Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.2544 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2544 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2544 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1092 | 0.2687 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2544 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1092 | 0.2687 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1092 | 0.2687 | 0.2687 |
Loa Loa (eye worm) | hypothetical protein | 0.2544 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2544 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2544 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1092 | 0.2687 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2544 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2544 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2544 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2544 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Serpulina (Treponema) hyodysenteriae (the causative organism of swine dysentery). | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Pasteurella multocida (an important animal respiratory pathogen). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.