TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.455 | Formula: C24H12N6O3S
H donors: 1 H acceptors: 5 LogP: 3.17 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(c2ccc(cc2)[N+](=O)[O-])c(C#N)c2n(c1=N)c1scc(c1c(=O)[nH]2)c1ccccc1
InChi: 1S/C24H12N6O3S/c25-10-16-19(14-6-8-15(9-7-14)30(32)33)17(11-26)22-28-23(31)20-18(13-4-2-1-3-5-13)12-34-24(20)29(22)21(16)27/h1-9,12,27H,(H,28,31)
InChiKey: XIMHKIKWMDJHHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Schistosoma mansoni	goodpasture antigen-binding protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.1087	0.1623
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Brugia malayi	Cadps2 protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0036	0.0109	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0417	0.321	0.321
Onchocerca volvulus		0.0036	0.0109	0.5
Echinococcus multilocularis	serine threonine protein kinase	0.0417	0.321	0.4793
Brugia malayi	probable spectrin beta chain	0.0036	0.0109	0.0109
Entamoeba histolytica	protein kinase, putative	0.1217	0.9711	0.9711
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Echinococcus granulosus	beta 1 syntrophin	0.0036	0.0109	0.0162
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0036	0.0109	0.0162
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0417	0.321	0.4793
Trichomonas vaginalis	kinesin light chain, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0809	0.6395	0.955
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0845	0.6683	0.6683
Loa Loa (eye worm)	syntrophin-1	0.0036	0.0109	0.0109
Plasmodium falciparum	importin beta, putative	0.003	0.0065	0.0101
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0036	0.0109	0.0162
Trichomonas vaginalis	protein transport protein sec7, putative	0.0036	0.0109	0.0109
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0417	0.321	0.321
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1253	1	1
Echinococcus multilocularis	pdz domain containing protein	0.0036	0.0109	0.0162
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0045	0.0182	0.0182
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0036	0.0109	0.0109
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1087	0.1087
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	centaurin gamma, putative	0.0036	0.0109	0.0109
Echinococcus multilocularis	Pleckstrin y	0.0036	0.0109	0.0162
Onchocerca volvulus		0.0036	0.0109	0.5
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0065	0.0096
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0036	0.0109	0.0162
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0809	0.6395	0.9568
Trypanosoma cruzi	PH domain containing protein, putative	0.0036	0.0109	0.0162
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0045	0.0182	0.0272
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0045	0.0182	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Schistosoma mansoni	zinc finger protein	0.0036	0.0109	0.0162
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0417	0.321	0.321
Echinococcus multilocularis	protein kinase c iota type	0.0417	0.321	0.4793
Plasmodium vivax	PH domain containing protein	0.0036	0.0109	0.017
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0417	0.321	0.321
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0036	0.0109	0.0162
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Schistosoma mansoni	goodpasture antigen-binding protein	0.0036	0.0109	0.0162
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0045	0.0182	1
Echinococcus multilocularis	nervana 2	0.08	0.6322	0.9441
Echinococcus granulosus	nervana 2	0.08	0.6322	0.9459
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0182	0.0182
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0417	0.321	0.321
Echinococcus granulosus	Pleckstrin y	0.0036	0.0109	0.0162
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0036	0.0109	0.0162
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Echinococcus granulosus	pdz domain containing protein	0.0036	0.0109	0.0162
Leishmania major	protein kinase, putative	0.0045	0.0182	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0109	0.5975
Trichomonas vaginalis	centaurin alpha, putative	0.0036	0.0109	0.0109
Entamoeba histolytica	protein kinase, putative	0.0045	0.0182	0.0182
Toxoplasma gondii	Oxysterol-binding protein	0.0036	0.0109	0.0112
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0036	0.0109	0.0109
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.08	0.6322	0.9441
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0036	0.0109	0.0162
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0036	0.0109	0.0162
Entamoeba histolytica	protein kinase 2, putative	0.0809	0.6395	0.6395
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0036	0.0109	0.0162
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0036	0.0109	0.0112
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0036	0.0109	0.0109
Brugia malayi	MAX-1A	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	Protein kinase B	0.0845	0.6683	1
Brugia malayi	hypothetical protein	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	NIMA-related kinase, putative	0.0045	0.0182	0.0272
Onchocerca volvulus	outspread protein homolog	0.0036	0.0109	0.5
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1253	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	myotubularin protein 13	0.0036	0.0109	0.0162
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0065	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	PH domain containing protein, putative	0.0036	0.0109	0.0162
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0036	0.0109	0.0162
Brugia malayi	TBC domain containing protein	0.0036	0.0109	0.0109
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0182	0.0182
