Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0453 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.2165 | 0.6997 | 0.8794 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0453 | 0.026 | 0.0327 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0453 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Echinococcus multilocularis | protein kinase c iota type | 0.0773 | 0.152 | 0.152 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0453 | 0.026 | 0.0327 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.2089 | 0.6697 | 0.6697 |
Echinococcus granulosus | protein kinase C gamma type | 0.2608 | 0.874 | 0.874 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0453 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0453 | 0.026 | 0.026 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0453 | 0.026 | 0.026 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0453 | 0.026 | 0.026 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0818 | 0.1698 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0453 | 0.026 | 0.026 |
Entamoeba histolytica | protein kinase, putative | 0.0453 | 0.026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 0.026 | 0.0327 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.2928 | 1 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0818 | 0.1698 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0453 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0453 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Brugia malayi | protein kinase C II. | 0.084 | 0.1782 | 0.1903 |
Echinococcus granulosus | NDR protein kinase | 0.0453 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0453 | 0.026 | 0.0327 |
Echinococcus granulosus | protein kinase c epsilon type | 0.084 | 0.1782 | 0.1782 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0818 | 0.1698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2409 | 0.7957 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0773 | 0.152 | 0.152 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.2089 | 0.6697 | 0.6697 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0818 | 0.1698 | 0.5 |
Schistosoma mansoni | serine/threonine kinase | 0.0453 | 0.026 | 0.026 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0818 | 0.1698 | 0.5 |
Brugia malayi | Protein kinase c protein 2 | 0.2485 | 0.8257 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0453 | 0.026 | 0.026 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0453 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0453 | 0.026 | 0.026 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.084 | 0.1782 | 0.1782 |
Entamoeba histolytica | protein kinase, putative | 0.0453 | 0.026 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2928 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.084 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.084 | 0.1782 | 0.2239 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0818 | 0.1698 | 0.1698 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0453 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Entamoeba histolytica | protein kinase, putative | 0.0453 | 0.026 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.2089 | 0.6697 | 0.6697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2928 | 1 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0453 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Onchocerca volvulus | 0.0387 | 0 | 0.5 | |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0453 | 0.026 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0773 | 0.152 | 0.152 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0818 | 0.1698 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase | 0.2608 | 0.874 | 0.874 |
Toxoplasma gondii | cathepsin CPC1 | 0.0818 | 0.1698 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0453 | 0.026 | 0.0327 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0453 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0453 | 0.026 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.2089 | 0.6697 | 0.8417 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0508 | 0.0476 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0453 | 0.026 | 0.026 |
Entamoeba histolytica | protein kinase, putative | 0.0453 | 0.026 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0453 | 0.026 | 0.1511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli ATCC 35218 by CLSI method | ChEMBL. | 22483965 | |
IC50 (functional) | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as plasmodial LDH activity | ChEMBL. | 22483965 | |
IC50 (functional) | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as plasmodial LDH activity | ChEMBL. | 22483965 | |
IC50 (functional) | Antileishmanial activity against Leishmania donovani promastigote by by Alamar Blue assay | ChEMBL. | 22483965 | |
IC90 (functional) | Antileishmanial activity against Leishmania donovani promastigote by by Alamar Blue assay | ChEMBL. | 22483965 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.