Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.036 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0351 | 0.036 | 0.036 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.2165 | 0.3101 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.033 | 0.0328 | 0.909 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.2165 | 0.3101 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0351 | 0.036 | 0.049 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0263 | 0.0227 | 0.0227 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.6288 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0263 | 0.0227 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0263 | 0.0227 | 0.0731 |
Brugia malayi | Ribokinase | 0.0258 | 0.0219 | 0.0219 |
Entamoeba histolytica | kinase, PfkB family | 0.0258 | 0.0219 | 0.6081 |
Entamoeba histolytica | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0258 | 0.0219 | 0.6081 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0263 | 0.0227 | 0.0227 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0217 | 0.0157 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0219 | 0.0219 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0258 | 0.0219 | 0.0707 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.2165 | 0.3101 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.033 | 0.0328 | 0.0328 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Echinococcus granulosus | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Echinococcus multilocularis | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0241 | 0.0193 | 0.0112 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0263 | 0.0227 | 0.0731 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Echinococcus granulosus | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Echinococcus granulosus | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.036 | 1 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0263 | 0.0227 | 0.0731 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0263 | 0.0227 | 0.0227 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0241 | 0.0193 | 0.0623 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0258 | 0.0219 | 0.6081 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0227 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0263 | 0.0227 | 0.0731 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0731 |
Onchocerca volvulus | 0.6729 | 1 | 1 | |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.2165 | 0.3101 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0219 | 0.016 | 0.0518 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0263 | 0.0227 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0219 | 0.016 | 0.0518 |
Trypanosoma cruzi | Protein kinase B | 0.0241 | 0.0193 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0219 | 0.0219 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0241 | 0.0193 | 0.5363 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0258 | 0.0219 | 0.0707 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.2165 | 0.3101 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.0033 | 0.091 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0227 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0217 | 0.0157 | 0.0506 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Giardia lamblia | Ribokinase | 0.0258 | 0.0219 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0241 | 0.0193 | 0.5363 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.033 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.0227 | 0.0227 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0263 | 0.0227 | 0.0731 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0217 | 0.0157 | 0.0506 |
Brugia malayi | Adenosine kinase-like | 0.0258 | 0.0219 | 0.0219 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.0026 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0263 | 0.0227 | 0.0731 |
Toxoplasma gondii | AGC kinase | 0.033 | 0.0328 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.6729 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0217 | 0.0157 | 0.0506 |
Entamoeba histolytica | protein kinase 2, putative | 0.0219 | 0.016 | 0.4453 |
Echinococcus multilocularis | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.6288 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0219 | 0.016 | 0.0518 |
Schistosoma mansoni | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Entamoeba histolytica | fructokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0263 | 0.0227 | 0.0227 |
Trypanosoma cruzi | ribokinase, putative | 0.0258 | 0.0219 | 0.02 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0241 | 0.0193 | 0.0623 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.2165 | 0.3101 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0351 | 0.036 | 0.036 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0241 | 0.0193 | 0.0623 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0263 | 0.0227 | 0.0026 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0241 | 0.0193 | 0.0623 |
Brugia malayi | Isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.0219 | 0.6081 |
Echinococcus multilocularis | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.727 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.635 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.51 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.397 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.366 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.182 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.169 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.122 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.924 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.818 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.