Detailed information for compound 1633112

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.632 | Formula: C33H32N4O4
  • H donors: 1 H acceptors: 2 LogP: 4.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N(CC(=O)N2[C@@H]1Cc1c([C@H]2c2ccc3c(c2)OCO3)[nH]c2c1cccc2)[C@@H]1CCN(C1)CCc1ccccc1
  • InChi: 1S/C33H32N4O4/c38-30-19-36(23-13-15-35(18-23)14-12-21-6-2-1-3-7-21)33(39)27-17-25-24-8-4-5-9-26(24)34-31(25)32(37(27)30)22-10-11-28-29(16-22)41-20-40-28/h1-11,16,23,27,32,34H,12-15,17-20H2/t23-,27-,32-/m1/s1
  • InChiKey: DDFNDADPVSFPRY-YYKZIPJASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitotic cyclin, putative 0.0140099 0.0274287 0.127753
Echinococcus granulosus neuroligin 0.0323141 0.0723953 0.0720452
Brugia malayi tailless protein 0.00619393 0.00822779 0.00695607
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.00619393 0.00822779 0.00822779
Echinococcus multilocularis cyclin y 0.0140099 0.0274287 0.0270616
Toxoplasma gondii hypothetical protein 0.0408158 0.0932807 1
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Plasmodium vivax cyclin 4, putative 0.0140099 0.0274287 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0323141 0.0723953 0.0720452
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0162661 0.0329713 0.0326063
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0236903 0.0512098 0.0512098
Schistosoma mansoni g1/s-specific cyclin C 0.0140099 0.0274287 0.0274287
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0131306 0.0252687 0.0240188
Echinococcus granulosus cyclin A3 4 0.0140099 0.0274287 0.0270616
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0236903 0.0512098 0.0508517
Loa Loa (eye worm) CAMK/PIM protein kinase 0.102903 0.245804 0.245662
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0119532 0.0223762 0.126677
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0131306 0.0252687 0.0249008
Trichomonas vaginalis cyclins, putative 0.0728323 0.171933 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0323141 0.0723953 0.0723953
Brugia malayi hypothetical protein 0.00619393 0.00822779 0.00695607
Brugia malayi ecdysone receptor 0.00619393 0.00822779 0.00695607
Echinococcus granulosus BC026374 protein S09 family 0.0323141 0.0723953 0.0720452
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Onchocerca volvulus 0.0140099 0.0274287 0.106935
Schistosoma mansoni serine/threonine protein kinase 0.102903 0.245804 0.245804
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0131306 0.0252687 0.0240188
Echinococcus granulosus mitogen activated protein kinase 14 0.0387823 0.0882852 0.0879411
Echinococcus granulosus roundabout 2 0.00338461 0.00132635 0.000949432
Loa Loa (eye worm) carboxylesterase 0.0323141 0.0723953 0.0722202
Trichomonas vaginalis cyclin A, putative 0.0140099 0.0274287 0.15618
Trichomonas vaginalis cyclin D, putative 0.0548257 0.127698 0.741692
Echinococcus multilocularis thyroid hormone receptor alpha 0.0131306 0.0252687 0.0249008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131306 0.0252687 0.0240188
Echinococcus multilocularis cyclin y 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) cyclin domain-containing protein 0.099742 0.23804 0.237897
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0344242 0.0775791 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.099742 0.23804 0.237753
Plasmodium vivax cyclin homologue, putative 0.0140099 0.0274287 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0456627 0.105188 0.10404
Loa Loa (eye worm) hypothetical protein 0.0728323 0.171933 0.171777
Echinococcus multilocularis cyclin G2 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00590199 0.00751062 0.018501
Onchocerca volvulus 0.00619393 0.00822779 0.028411
Echinococcus granulosus cyclin 0.0140099 0.0274287 0.0270616
Trypanosoma cruzi UNC119 0.00524282 0.00589128 0.00961876
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.026835 0.0589352 0.0589352
Trichomonas vaginalis conserved hypothetical protein 0.0140099 0.0274287 0.15618
Brugia malayi nuclear receptor NHR-88 0.00619393 0.00822779 0.00695607
Brugia malayi Nuclear hormone receptor E75 0.00619393 0.00822779 0.00695607
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Brugia malayi Cyclin, N-terminal domain containing protein 0.0140099 0.0274287 0.0261816
Trypanosoma cruzi cdc2-related kinase 1 0.00590199 0.00751062 0.018501
Loa Loa (eye worm) carboxylesterase 0.191247 0.462833 0.462732
Leishmania major cyclin 9, putative 0.0140099 0.0274287 0.127753
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.00452899 0.00413766 0.00286069
Echinococcus multilocularis FTZ F1 alpha 0.0131306 0.0252687 0.0249008
Schistosoma mansoni serine/threonine protein kinase 0.00590199 0.00751062 0.00751062
Brugia malayi conserved hypotetical protein 0.00619393 0.00822779 0.00695607
Schistosoma mansoni memapsin-2 (A01 family) 0.0499642 0.115755 0.115755
Onchocerca volvulus 0.0323141 0.0723953 0.290829
Brugia malayi orphan nuclear receptor NR2E1 0.00619393 0.00822779 0.00695607