Brugia malayi	Cytohesin 3	0.0036	0.0109	0.0109
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0045	0.0182	0.0182
Entamoeba histolytica	hypothetical protein	0.0036	0.0109	0.0109
Schistosoma mansoni	myotubularin-related protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	oxysterol binding protein 3	0.0036	0.0109	0.0162
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0018	0.1008
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	rac serine:threonine kinase	0.0845	0.6683	0.9981
Echinococcus multilocularis	cytohesin 1	0.0036	0.0109	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Trypanosoma cruzi	NIMA-related kinase, putative	0.0045	0.0182	0.0272
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Echinococcus granulosus	serine threonine protein kinase nrc	0.0809	0.6395	0.9568
Schistosoma mansoni	oxysterol-binding protein 1	0.0036	0.0109	0.0162
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0018	0.0018
Brugia malayi	Muscleblind-like protein	0.0156	0.1087	0.1087
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0036	0.0109	0.0162
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	DCC interacting protein 13 beta	0.0036	0.0109	0.0162
Echinococcus multilocularis	Pleckstrin y	0.0036	0.0109	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1217	0.9711	0.9711
Leishmania major	folate/biopterin transporter, putative	0.0045	0.0182	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0036	0.0109	0.0162
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0045	0.0182	0.0284
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0036	0.0109	0.0109
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0036	0.0109	0.0162
Entamoeba histolytica	protein kinase, putative	0.0045	0.0182	0.0182
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0417	0.321	0.4793
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0036	0.0109	0.017
Trichomonas vaginalis	alpha chimerin, putative	0.0036	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0036	0.0109	0.0109
Onchocerca volvulus	Putative zinc finger protein	0.0036	0.0109	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Echinococcus granulosus	serine/threonine protein kinase	0.0845	0.6683	1
Echinococcus granulosus	GRB2 associated binding protein 3	0.0036	0.0109	0.0162
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0109	0.017
Brugia malayi	protein kinase C II.	0.0417	0.321	0.321
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0036	0.0109	0.0162
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Echinococcus granulosus	Rho GTPase activating protein 24	0.0036	0.0109	0.0162
Entamoeba histolytica	protein kinase, putative	0.0417	0.321	0.321
Echinococcus multilocularis	Pleckstrin y	0.0036	0.0109	0.0162
Echinococcus granulosus	importin subunit beta 1	0.003	0.0065	0.0097
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0182	0.0182
Schistosoma mansoni	serine/threonine kinase	0.0417	0.321	0.4802
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0417	0.321	0.321
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0036	0.0109	0.0109
Brugia malayi	Pleckstrin Homology Domain	0.0036	0.0109	0.0109
Onchocerca volvulus	Protein melted homolog	0.0036	0.0109	0.5
Loa Loa (eye worm)	rho-GTPase-activating	0.0036	0.0109	0.0109
Echinococcus multilocularis	protein kinase c epsilon type	0.0417	0.321	0.4793
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0036	0.0109	0.0109
Trichomonas vaginalis	centaurin/arf, putative	0.0036	0.0109	0.0109
Schistosoma mansoni	dynamin	0.0036	0.0109	0.0162
Giardia lamblia	Kinase, AGC PKA	0.0809	0.6395	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Schistosoma mansoni	rho gtpase activating protein	0.0036	0.0109	0.0162
Brugia malayi	Importin beta-1 subunit	0.003	0.0065	0.0065
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0417	0.321	0.4793
Schistosoma mansoni	vav2	0.0036	0.0109	0.0162
Entamoeba histolytica	PH domain containing protein	0.0036	0.0109	0.0109
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0809	0.6395	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0045	0.0182	0.0272
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0036	0.0109	0.0162
Entamoeba histolytica	protein kinase, putative	0.1253	1	1
Echinococcus multilocularis	myotubularin protein 13	0.0036	0.0109	0.0162
Brugia malayi	Oxysterol binding protein	0.0036	0.0109	0.0109
Schistosoma mansoni	hypothetical protein	0.0321	0.243	0.3636
Schistosoma mansoni	zinc finger protein	0.0036	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Brugia malayi	Variant SH3 domain containing protein	0.0036	0.0109	0.0109
Brugia malayi	RNA, U transporter 1	0.0086	0.0515	0.0515
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0417	0.321	0.4802
Echinococcus granulosus	cytohesin 1	0.0036	0.0109	0.0162
Brugia malayi	Hr1 repeat family protein	0.0417	0.321	0.321
Echinococcus granulosus	Protein kinase C brain isozyme	0.0417	0.321	0.4802
Brugia malayi	Oxysterol-binding protein	0.0036	0.0109	0.0109
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0036	0.0109	0.0162
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0036	0.0109	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Entamoeba histolytica	hypothetical protein	0.0045	0.0182	0.0182
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0408	0.3137	0.3137
Entamoeba histolytica	hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0036	0.0109	0.0162
Echinococcus granulosus	muscleblind protein	0.0156	0.1087	0.1626
Loa Loa (eye worm)	cytohesin 3	0.0036	0.0109	0.0109
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0018	0.0027
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.08	0.6322	0.9459
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0045	0.0182	0.0187
