Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0308 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0308 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0153 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0308 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0308 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0308 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.019 | 0.2407 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0308 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0308 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0273 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0308 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0308 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0155 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0308 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0153 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0273 | 0.7743 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0308 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.019 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0308 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0308 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0308 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0308 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0308 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0308 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0308 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0308 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0308 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant topoisomerase 1-mediated DNA cleavage using [32P]-3'-end-labeled 117-bp DNA fragment as substrate at 0.1 to 100 uM after 20 mins by SDS-PAGE analysis | ChEMBL. | 22329436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.