Echinococcus multilocularis cyclin t1 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis conserved hypothetical protein 0.0191613 0.0400838 0.230078
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.00693672 0.0100525 0.00986575
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00619393 0.00822779 0.028411
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.191247 0.462833 0.462833
Brugia malayi cell division control protein 2 homolog 0.00590199 0.00751062 0.00623798
Loa Loa (eye worm) hypothetical protein 0.00452899 0.00413766 0.00394974
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0323141 0.0723953 1
Trypanosoma brucei UNC119 0.00524282 0.00589128 0.00961876
Trichomonas vaginalis conserved hypothetical protein 0.00452899 0.00413766 0.0201741
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00340401 0.00137403 0.0000935131
Loa Loa (eye worm) carboxylesterase 0.0323141 0.0723953 0.0722202
Echinococcus granulosus ecdysone induced protein 78C 0.0131306 0.0252687 0.0249008
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis spcc417.12 protein, putative 0.0323141 0.0723953 0.418758
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0140099 0.0274287 0.261277
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131306 0.0252687 0.0240188
Brugia malayi Nuclear hormone receptor-like 1 0.0131306 0.0252687 0.0240188
Plasmodium vivax protein kinase Crk2 0.00590199 0.00751062 0.144818
Brugia malayi Carboxylesterase family protein 0.191247 0.462833 0.462144
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0131306 0.0252687 0.0240188
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00590199 0.00751062 0.00732334
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.00619393 0.00822779 0.00785348
Trichomonas vaginalis cyclins, putative 0.0728323 0.171933 1
Trichomonas vaginalis CMGC family protein kinase 0.00590199 0.00751062 0.0398703
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Brugia malayi Cyclin, N-terminal domain containing protein 0.298784 0.727013 0.726663
Trichomonas vaginalis cyclin B, putative 0.0728323 0.171933 1
Brugia malayi Nuclear hormone receptor-like 1 0.00693672 0.0100525 0.00878316
Trichomonas vaginalis conserved hypothetical protein 0.0117371 0.0218452 0.123576
Echinococcus multilocularis cyclin dependent kinase 1 0.00590199 0.00751062 0.00713604
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0140099 0.0274287 0.127753
Echinococcus granulosus titin 0.003366 0.00128063 0.000903702
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Trichomonas vaginalis cyclin A, putative 0.0728323 0.171933 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0131306 0.0252687 0.0240188
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0131306 0.0252687 0.0249008
Schistosoma mansoni Cyclin fold protein 0.0140099 0.0274287 0.0274287
Brugia malayi Carboxylesterase family protein 0.0323141 0.0723953 0.0712058
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.00452899 0.00413766 0.00286069
Echinococcus granulosus twitchin 0.00455104 0.00419184 0.003816
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.00452899 0.00413766 0.00286069
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0140099 0.0274287 0.1885
Trypanosoma cruzi cyclin, putative 0.0728323 0.171933 0.920372
Brugia malayi nuclear receptor RXR 0.00619393 0.00822779 0.00695607
Loa Loa (eye worm) CAMK/PIM protein kinase 0.102903 0.245804 0.245662
Onchocerca volvulus 0.0131306 0.0252687 0.0981012
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.409907 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0131306 0.0252687 0.0240188
Trichomonas vaginalis conserved hypothetical protein 0.00452899 0.00413766 0.0201741
Trypanosoma cruzi cdc2-related kinase 1 0.00590199 0.00751062 0.018501
Trichomonas vaginalis cyclins, putative 0.0140099 0.0274287 0.15618
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Schistosoma mansoni serine/threonine protein kinase 0.00590199 0.00751062 0.00751062
Brugia malayi hypothetical protein 0.00693672 0.0100525 0.00878316
Trichomonas vaginalis conserved hypothetical protein 0.0548257 0.127698 0.741692
Trypanosoma cruzi cdc2-related kinase 3 0.00590199 0.00751062 0.018501
Loa Loa (eye worm) steroid hormone receptor 0.0131306 0.0252687 0.0250848
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.099742 0.23804 0.237753
Leishmania major C-8 sterol isomerase-like protein 0.0787416 0.18645 1
Brugia malayi Carboxylesterase family protein 0.0323141 0.0723953 0.0712058
Trichomonas vaginalis cyclin B, putative 0.0140099 0.0274287 0.15618
Brugia malayi photoreceptor-specific nuclear receptor 0.0131306 0.0252687 0.0240188
Loa Loa (eye worm) hypothetical protein 0.026835 0.0589352 0.0587576
Brugia malayi hypothetical protein 0.00619393 0.00822779 0.00695607
Echinococcus granulosus thyroid hormone receptor alpha 0.00619393 0.00822779 0.00785348
Onchocerca volvulus 0.0323141 0.0723953 0.290829
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131306 0.0252687 0.0249008
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Onchocerca volvulus Cyclin L homolog 0.0140099 0.0274287 0.106935
