Reference
Affinity (binding) = 479 nM Binding affinity against human renin enzyme ChEMBL. 7636850
Affinity (binding) = 479 nM Binding affinity against human renin enzyme ChEMBL. 7636850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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