Detailed information for compound 1635649

Basic information

Technical information
  • TDR Targets ID: 1635649
  • Name: 2-chloro-N-(2,4,5-trichlorophenyl)acetamide
  • MW: 272.943 | Formula: C8H5Cl4NO
  • H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCC(=O)Nc1cc(Cl)c(cc1Cl)Cl
  • InChi: 1S/C8H5Cl4NO/c9-3-8(14)13-7-2-5(11)4(10)1-6(7)12/h1-2H,3H2,(H,13,14)
  • InChiKey: GQRWKOPRUXSOBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(2,4,5-trichlorophenyl)ethanamide
  • 23595-42-8
  • 2',4',5'-Trichloro-2-chloroacetanilide
  • 2,2',4',5'-Tetrachloroacetanilide
  • ACETANILIDE, 2,2',4',5'-TETRACHLORO-
  • Acetamide, 2-chloro-N-(2,4,5-trichlorophenyl)- (9CI)
  • BRN 2214980
  • NSC 165604
  • NCI60_001272
  • ZINC01648953
  • WLN: G1VMR BG DG EG
  • Acetamide, 2-chloro-N-(2,4,5-trichlorophenyl)-
  • NSC165604
  • ST5214164

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0188 0.0188
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Schistosoma mansoni nuclear receptor 0.0134 0.1409 0.1268
Echinococcus granulosus ecdysone induced protein 78C 0.0285 0.356 0.356
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0134 0.1409 0.1626
Loa Loa (eye worm) nuclear receptor NHR-67 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0151 0.1639 0.1897
Trichomonas vaginalis set domain proteins, putative 0.0717 0.9735 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.2813 1
Brugia malayi nuclear hormone receptor 0.0285 0.356 0.417
Loa Loa (eye worm) hypothetical protein 0.0071 0.0497 0.0546
Loa Loa (eye worm) steroid hormone receptor 0.0285 0.356 0.4169
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 0.5
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Echinococcus granulosus lysine specific demethylase 5A 0.0179 0.2041 0.2041
Loa Loa (eye worm) hypothetical protein 0.0125 0.128 0.1472
Loa Loa (eye worm) hypothetical protein 0.0107 0.1022 0.1167
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0161 0.0149
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0151 0.1639 0.1502
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0154 0.1694 0.1694
Schistosoma mansoni bromodomain containing protein 0.0063 0.039 0.0233
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.1694 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0285 0.356 0.356
Brugia malayi hypothetical protein 0.0073 0.0532 0.0589
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0285 0.356 0.356
Schistosoma mansoni retinoic acid receptor RXR 0.0285 0.356 0.3455
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0191
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0209 0.2479 0.8699
Echinococcus multilocularis lysine specific demethylase 5A 0.0177 0.2014 0.2014
Loa Loa (eye worm) hypothetical protein 0.025 0.3066 0.3584
Brugia malayi PHD-finger family protein 0.0146 0.1574 0.1822
Brugia malayi hypothetical protein 0.0134 0.1409 0.1626
Plasmodium vivax SET domain protein, putative 0.009 0.0779 0.4028
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.1409 0.1409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0285 0.356 0.417
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0285 0.356 0.4169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0396 0.5152 0.6052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0285 0.356 0.4169
Echinococcus granulosus GPCR family 2 0.0125 0.128 0.128
Plasmodium falciparum phd finger protein, putative 0.0146 0.1574 0.9218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0285 0.356 0.417
Brugia malayi Pre-SET motif family protein 0.063 0.8491 1
Schistosoma mansoni hypothetical protein 0.0125 0.128 0.1137
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.1639 0.1898
Brugia malayi nuclear receptor NHR-88 0.0134 0.1409 0.1626
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0285 0.356 0.3455
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.1409 0.1292
Brugia malayi jmjC domain containing protein 0.0047 0.0161 0.015
Schistosoma mansoni jumonji domain containing protein 0.038 0.4918 0.4835
Brugia malayi ecdysone receptor 0.0134 0.1409 0.1626
Brugia malayi jmjC domain containing protein 0.0047 0.0161 0.015
Brugia malayi hypothetical protein 0.0151 0.1639 0.1898
Schistosoma mansoni hypothetical protein 0.0048 0.0169 0.0009
Brugia malayi glutathione reductase 0.0092 0.0799 0.0905
Schistosoma mansoni jumonji/arid domain-containing protein 0.0179 0.2041 0.1911
Brugia malayi jmjC domain containing protein 0.0047 0.0161 0.015
Schistosoma mansoni nuclear receptor 0.0134 0.1409 0.1268
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0169 0.0055
Brugia malayi nuclear receptor RXR 0.0151 0.1639 0.1898
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0285 0.356 0.417
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0799 0.0799
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0101 0.0934 0.0671
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 1
Schistosoma mansoni microtubule-associated protein tau 0.0735 1 1
Onchocerca volvulus 0.0134 0.1409 0.1292
Plasmodium falciparum thioredoxin reductase 0.0092 0.0799 0.416
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.0169 0.0055