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0323141 0.0723953 0.0723953
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00590199 0.00751062 0.00732334
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0236903 0.0512098 0.258195
Brugia malayi Serine/threonine-protein kinase Pim-3 0.102903 0.245804 0.244837
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0236903 0.0512098 0.258195
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis cyclins, putative 0.0320165 0.0716641 0.414488
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Loa Loa (eye worm) cyclin domain-containing protein 0.0140099 0.0274287 0.0272452
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0131306 0.0252687 0.0252687
Schistosoma mansoni steroid hormone receptor ad4bp 0.0131306 0.0252687 0.0252687
Entamoeba histolytica cyclin, putative 0.0728323 0.171933 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.00452899 0.00413766 0.0037618
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0162661 0.0329713 0.0317313
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.00452899 0.00413766 0.0037618
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Loa Loa (eye worm) hypothetical protein 0.00452899 0.00413766 0.00394974
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0131306 0.0252687 0.0249008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.00619393 0.00822779 0.00785348
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.102903 0.245804 0.24552
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0236903 0.0512098 0.0508517
Brugia malayi Cyclin, N-terminal domain containing protein 0.0140099 0.0274287 0.0261816
Brugia malayi nuclear receptor NHR-88 0.0131306 0.0252687 0.0240188
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0728323 0.171933 0.920372
Echinococcus granulosus cyclin k 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Echinococcus granulosus titin 0.003366 0.00128063 0.000903702
Brugia malayi Cyclin, N-terminal domain containing protein 0.0140099 0.0274287 0.0261816
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.00452899 0.00413766 0.0037618
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00340401 0.00137403 0.00118559
Trichomonas vaginalis CMGC family protein kinase 0.00590199 0.00751062 0.0398703
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Trichomonas vaginalis cyclins, putative 0.0140099 0.0274287 0.15618
Brugia malayi Cyclin, N-terminal domain containing protein 0.0728323 0.171933 0.170871
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Brugia malayi Cyclin, N-terminal domain containing protein 0.0140099 0.0274287 0.0261816
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0162661 0.0329713 0.188545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131306 0.0252687 0.0249008
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0323141 0.0723953 0.0720452
Loa Loa (eye worm) hypothetical protein 0.0787416 0.18645 0.186297
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Brugia malayi Stress-activated protein kinase jnk-1 0.409907 1 1
Trypanosoma brucei cdc2-related kinase 3 0.00590199 0.00751062 0.018501
Brugia malayi Carboxylesterase family protein 0.0323141 0.0723953 0.0712058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00619393 0.00822779 0.00785348
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0140099 0.0274287 0.261277
Loa Loa (eye worm) CAMK protein kinase 0.003366 0.00128063 0.00109218
Loa Loa (eye worm) cyclin domain-containing protein 0.0140099 0.0274287 0.0272452
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0131306 0.0252687 0.0252687
Brugia malayi steroid hormone receptor 0.0131306 0.0252687 0.0240188
Loa Loa (eye worm) cyclin domain-containing protein 0.0140099 0.0274287 0.0272452
Trichomonas vaginalis cyclin B, putative 0.0548257 0.127698 0.741692
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0140099 0.0274287 1
Brugia malayi cyclin fold protein 1 variant b 0.0140099 0.0274287 0.0261816
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0140099 0.0274287 0.0272452
Brugia malayi P38 map kinase family protein 2 0.0387823 0.0882852 0.0871161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00693672 0.0100525 0.0100525
Loa Loa (eye worm) hypothetical protein 0.0404329 0.0923402 0.0921689
Onchocerca volvulus Protein CNPPD1 homolog 0.0140099 0.0274287 0.106935
Trypanosoma cruzi cyclin 6, putative 0.0728323 0.171933 0.920372
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00452899 0.00413766 0.0037618
Schistosoma mansoni cyclin l 0.0140099 0.0274287 0.0274287
Schistosoma mansoni serine/threonine protein kinase 0.003366 0.00128063 0.00128063
Echinococcus multilocularis titin 0.003366 0.00128063 0.000903702
Brugia malayi hypothetical protein 0.0140099 0.0274287 0.0261816
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Echinococcus granulosus cyclin y 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis conserved hypothetical protein 0.0140099 0.0274287 0.15618
Loa Loa (eye worm) hypothetical protein 0.00693672 0.0100525 0.00986575
