Detailed information for compound 1633551

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1200.64 | Formula: C63H113N11O11
  • H donors: 4 H acceptors: 11 LogP: 8.39 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: C/C=C/CC(C([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)C)C
  • InChi: 1S/C63H113N11O11/c1-26-28-29-41(15)42(16)53-57(79)66-45(27-2)59(81)68(19)34-50(75)69(20)46(30-35(3)4)56(78)67-51(39(11)12)62(84)70(21)47(31-36(5)6)55(77)64-43(17)54(76)65-44(18)58(80)71(22)48(32-37(7)8)60(82)72(23)49(33-38(9)10)61(83)73(24)52(40(13)14)63(85)74(53)25/h26,28,35-49,51-53H,27,29-34H2,1-25H3,(H,64,77)(H,65,76)(H,66,79)(H,67,78)/b28-26+/t41?,42?,43-,44+,45-,46-,47-,48-,49-,51-,52+,53-/m0/s1
  • InChiKey: RKGFOGQBSWVWRE-VKSGXJPYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens formyl peptide receptor 1 Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0126 0.1537 0.2138
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0698 0.063
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus Netrin receptor DCC 0.0031 0.0208 0.0136
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0528 0.7186 0.7165
Brugia malayi G-protein coupled receptor 0.0528 0.7186 1
Echinococcus multilocularis titin 0.0031 0.0208 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.0528 0.7186 1
Echinococcus granulosus fmrfamide receptor 0.0528 0.7186 0.7165
Schistosoma mansoni cell adhesion molecule 0.0031 0.0208 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Echinococcus multilocularis serotonin receptor 0.0528 0.7186 0.7165
Brugia malayi larval opioid receptor 0.0528 0.7186 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0031 0.0208 0.019
Schistosoma mansoni myosin xvIII 0.0528 0.7186 0.7165
Loa Loa (eye worm) neuropeptide F receptor 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0601 0.8214 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) lethal protein 805 0.0031 0.0208 0.019
Echinococcus granulosus 7tm_1 domain containing protein 0.0528 0.7186 0.7165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.3893 0.3848
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0272 0.3587 0.3539
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3893 0.3848
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0208 0.0136
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0528 0.7186 0.7165
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0031 0.0208 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) G-protein coupled receptor 0.0528 0.7186 1
Brugia malayi hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0031 0.0208 0.0136
Schistosoma mansoni growth hormone secretagogue receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0208 0.0136
Echinococcus multilocularis G protein coupled receptor 139 0.0528 0.7186 0.7165
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0528 0.7186 1
Schistosoma mansoni neuropeptide F-like receptor 0.0528 0.7186 0.7165
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Brugia malayi Dopamine receptor 0.0528 0.7186 1
Schistosoma mansoni myosin-binding protein-related 0.0031 0.0208 0.0136
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0031 0.0208 0.029
Schistosoma mansoni neuropeptide receptor 0.0528 0.7186 0.7165
Echinococcus granulosus peptide allatostatin:somatostatin 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Brugia malayi Lethal protein 805 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus granulosus titin 0.0031 0.0208 0.0136
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0528 0.7186 1
Brugia malayi Serotonin receptor 0.0528 0.7186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0031 0.0208 0.0136
Echinococcus multilocularis usherin 0.0031 0.0208 0.0136
Brugia malayi Serotonin receptor 0.0528 0.7186 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Onchocerca volvulus 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni hypothetical protein 0.0528 0.7186 0.7165
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0528 0.7186 1
Onchocerca volvulus 0.0031 0.0208 0.019
Schistosoma mansoni amine GPCR 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0073 0.0101
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0031 0.0208 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2712 0.371
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis neuropeptide receptor A26 0.0528 0.7186 0.7165
Schistosoma mansoni biogenic amine receptor 0.0528 0.7186 0.7165
Schistosoma mansoni titin 0.0031 0.0208 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.0528 0.7186 1
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus multilocularis titin 0.0031 0.0208 0.0136
Schistosoma mansoni amine GPCR 0.0528 0.7186 0.7165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0031 0.0208 0.019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0528 0.7186 0.7165
Schistosoma mansoni factor for adipocyte differentiation 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0528 0.7186 1
Loa Loa (eye worm) myotactin form A 0.0031 0.0208 0.019
Echinococcus multilocularis g protein coupled receptor 0.0528 0.7186 0.7165
Echinococcus granulosus GPCR family 2 0.0066 0.0698 0.063
Brugia malayi hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0528 0.7186 0.7165
Echinococcus granulosus orexin receptor type 2 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus granulosus allatostatin A receptor 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0208 1
Brugia malayi hypothetical protein 0.0031 0.0208 0.029
Brugia malayi hypothetical protein 0.0031 0.0208 0.029
Schistosoma mansoni hypothetical protein 0.0031 0.0208 0.0136
Onchocerca volvulus Neuropeptide F receptor homolog 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0528 0.7186 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0528 0.7186 1
Schistosoma mansoni hypothetical protein 0.0066 0.0698 0.063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0073 0.0101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Schistosoma mansoni titin 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0031 0.0208 0.019
