Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0102 | 0.3188 | 0.5 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0128 | 0.4867 | 1 |
Echinococcus granulosus | heat shock protein | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0075 | 0.1488 | 0.3058 |
Plasmodium vivax | endoplasmin, putative | 0.0128 | 0.4867 | 1 |
Echinococcus multilocularis | heat shock protein | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Schistosoma mansoni | heat shock protein | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0102 | 0.3188 | 0.655 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0102 | 0.3188 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0102 | 0.3188 | 0.655 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0128 | 0.4867 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0078 | 0.1679 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Brugia malayi | Endoplasmin precursor | 0.0128 | 0.4867 | 0.4867 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0128 | 0.4867 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0102 | 0.3188 | 0.655 |
Trichomonas vaginalis | heat shock protein, putative | 0.0102 | 0.3188 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0102 | 0.3188 | 0.655 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0102 | 0.3188 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0102 | 0.3188 | 0.655 |
Brugia malayi | heat shock protein 90 | 0.0128 | 0.4867 | 0.4867 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0128 | 0.4867 | 1 |
Treponema pallidum | heat shock protein 90 | 0.0102 | 0.3188 | 0.5 |
Plasmodium falciparum | heat shock protein 90 | 0.0128 | 0.4867 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0102 | 0.3188 | 0.655 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0102 | 0.3188 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0128 | 0.4867 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0078 | 0.1679 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0128 | 0.4867 | 0.4867 |
Schistosoma mansoni | heat shock protein | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Schistosoma mansoni | endoplasmin | 0.0128 | 0.4867 | 1 |
Schistosoma mansoni | endoplasmin | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0102 | 0.3188 | 0.655 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0102 | 0.3188 | 0.5 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0102 | 0.3188 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0128 | 0.4867 | 1 |
Echinococcus granulosus | endoplasmin | 0.0102 | 0.3188 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0078 | 0.1679 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0128 | 0.4867 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0128 | 0.4867 | 0.4867 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Partial agonist activity at human LXRbeta-LBD expressed in HEK293 cells co-expressing GAL4-DBD by beta-galactosidase luciferase reporter gene assay relative to N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide | ChEMBL. | 22406115 | |
IC50 (binding) | = 0.5 uM | Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRalpa by scintillation proximity assay | ChEMBL. | 22406115 |
IC50 (binding) | = 1.5 uM | Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from LXRbeta by scintillation proximity assay | ChEMBL. | 22406115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.