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Brugia malayi Protein kinase domain containing protein 0.00590199 0.00751062 0.00623798
Schistosoma mansoni BC026374 protein (S09 family) 0.0323141 0.0723953 0.0723953
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.00452899 0.00413766 0.00413766
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Loa Loa (eye worm) hypothetical protein 0.00338461 0.00132635 0.0011379
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0162661 0.0329713 0.0317313
Onchocerca volvulus 0.0728323 0.171933 0.697898
Echinococcus granulosus Nuclear hormone receptor HR96 0.00619393 0.00822779 0.00785348
Schistosoma mansoni nuclear hormone receptor 0.0131306 0.0252687 0.0252687
Trypanosoma brucei cyclin 3 0.0140099 0.0274287 0.127753
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003366 0.00128063 0.00109218
Echinococcus granulosus nuclear receptor nhr 48 0.00619393 0.00822779 0.00785348
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0787416 0.18645 1
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Mycobacterium tuberculosis Carboxylesterase LipT 0.0323141 0.0723953 1
Brugia malayi nuclear receptor RXR 0.00693672 0.0100525 0.00878316
Loa Loa (eye worm) acetylcholinesterase 1 0.191247 0.462833 0.462732
Loa Loa (eye worm) cyclin domain-containing protein 0.0140099 0.0274287 0.0272452
Schistosoma mansoni voltage-gated potassium channel 0.00375299 0.00223132 0.00223132
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00619393 0.00822779 0.028411
Plasmodium falciparum cyclin 0.0548257 0.127698 1
Trichomonas vaginalis conserved hypothetical protein 0.0191613 0.0400838 0.230078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0131306 0.0252687 0.0240188
Loa Loa (eye worm) hypothetical protein 0.0140099 0.0274287 0.0272452
Loa Loa (eye worm) cyclin domain-containing protein 0.0140099 0.0274287 0.0272452
Echinococcus multilocularis BC026374 protein (S09 family) 0.0323141 0.0723953 0.0720452
Trichomonas vaginalis conserved hypothetical protein 0.0140099 0.0274287 0.15618
Echinococcus granulosus cyclin dependent kinase 0.00590199 0.00751062 0.00713604
Brugia malayi Carboxylesterase family protein 0.191247 0.462833 0.462144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0131306 0.0252687 0.0240188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0131306 0.0252687 0.0250848
Schistosoma mansoni acetylcholinesterase 0.0323141 0.0723953 0.0723953
Brugia malayi hypothetical protein 0.00693672 0.0100525 0.00878316
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis conserved hypothetical protein 0.0140099 0.0274287 0.15618
Brugia malayi hypothetical protein 0.00524282 0.00589128 0.00461656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00619393 0.00822779 0.00785348
Echinococcus multilocularis cyclin G2 0.0140099 0.0274287 0.0270616
Echinococcus multilocularis G1:S specific cyclin D1 0.298784 0.727013 0.72691
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Schistosoma mansoni thyroid hormone receptor 0.0131306 0.0252687 0.0252687
Trichomonas vaginalis cyclin B3, putative 0.0548257 0.127698 0.741692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0131306 0.0252687 0.0250848
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0323141 0.0723953 1
Echinococcus granulosus para nitrobenzyl esterase 0.0323141 0.0723953 0.0720452
Trichomonas vaginalis cyclin B, putative 0.0728323 0.171933 1
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0140099 0.0274287 0.1885
Schistosoma mansoni cyclin k 0.0140099 0.0274287 0.0274287
Giardia lamblia Cyclin fold protein 1, putative 0.0140099 0.0274287 0.138806
Toxoplasma gondii cyclin dependent kinase binding protein 0.0140099 0.0274287 0.261277
Echinococcus granulosus fibroblast growth factor receptor 4 0.0608271 0.142441 0.142117
Trichomonas vaginalis cyclins, putative 0.0548257 0.127698 0.741692
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0131306 0.0252687 0.0252687
Echinococcus multilocularis cyclin B 0.0728323 0.171933 0.171621
Trypanosoma cruzi cyclin 9, putative 0.0140099 0.0274287 0.127753
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Giardia lamblia G2/mitotic-specific cyclin B 0.0728323 0.171933 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Leishmania major hypothetical protein, conserved 0.00524282 0.00589128 0.00961876
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Schistosoma mansoni nuclear hormone receptor 0.00619393 0.00822779 0.00822779
Schistosoma mansoni retinoic acid receptor RXR 0.0131306 0.0252687 0.0252687
Schistosoma mansoni nuclear receptor 0.00619393 0.00822779 0.00822779
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0140099 0.0274287 0.0274287
Echinococcus multilocularis neuroligin 0.0323141 0.0723953 0.0720452
Echinococcus multilocularis cyclin B3 1 0.0548257 0.127698 0.127368
Schistosoma mansoni cyclin G2 0.0140099 0.0274287 0.0274287
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0131306 0.0252687 0.0249008
Loa Loa (eye worm) hypothetical protein 0.00434923 0.00369606 0.00350806
Brugia malayi Carboxylesterase family protein 0.0323141 0.0723953 0.0712058
