Detailed information for compound 163483

Basic information

Technical information
  • TDR Targets ID: 163483
  • Name: 2-hydroxy-6-octadecoxybenzoic acid
  • MW: 406.599 | Formula: C25H42O4
  • H donors: 2 H acceptors: 3 LogP: 10.45 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCCCOc1cccc(c1C(=O)O)O
  • InChi: 1S/C25H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-29-23-20-18-19-22(26)24(23)25(27)28/h18-20,26H,2-17,21H2,1H3,(H,27,28)
  • InChiKey: HZPGOSJHMHNCHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-hydroxy-6-octadecoxy-benzoic acid
  • 2-hydroxy-6-stearyloxy-benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis replication factor C large subunit, putative 0.0028 0.002 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0077 0.0247
Toxoplasma gondii ATPase, AAA family protein 0.0028 0.002 0.0075
Mycobacterium leprae Probable lipase LipE 0.0039 0.0056 0.0168
Echinococcus granulosus chromobox protein 1 0.0111 0.0292 0.0349
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Echinococcus multilocularis tumor protein p63 0.1186 0.3814 0.456
Echinococcus granulosus tar DNA binding protein 0.0189 0.055 0.0658
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus multilocularis nibrin 0.0028 0.002 0.0024
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Onchocerca volvulus 0.0034 0.0041 0.0124
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0056 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0149 0.0481
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0025 0.0012 0.0045
Schistosoma mansoni hypothetical protein 0.0054 0.0105 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.034 0.1041 0.1245
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.0167 0.0534
Leishmania major hypothetical protein, conserved 0.0037 0.005 0.0739
Echinococcus multilocularis Spectrin alpha actinin 0.0027 0.0019 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0167 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0019 0.0011
Brugia malayi hypothetical protein 0.0031 0.0031 0.0099
Echinococcus multilocularis Smad4 0.0049 0.0092 0.0109
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0351 0.1078 0.3251
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0088 0.0326
Onchocerca volvulus 0.0031 0.0031 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0085 0.0085
Echinococcus granulosus snurportin 1 0.0282 0.0853 0.102
Loa Loa (eye worm) nuclear factor I 0.0027 0.0019 0.0055
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0056 0.0056
Echinococcus granulosus smad 0.0049 0.0092 0.0109
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0019 0.0023
Leishmania major hypothetical protein, conserved 0.0039 0.0056 0.0856
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0151 0.0425 0.1281
Schistosoma mansoni serine/threonine protein kinase 0.017 0.0488 0.0965
Loa Loa (eye worm) apoptosis regulator protein 0.034 0.1041 0.3354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0181 0.0523 0.1943
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Trypanosoma brucei unspecified product 0.0033 0.0037 0.0479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.0766 0.2464
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0028 0.002 0.0157
Onchocerca volvulus 0.0039 0.0056 0.0173
Loa Loa (eye worm) hypothetical protein 0.011 0.0291 0.0933
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Brugia malayi hypothetical protein 0.0028 0.002 0.0065
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0034 0.0041 0.0559
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Schistosoma mansoni chromobox protein 0.0111 0.0292 0.0577
Schistosoma mansoni smad 0.0049 0.0092 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Brugia malayi RNA, U transporter 1 0.0075 0.0176 0.0566
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.017 0.0485 0.0579
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0016 0.0081
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0217 0.0641 0.2382
Schistosoma mansoni peroxidasin 0.0031 0.0031 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0092 0.0289
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0025 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0692 0.1017
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Schistosoma mansoni DNA polymerase eta 0.0067 0.0149 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Echinococcus multilocularis chromobox protein 1 0.0111 0.0292 0.0349
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0021 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.002 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.0054 0.0105 0.0126
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Schistosoma mansoni hypothetical protein 0.1566 0.5056 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0084 0.0321
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0194 0.0232
Echinococcus multilocularis tar DNA binding protein 0.0189 0.055 0.0658
Mycobacterium ulcerans hypothetical protein 0.0414 0.1284 0.4923
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Loa Loa (eye worm) hypothetical protein 0.0062 0.0133 0.0422
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0107 0.0279 0.1038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0718 0.2281 0.4511
Brugia malayi ADAMTS-like protease 0.0107 0.0281 0.0906
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0028 0.002 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0009 0.0034
Brugia malayi hypothetical protein 0.0024 0.0007 0.0023
Brugia malayi chromobox protein homolog 3 0.0062 0.0133 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.017 0.0488 0.9321
Schistosoma mansoni hypothetical protein 0.0175 0.0501 0.0991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Mycobacterium tuberculosis Probable aminotransferase 0.0151 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Brugia malayi Thioredoxin reductase 0.004 0.0062 0.02
Echinococcus multilocularis peregrin 0.0063 0.0135 0.0161
Brugia malayi hypothetical protein 0.0024 0.0007 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0107 0.0279 0.0334
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0002 0.0002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0088 0.148
Schistosoma mansoni rotamase 0.0027 0.0019 0.0037
Onchocerca volvulus 0.0039 0.0056 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0133 0.0182
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0077 0.0152
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0843 0.269 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0042 0.0157
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0756 0.2405 0.4756