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus hypothetical protein 0.0528 0.7186 0.7165
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0031 0.0208 0.0136
Brugia malayi sulfakinin receptor protein 0.0528 0.7186 1
Echinococcus multilocularis Fibronectin, type III 0.0031 0.0208 0.0136
Echinococcus granulosus nephrin 0.0031 0.0208 0.0136
Brugia malayi myotactin form B 0.0031 0.0208 0.029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Brugia malayi hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0031 0.0208 0.019
Brugia malayi G protein-coupled receptor F59B2.13 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Brugia malayi hypothetical protein 0.0528 0.7186 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.2712 0.3774
Schistosoma mansoni titin 0.0031 0.0208 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0528 0.7186 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0073 0.0101
Schistosoma mansoni neuropeptide receptor 0.0528 0.7186 0.7165
Echinococcus granulosus g-protein coupled receptor 0.0528 0.7186 0.7165
Echinococcus granulosus anosmin 1 0.0031 0.0208 0.0136
Schistosoma mansoni neuroglian 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus g protein coupled receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0031 0.0208 0.0136
Brugia malayi SPRY domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0031 0.0208 0.019
Loa Loa (eye worm) CAMK protein kinase 0.0031 0.0208 0.019
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0031 0.0208 0.019
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0031 0.0208 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0128 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) UNCoordinated family member 0.0031 0.0208 0.019
Brugia malayi steroid hormone receptor 0.0022 0.0073 0.0101
Brugia malayi neuropeptide F receptor 0.0528 0.7186 1
Echinococcus granulosus dro:myosuppressin receptor 0.0528 0.7186 0.7165
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0528 0.7186 1
Echinococcus multilocularis microtubule associated protein 2 0.0728 1 1
Echinococcus granulosus g protein coupled receptor 0.0528 0.7186 0.7165
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Schistosoma mansoni hypothetical protein 0.0066 0.0698 0.063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0528 0.7186 0.7165
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Onchocerca volvulus 0.0528 0.7186 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0528 0.7186 0.7165
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0528 0.7186 0.7165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0073 0.0101
Echinococcus multilocularis orexin receptor type 2 0.0528 0.7186 0.7165
Brugia malayi Tachykinin-like peptides receptor 99D 0.0528 0.7186 1
Echinococcus multilocularis Netrin receptor DCC 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus anosmin 1 0.0031 0.0208 0.0136
Brugia malayi Dopamine receptor protein 1 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0031 0.0208 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.7186 0.7165
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0031 0.0208 0.019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0698 0.063
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Schistosoma mansoni neuropeptide receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptide Y receptor 0.0528 0.7186 0.7165
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0128 0.5
Loa Loa (eye worm) projectin 0.0031 0.0208 0.019
Echinococcus multilocularis Netrin receptor DCC 0.0031 0.0208 0.0136
Schistosoma mansoni biogenic amine receptor 0.0528 0.7186 0.7165
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0066 0.0698 0.0879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0698 0.063
Schistosoma mansoni cell adhesion molecule 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0031 0.0208 0.029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0528 0.7186 0.7165
Schistosoma mansoni factor for adipocyte differentiation 0.0031 0.0208 0.0136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0528 0.7186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Echinococcus multilocularis neuroglian 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0031 0.0208 0.019
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0528 0.7186 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus neuropeptides capa receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis sex peptide receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni hypothetical protein 0.0143 0.178 0.1719
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0272 0.3587 0.3539
Echinococcus granulosus fibronectin type III domain-containing protein 0.0031 0.0208 0.0136
Echinococcus granulosus Fibronectin type III 0.0031 0.0208 0.0136
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptides capa receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0698 0.0879
Echinococcus multilocularis fmrfamide receptor 0.0528 0.7186 0.7165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0528 0.7186 1
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0601 0.8214 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0031 0.0208 0.019
Brugia malayi ecdysteroid receptor 0.0022 0.0073 0.0101
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0073 0.0101
Echinococcus granulosus EG95 0.0031 0.0208 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0073 0.0101
Echinococcus multilocularis serotonin receptor 0.0528 0.7186 0.7165
Echinococcus granulosus sex peptide receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0528 0.7186 0.7165
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0031 0.0208 0.0136
Brugia malayi myotactin form A 0.0031 0.0208 0.029
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0031 0.0208 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1537 0.2058