Brugia malayi nuclear hormone receptor family member odr-7 0.00619393 0.00822779 0.00695607
Schistosoma mansoni nuclear receptor 0.00619393 0.00822779 0.00822779
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0236903 0.0512098 0.258195
Schistosoma mansoni cyclin d 0.298784 0.727013 0.727013
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0608271 0.142441 0.142117
Trichomonas vaginalis cyclin B, putative 0.0728323 0.171933 1
Echinococcus granulosus carboxylesterase 5A 0.191247 0.462833 0.46263
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0236903 0.0512098 0.258195
Schistosoma mansoni tyrosine kinase 0.0608271 0.142441 0.142441
Onchocerca volvulus 0.0323141 0.0723953 0.290829
Loa Loa (eye worm) hypothetical protein 0.284775 0.692595 0.692537
Brugia malayi Nuclear hormone receptor E75 0.00619393 0.00822779 0.00695607
Brugia malayi hypothetical protein 0.0323141 0.0723953 0.0712058
Echinococcus multilocularis cyclin dependent kinase 5 0.00590199 0.00751062 0.00713604
Echinococcus multilocularis carboxylesterase 5A 0.191247 0.462833 0.46263
Echinococcus multilocularis cyclin dependent kinase 1 0.00590199 0.00751062 0.00713604
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.026835 0.0589352 0.340159
Plasmodium falciparum protein kinase 5 0.00590199 0.00751062 0.0272982
Trichomonas vaginalis CMGC family protein kinase 0.00590199 0.00751062 0.0398703
Echinococcus granulosus c-Jun N-terminal kinases 0.409907 1 1
Brugia malayi hypothetical protein 0.026835 0.0589352 0.0577285
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00590199 0.00751062 0.00732334
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0131306 0.0252687 0.0240188
Mycobacterium leprae conserved hypothetical protein 0.0117371 0.0218452 0.5
Schistosoma mansoni cyclins 0.0548257 0.127698 0.127698
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.00452899 0.00413766 0.0037618
Brugia malayi Cyclin C 0.0140099 0.0274287 0.0261816
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119532 0.0223762 0.10004
Schistosoma mansoni gliotactin 0.0323141 0.0723953 0.0723953
Echinococcus granulosus cyclins 0.0548257 0.127698 0.127368
Loa Loa (eye worm) hypothetical protein 0.0728323 0.171933 0.171777
Entamoeba histolytica cyclin family protein 0.0548257 0.127698 0.730965
Plasmodium falciparum cyclin 1 0.0140099 0.0274287 0.1885
Loa Loa (eye worm) PDE1B protein 0.00452899 0.00413766 0.00394974
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.00693672 0.0100525 0.0100525
Loa Loa (eye worm) hypothetical protein 0.0162661 0.0329713 0.0327888
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131306 0.0252687 0.0240188
Brugia malayi Immunoglobulin I-set domain containing protein 0.0626403 0.146895 0.145801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0131306 0.0252687 0.0250848
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0323141 0.0723953 0.0720452
Brugia malayi nuclear receptor NHR-67 0.00619393 0.00822779 0.00695607
Loa Loa (eye worm) cyclin domain-containing protein 0.0456627 0.105188 0.105019
Schistosoma mansoni nephrin 0.00299827 0.000377272 0.000377272
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Brugia malayi Cyclin, N-terminal domain containing protein 0.099742 0.23804 0.237063
Loa Loa (eye worm) nuclear hormone receptor 0.00619393 0.00822779 0.00804065
Loa Loa (eye worm) hypothetical protein 0.00452899 0.00413766 0.00394974
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0387823 0.0882852 0.0881132
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.102903 0.245804 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0131306 0.0252687 0.0240188
Entamoeba histolytica cyclin, domain containing protein 0.0140099 0.0274287 0.12114
Loa Loa (eye worm) nuclear receptor NHR-67 0.00619393 0.00822779 0.00804065
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00590199 0.00751062 0.0378377
Trichomonas vaginalis cyclin D, putative 0.0140099 0.0274287 0.15618
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0162661 0.0329713 0.0329713
Echinococcus multilocularis roundabout 2 0.00338461 0.00132635 0.000949432
Trichomonas vaginalis cyclin B3, putative 0.0140099 0.0274287 0.15618
Brugia malayi hypothetical protein 0.0140099 0.0274287 0.0261816
Echinococcus multilocularis c Jun NH2 terminal kinase 0.409907 1 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0387823 0.0882852 0.461556
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trypanosoma cruzi hypothetical protein, conserved 0.0140099 0.0274287 0.127753
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0131306 0.0252687 0.0250848
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00452899 0.00413766 0.0037618
Plasmodium falciparum GAF domain-related protein, putative 0.0117371 0.0218452 0.143312
Schistosoma mansoni neuroligin 3 (S09 family) 0.0323141 0.0723953 0.0723953
Giardia lamblia Hypothetical protein 0.0140099 0.0274287 0.138806
Schistosoma mansoni hypothetical protein 0.0140099 0.0274287 0.0274287
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis cyclin B, putative 0.0140099 0.0274287 0.15618