Mycobacterium leprae Conserved membrane protein 0.0414 0.1284 0.3872
Brugia malayi PHD-finger family protein 0.0054 0.0105 0.034
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0007 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0016 0.006
Echinococcus multilocularis ryanodine receptor 44f 0.0756 0.2405 0.2875
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0033 0.0032
Brugia malayi MIR domain containing protein 0.0756 0.2405 0.7754
Onchocerca volvulus 0.0071 0.0161 0.0514
Onchocerca volvulus 0.0025 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0034 0.0041 0.0124
Trichomonas vaginalis bromodomain-containing protein, putative 0.0107 0.0279 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.055 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0077 0.0247
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0146 0.0408 0.0488
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0194 0.0232
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0267
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Leishmania major DNA polymerase eta, putative 0.0067 0.0149 0.2684
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.005 0.0185
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.005 0.0739
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0222 0.0266
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0232 0.0232
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Plasmodium vivax cytochrome b 0.0843 0.269 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0028 0.002 0.004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0085 0.0085
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0047 0.0085 0.0101
Echinococcus multilocularis snurportin 1 0.0282 0.0853 0.102
Onchocerca volvulus 0.0034 0.0041 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0077 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0077 0.0247
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0077 0.0092
Echinococcus granulosus ring and YY1 binding protein 0.0025 0.0012 0.0014
Onchocerca volvulus Cell death protein 3 homolog 0.0025 0.0012 0.0033
Loa Loa (eye worm) Smad1 0.0049 0.0092 0.0289
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0028 0.002 0.0077
Brugia malayi angiogenesis inhibito 0.0107 0.0281 0.0906
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.017 0.0488 0.1568
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0194 0.062
Brugia malayi Cell death protein 3 precursor 0.0025 0.0012 0.0039
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0045 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0077 0.0151
Treponema pallidum replicative DNA helicase (dnaB) 0.0351 0.1078 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0056 0.0214
Onchocerca volvulus 0.0025 0.0012 0.0032
Onchocerca volvulus Peroxidase homolog 0.0031 0.0031 0.0093
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0025 0.0012 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0266 0.0266
Brugia malayi jmjC domain containing protein 0.0071 0.0163 0.0526
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0085 0.0273
Echinococcus granulosus cytochrome B 0.0843 0.269 0.3215
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.005 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma cruzi aldo/keto reductase, putative 0.0034 0.0041 0.0559
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Schistosoma mansoni cpg binding protein 0.0116 0.031 0.0613
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Onchocerca volvulus 0.0066 0.0146 0.0465
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0077 0.0247
Loa Loa (eye worm) hypothetical protein 0.0047 0.0083 0.0263
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.01 0.0258 0.051
Echinococcus granulosus zinc finger protein Ran binding 0.0025 0.0012 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0056 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0149 0.2684
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0293 0.0938
Entamoeba histolytica acetyltransferase, GNAT family 0.0098 0.025 0.0977
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0054 0.0105 0.0209
Toxoplasma gondii ran binding protein 0.0025 0.0012 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0077 0.0152
Brugia malayi Matrixin family protein 0.0113 0.0299 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni cellular tumor antigen P53 0.0174 0.0498 0.0985
Echinococcus multilocularis caspase 2 0.0025 0.0012 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0019 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Trichomonas vaginalis mannosyltransferase 1, putative 0.0756 0.2405 0.3575
Loa Loa (eye worm) cytochrome b 0.0843 0.269 0.8672
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0163 0.0322
Loa Loa (eye worm) matrixin family protein 0.0103 0.0268 0.0859
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0085 0.011
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0025 0.0012 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0084 0.0084
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0007 0.0023
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.2576 0.8364 1
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.007 0.0089
Loa Loa (eye worm) acetyltransferase 0.0363 0.1118 0.3602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0046
Onchocerca volvulus 0.0034 0.0041 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Echinococcus granulosus PHD finger protein rhinoceros 0.0054 0.0105 0.0126
Loa Loa (eye worm) hypothetical protein 0.0089 0.0222 0.071
Schistosoma mansoni pol-related 0.0034 0.0041 0.008
Loa Loa (eye worm) hypothetical protein 0.034 0.1041 0.3354
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0007 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0028 0.002 0.0014
Brugia malayi acetyltransferase, GNAT family protein 0.0363 0.1118 0.3606
Brugia malayi hypothetical protein 0.033 0.1011 0.326
Echinococcus granulosus SWI:SNF matrix associated 0.0071 0.0161 0.0193
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Chlamydia trachomatis recombinase RecA 0.0098 0.025 0.2322
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0726 0.2306 0.7436
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0077 0.0152
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0085 0.0267
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0085 0.0324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0073 0.0093
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0071 0.0161 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0077 0.0247
