Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.4101 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.4101 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4101 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4101 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.4101 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.4101 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4101 | 1 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0265 | 0.0242 | 0.0064 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0517 | 0.0883 | 0.0883 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.4101 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0517 | 0.0883 | 0.0656 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.4101 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4101 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4101 | 1 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0265 | 0.0242 | 0.0242 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.4101 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.4101 | 1 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0252 | 0.0209 | 0.003 |
Giardia lamblia | Kinase, CMGC MAPK | 0.4101 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.4101 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0517 | 0.0883 | 0.0883 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4101 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4101 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.4101 | 1 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0435 | 0.0674 | 0.0442 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0265 | 0.0242 | 0.0242 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.4101 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.4101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.377 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.268 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.028 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.