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Toxoplasma gondii hypothetical protein 0.0140099 0.0274287 0.261277
Schistosoma mansoni cyclin G 0.0140099 0.0274287 0.0274287
Brugia malayi Serotonin receptor 0.0467187 0.107782 0.106638
Echinococcus multilocularis mitogen activated protein kinase 11 0.0387823 0.0882852 0.0879411
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Loa Loa (eye worm) nuclear receptor nhr-7B 0.00619393 0.00822779 0.00804065
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.102903 0.245804 0.24552
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00619393 0.00822779 0.00785348
Schistosoma mansoni hypothetical protein 0.0140099 0.0274287 0.0274287
Loa Loa (eye worm) hypothetical protein 0.00693672 0.0100525 0.00986575
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Entamoeba histolytica cyclin family protein 0.0548257 0.127698 0.730965
Echinococcus granulosus acetylcholinesterase 0.191247 0.462833 0.46263
Brugia malayi nuclear hormone receptor family member nhr-6 0.00619393 0.00822779 0.00695607
Mycobacterium ulcerans carboxylesterase, LipT 0.0323141 0.0723953 0.906991
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0131306 0.0252687 0.0249008
Giardia lamblia Kinase, CMGC CDK 0.00590199 0.00751062 0.0201016
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Echinococcus granulosus cyclin B 0.0728323 0.171933 0.171621
Echinococcus multilocularis cyclin A3 4 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Echinococcus granulosus G1:S specific cyclin D1 0.298784 0.727013 0.72691
Schistosoma mansoni nuclear hormone receptor 0.00619393 0.00822779 0.00822779
Echinococcus multilocularis Cyclin L1 0.0140099 0.0274287 0.0270616
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0608271 0.142441 0.142117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0131306 0.0252687 0.0249008
Trichomonas vaginalis conserved hypothetical protein 0.0191613 0.0400838 0.230078
Onchocerca volvulus 0.0323141 0.0723953 0.290829
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.00452899 0.00413766 0.0037618
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0131306 0.0252687 0.0250848
Brugia malayi Cyclin, N-terminal domain containing protein 0.0728323 0.171933 0.170871
Echinococcus multilocularis mitogen activated protein kinase 14 0.0387823 0.0882852 0.0879411
Entamoeba histolytica cyclin C, putative 0.0140099 0.0274287 0.12114
Onchocerca volvulus 0.00619393 0.00822779 0.028411
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0162661 0.0329713 0.188545
Loa Loa (eye worm) hypothetical protein 0.00338461 0.00132635 0.0011379
Brugia malayi Protein kinase domain containing protein 0.102903 0.245804 0.244837
Onchocerca volvulus Bile acid receptor homolog 0.0131306 0.0252687 0.0981012
Trypanosoma cruzi UNC119 0.00524282 0.00589128 0.00961876
Echinococcus multilocularis twitchin 0.003366 0.00128063 0.000903702
Entamoeba histolytica cyclin, domain containing protein 0.0140099 0.0274287 0.12114
Schistosoma mansoni zinc finger protein 0.00619393 0.00822779 0.00822779
Plasmodium vivax hypothetical protein, conserved 0.0117371 0.0218452 0.760275
Echinococcus granulosus cyclin G2 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0131306 0.0252687 0.0250848
Brugia malayi nuclear hormone receptor 0.0131306 0.0252687 0.0240188
Echinococcus multilocularis mitogen activated protein kinase 14 0.0387823 0.0882852 0.0879411
Loa Loa (eye worm) hypothetical protein 0.0180066 0.037247 0.0370653
Brugia malayi Cyclin, N-terminal domain containing protein 0.0140099 0.0274287 0.0261816
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Onchocerca volvulus Cyclin L homolog 0.0140099 0.0274287 0.106935
Brugia malayi Nuclear hormone receptor-like 1 0.00693672 0.0100525 0.00878316
Loa Loa (eye worm) hypothetical protein 0.00693672 0.0100525 0.00986575
Giardia lamblia Hypothetical protein 0.0140099 0.0274287 0.138806
Giardia lamblia Cyclin A 0.0548257 0.127698 0.736373
Trypanosoma cruzi cyclin, putative 0.0728323 0.171933 0.920372
Trichomonas vaginalis cyclins, putative 0.0728323 0.171933 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0131306 0.0252687 0.0249008
Entamoeba histolytica cyclin, putative 0.0548257 0.127698 0.730965
Leishmania major mitotic cyclin, putative 0.0140099 0.0274287 0.127753
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Onchocerca volvulus 0.0323141 0.0723953 0.290829
Echinococcus granulosus cyclins 0.0548257 0.127698 0.127368
Echinococcus granulosus cyclin t1 0.0140099 0.0274287 0.0270616
Giardia lamblia Kinase, CMGC CDK 0.00590199 0.00751062 0.0201016
Giardia lamblia Hypothetical protein 0.0548257 0.127698 0.736373
Loa Loa (eye worm) hypothetical protein 0.00693672 0.0100525 0.00986575
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0162661 0.0329713 0.0326063
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00590199 0.00751062 0.00713604
Trypanosoma cruzi CYC2-like cyclin, putative 0.0728323 0.171933 0.920372
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Echinococcus granulosus cyclin dependent kinase 5 0.00590199 0.00751062 0.00713604