Schistosoma mansoni cpg binding protein 0.011 0.029 0.0573
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0088 0.0173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0227 0.0448
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0077 0.0092
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Echinococcus granulosus serine:threonine protein kinase PLK1 0.017 0.0488 0.0583
Trypanosoma brucei prostaglandin f synthase 0.0034 0.0041 0.0559
Echinococcus granulosus Niemann Pick C1 protein 0.0128 0.0348 0.0416
Chlamydia trachomatis replicative DNA helicase 0.0351 0.1078 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0092 0.0109
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0363 0.1118 0.2212
Brugia malayi RNA binding protein 0.0189 0.055 0.1774
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Brugia malayi Pax transcription activation domain interacting protein 0.0028 0.002 0.0065
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0028 0.002 0.0075
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0363 0.1118 0.1337
Loa Loa (eye worm) twinkle helicase 0.01 0.0258 0.0825
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0167 0.02
Echinococcus granulosus adam 0.01 0.0258 0.0308
Schistosoma mansoni Replicative DNA helicase 0.0351 0.1078 0.2132
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0056 0.0067
Onchocerca volvulus Peroxidase homolog 0.0031 0.0031 0.0093
Plasmodium falciparum replication factor C subunit 1, putative 0.0028 0.002 0.0075
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0092 0.0109
Loa Loa (eye worm) RNA binding protein 0.0189 0.055 0.1769
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Brugia malayi hypothetical protein 0.0181 0.0523 0.1685
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0047 0.0082 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Plasmodium falciparum importin beta, putative 0.0026 0.0016 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0077 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus multilocularis apoptotic protease activating factor 1 0.0025 0.0012 0.0015
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0206 0.0291
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0062 0.0194
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0233 0.0693 0.1371
Brugia malayi isocitrate dehydrogenase 0.0048 0.0088 0.0282
Plasmodium vivax importin-beta 2, putative 0.0026 0.0016 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0007 0.0009
Loa Loa (eye worm) brahma associated protein 0.0071 0.0161 0.0514
Brugia malayi glutathione reductase 0.004 0.0062 0.02
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.0167 0.054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0045 0.0172
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0027 0.0017 0.0092
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0818 0.2608 1
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0222 0.0266
Trypanosoma cruzi DNA repair protein, putative 0.003 0.0028 0.0319
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0267
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0194 0.0626
Echinococcus multilocularis expressed conserved protein 0.0084 0.0204 0.0244
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0232 0.0232
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0056 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0056 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0017 0.0092
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0055 0.0066
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0055 0.0066
Schistosoma mansoni hypothetical protein 0.0027 0.0019 0.0037
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.034 0.1041 0.206
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Brugia malayi YY1-associated factor 2 0.0025 0.0012 0.0039
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0047 0.0085 0.0101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0088 0.0326
Echinococcus multilocularis stromal cell derived factor 2 0.0756 0.2405 0.2875
Echinococcus multilocularis chromobox protein 1 0.0111 0.0292 0.0349
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0056 0.0056
Echinococcus granulosus nibrin 0.0028 0.002 0.0024
Giardia lamblia Aldose reductase 0.0034 0.0041 0.0438
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0146 0.0408 0.0488
Schistosoma mansoni Smad4 0.0022 0.0002 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0088 0.0326
Brugia malayi MH2 domain containing protein 0.0726 0.2306 0.7437
Echinococcus granulosus tumor protein p63 0.1186 0.3814 0.456
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0034 0.0041 0.0122
Onchocerca volvulus 0.0818 0.2608 0.8408
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0088 0.0282
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0028 0.002 0.0013
Chlamydia trachomatis DNA ligase 0.0028 0.002 0.0186
Echinococcus multilocularis GPCR, family 2 0.0081 0.0194 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0105 0.0392
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0088 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0077 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0077 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0077 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0077 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0077 0.0247
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0071 0.0161 0.06
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Echinococcus granulosus geminin 0.0466 0.1455 0.174
Schistosoma mansoni zinc finger protein 0.0025 0.0012 0.0024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0055 0.0172
Giardia lamblia Histone acetyltransferase GCN5 0.0098 0.025 0.4916
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0818 0.2608 0.5158
Echinococcus granulosus jumonji domain containing protein 0.0075 0.0174 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Leishmania major DNA polymerase eta, putative 0.0034 0.0042 0.059
Schistosoma mansoni importin beta-1 0.0026 0.0016 0.0032
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0351 0.1078 0.4134
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0085 0.1422
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0077 0.0152
Trichomonas vaginalis mannosyltransferase, putative 0.0414 0.1284 0.1901
Schistosoma mansoni Smad4 0.0049 0.0092 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0027 0.0019 0.0054
Schistosoma mansoni topbp1 0.0028 0.002 0.004
Echinococcus granulosus replication factor c subunit 1 0.0028 0.002 0.0024
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0077 0.0152
