Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0048 | 0.0024 | 0.0024 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0101 | 0.0152 | 0.0152 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.4205 | 1 | 1 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0039 | 0.0002 | 0.0051 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0272 | 0.056 | 0.056 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0039 | 0.0002 | 0.0002 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0616 | 0.1386 | 0.1386 |
Schistosoma mansoni | sodium/calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Plasmodium falciparum | cation/H+ antiporter | 0.0039 | 0.0002 | 0.0228 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0039 | 0.0002 | 0.0228 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4205 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.4205 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.0085 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0195 | 0.0378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.1386 | 0.1386 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.4205 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0074 | 0.0085 | 0.0085 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0039 | 0.0002 | 0.0002 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.4205 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0074 | 0.0085 | 0.0085 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.4205 | 1 | 1 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0039 | 0.0002 | 0.0002 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0074 | 0.0085 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4205 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.4205 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.4205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0048 | 0.0024 | 0.2864 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0101 | 0.0152 | 0.0152 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.4205 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0272 | 0.056 | 0.056 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.0085 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0074 | 0.0085 | 0.0085 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.4205 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0048 | 0.0024 | 0.0646 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0039 | 0.0002 | 1 |
Loa Loa (eye worm) | solute carrier family 8 | 0.1539 | 0.3603 | 0.3603 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.4205 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0048 | 0.0024 | 0.0646 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0074 | 0.0085 | 1 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0039 | 0.0002 | 0.0002 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0039 | 0.0002 | 0.0002 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.4205 | 1 | 1 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0039 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0039 | 0.0002 | 0.0002 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0074 | 0.0085 | 0.0085 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.4205 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0048 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.4205 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4205 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0039 | 0.0002 | 0.0002 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0039 | 0.0002 | 0.0228 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0101 | 0.0152 | 0.0152 |
Echinococcus granulosus | sodium calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0039 | 0.0002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0085 | 0.0085 |
Schistosoma mansoni | na/ca exchanger | 0.0039 | 0.0002 | 0.0002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.