Echinococcus multilocularis	Glutaredoxin protein 5	0.08	0.6322	0.9441
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	oxysterol binding protein 3	0.0036	0.0109	0.0162
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0036	0.0109	0.0109
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0036	0.0109	0.0162
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0036	0.0109	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Toxoplasma gondii	hypothetical protein	0.0036	0.0109	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Schistosoma mansoni	hypothetical protein	0.0036	0.0109	0.0162
Echinococcus granulosus	NDR protein kinase	0.0417	0.321	0.4802
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0809	0.6395	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0036	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Brugia malayi	Variant SH3 domain containing protein	0.0036	0.0109	0.0109
Brugia malayi	Syntrophin-1	0.0036	0.0109	0.0109
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Toxoplasma gondii	hypothetical protein	0.0036	0.0109	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0109	0.017
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0065	0.0066
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0321	0.243	0.243
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0417	0.321	0.4802
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	p21-activated kinase	0.0045	0.0182	0.0182
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0036	0.0109	0.017
Plasmodium falciparum	oxysterol-binding protein, putative	0.0036	0.0109	0.017
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0036	0.0109	0.017
Echinococcus multilocularis	actin binding protein anillin	0.0036	0.0109	0.0162
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0809	0.6395	0.9568
Loa Loa (eye worm)	uncoordinated protein 104	0.0036	0.0109	0.0109
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Trichomonas vaginalis	centaurin/arf, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	protein kinase c epsilon type	0.0417	0.321	0.4802
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0036	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Schistosoma mansoni	dynamin	0.0036	0.0109	0.0162
Schistosoma mansoni	oxysterol-binding protein 1	0.0036	0.0109	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0846	0.6696	1
Schistosoma mansoni	importin beta-1	0.003	0.0065	0.0097
Trichomonas vaginalis	AGC family protein kinase	0.0453	0.3498	0.3498
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0045	0.0182	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0417	0.321	0.321
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Leishmania major	hypothetical protein, conserved	0.0036	0.0109	0.5975
Loa Loa (eye worm)	PH domain-containing protein	0.0036	0.0109	0.0109
Echinococcus granulosus	Pleckstrin y	0.0036	0.0109	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	serine:threonine protein kinase N2	0.0417	0.321	0.4802
Toxoplasma gondii	AGC kinase	0.1217	0.9711	1
Onchocerca volvulus		0.0036	0.0109	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0845	0.6683	1
Onchocerca volvulus		0.0036	0.0109	0.5
Echinococcus multilocularis	oxysterol binding protein 1	0.0036	0.0109	0.0162
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0417	0.321	0.4793
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0036	0.0109	0.0109
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0045	0.0182	0.0182
Schistosoma mansoni	centaurin alpha	0.0036	0.0109	0.0162
Leishmania major	serine/threonine-protein kinase a, putative	0.0045	0.0182	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0036	0.0109	0.0162
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0182	0.0182
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0045	0.0182	0.0272
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0036	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Entamoeba histolytica	protein kinase, putative	0.0045	0.0182	0.0182
Brugia malayi	Plekhf2 protein	0.0036	0.0109	0.0109
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0036	0.0109	0.0109
Echinococcus granulosus	snurportin 1	0.0321	0.243	0.3636
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0109	0.017
Schistosoma mansoni	atypical protein kinase C	0.0417	0.321	0.4802
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	nervana 2	0.08	0.6322	0.9459
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0045	0.0182	0.0272
Trypanosoma cruzi	PH domain containing protein, putative	0.0036	0.0109	0.0162
Entamoeba histolytica	PH domain containing protein	0.0036	0.0109	0.0109
Echinococcus granulosus	Pleckstrin y	0.0036	0.0109	0.0162
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0045	0.0182	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	protein kinase c iota type	0.0417	0.321	0.4802
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0045	0.0182	0.0272
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0036	0.0109	0.0109
Brugia malayi	Dynamin	0.0036	0.0109	0.0109
Brugia malayi	Uncoordinated protein 104	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	Glutaredoxin protein 5	0.08	0.6322	0.9459
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0036	0.0109	0.0162
Trichomonas vaginalis	hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma brucei	PH domain containing protein, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0417	0.321	0.4802
Trichomonas vaginalis	protein transport protein sec7, putative	0.0036	0.0109	0.0109
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0036	0.0109	0.0109
Echinococcus granulosus	pleckstrin y domain containing family A	0.0036	0.0109	0.0162
Schistosoma mansoni	serine/threonine-protein kinase	0.0845	0.6683	1
Echinococcus granulosus	calcium dependent secretion activator 1	0.0036	0.0109	0.0162