Brugia malayi MH2 domain containing protein 0.0049 0.0092 0.0295
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0077 0.0247
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0151 0.0425 0.0425
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0176 0.0506 0.0605
Loa Loa (eye worm) hypothetical protein 0.0255 0.0766 0.2464
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0692 0.1017
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0175 0.0501 0.1611
Brugia malayi topoisomerase 0.0028 0.002 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Brugia malayi SWIB/MDM2 domain containing protein 0.0071 0.0161 0.052
Brugia malayi hypothetical protein 0.01 0.0258 0.0831
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Schistosoma mansoni hypothetical protein 0.0027 0.0019 0.0037
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0092 0.0289
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0009 0.0034
Loa Loa (eye worm) matrix metalloproteinase 0.0047 0.0082 0.0259
Brugia malayi Augmenter of liver regeneration 0.0037 0.005 0.0161
Loa Loa (eye worm) blistered cuticle protein 3 0.0031 0.0031 0.0093
Trypanosoma brucei polo-like protein kinase 0.017 0.0488 0.9321
Schistosoma mansoni smad 0.0022 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0077 0.0241
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0021 0.0025
Onchocerca volvulus 0.0818 0.2608 0.8408
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.035 0.1075 0.3461
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0092 0.0231 0.0739
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0085 0.0284
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0232 0.0699
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0161 0.052
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Leishmania major hypothetical protein, conserved 0.0181 0.0523 1
Brugia malayi serine/threonine-protein kinase plk-2 0.017 0.0488 0.1573
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0056 0.011
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0139 0.0386 0.124
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0092 0.0109
Schistosoma mansoni hypothetical protein 0.0466 0.1455 0.2878
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0056 0.0856
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0056 0.0214
Plasmodium falciparum glutathione reductase 0.004 0.0062 0.0231
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Loa Loa (eye worm) spectraplakin 0.0027 0.0019 0.0054
Mycobacterium ulcerans hypothetical protein 0.0047 0.0084 0.0321
Loa Loa (eye worm) TAR-binding protein 0.0189 0.055 0.1769
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Onchocerca volvulus 0.0818 0.2608 0.8408
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0092 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0077 0.0241
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0057 0.0116 0.0373
Loa Loa (eye worm) hypothetical protein 0.0054 0.0105 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0033
Schistosoma mansoni TRABID protein (C64 family) 0.0025 0.0012 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0045 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Onchocerca volvulus Papilin homolog 0.011 0.0291 0.0933
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Giardia lamblia PHD finger protein 15 0.0054 0.0105 0.1826
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Onchocerca volvulus Chorion peroxidase homolog 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2576 0.8364 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0498 0.1601
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0107 0.0279 0.1038
Echinococcus granulosus stromal cell derived factor 2 0.0756 0.2405 0.2875
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.0181 0.0523 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0103 0.0268 0.0859
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0056 0.0173
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0232 0.0232
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0002 0.0002
Schistosoma mansoni chromobox protein 0.0111 0.0292 0.0577
Giardia lamblia DINP protein human, muc B family 0.0047 0.0085 0.138
Mycobacterium ulcerans hypothetical protein 0.0039 0.0056 0.0214
Onchocerca volvulus 0.0756 0.2405 0.7752
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0084 0.0253
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0085 0.011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0027 0.0023
Echinococcus multilocularis cpg binding protein 0.0116 0.031 0.0371
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0088 0.0105
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0028 0.002 0.0075
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.005 0.0185
Loa Loa (eye worm) matrixin family protein 0.0113 0.0299 0.0957
Echinococcus multilocularis dnaJ subfamily B 0.1566 0.5056 0.6045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Schistosoma mansoni peroxidasin 0.0031 0.0031 0.0061
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.0514
Toxoplasma gondii cytochrome b 0.0843 0.269 1
Schistosoma mansoni kinase 0.0087 0.0213 0.0422
Onchocerca volvulus 0.0969 0.3101 1
Mycobacterium ulcerans oxidoreductase 0.0034 0.0041 0.0156
Onchocerca volvulus 0.0039 0.0056 0.0173
Echinococcus multilocularis geminin 0.0466 0.1455 0.174
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0077 0.0152
Brugia malayi hypothetical protein 0.0117 0.0312 0.1007
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Brugia malayi MH1 domain containing protein 0.0049 0.0092 0.0295
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Toxoplasma gondii peptidylprolyl isomerase 0.0027 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0366
Brugia malayi beta-lactamase 0.0039 0.0056 0.018
Onchocerca volvulus 0.0034 0.0041 0.0124
Echinococcus granulosus chromobox protein 1 0.0111 0.0292 0.0349
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Brugia malayi metalloprotease 0.0047 0.0085 0.0273
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0081 0.0196 0.0234
Echinococcus granulosus histone acetyltransferase KAT2B 0.0353 0.1085 0.1297
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0009 0.0019
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0007 0.0008
Echinococcus granulosus dna polymerase kappa 0.0047 0.0085 0.0101
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0077 0.0152
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.034 0.1041 0.1245
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0088 0.0105
Brugia malayi hypothetical protein 0.0028 0.002 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0163 0.052