Echinococcus multilocularis roundabout 2 0.0031 0.0208 0.0136
Echinococcus granulosus biogenic amine 5HT receptor 0.0528 0.7186 0.7165
Schistosoma mansoni biogenic amine (5HT) receptor 0.0528 0.7186 0.7165
Echinococcus granulosus Fibronectin type III domain containing protein 0.0031 0.0208 0.0136
Brugia malayi hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Brugia malayi Protein-tyrosine phosphatase 0.0031 0.0208 0.029
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0031 0.0208 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.7186 0.7165
Schistosoma mansoni histamine h1 receptor 0.0528 0.7186 0.7165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.2712 0.3774
Echinococcus granulosus neuropeptide Y receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptide receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1537 0.2058
Echinococcus multilocularis GPCR, family 2 0.0066 0.0698 0.063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0208 0.019
Echinococcus multilocularis roundabout 2 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis g protein coupled receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0528 0.7186 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptide Y receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0528 0.7186 0.7165
Echinococcus granulosus neuropeptide receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis somatostatin receptor 0.0528 0.7186 0.7165
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0073 0.0101
Schistosoma mansoni hypothetical protein 0.0031 0.0208 0.0136
Schistosoma mansoni nephrin 0.0031 0.0208 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0528 0.7186 0.7165
Brugia malayi follicle stimulating hormone receptor 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Brugia malayi hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus neuropeptide receptor 0.0528 0.7186 0.7165
Schistosoma mansoni hypothetical protein 0.0528 0.7186 0.7165
Loa Loa (eye worm) G-protein coupled receptor 0.0528 0.7186 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0601 0.8214 0.5
Echinococcus granulosus somatostatin receptor 0.0528 0.7186 0.7165
Echinococcus granulosus cell adhesion molecule 0.0031 0.0208 0.0136
Schistosoma mansoni hemicentin 0.0031 0.0208 0.0136
Brugia malayi RE15519p 0.0528 0.7186 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0528 0.7186 0.7165
Schistosoma mansoni protein tyrosine phosphatase 0.0031 0.0208 0.0136
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0208 0.019
Brugia malayi nuclear receptor NHR-88 0.0022 0.0073 0.0101
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Schistosoma mansoni cell adhesion molecule 0.0031 0.0208 0.0136
Schistosoma mansoni hypothetical protein 0.0066 0.0698 0.063
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptide s receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis roundabout 2 0.0031 0.0208 0.0136
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0031 0.0208 1
Schistosoma mansoni hypothetical protein 0.0528 0.7186 0.7165
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus Netrin receptor DCC 0.0031 0.0208 0.0136
Schistosoma mansoni hypothetical protein 0.0031 0.0208 0.0136
Schistosoma mansoni microtubule-associated protein tau 0.0728 1 1
Brugia malayi G-protein coupled receptor 0.0528 0.7186 1
Brugia malayi hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0031 0.0208 0.0136
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0528 0.7186 0.7165
Echinococcus granulosus alpha 1A adrenergic receptor 0.0528 0.7186 0.7165
Schistosoma mansoni alpha-1 adrenergic receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0031 0.0208 0.019
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0208 0.0136
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0031 0.0208 0.0136
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0031 0.0208 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0073 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0073 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Onchocerca volvulus 0.0528 0.7186 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0528 0.7186 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0528 0.7186 1
Echinococcus multilocularis anosmin 1 0.0031 0.0208 0.0136
Schistosoma mansoni hypothetical protein 0.0066 0.0698 0.063
Brugia malayi hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni amine GPCR 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0208 0.019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni adenoreceptor 0.0528 0.7186 0.7165
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0528 0.7186 0.7165
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus roundabout 2 0.0031 0.0208 0.0136
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0208 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis anosmin 1 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0528 0.7186 1
Schistosoma mansoni amine GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni factor for adipocyte differentiation 0.0031 0.0208 0.0136
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0073 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0073 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni hypothetical protein 0.0272 0.3587 0.3539
Brugia malayi Melatonin receptor type 1A 0.0528 0.7186 1
Brugia malayi Lethal protein 805 0.0031 0.0208 0.029
Echinococcus multilocularis allatostatin A receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0128 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0031 0.0208 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Echinococcus granulosus serotonin receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0528 0.7186 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0528 0.7186 0.7165
Brugia malayi putative neuropeptide receptor 0.0528 0.7186 1
Brugia malayi G protein-coupled receptor 0.0528 0.7186 1
Echinococcus granulosus titin 0.0031 0.0208 0.0136
Echinococcus granulosus roundabout 2 0.0031 0.0208 0.0136