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0140099 0.0274287 0.0270616
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.00452899 0.00413766 0.00413766
Onchocerca volvulus Protein ultraspiracle homolog 0.0131306 0.0252687 0.0981012
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0608271 0.142441 0.142117
Echinococcus granulosus FTZ F1 alpha 0.0131306 0.0252687 0.0249008
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00452899 0.00413766 0.0037618
Trypanosoma brucei mitotic cyclin 0.0140099 0.0274287 0.127753
Loa Loa (eye worm) cyclin C 0.0140099 0.0274287 0.0272452
Trypanosoma brucei cyclin 9 0.0140099 0.0274287 0.127753
Echinococcus granulosus cyclins 0.0548257 0.127698 0.127368
Toxoplasma gondii hypothetical protein 0.0117371 0.0218452 0.198643
Echinococcus multilocularis ecdysone induced protein 78C 0.0131306 0.0252687 0.0249008
Plasmodium vivax hypothetical protein, conserved 0.0140099 0.0274287 1
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Trypanosoma cruzi mitotic cyclin, putative 0.0140099 0.0274287 0.127753
Giardia lamblia Cyclin B-like protein 0.0140099 0.0274287 0.138806
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0323141 0.0723953 0.418758
Echinococcus granulosus hypothetical protein 0.0694701 0.163673 0.163358
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00590199 0.00751062 0.018501
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.00693672 0.0100525 0.00967893
Echinococcus multilocularis cyclins 0.0548257 0.127698 0.127368
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.032 0.0716236 0.984734
Loa Loa (eye worm) hypothetical protein 0.191247 0.462833 0.462732
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00375233 0.00222971 0.00204143
Loa Loa (eye worm) hypothetical protein 0.0117371 0.0218452 0.0216607
Trypanosoma brucei C-8 sterol isomerase, putative 0.0787416 0.18645 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.00619393 0.00822779 0.00785348
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0323141 0.0723953 0.0723953
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0131306 0.0252687 0.0252687
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.00619393 0.00822779 0.00822779
Echinococcus granulosus acetylcholinesterase 0.191247 0.462833 0.46263
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Echinococcus multilocularis acetylcholinesterase 0.191247 0.462833 0.46263
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trichomonas vaginalis conserved hypothetical protein 0.0236903 0.0512098 0.295048
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00340401 0.00137403 0.000997131
Trichomonas vaginalis cyclins, putative 0.0728323 0.171933 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.00452899 0.00413766 0.0037618
Trypanosoma cruzi mitotic cyclin, putative 0.0140099 0.0274287 0.127753
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0131306 0.0252687 0.0981012
Brugia malayi nuclear hormone receptor 0.00619393 0.00822779 0.00695607
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Loa Loa (eye worm) hypothetical protein 0.0323141 0.0723953 0.0722202
Echinococcus multilocularis mitogen activated protein kinase 11 0.0387823 0.0882852 0.0879411
Giardia lamblia Hypothetical protein 0.00524282 0.00589128 0.0104509
Echinococcus granulosus Cyclin L1 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131306 0.0252687 0.0240188
Echinococcus multilocularis cyclin dependent kinase 0.00590199 0.00751062 0.00713604
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0131306 0.0252687 0.0240188
Echinococcus granulosus cyclins 0.0548257 0.127698 0.127368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00481034 0.00482885 0.00775378
Loa Loa (eye worm) TK protein kinase 0.0626403 0.146895 0.146734
Schistosoma mansoni coup transcription factor 0.0131306 0.0252687 0.0252687
Echinococcus granulosus cyclin dependent kinase 1 0.00590199 0.00751062 0.00713604
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0131306 0.0252687 0.0252687
Schistosoma mansoni cyclin B3 0.099742 0.23804 0.23804
Echinococcus granulosus cyclin G2 0.0140099 0.0274287 0.0270616
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0131306 0.0252687 0.0249008
Brugia malayi ecdysteroid receptor 0.0131306 0.0252687 0.0240188
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00452899 0.00413766 0.0037618
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0387823 0.0882852 0.461556
Trypanosoma brucei cdc2-related kinase 1 0.00590199 0.00751062 0.018501
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0140099 0.0274287 0.0270616
Schistosoma mansoni serine/threonine protein kinase 0.003366 0.00128063 0.00128063
Trichomonas vaginalis cyclin B3, putative 0.0140099 0.0274287 0.15618
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0787416 0.18645 0.185407
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Echinococcus granulosus cyclins 0.0548257 0.127698 0.127368
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0131306 0.0252687 0.0249008