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0062 0.0133 0.0422
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Trypanosoma brucei unspecified product 0.0033 0.0037 0.0479
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0064 0.0076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0077 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0351 0.1078 0.4008
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0071 0.0161 0.06
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0056 0.018
Loa Loa (eye worm) beta-lactamase 0.0039 0.0056 0.0173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0194 0.0626
Brugia malayi Pax transcription factor protein 2 0.0969 0.3101 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0064 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0726 0.2306 0.7436
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0056 0.0856
Schistosoma mansoni hypothetical protein 0.0028 0.0021 0.0041
Echinococcus multilocularis ring and YY1 binding protein 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0077 0.0092
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.0766 0.2469
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0056 0.0856
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0002 0.0002
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.005 0.006
Entamoeba histolytica MIR domain protein 0.0756 0.2405 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0041 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.005 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Onchocerca volvulus 0.0028 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0025 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0062 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0107 0.0279 0.1038
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0047 0.0085 0.0168
Trypanosoma cruzi DNA repair protein, putative 0.003 0.0028 0.0319
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Onchocerca volvulus 0.011 0.029 0.0928
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0163 0.0195
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Brugia malayi Smad1 0.0049 0.0092 0.0295
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0266 0.0266
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Schistosoma mansoni cpg binding protein 0.0116 0.031 0.0613
Schistosoma mansoni caspase-7 (C14 family) 0.0025 0.0012 0.0024
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0055 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Brugia malayi CHE-14 protein 0.0038 0.0055 0.0178
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0081 0.0196 0.0234
Brugia malayi PHD-finger family protein 0.0024 0.0008 0.0025
Brugia malayi Importin beta-1 subunit 0.0026 0.0016 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.0766 0.2469
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0077 0.0152
Giardia lamblia Aldose reductase 0.0034 0.0041 0.0438
Brugia malayi N-terminal motif family protein 0.0139 0.0386 0.1246
Schistosoma mansoni RNA binding protein 0.0025 0.0012 0.0024
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.0024
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0028 0.002 0.0013
Brugia malayi jmjC domain containing protein 0.0176 0.0506 0.163
Echinococcus granulosus cpg binding protein 0.0116 0.031 0.0371
Brugia malayi MH1 domain containing protein 0.0027 0.0019 0.0062
Trypanosoma brucei trypanothione reductase 0.004 0.0062 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0077 0.0241
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0232 0.0232
Echinococcus granulosus Zinc finger RanBP2 type 0.0025 0.0012 0.0014
Echinococcus multilocularis Niemann Pick C1 protein 0.0128 0.0348 0.0416
Schistosoma mansoni jumonji domain containing protein 0.014 0.0387 0.0766
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0062 0.0062
Toxoplasma gondii apocytochrome b, putative 0.0843 0.269 1
Onchocerca volvulus 0.0818 0.2608 0.8408
Loa Loa (eye worm) hypothetical protein 0.0053 0.0103 0.0325
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0084 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Brugia malayi MH1 domain containing protein 0.0049 0.0092 0.0295
Brugia malayi nuclear receptor RXR 0.0024 0.0007 0.0023
Plasmodium falciparum histone acetyltransferase GCN5 0.0098 0.025 0.093
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0056 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0084 0.0281
Brugia malayi nuclear receptor NHR-88 0.0045 0.0077 0.0247
Toxoplasma gondii aldose reductase, putative 0.0034 0.0041 0.0151
Echinococcus granulosus dna polymerase eta 0.0067 0.0149 0.0178
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.002 0.0157
Trypanosoma cruzi aldo-keto reductase 0.0034 0.0041 0.0559
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0149 0.2684
Loa Loa (eye worm) reprolysin 0.0047 0.0085 0.0267
Schistosoma mansoni ryanodine receptor related 0.0756 0.2405 0.4756
Trichomonas vaginalis esterase, putative 0.0039 0.0056 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.01
Schistosoma mansoni Smad4 0.0022 0.0002 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0067 0.0148 0.0472
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0054
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0012 0.0039
Plasmodium falciparum phd finger protein, putative 0.0054 0.0105 0.0392
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0176 0.0506 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Schistosoma mansoni cytochrome b 0.0843 0.269 0.5319
Leishmania major prostaglandin f synthase, putative 0.0034 0.0041 0.0559
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0084 0.0321
Schistosoma mansoni aldo-keto reductase 0.0034 0.0041 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0206 0.0291
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0056 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Echinococcus granulosus importin subunit beta 1 0.0026 0.0016 0.0019
Brugia malayi Peroxidasin 0.0031 0.0031 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0041 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0077 0.0247
Schistosoma mansoni smad1 5 8 and 0.0049 0.0092 0.0181
Echinococcus multilocularis protein dispatched 1 0.0044 0.0073 0.0087
Mycobacterium leprae Conserved hypothetical protein 0.1034 0.3315 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.005 0.0739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0027 0.0019 0.0061
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0032
Trypanosoma brucei unspecified product 0.0047 0.0085 0.1422
