Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0361 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0361 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0361 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.5335 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0361 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0361 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0361 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.5335 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.3111 | 0.553 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.5335 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0361 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.5335 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.5335 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.5335 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0361 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0361 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.5335 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0361 | 0 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0455 | 0.0189 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0361 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0361 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0361 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.0189 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.5335 | 1 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.3111 | 0.553 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0361 | 0 | 0.5 |
Onchocerca volvulus | 0.0455 | 0.0189 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.