Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | dihydroorotate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CAMK CAMKL | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0205 | 0.8246 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.8015 | 0.972 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0078 | 0.2019 | 0.2449 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0205 | 0.8246 | 0.8246 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 0.8015 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0205 | 0.8246 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.024 | 1 | 1 |
Schistosoma mansoni | kinase | 0.0205 | 0.8246 | 1 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 0.8015 | 0.972 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 0.8015 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.8015 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 0.8015 | 1 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2019 | 0.2019 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2019 | 0.2019 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.8015 | 0.972 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.8015 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 0.8015 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2019 | 0.2019 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 0.8015 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2019 | 0.2019 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.8015 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0205 | 0.8246 | 0.8246 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 0.8015 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.8015 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.8015 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 0.2519 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.8246 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2019 | 1 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0205 | 0.8246 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2019 | 0.2449 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 0.8015 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 26 ml/min.kg | Clearance in mouse liver microsomes by LC-MS/MS analysis | ChEMBL. | 24900364 |
IC50 (functional) | = 4 nM | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human renal proximal tubule cells after 72 hrs by SYBR green assay | ChEMBL. | 24900364 |
IC50 (binding) | = 21 nM | Inhibition of Plasmodium falciparum DHODH after 20 mins by 2,6-dichloroindophenol-reduction based assay | ChEMBL. | 24900364 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 24900364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.