Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor gamma | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.4408 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0487 | 0.4077 | 0.925 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0.3785 | 0.9283 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.4408 | 0.8285 |
Onchocerca volvulus | Putative nachr subunit | 0.0487 | 0.4077 | 0.4077 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0561 | 0.532 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0487 | 0.4077 | 0.4348 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0561 | 0.532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.8821 | 0.9407 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0487 | 0.4077 | 0.925 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0487 | 0.4077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 0.3426 | 0.3653 |
Onchocerca volvulus | 0.0561 | 0.532 | 0.532 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0487 | 0.4077 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0487 | 0.4077 | 0.925 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0487 | 0.4077 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 0.4077 | 0.4348 |
Brugia malayi | Cation transporter family protein | 0.0561 | 0.532 | 0.5674 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0487 | 0.4077 | 0.4348 |
Onchocerca volvulus | 0.0561 | 0.532 | 0.532 | |
Onchocerca volvulus | 0.0561 | 0.532 | 0.532 | |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 0.532 | 0.5674 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 0.532 | 0.5674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2019 nM | Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 2019 nM | Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 2191 nM | Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 2191 nM | Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 2200 nM | Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 2200 nM | Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma | ChEMBL. | 8071941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.