TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.417 | Formula: C18H17FN4OS
H donors: 0 H acceptors: 4 LogP: 3.66 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)c1ccccc1F)c1nnc(s1)c1cccnc1
InChi: 1S/C18H17FN4OS/c1-2-3-11-23(17(24)14-8-4-5-9-15(14)19)18-22-21-16(25-18)13-7-6-10-20-12-13/h4-10,12H,2-3,11H2,1H3
InChiKey: KCEMFWGNOKFZSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sphingosine-1-phosphate receptor 1	Starlite/ChEMBL	References
Homo sapiens	sphingosine-1-phosphate receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	voltage-dependent calcium channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent calcium channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0342	0.3169	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0022	0.0044	0.0044
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0022	0.0044	0.0044
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0022	0.0044	0.5
Echinococcus granulosus	short transient receptor potential channel 6	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent calcium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential channel	0.0022	0.0044	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0044	0.0044
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Toxoplasma gondii	hypothetical protein	0.0022	0.0044	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0022	0.0044	0.0044
Giardia lamblia	Protein 21.1	0.0018	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0022	0.0044	0.0044
Schistosoma mansoni	vesicular amine transporter	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0022	0.0044	0.0044
Brugia malayi	Transient-receptor-potential like protein	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0022	0.0044	0.0044
Echinococcus granulosus	ryanodine receptor 44f	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-dependent calcium channel	0.0022	0.0044	0.0044
Brugia malayi	cation channel family protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Brugia malayi	olfactory channel protein osm-9	0.0022	0.0044	0.0044
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	ion channel NompC	0.0022	0.0044	0.0044
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0022	0.0044	0.5
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0022	0.0044	0.0044
Schistosoma mansoni	two-pore calcium channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	shaker cognate	0.0022	0.0044	0.0044
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0022	0.0044	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0044	0.5
Schistosoma mansoni	voltage-gated cation channel	0.0022	0.0044	0.0044
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0022	0.0044	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0022	0.0044	0.0044
Echinococcus granulosus	short transient receptor potential channel 6	0.0022	0.0044	0.0044
Echinococcus multilocularis	calcium activated potassium channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Schistosoma mansoni	ryanodine receptor related	0.0022	0.0044	0.0044
Echinococcus multilocularis	sodium leak channel non selective protein	0.0022	0.0044	0.0044
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage dependent calcium channel	0.0022	0.0044	0.0044
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0022	0.0044	0.5
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Schistosoma mansoni	60S ribosomal protein L21	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	sodium channel protein	0.0342	0.3169	0.3169
Echinococcus granulosus	two pore calcium channel protein 2	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0022	0.0044	0.0044
Echinococcus granulosus	hyperpolarization activated cyclic	0.0022	0.0044	0.0044
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0044	0.0044
Schistosoma mansoni	protein kinase	0.1041	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	sodium leak channel non selective protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0022	0.0044	0.0044
Toxoplasma gondii	transporter, cation channel family protein	0.0022	0.0044	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0022	0.0044	0.0044
Echinococcus multilocularis	ryanodine receptor 44f	0.0022	0.0044	0.0044
Echinococcus multilocularis	sodium channel protein	0.0342	0.3169	0.3169
Entamoeba histolytica	ankyrin repeat protein	0.0018	0	0.5
Loa Loa (eye worm)	voltage-gated potassium channel	0.0022	0.0044	0.0044
Entamoeba histolytica	protein kinase, putative	0.0018	0	0.5
Schistosoma mansoni	protein kinase	0.1041	1	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0022	0.0044	0.0044
Loa Loa (eye worm)	ryanodine receptor	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium large conductance calcium activated	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential channel	0.0022	0.0044	0.0044
Brugia malayi	cation channel family protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential channel 4	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0022	0.0044	0.0044
Brugia malayi	ion channel NompC	0.0022	0.0044	0.0044
Echinococcus granulosus	TRP transient receptor potential channel	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0022	0.0044	0.0044
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	calcium-activated potassium channel	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential channel	0.0022	0.0044	0.0044
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0022	0.0044	0.5
Echinococcus multilocularis	short transient receptor potential channel 6	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0022	0.0044	0.0044
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0022	0.0044	0.0044
Echinococcus granulosus	two pore calcium channel protein 1	0.0022	0.0044	0.0044
Entamoeba histolytica	protein kinase, putative	0.0018	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	hyperpolarization activated cyclic	0.0022	0.0044	0.0044
Echinococcus multilocularis	conserved hypothetical protein	0.0022	0.0044	0.0044
Echinococcus multilocularis	integrin linked protein kinase	0.1041	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0044	0.0044
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0044	1
Echinococcus granulosus	transient receptor potential gamma protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	voltage-gated calcium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	integrin linked protein kinase	0.1041	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0022	0.0044	0.0044
Echinococcus multilocularis	short transient receptor potential channel 6	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium large conductance calcium activated	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated ion channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	shaker cognate	0.0022	0.0044	0.0044
Echinococcus granulosus	hypothetical protein	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0022	0.0044	0.0044
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0022	0.0044	0.0044
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0044	0.0044
Toxoplasma gondii	hypothetical protein	0.0022	0.0044	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0022	0.0044	0.0044
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	two pore calcium channel protein 2	0.0022	0.0044	0.0044
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0022	0.0044	0.0044
Echinococcus multilocularis	transient receptor potential gamma protein	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage gated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Toxoplasma gondii	transporter, cation channel family protein	0.0022	0.0044	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.1041	1	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0044	0.0044
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0044	1
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0022	0.0044	0.0044
Schistosoma mansoni	hypothetical protein	0.0022	0.0044	0.0044
Echinococcus granulosus	calcium activated potassium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0022	0.0044	0.0044
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0022	0.0044	1
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0022	0.0044	0.0044
Onchocerca volvulus		0.0022	0.0044	1
Toxoplasma gondii	transporter, cation channel family protein	0.0022	0.0044	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	transfer RNA-Gly	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0342	0.3169	0.3169
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Echinococcus multilocularis	two pore calcium channel protein 1	0.0022	0.0044	0.0044
Loa Loa (eye worm)	calcium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	voltage dependent calcium channel	0.0022	0.0044	0.0044
Echinococcus granulosus	transient receptor potential cation channel	0.0022	0.0044	0.0044
Brugia malayi	hypothetical protein	0.0022	0.0044	0.0044
Giardia lamblia	Kinase, NEK	0.0018	0	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0022	0.0044	0.0044
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0022	0.0044	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0022	0.0044	0.0044
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0022	0.0044	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 5	Agonist activity at human S1P3R expressed in HEK293T cells by Ca(2+) mobilization assay	ChEMBL.	22386243
EC50 (functional)	= 6.5	Agonist activity at human S1P1 receptor expressed in human U2OS cells assessed as beta-arrestin-mediated receptor internalization by beta-lactamase reporter assay	ChEMBL.	22386243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011710

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1634992