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0134 0.1409 0.1268
Schistosoma mansoni peptidase Clp (S14 family) 0.0154 0.1694 0.1559
Brugia malayi jmjC domain containing protein 0.0179 0.2041 0.2373
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0151 0.1639 0.1897
Schistosoma mansoni steroid hormone receptor ad4bp 0.0285 0.356 0.3455
Brugia malayi F/Y-rich N-terminus family protein 0.0053 0.0244 0.0249
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0101 0.0934 0.2675
Brugia malayi Nuclear hormone receptor E75 0.0134 0.1409 0.1626
Brugia malayi Nuclear hormone receptor E75 0.0134 0.1409 0.1626
Brugia malayi jmjC domain containing protein 0.0047 0.0161 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0179 0.2041 0.2372
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.0799 0.0903
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.0169 0.0133
Echinococcus granulosus FTZ F1 alpha 0.0285 0.356 0.356
Schistosoma mansoni RAR-like nuclear receptor 0.0285 0.356 0.3455
Loa Loa (eye worm) hypothetical protein 0.0151 0.1639 0.1897
Schistosoma mansoni nuclear hormone receptor 0.0134 0.1409 0.1268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0285 0.356 0.417
Onchocerca volvulus 0.009 0.0779 0.0633
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0047 0.0161 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.128 0.128
Brugia malayi Bromodomain containing protein 0.0075 0.0558 0.0619
Schistosoma mansoni nuclear hormone receptor 0.0285 0.356 0.3455
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0146 0.1574 0.1437
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0285 0.356 0.356
Leishmania major trypanothione reductase 0.0092 0.0799 1
Brugia malayi hypothetical protein 0.0134 0.1409 0.1626
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0285 0.356 0.356
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0478 0.6324 0.6324
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0285 0.356 0.3543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0134 0.1409 0.1409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0285 0.356 0.356
Entamoeba histolytica hypothetical protein 0.0073 0.0532 0.5
Onchocerca volvulus 0.0134 0.1409 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0779 0.0628
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0285 0.356 0.417
Brugia malayi nuclear hormone receptor 0.0134 0.1409 0.1626
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.128 0.128
Schistosoma mansoni thyroid hormone receptor 0.0285 0.356 0.3455
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Mycobacterium tuberculosis Probable dehydrogenase 0.0209 0.2479 0.8342
Echinococcus multilocularis tumor protein p63 0.0328 0.4172 0.4172
Loa Loa (eye worm) hypothetical protein 0.0151 0.1639 0.1897
Onchocerca volvulus Alhambra homolog 0.0146 0.1574 0.1466
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0101 0.0934 0.0671
Brugia malayi latrophilin 2 splice variant baaae 0.0271 0.336 0.3933
Entamoeba histolytica hypothetical protein 0.0073 0.0532 0.5
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Brugia malayi nuclear hormone receptor family member nhr-6 0.0134 0.1409 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0285 0.356 0.4169
Brugia malayi jmjC domain containing protein 0.0478 0.6324 0.7437
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0532 0.0532
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0285 0.356 0.3455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0285 0.356 0.4169
Loa Loa (eye worm) hypothetical protein 0.0146 0.1574 0.1821
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Brugia malayi PHD-finger family protein 0.005 0.0197 0.0192
Schistosoma mansoni nuclear hormone receptor 0.0134 0.1409 0.1268
Brugia malayi AF-10 protein 0.0048 0.0169 0.016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.2813 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Echinococcus multilocularis GPCR, family 2 0.0125 0.128 0.128
Plasmodium vivax glutathione reductase, putative 0.0092 0.0799 0.416
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.1639 0.1898
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0134 0.1409 0.1409
Trypanosoma brucei trypanothione reductase 0.0092 0.0799 1
Loa Loa (eye worm) PHD-finger family protein 0.0146 0.1574 0.1821
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0209 0.2479 0.8342
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0285 0.356 0.417
Echinococcus multilocularis peregrin 0.0148 0.1608 0.1608
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0285 0.356 0.417
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Onchocerca volvulus Protein ultraspiracle homolog 0.0285 0.356 0.3543
Brugia malayi tailless protein 0.0134 0.1409 0.1626
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0248 0.0565
Schistosoma mansoni nuclear receptor nhr-48 0.0134 0.1409 0.1268
Plasmodium falciparum glutathione reductase 0.0092 0.0799 0.416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0217 0.0057
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0285 0.356 0.356
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0154 0.1694 1
