Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase shark | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0176 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0176 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0176 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0176 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0176 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0176 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0176 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0176 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0176 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0176 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0176 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0176 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
INH (functional) | > 10 uM | Antagonist activity at adenosine A3 receptor | ChEMBL. | 22220592 |
Kd (binding) | = 8.9 | Binding affinity to adenosine A2A receptor by surface plasmon resonance | ChEMBL. | 22220592 |
Ki (binding) | = 7.07 | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting | ChEMBL. | 22220592 |
Ki (binding) | = 7.3 | Inhibition of adenosine A2B receptor | ChEMBL. | 22220592 |
Ki (binding) | = 8.11 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22220592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.