Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0809 | 0.8534 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0862 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0502 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0862 | 1 | 0.5 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0809 | 0.8534 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0862 | 1 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0809 | 0.8534 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0862 | 1 | 0.5 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0809 | 0.8534 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0862 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0862 | 1 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0809 | 0.8534 | 0.5 |
Toxoplasma gondii | cathepsin CPC1 | 0.0809 | 0.8534 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0809 | 0.8534 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0862 | 1 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0809 | 0.8534 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0862 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0862 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.467 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.404 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.374 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.366 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.325 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.311 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.