Brugia malayi steroid hormone receptor 0.0285 0.356 0.417
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0779 0.0628
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.2813 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0779 0.4028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0285 0.356 0.4169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0285 0.356 0.356
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0779 0.0779
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0285 0.356 0.417
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0134 0.1409 0.1409
Onchocerca volvulus 0.0717 0.9735 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.1022 0.1022
Schistosoma mansoni hypothetical protein 0.0271 0.336 0.3251
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0161 0.0161
Toxoplasma gondii hypothetical protein 0.0053 0.0248 0.0565
Echinococcus granulosus tumor protein p63 0.0328 0.4172 0.4172
Loa Loa (eye worm) DR-78 0.0134 0.1409 0.1625
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0339 0.0339
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0285 0.356 0.3455
Toxoplasma gondii PHD-finger domain-containing protein 0.0146 0.1574 0.9218
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.0169 0.0133
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0799 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0285 0.356 0.417
Echinococcus multilocularis jumonji domain containing protein 0.0203 0.2392 0.2392
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0285 0.356 0.356
Loa Loa (eye worm) hypothetical protein 0.0047 0.0161 0.0149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.128 0.1473
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.063 0.8491 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0396 0.5152 0.6052
Schistosoma mansoni zinc finger protein 0.0134 0.1409 0.1268
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0285 0.356 0.3455
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0134 0.1409 0.1409
Brugia malayi Bromodomain containing protein 0.0148 0.1608 0.1862
Loa Loa (eye worm) hypothetical protein 0.0151 0.1639 0.1897
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0731 0.0731
Onchocerca volvulus 0.0285 0.356 0.3543
Brugia malayi orphan nuclear receptor NR2E1 0.0134 0.1409 0.1626
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0532 0.0532
Brugia malayi Pre-SET motif family protein 0.009 0.0779 0.0881
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0799 1
Brugia malayi Steroid receptor seven-up type 2 0.0285 0.356 0.417
Brugia malayi nuclear receptor NHR-67 0.0134 0.1409 0.1626
Echinococcus granulosus nuclear receptor nhr 48 0.0134 0.1409 0.1409
Echinococcus granulosus jumonji domain containing protein 0.0203 0.2392 0.2392
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.1022 0.1022
Brugia malayi nuclear hormone receptor family member odr-7 0.0134 0.1409 0.1626
Echinococcus multilocularis ecdysone induced protein 78C 0.0285 0.356 0.356
Brugia malayi photoreceptor-specific nuclear receptor 0.0285 0.356 0.417
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.0799 0.416
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.128 0.128
Brugia malayi ecdysteroid receptor 0.0285 0.356 0.417
Echinococcus granulosus PHD finger protein rhinoceros 0.0146 0.1574 0.1574
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0161 0.0149
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0154 0.1694 0.1694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0285 0.356 0.4169
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.115 0.1319
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0154 0.1694 0.5639
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.115 0.1319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0285 0.356 0.4169
Brugia malayi Probable ClpP-like protease 0.0154 0.1694 0.1963
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0125 0.128 0.1137
Schistosoma mansoni hypothetical protein 0.0146 0.1574 0.1437
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Entamoeba histolytica hypothetical protein 0.0073 0.0532 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0072
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.1409 0.1409
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 0.5
Giardia lamblia PHD finger protein 15 0.0146 0.1574 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1022 0.0875
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.1409 0.1409
Onchocerca volvulus Bile acid receptor homolog 0.0285 0.356 0.3543
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0151 0.1639 0.1639
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0151 0.1639 0.1639
Echinococcus multilocularis peptidase Clp (S14 family) 0.0101 0.0934 0.0934
Mycobacterium tuberculosis Probable reductase 0.0209 0.2479 0.8342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1022 0.0875
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0048 0.0169 0.0055
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0161 0.0161
Brugia malayi nuclear receptor NHR-88 0.0285 0.356 0.417
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0285 0.356 0.417