Schistosoma mansoni hypothetical protein 0.034 0.1041 0.206
Onchocerca volvulus 0.0034 0.0041 0.0124
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.005 0.006
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.017 0.0485 0.0579
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0085 0.0167
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0027 0.0019 0.0133
Brugia malayi Bromodomain containing protein 0.0063 0.0135 0.0434
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.005 0.0739
Chlamydia trachomatis SWIB complex protein 0.0071 0.0161 0.1496
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0264
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0077 0.0247
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0034 0.0041 0.0559
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0027 0.0017 0.0092
Onchocerca volvulus 0.0047 0.0084 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0161 0.0193
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0084 0.027
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0047 0.0085 0.0168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0077 0.0092
Schistosoma mansoni hypothetical protein 0.0081 0.0194 0.0384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Trichomonas vaginalis rotamase, putative 0.0027 0.0017 0.0008
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0085 0.0167
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0027 0.0019 0.0061
Brugia malayi cytochrome b 0.0843 0.269 0.8673
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0148 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0033 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0016 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Trichomonas vaginalis mannosyltransferase 1, putative 0.207 0.6707 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0077 0.0241
Loa Loa (eye worm) pax transcription factor protein 2 0.0969 0.3101 1
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.005 0.0185
Echinococcus granulosus peregrin 0.0063 0.0135 0.0161
Echinococcus granulosus Smad4 0.0049 0.0092 0.0109
Echinococcus multilocularis dna polymerase eta 0.0067 0.0149 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0077 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0077 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0077 0.0241
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0161 0.06
Onchocerca volvulus 0.0047 0.0082 0.0259
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.005 0.0185
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0077 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0077 0.0152
Echinococcus granulosus GPCR family 2 0.0081 0.0194 0.0232
Trypanosoma cruzi polo-like protein kinase, putative 0.017 0.0488 0.9321
Loa Loa (eye worm) glutathione reductase 0.004 0.0062 0.0194
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0084 0.0281
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0017
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0151 0.0425 0.1628
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.007 0.0089
Brugia malayi TAR-binding protein 0.0189 0.055 0.1774
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0088 0.148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1603 0.5179 0.6192
Schistosoma mansoni apoptosis regulator bax 0.034 0.1041 0.206
Onchocerca volvulus 0.0174 0.0498 0.1601
Onchocerca volvulus 0.0025 0.0012 0.0032
Toxoplasma gondii ABC1 family protein 0.0039 0.0056 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0085 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.207 0.6707 1
Mycobacterium ulcerans recombinase A 0.0098 0.025 0.096
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0045 0.0045
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0016 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0077 0.0247
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0105 0.0392
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0077 0.0152
Schistosoma mansoni aldo-keto reductase 0.0034 0.0041 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0523 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0163 0.0322
Brugia malayi hypothetical protein 0.0028 0.0021 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Echinococcus granulosus aldo keto reductase 0.0034 0.0041 0.0049
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0084 0.0321
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0222 0.086
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0077 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0142 0.017
Echinococcus granulosus ryanodine receptor 44f 0.0756 0.2405 0.2875
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0167 0.02
Brugia malayi cation channel family protein 0.0756 0.2405 0.7754
Loa Loa (eye worm) hypothetical protein 0.0049 0.0089 0.028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0266 0.0801
Echinococcus multilocularis translocator protein 0.0818 0.2608 0.3118
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Echinococcus granulosus dnaJ subfamily B 0.1566 0.5056 0.6045
Schistosoma mansoni brg-1 associated factor 0.0071 0.0161 0.0319
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Brugia malayi TspO/MBR family protein 0.0818 0.2608 0.8409
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Treponema pallidum recombinase A 0.0098 0.025 0.2176
Chlamydia trachomatis DNA topoisomerase I 0.0071 0.0161 0.1496
Echinococcus multilocularis peroxidasin 0.0031 0.0031 0.0037
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0167 0.0331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0056 0.011
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0009 0.0024
Trypanosoma brucei aldo-keto reductase, putative 0.0034 0.0041 0.0559
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0523 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0161 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis rotamase, putative 0.0027 0.0019 0.0011
Brugia malayi CHD4 protein 0.0024 0.0009 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0056 0.0056
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0077 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Schistosoma mansoni DNA ligase IV 0.0028 0.002 0.004
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0098 0.025 0.0755
Brugia malayi MH2 domain containing protein 0.0022 0.0002 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Loa Loa (eye worm) hypothetical protein 0.0139 0.0386 0.124
Entamoeba histolytica aldose reductase, putative 0.0034 0.0041 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0084 0.1406
