Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1d (5-HT1d) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0469 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Entamoeba histolytica | ribokinase, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1378 | 0.3778 |
Echinococcus multilocularis | neuroligin | 0.0079 | 0.13 | 0.13 |
Trypanosoma brucei | adenosine kinase, putative | 0.0184 | 0.3649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Schistosoma mansoni | adenosine kinase | 0.0184 | 0.3649 | 0.3649 |
Leishmania major | adenosine kinase, putative | 0.0184 | 0.3649 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.13 | 0.13 |
Echinococcus granulosus | adenosine kinase | 0.0184 | 0.3649 | 0.3649 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.13 | 0.13 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0079 | 0.13 | 0.13 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0184 | 0.3649 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0083 | 0.1378 | 0.3778 |
Loa Loa (eye worm) | carboxylesterase | 0.0469 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0469 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0469 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0469 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0079 | 0.13 | 0.13 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0079 | 0.13 | 0.13 |
Trypanosoma brucei | adenosine kinase, putative | 0.0184 | 0.3649 | 1 |
Onchocerca volvulus | 0.0079 | 0.13 | 0.2065 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0079 | 0.13 | 1 |
Entamoeba histolytica | kinase, PfkB family | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0079 | 0.13 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0469 | 1 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0.1378 | 0.3778 |
Entamoeba histolytica | fructokinase, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.022 | 0.4447 | 0.4447 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.13 | 0.13 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0079 | 0.13 | 0.13 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0079 | 0.13 | 0.13 |
Schistosoma mansoni | adenosine kinase | 0.0184 | 0.3649 | 0.3649 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0079 | 0.13 | 0.13 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0.1378 | 0.3778 |
Onchocerca volvulus | 0.0079 | 0.13 | 0.2065 | |
Brugia malayi | Adenosine kinase-like | 0.0184 | 0.3649 | 0.3649 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0021 | 0 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0.1378 | 1 |
Schistosoma mansoni | gliotactin | 0.0079 | 0.13 | 0.13 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0079 | 0.13 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.3649 | 0.3649 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0079 | 0.13 | 0.13 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0079 | 0.13 | 1 |
Onchocerca volvulus | 0.0079 | 0.13 | 0.2065 | |
Trypanosoma cruzi | adenosine kinase, putative | 0.0184 | 0.3649 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0079 | 0.13 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Echinococcus granulosus | neuroligin | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.6572 | 0.6572 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0.1378 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0.1378 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0079 | 0.13 | 0.13 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.13 | 0.13 |
Echinococcus granulosus | acetylcholinesterase | 0.0469 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0079 | 0.13 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0469 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Onchocerca volvulus | 0.0079 | 0.13 | 0.2065 | |
Onchocerca volvulus | 0.0163 | 0.3179 | 0.5051 | |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0469 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.13 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.13 | 0.13 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0.1378 | 0.3778 |
Onchocerca volvulus | 0.0079 | 0.13 | 0.2065 | |
Echinococcus multilocularis | adenosine kinase | 0.0184 | 0.3649 | 0.3649 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.13 | 0.13 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0079 | 0.13 | 0.13 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0303 | 0.6295 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0184 | 0.3649 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0469 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase (functional) | 0 % | In vivo percent increase in seizure threshold in rat MEST model at the dose of 10 mg/kg p.o. recorded 4 hr post dose; Not determined | ChEMBL. | 10021946 |
Increase (functional) | = 70 % | In vivo percent increase in seizure threshold in mouse MEST model 1 hour following 10 mg/kg p.o. | ChEMBL. | 10021946 |
Increase (functional) | = 70 % | In vivo percent increase in seizure threshold in mouse MEST model 1 hour following 10 mg/kg p.o. | ChEMBL. | 10021946 |
Ki (binding) | = -7.1 | Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement. | ChEMBL. | 10021946 |
Log Ki (binding) | = 7.1 | Binding affinity to 5-hydroxytryptamine 1D receptor in the rat forebrain by [3H]- SB-204269 displacement. | ChEMBL. | 10021946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.