TDR Targets

Basic information

Technical information

TDR Targets ID: 1635655
Name: NCI60_008578
MW: 293.36 | Formula: C19H19NO2
H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1cc2C3C=CCC3CN3c2c(c1)[C@H]1C=CC[C@H]1C3
InChi: 1S/C19H19NO2/c21-19(22)13-7-16-14-5-1-3-11(14)9-20-10-12-4-2-6-15(12)17(8-13)18(16)20/h1-2,5-8,11-12,14-15H,3-4,9-10H2,(H,21,22)/t11-,12?,14-,15?/m0/s1
InChiKey: IMJRVLOUNFCYRI-CNFGXJBXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Brugia malayi	Nuclear hormone receptor-like 1	0.011	0.1216	0.3096
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0208	0.2744	0.2744
Loa Loa (eye worm)	jmjC domain-containing protein	0.0179	0.2292	0.6057
Brugia malayi	Steroid receptor seven-up type 2	0.0208	0.2744	0.699
Brugia malayi	steroid hormone receptor	0.0208	0.2744	0.699
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0208	0.2744	0.2744
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0078	0.0714	0.0714
Trypanosoma brucei	trypanothione reductase	0.0092	0.0936	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0086	0.0854	0.9118
Brugia malayi	nuclear hormone receptor	0.0208	0.2744	0.699
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.3106	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0208	0.2744	0.7776
Brugia malayi	ecdysteroid receptor	0.0208	0.2744	0.699
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0695	0.0695
Echinococcus multilocularis	FTZ F1 alpha	0.0208	0.2744	0.2744
Brugia malayi	nuclear receptor RXR	0.011	0.1216	0.3096
Echinococcus multilocularis	jumonji domain containing protein	0.012	0.1383	0.1383
Echinococcus granulosus	thyroid hormone receptor alpha	0.0098	0.1032	0.1032
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0208	0.2744	0.2744
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0208	0.2744	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Loa Loa (eye worm)	PHD-finger family protein	0.0086	0.0854	0.0602
Schistosoma mansoni	nuclear receptor nhr-48	0.0098	0.1032	0.1032
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0695	0.7425
Loa Loa (eye worm)	DR-78	0.0098	0.1032	0.1279
Brugia malayi	Nuclear hormone receptor E75	0.0098	0.1032	0.2629
Trypanosoma cruzi	trypanothione reductase, putative	0.0092	0.0936	1
Onchocerca volvulus	Bile acid receptor homolog	0.0208	0.2744	0.8393
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.011	0.1216	0.1216
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0285	0.0285
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0245	0.3331	0.8484
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0695	0.7425
Schistosoma mansoni	zinc finger protein	0.0098	0.1032	0.1032
Schistosoma mansoni	hypothetical protein	0.0078	0.0714	0.0714
Plasmodium vivax	glutathione reductase, putative	0.0092	0.0936	1
Schistosoma mansoni	coup transcription factor	0.0208	0.2744	0.2744
Brugia malayi	hypothetical protein	0.0098	0.1032	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0098	0.1032	0.1032
Entamoeba histolytica	hypothetical protein	0.007	0.0594	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0092	0.0936	0.0915
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0098	0.1032	0.1279
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0208	0.2744	0.8393
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0086	0.0854	0.0854
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0098	0.1032	0.1032
Mycobacterium tuberculosis	Probable reductase	0.0209	0.2772	0.8837
Brugia malayi	nuclear receptor NHR-67	0.0098	0.1032	0.2629
Echinococcus granulosus	jumonji domain containing protein	0.012	0.1383	0.1383
Schistosoma mansoni	nuclear hormone receptor	0.0208	0.2744	0.2744
Brugia malayi	MH2 domain containing protein	0.0116	0.132	0.3362
Loa Loa (eye worm)	nuclear hormone receptor	0.0098	0.1032	0.1279
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0208	0.2744	0.2744
Toxoplasma gondii	PHD-finger domain-containing protein	0.0086	0.0854	0.9118
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0208	0.2744	0.699
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0208	0.2744	0.699
Onchocerca volvulus		0.0208	0.2744	0.8393
Schistosoma mansoni	hypothetical protein	0.0078	0.0714	0.0714
Echinococcus multilocularis	lysine specific demethylase 5A	0.0105	0.1138	0.1138
Brugia malayi	Thioredoxin reductase	0.0092	0.0936	0.2385
Brugia malayi	Latrophilin receptor protein 2	0.0078	0.0714	0.182
Brugia malayi	nuclear receptor NHR-88	0.0098	0.1032	0.2629
Brugia malayi	nuclear receptor RXR	0.0098	0.1032	0.2629
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0092	0.0936	0.2985
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0098	0.1032	0.1032
Schistosoma mansoni	hypothetical protein	0.0078	0.0714	0.0714
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0208	0.2744	0.699
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0208	0.2744	0.2744
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0208	0.2744	0.699
Echinococcus granulosus	lysine specific demethylase 5A	0.0105	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0208	0.2744	0.699
Brugia malayi	glutathione reductase	0.0092	0.0936	0.2385