Schistosoma mansoni thyroid hormone receptor 0.0131306 0.0252687 0.0252687
Loa Loa (eye worm) hypothetical protein 0.191247 0.462833 0.462732
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00340401 0.00137403 0.000997131
Leishmania major cyclin 0.0728323 0.171933 0.920372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0131306 0.0252687 0.0250848
Schistosoma mansoni cyclin B 0.0728323 0.171933 0.171933
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Trichomonas vaginalis cyclin D, putative 0.0548257 0.127698 0.741692
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Schistosoma mansoni serine/threonine protein kinase 0.409907 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.00619393 0.00822779 0.00785348
Schistosoma mansoni nuclear receptor nhr-48 0.00619393 0.00822779 0.00822779
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0131306 0.0252687 0.0252687
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.00619393 0.00822779 0.00695607
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119532 0.0223762 0.126677
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Loa Loa (eye worm) hypothetical protein 0.00693672 0.0100525 0.00986575
Echinococcus granulosus cyclin y 0.0140099 0.0274287 0.0270616
Echinococcus multilocularis conserved hypothetical protein 0.0682542 0.160686 0.16037
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0387823 0.0882852 0.461556
Echinococcus multilocularis acetylcholinesterase 0.191247 0.462833 0.46263
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.00452899 0.00413766 0.00286069
Entamoeba histolytica hypothetical protein 0.0140099 0.0274287 0.12114
Toxoplasma gondii cyclin 4, putative 0.0140099 0.0274287 0.261277
Toxoplasma gondii hypothetical protein 0.0117371 0.0218452 0.198643
Toxoplasma gondii GAF domain-containing protein 0.0117371 0.0218452 0.198643
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.00452899 0.00413766 0.0201741
Loa Loa (eye worm) hypothetical protein 0.0131306 0.0252687 0.0250848
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00481034 0.00482885 0.00775378
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0131306 0.0252687 0.0249008
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00452899 0.00413766 0.00413766
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.00452899 0.00413766 0.0037618
Echinococcus multilocularis cyclin 0.0140099 0.0274287 0.0270616
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Loa Loa (eye worm) DR-78 0.00619393 0.00822779 0.00804065
Loa Loa (eye worm) CYL-1 protein 0.0140099 0.0274287 0.0272452
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0236903 0.0512098 0.295048
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00619393 0.00822779 0.00785348
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.00452899 0.00413766 0.00394974
Loa Loa (eye worm) hypothetical protein 0.298784 0.727013 0.726961
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.00693672 0.0100525 0.00967893
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0131306 0.0252687 0.0249008
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.00452899 0.00413766 0.0037618
Schistosoma mansoni RAR-like nuclear receptor 0.0131306 0.0252687 0.0252687
Trichomonas vaginalis cyclin B, putative 0.0728323 0.171933 1
Trypanosoma brucei mitotic cyclin 6 0.0728323 0.171933 0.920372
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0236903 0.0512098 0.258195
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0344242 0.0775791 1
Loa Loa (eye worm) hypothetical protein 0.00524282 0.00589128 0.0057037
Echinococcus granulosus Nuclear hormone receptor HR96 0.00619393 0.00822779 0.00785348
Trypanosoma cruzi cdc2-related kinase 3 0.00590199 0.00751062 0.018501
Echinococcus granulosus cyclin b3 0.0548257 0.127698 0.127368
Echinococcus multilocularis cyclin k 0.0140099 0.0274287 0.0270616
Loa Loa (eye worm) hypothetical protein 0.00619393 0.00822779 0.00804065
Echinococcus granulosus cyclins 0.0140099 0.0274287 0.0270616
Echinococcus granulosus cyclin B3 1 0.0548257 0.127698 0.127368
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0387823 0.0882852 0.461556
Schistosoma mansoni titin 0.003366 0.00128063 0.00128063
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0162661 0.0329713 0.188545
Echinococcus granulosus mitogen activated protein kinase 11 0.0387823 0.0882852 0.0879411
Schistosoma mansoni voltage-gated potassium channel 0.00375299 0.00223132 0.00223132
Echinococcus multilocularis cyclin b3 0.0548257 0.127698 0.127368
Toxoplasma gondii hypothetical protein 0.0191613 0.0400838 0.403241

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 1 uM Cytotoxicity against human MRC5 SV2 cells after 72 hrs using resazurin by fluorimetry ChEMBL. 22204607
IC50 (functional) = 5.3 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum GHA infected in human erythrocytes after 72 hrs using malstat staining by spectrophotometry ChEMBL. 22204607

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 22204607

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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