Schistosoma mansoni opsin-like receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis transfer RNA-Phe 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.178 0.24
Echinococcus multilocularis g protein coupled receptor 0.0528 0.7186 0.7165
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0031 0.0208 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni opsin-like receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Onchocerca volvulus 0.0528 0.7186 1
Schistosoma mansoni neuropeptide receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0031 0.0208 0.019
Brugia malayi neuropeptide F receptor 0.0528 0.7186 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) neuropeptide F receptor 0.0528 0.7186 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0208 0.019
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0528 0.7186 0.7165
Schistosoma mansoni amine GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus contactin 0.0031 0.0208 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni cell adhesion molecule 0.0031 0.0208 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0073 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.178 0.2477
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus usherin 0.0031 0.0208 0.0136
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0528 0.7186 0.7165
Brugia malayi hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0031 0.0208 0.0136
Echinococcus granulosus neuroglian 0.0031 0.0208 0.0136
Echinococcus granulosus neuropeptide receptor A26 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0073 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus granulosus G protein coupled receptor 139 0.0528 0.7186 0.7165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0073 0.0101
Brugia malayi nuclear hormone receptor 0.0022 0.0073 0.0101
Echinococcus granulosus g protein coupled receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.2712 0.371
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0698 0.0972
Echinococcus multilocularis dro:myosuppressin receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus neuropeptide s receptor 0.0528 0.7186 0.7165
Schistosoma mansoni neuropeptide F-like receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis cell adhesion molecule 0.0031 0.0208 0.0136
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0031 0.0208 0.0136
Brugia malayi AKH receptor 0.0528 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Leishmania major hypothetical protein, conserved 0.0031 0.0208 1
Echinococcus multilocularis g-protein coupled receptor 0.0528 0.7186 0.7165
Schistosoma mansoni tripartite motif protein trim9 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni biogenic amine receptor 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0073 0.0101
Schistosoma mansoni opsin-like receptor 0.0528 0.7186 0.7165
Brugia malayi hypothetical protein 0.0528 0.7186 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0031 0.0208 0.019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis neuropeptides capa receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus G1Y162 protein 0.0031 0.0208 0.0136
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0528 0.7186 0.7165
Echinococcus multilocularis fmrfamide receptor 0.0528 0.7186 0.7165
Brugia malayi hypothetical protein 0.0026 0.0128 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Schistosoma mansoni hypothetical protein 0.0528 0.7186 0.7165
Echinococcus multilocularis anosmin 1 0.0031 0.0208 0.0136
Brugia malayi ORL1-like opioid receptor 0.0528 0.7186 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0073 0.0101
Echinococcus multilocularis neuropeptide receptor 0.0528 0.7186 0.7165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0698 0.0972
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0208 0.019
Echinococcus granulosus 7TM GPCR rhodopsin 0.0528 0.7186 0.7165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0208 0.029
Schistosoma mansoni nephrin 0.0031 0.0208 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0698 0.063
Schistosoma mansoni ephrin receptor 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0031 0.0208 0.0136
Onchocerca volvulus 0.0528 0.7186 1
Brugia malayi protein unc-22 0.0031 0.0208 0.029
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0031 0.0208 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0528 0.7186 0.7165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.019
Echinococcus granulosus neuropeptides capa receptor 0.0528 0.7186 0.7165
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0208 0.0136
Loa Loa (eye worm) hypothetical protein 0.0528 0.7186 1
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3893 0.3848
Echinococcus multilocularis rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Echinococcus granulosus rhodopsin orphan GPCR 0.0528 0.7186 0.7165
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0528 0.7186 0.7165
Echinococcus granulosus biogenic amine 5HT receptor 0.0528 0.7186 0.7165
Onchocerca volvulus 0.0031 0.0208 0.019
Echinococcus granulosus roundabout 2 0.0031 0.0208 0.0136
Brugia malayi Dopamine receptor protein 2 0.0528 0.7186 1
Toxoplasma gondii pantoate-beta-alanine ligase 0.0601 0.8214 1
Brugia malayi GnHR receptor homolog 0.0528 0.7186 1
Echinococcus granulosus anosmin 1 0.0031 0.0208 0.0136
Schistosoma mansoni cell adhesion molecule 0.0031 0.0208 0.0136

Activities

Activity type Activity value Assay description Source Reference
IC20 (binding) = 0.03 uM Inhibitory activity against Human formylpeptide receptor (FPR) of human leukemia HL-60 cells ChEMBL. 12361388
IC50 (binding) = 0.15 uM Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells ChEMBL. 12361388
IC50 (binding) = 15.5 uM Inhibitory activity against Human MDR1 P-Glycoprotein ABC Transporter using leukemia CEM cells ChEMBL. 12361387

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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