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0714	0.0073
Entamoeba histolytica	hypothetical protein	0.007	0.0594	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0208	0.2744	0.2744
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0245	0.3331	0.8484
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0208	0.2744	0.699
Entamoeba histolytica	hypothetical protein	0.007	0.0594	0.5
Schistosoma mansoni	hypothetical protein	0.0086	0.0854	0.0854
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0098	0.1032	0.2629
Brugia malayi	Probable ClpP-like protease	0.0076	0.0695	0.1771
Echinococcus granulosus	FTZ F1 alpha	0.0208	0.2744	0.2744
Brugia malayi	photoreceptor-specific nuclear receptor	0.0208	0.2744	0.699
Mycobacterium tuberculosis	Probable oxidoreductase	0.0233	0.3137	1
Echinococcus multilocularis	microtubule associated protein 2	0.0672	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0208	0.2744	0.2744
Echinococcus multilocularis	GPCR, family 2	0.0078	0.0714	0.0714
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0208	0.2744	0.699
Brugia malayi	Nuclear hormone receptor-like 1	0.0208	0.2744	0.699
Brugia malayi	hypothetical protein	0.011	0.1216	0.3096
Brugia malayi	tailless protein	0.0098	0.1032	0.2629
Loa Loa (eye worm)	hypothetical protein	0.011	0.1216	0.1975
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.011	0.1216	0.1216
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0695	0.0695
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.2669	0.749
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0078	0.0714	0.182
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0208	0.2744	0.2744
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Brugia malayi	jmjC domain containing protein	0.0105	0.1138	0.2898
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0208	0.2744	0.2744
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	0.7425
Toxoplasma gondii	thioredoxin reductase	0.0092	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.0594	0.0594
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0098	0.1032	0.1032
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.1216	0.1975
Brugia malayi	hypothetical protein	0.011	0.1216	0.3096
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0078	0.0714	0.0714
Schistosoma mansoni	microtubule-associated protein tau	0.0672	1	1
Schistosoma mansoni	hypothetical protein	0.0078	0.0714	0.0714
Echinococcus granulosus	nuclear receptor nhr 48	0.0098	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.011	0.1216	0.1975
Echinococcus granulosus	thioredoxin glutathione reductase	0.0092	0.0936	0.0936
Schistosoma mansoni	hypothetical protein	0.0168	0.212	0.212
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0245	0.3331	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0208	0.2744	0.2744
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0208	0.2744	0.2744
Brugia malayi	orphan nuclear receptor NR2E1	0.0098	0.1032	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Mycobacterium tuberculosis	Probable dehydrogenase	0.0209	0.2772	0.8837
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0098	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Echinococcus multilocularis	ecdysone induced protein 78C	0.0208	0.2744	0.2744
Brugia malayi	ecdysone receptor	0.0098	0.1032	0.2629
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0208	0.2744	0.699
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Schistosoma mansoni	nuclear receptor	0.0098	0.1032	0.1032
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0233	0.3137	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.1032	0.1032
Plasmodium falciparum	glutathione reductase	0.0092	0.0936	1
Schistosoma mansoni	hypothetical protein	0.007	0.0594	0.0594
Loa Loa (eye worm)	hypothetical protein	0.011	0.1216	0.1975
Leishmania major	trypanothione reductase	0.0092	0.0936	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0168	0.212	0.5399
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0208	0.2744	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0695	0.0695
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0208	0.2744	0.2744
Brugia malayi	hypothetical protein	0.007	0.0594	0.1512
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0098	0.1032	0.1279
Echinococcus granulosus	GPCR family 2	0.0078	0.0714	0.0714
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0208	0.2744	0.2744
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0208	0.2744	0.2744
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0098	0.1032	0.0792
Loa Loa (eye worm)	glutathione reductase	0.0092	0.0936	0.0915
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0209	0.2772	0.8721
Brugia malayi	jmjC domain containing protein	0.0283	0.3926	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.1216	0.1975
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0209	0.2772	0.8837
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0233	0.3137	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0105	0.1138	0.168
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0208	0.2744	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0105	0.1138	0.1138