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0417	0.321	0.321
Trichomonas vaginalis	AGC family protein kinase	0.0417	0.321	0.321
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0018	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Onchocerca volvulus		0.0036	0.0109	0.5
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0036	0.0109	0.0162
Onchocerca volvulus		0.0036	0.0109	0.5
Echinococcus multilocularis	muscleblind protein	0.0156	0.1087	0.1623
Loa Loa (eye worm)	oxysterol binding protein	0.0036	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Entamoeba histolytica	protein kinase, putative	0.1253	1	1
Schistosoma mansoni	syntrophin	0.0036	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.003	0.0065	0.0065
Echinococcus granulosus	dynamin 1	0.0036	0.0109	0.0162
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0036	0.0109	0.0162
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	nervana 2	0.08	0.6322	0.9441
Trypanosoma cruzi	PH domain containing protein, putative	0.0036	0.0109	0.0162
Echinococcus granulosus	protein kinase C gamma type	0.0417	0.321	0.4802
Leishmania major	protein kinase, putative	0.0045	0.0182	1
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0036	0.0109	0.5
Brugia malayi	p70 ribosomal S6 kinase beta	0.1217	0.9711	0.9711
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0045	0.0182	0.0272
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0845	0.6683	0.6683
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Echinococcus multilocularis	dynamin 1	0.0036	0.0109	0.0162
Plasmodium falciparum	PH domain-containing protein, putative	0.0036	0.0109	0.017
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Toxoplasma gondii	protein kinase domain-containing protein	0.0045	0.0182	0.0187
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0036	0.0109	0.0162
Toxoplasma gondii	AtPH1 family protein	0.0036	0.0109	0.0112
Plasmodium vivax	importin-beta 2, putative	0.003	0.0065	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	centaurin beta, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	oxysterol binding protein 1	0.0036	0.0109	0.0162
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0845	0.6683	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0036	0.0109	0.0162
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Echinococcus multilocularis	oxysterol binding protein 9	0.0036	0.0109	0.0162
Schistosoma mansoni	growth factor receptor-bound protein	0.0036	0.0109	0.0162
Entamoeba histolytica	protein kinase, putative	0.0045	0.0182	0.0182
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Echinococcus multilocularis	Oxysterol binding protein 11	0.0036	0.0109	0.0162
Trypanosoma cruzi	hypothetical protein	0.0036	0.0109	0.0162
Onchocerca volvulus		0.0036	0.0109	0.5
Brugia malayi	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1087	0.1087
Entamoeba histolytica	PH domain containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0045	0.0182	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Brugia malayi	Protein kinase domain containing protein	0.0417	0.321	0.321
Trichomonas vaginalis	AGC family protein kinase	0.1253	1	1
Brugia malayi	Dynamin	0.0036	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0024	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0036	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Echinococcus granulosus	Oxysterol binding protein 11	0.0036	0.0109	0.0162
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0417	0.321	0.4802
Entamoeba histolytica	hypothetical protein	0.0045	0.0182	0.0182
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0036	0.0109	0.0109
Echinococcus granulosus	oxysterol binding protein 9	0.0036	0.0109	0.0162
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0036	0.0109	0.0162
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0417	0.321	0.4793
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0417	0.321	0.4793
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0417	0.321	0.4793
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0417	0.321	0.321
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0045	0.0182	1
Brugia malayi	Protein kinase domain containing protein	0.0417	0.321	0.321
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0036	0.0109	0.017
Schistosoma mansoni	hypothetical protein	0.0036	0.0109	0.0162
Entamoeba histolytica	hypothetical protein	0.0036	0.0109	0.0109
Echinococcus multilocularis	snurportin 1	0.0321	0.243	0.3629
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0045	0.0182	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0109
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0045	0.0182	0.0272
Entamoeba histolytica	protein kinase, putative	0.0045	0.0182	0.0182
Loa Loa (eye worm)	Plekhf2 protein	0.0036	0.0109	0.0109
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0036	0.0109	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0182	0.0182
Schistosoma mansoni	hypothetical protein	0.0036	0.0109	0.0162
Trypanosoma brucei	protein kinase, putative	0.0045	0.0182	0.0182
Echinococcus multilocularis	beta 1 syntrophin	0.0036	0.0109	0.0162

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 0 mm	Antifungal activity against Candida albicans 155965 at 1 mg/ml after 48 hrs by agar-well diffusion technique	ChEMBL.	22464424
IZ (functional)	= 0 mm	Antifungal activity against Saccharomyces cerevisiae 156250 at 1 mg/ml after 48 hrs by agar-well diffusion technique	ChEMBL.	22464424
IZ (functional)	= 4 mm	Antibacterial activity against Escherichia coli 124300 at 1 mg/ml after 24 hrs by agar-well diffusion technique	ChEMBL.	22464424

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2022811

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1631969