Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0097 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Brugia malayi | SH2 domain containing protein | 0.0097 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0097 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0097 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0097 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Brugia malayi | protein-tyrosine kinase | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0097 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0097 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0097 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0097 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0097 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0097 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0097 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0097 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0097 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0097 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0097 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 9.8 | Binding affinity to adenosine A2A receptor by surface plasmon resonance | ChEMBL. | 22220592 |
Ki (binding) | = 7.78 | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting | ChEMBL. | 22220592 |
Ki (binding) | = 8.39 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22220592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.