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0161 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0396 0.5152 0.6052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.1409 0.1292
Brugia malayi hypothetical protein 0.0151 0.1639 0.1898
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0285 0.356 0.356
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0048 0.0169 0.0055
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.1694 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0179 0.2041 0.1911
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0173 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0285 0.356 0.4169
Echinococcus multilocularis FTZ F1 alpha 0.0285 0.356 0.356
Brugia malayi MH2 domain containing protein 0.0116 0.115 0.132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0285 0.356 0.3455
Brugia malayi nuclear receptor RXR 0.0134 0.1409 0.1626
Echinococcus granulosus phd:f box containing protein 0.0047 0.0161 0.0161
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1574 0.9218
Toxoplasma gondii thioredoxin reductase 0.0092 0.0799 0.416
Schistosoma mansoni hypothetical protein 0.0073 0.0532 0.0377
Schistosoma mansoni hypothetical protein 0.0125 0.128 0.1137
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0285 0.356 0.417
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0285 0.356 0.356
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0134 0.1409 0.1268
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0151 0.1639 0.1897
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0161 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0285 0.356 0.356
Echinococcus granulosus peptidase Clp S14 family 0.0101 0.0934 0.0934
Loa Loa (eye worm) jmjC domain-containing protein 0.0301 0.3797 0.4449
Loa Loa (eye worm) hypothetical protein 0.0271 0.336 0.3932
Echinococcus multilocularis nuclear receptor nhr 48 0.0134 0.1409 0.1409
Echinococcus multilocularis microtubule associated protein 2 0.0735 1 1
Brugia malayi Latrophilin receptor protein 2 0.0125 0.128 0.1473
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0285 0.356 0.356
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 0.5
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0188 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0285 0.356 0.3455
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0285 0.356 0.3455
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0285 0.356 0.417
Loa Loa (eye worm) nuclear hormone receptor 0.0134 0.1409 0.1625
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0151 0.1639 0.1502
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.128 0.1472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0209 0.2479 0.8342
Loa Loa (eye worm) hypothetical protein 0.0154 0.1694 0.1963
Echinococcus granulosus thyroid hormone receptor alpha 0.0134 0.1409 0.1409
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0209 0.2479 0.8342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0339 0.0339
Echinococcus multilocularis thyroid hormone receptor alpha 0.0285 0.356 0.356
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0154 0.1694 0.5
Loa Loa (eye worm) glutathione reductase 0.0092 0.0799 0.0903
Brugia malayi conserved hypotetical protein 0.0134 0.1409 0.1626
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0161 0.0161
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.2813 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0478 0.6324 0.6324
Toxoplasma gondii PHD-finger domain-containing protein 0.0146 0.1574 0.9218
Echinococcus multilocularis PHD finger protein rhinoceros 0.0146 0.1574 0.1574
Echinococcus granulosus peregrin 0.0148 0.1608 0.1608
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0134 0.1409 0.1409
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0248 0.0565
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0134 0.1409 0.1625
Loa Loa (eye worm) hypothetical protein 0.0048 0.0173 0.0163
Brugia malayi Thioredoxin reductase 0.0092 0.0799 0.0905
Schistosoma mansoni hypothetical protein 0.0125 0.128 0.1137
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0209 0.2479 0.8342
Schistosoma mansoni coup transcription factor 0.0285 0.356 0.3455
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0285 0.356 0.356
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.128 0.128
Brugia malayi Nuclear hormone receptor-like 1 0.0285 0.356 0.417
Loa Loa (eye worm) hypothetical protein 0.0396 0.5152 0.6052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0285 0.356 0.417
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0532 0.0377
Entamoeba histolytica hypothetical protein 0.0073 0.0532 0.5

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.819 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.777 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.771 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.769 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.653 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.55 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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