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0028 0.002 0.0013
Mycobacterium ulcerans hypothetical protein 0.0151 0.0425 0.1628
Brugia malayi ADAM-TS Spacer 1 family protein 0.035 0.1075 0.3465
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Schistosoma mansoni coup transcription factor 0.0045 0.0077 0.0152
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0756 0.2405 0.4756
Schistosoma mansoni cytochrome b 0.0843 0.269 0.5319
Onchocerca volvulus Matrilysin homolog 0.0047 0.0082 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.1284 0.1901
Mycobacterium tuberculosis Conserved membrane protein 0.0181 0.0521 0.0521
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0107 0.0279 0.04
Loa Loa (eye worm) hypothetical protein 0.0756 0.2405 0.7752
Mycobacterium ulcerans beta-lactamase 0.0039 0.0056 0.0214
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0028 0.002 0.0013
Echinococcus granulosus hypothetical protein 0.0034 0.0041 0.0049
Onchocerca volvulus Matrilysin homolog 0.0103 0.0268 0.0859
Onchocerca volvulus Dual oxidase homolog 0.0031 0.0031 0.0093
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0077 0.0092
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0151 0.0425 0.0617
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0025 0.0012 0.0032
Trypanosoma cruzi FHA domain containing protein, putative 0.0028 0.002 0.0157
Trichomonas vaginalis mannosyltransferase 1, putative 0.0414 0.1284 0.1901
Onchocerca volvulus 0.0049 0.0089 0.028
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Echinococcus granulosus Spectrin alpha actinin 0.0027 0.0019 0.0023
Echinococcus granulosus apoptotic protease activating factor 1 0.0025 0.0012 0.0015
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0045 0.0416
Brugia malayi MH2 domain containing protein 0.0049 0.0092 0.0295
Schistosoma mansoni hypothetical protein 0.0071 0.0161 0.0319
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0031 0.0093
Onchocerca volvulus 0.0034 0.0041 0.0124
Plasmodium vivax ataxin-2 like protein, putative 0.0181 0.0523 0.1943
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0097 0.0313
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.017 0.0488 0.0583
Loa Loa (eye worm) heterochromatin protein 1 0.0111 0.0292 0.0935
Leishmania major trypanothione reductase 0.004 0.0062 0.0981
Plasmodium vivax glutathione reductase, putative 0.004 0.0062 0.0231
Brugia malayi nuclear hormone receptor 0.0045 0.0077 0.0247
Echinococcus granulosus aldehyde reductase 0.0024 0.0008 0.001
Onchocerca volvulus Serine\/threonine kinase homolog 0.017 0.0488 0.1568
Echinococcus multilocularis zinc finger protein Ran binding 0.0025 0.0012 0.0014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0017 0.0092
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0282 0.0853 0.2747
Onchocerca volvulus Alhambra homolog 0.0054 0.0105 0.0334
Loa Loa (eye worm) MIR domain-containing protein 0.0756 0.2405 0.7752
Loa Loa (eye worm) PHD-finger family protein 0.0054 0.0105 0.0334
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Echinococcus multilocularis smad 0.0049 0.0092 0.0109
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0098 0.025 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0521 0.0762
Schistosoma mansoni topbp1 0.0028 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0194 0.062
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0077 0.0092
Plasmodium falciparum cytochrome b 0.0843 0.269 1
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Loa Loa (eye worm) oxidoreductase 0.0034 0.0041 0.0124
Onchocerca volvulus 0.0031 0.0031 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.007 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0133 0.0182
Mycobacterium ulcerans hydrolase 0.0057 0.0116 0.0443
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.0735 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.055 0.1774
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0008 0.0025
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0071 0.0161 0.06
Plasmodium falciparum thioredoxin reductase 0.004 0.0062 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.0501 0.1616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Entamoeba histolytica serine/threonine protein kinase, putative 0.017 0.0488 0.1973
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0058
Leishmania major aldo-keto reductase-like protein 0.0034 0.0041 0.0559
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0085 0.0101
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0475
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0092 0.0181
Brugia malayi Heterochromatin protein 1 0.0111 0.0292 0.0941
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0138
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0105 0.0392
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0077 0.0241
Echinococcus multilocularis protein patched 0.0038 0.0055 0.0066
Echinococcus granulosus expressed conserved protein 0.0084 0.0204 0.0244
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0088 0.0326
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0047 0.0085 0.0168
Onchocerca volvulus 0.0045 0.0077 0.0241
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.2823 0.9172 0.9172
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0084 0.0084
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0088 0.0088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0194 0.0232
Plasmodium vivax replication factor C subunit 1, putative 0.0028 0.002 0.0075
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0756 0.2405 0.7754
Trichomonas vaginalis chromobox protein, putative 0.0111 0.0292 0.0419
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0077 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0062 0.0981
Loa Loa (eye worm) hypothetical protein 0.01 0.0258 0.0826
Loa Loa (eye worm) hypothetical protein 0.0181 0.0523 0.168
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0071 0.0161 0.0193
Echinococcus multilocularis expressed protein 0.0027 0.0019 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0077 0.0247
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0088 0.148
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0222 0.0716
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Echinococcus granulosus peroxidasin 0.0031 0.0031 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0077 0.0092
Echinococcus granulosus caspase 2 0.0025 0.0012 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0077 0.0092
Schistosoma mansoni hypothetical protein 0.0081 0.0196 0.0387
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0042 0.059
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0019 0.0023
Schistosoma mansoni hypothetical protein 0.0282 0.0853 0.1688
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0077 0.0241
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0161 0.052
Onchocerca volvulus 0.0025 0.0012 0.0032
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0066 0.0146 0.0289
Brugia malayi beta-lactamase family protein 0.0039 0.0056 0.018
Brugia malayi ecdysteroid receptor 0.0045 0.0077 0.0247
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0056 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.1088
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0021 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0007 0.0023
Brugia malayi CXXC zinc finger family protein 0.011 0.029 0.0934
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Echinococcus multilocularis jumonji domain containing protein 0.0075 0.0174 0.0208
Echinococcus multilocularis adam 0.01 0.0258 0.0308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Loa Loa (eye worm) metalloprotease 0.0047 0.0085 0.0267
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0085 0.0101
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0073 0.0093
Onchocerca volvulus 0.0031 0.0031 0.0093
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0041 0.0131
Schistosoma mansoni fusion 0.0025 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0055
Toxoplasma gondii thioredoxin reductase 0.004 0.0062 0.0231
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0009 0.0011
Brugia malayi beta-lactamase family protein 0.0039 0.0056 0.018
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0031 0.0099
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0041 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0055 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0148 0.0205
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0084 0.0321
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0041 0.0049
Echinococcus multilocularis replication factor c subunit 1 0.0028 0.002 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0085 0.0324
Echinococcus granulosus translocator protein 0.0818 0.2608 0.3118
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0194 0.0232
Brugia malayi hypothetical protein 0.0025 0.0012 0.0039
Brugia malayi DKFZp564C0469 protein 0.0028 0.002 0.0065
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0028 0.002 0.0061
Brugia malayi Matrixin family protein 0.0047 0.0082 0.0265
Echinococcus granulosus expressed protein 0.0027 0.0019 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0077 0.0092
Onchocerca volvulus 0.0025 0.0012 0.0033
Loa Loa (eye worm) histone methyltransferase 0.0034 0.0041 0.0126
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.003 0.0028 0.0319
Brugia malayi Blistered cuticle protein 3 0.0031 0.0031 0.0099
Brugia malayi MH1 domain containing protein 0.0027 0.0019 0.0062
Schistosoma mansoni patched 1 0.0038 0.0055 0.0109
Echinococcus multilocularis aldehyde reductase 0.0024 0.0008 0.001
Giardia lamblia Kinase, PLK 0.017 0.0488 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0085 0.1422
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0084 0.0281
Trichomonas vaginalis chromobox protein, putative 0.0111 0.0292 0.0419
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0093
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0049
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0057 0.0116 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0037 0.0479
Loa Loa (eye worm) CXXC zinc finger family protein 0.011 0.029 0.0928
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0041 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.002 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Loa Loa (eye worm) hypothetical protein 0.0818 0.2608 0.8408
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0085 0.1422
Echinococcus multilocularis aldo keto reductase 0.0034 0.0041 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0167 0.02
Trypanosoma cruzi polo-like protein kinase, putative 0.017 0.0488 0.9321
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0007 0.0014
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0146 0.0408 0.0807
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0028 0.002 0.0157
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0259
Mycobacterium ulcerans lipase LipD 0.0039 0.0056 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.017 0.0488 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0039 0.0039
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.034 0.1041 0.3358
Schistosoma mansoni hypothetical protein 0.0466 0.1455 0.2878
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0088 0.0105
Brugia malayi Reprolysin 0.0047 0.0085 0.0273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0077 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0056 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0077 0.0092
Brugia malayi Hemopexin family protein 0.0066 0.0146 0.0471
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0084 0.0253
Mycobacterium tuberculosis Probable reductase 0.0092 0.0232 0.0232
Mycobacterium leprae PROBABLE HYDROLASE 0.0057 0.0116 0.0349
Brugia malayi VAB-10A protein 0.0027 0.0019 0.0061
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0007 0.0009
Loa Loa (eye worm) angiogenesis inhibito 0.0054 0.0108 0.0341
Mycobacterium tuberculosis Conserved protein 0.0039 0.0056 0.0056
Brugia malayi steroid hormone receptor 0.0045 0.0077 0.0247

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 63 uM Ability to inhibit autophosphorylation of KinA and/or Sp0F TCS proteins from Bacillus subtilis ChEMBL. 10571153
IC50 (functional) = 130 uM Ability to inhibit autophosphorylation of NR11 and/or transphosphorylation of NR1 TCS proteins from E. coli ChEMBL. 10571153
IC50 (functional) = 130 uM Ability to inhibit autophosphorylation of NR11 and/or transphosphorylation of NR1 TCS proteins from E. coli ChEMBL. 10571153
MIC (functional) 0 ug ml-1 In vitro antibacterial activity against against E. faecalis strain, OC3041; NT-Not tested ChEMBL. 10571153
MIC (functional) = 128 ug ml-1 In vitro antibacterial activity against against Staphylococcus aureus strain, ATCC29213 ChEMBL. 10571153
MIC (functional) = 128 ug ml-1 In vitro antibacterial activity against against methicillin resistant Staphylococcus aureus (MRSA) strain, OC2089 ChEMBL. 10571153
MIC (functional) = 128 ug ml-1 In vitro antibacterial activity against against E. faecium(VR) strain, OC3312 Van R ChEMBL. 10571153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.