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0695	0.7425
Schistosoma mansoni	jumonji domain containing protein	0.0225	0.3017	0.3017
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0208	0.2744	0.2744
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0208	0.2744	0.699
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0208	0.2744	0.2744
Loa Loa (eye worm)	hypothetical protein	0.0168	0.212	0.5405
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0098	0.1032	0.2629
Loa Loa (eye worm)	hypothetical protein	0.011	0.1216	0.1975
Brugia malayi	Nuclear hormone receptor-like 1	0.011	0.1216	0.3096
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0208	0.2744	0.699
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Schistosoma mansoni	RAR-like nuclear receptor	0.0208	0.2744	0.2744
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0208	0.2744	0.699
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0209	0.2772	0.8837
Onchocerca volvulus		0.0098	0.1032	0.0792
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.011	0.1216	0.1216
Onchocerca volvulus	Protein ultraspiracle homolog	0.0208	0.2744	0.8393
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0092	0.0936	0.0936
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0208	0.2744	0.699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0208	0.2744	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0245	0.3331	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0098	0.1032	0.1032
Loa Loa (eye worm)	steroid hormone receptor	0.0208	0.2744	0.7776
Brugia malayi	PHD-finger family protein	0.0086	0.0854	0.2175
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0098	0.1032	0.0792
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0695	0.144
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0854	0.9118
Onchocerca volvulus		0.0231	0.3106	1
Onchocerca volvulus		0.0098	0.1032	0.0792
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0078	0.0714	0.0714
Brugia malayi	nuclear receptor NHR-88	0.0208	0.2744	0.699
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.132	0.2371
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0854	0.0602
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.0594	0.0594
Brugia malayi	hypothetical protein	0.0098	0.1032	0.2629
Echinococcus granulosus	ecdysone induced protein 78C	0.0208	0.2744	0.2744
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0098	0.1032	0.1032
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0105	0.1138	0.1138
Brugia malayi	nuclear hormone receptor	0.0098	0.1032	0.2629
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0098	0.1032	0.1032
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0209	0.2772	0.8837
Plasmodium vivax	thioredoxin reductase, putative	0.0092	0.0936	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.132	0.2371
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0208	0.2744	0.2744
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0098	0.1032	0.1032
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0233	0.3137	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0208	0.2744	0.7776
Schistosoma mansoni	thyroid hormone receptor	0.0208	0.2744	0.2744
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0285	0.0285
Plasmodium falciparum	thioredoxin reductase	0.0092	0.0936	1
Echinococcus granulosus	peregrin	0.0086	0.0854	0.0854
Schistosoma mansoni	nuclear receptor	0.0098	0.1032	0.1032
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0285	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1032	0.1279
Brugia malayi	Pre-SET motif family protein	0.0203	0.2669	0.6799
Giardia lamblia	PHD finger protein 15	0.0086	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Plasmodium falciparum	phd finger protein, putative	0.0086	0.0854	0.9118
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0086	0.0854	0.0854
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0078	0.0714	0.0073
Echinococcus multilocularis	nuclear receptor nhr 48	0.0098	0.1032	0.1032
Brugia malayi	Bromodomain containing protein	0.0086	0.0854	0.2175
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0208	0.2744	0.7776
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0283	0.3926	0.3926
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.0594	0.0594
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0208	0.2744	0.2744
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0208	0.2744	0.699
Echinococcus multilocularis	peregrin	0.0086	0.0854	0.0854
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.011	0.1216	0.1216
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.1032	0.1032
Echinococcus granulosus	PHD finger protein rhinoceros	0.0086	0.0854	0.0854
Brugia malayi	conserved hypotetical protein	0.0098	0.1032	0.2629
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0208	0.2744	0.2744
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0209	0.2772	0.8837
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0208	0.2744	0.2744
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0208	0.2744	0.2744
Brugia malayi	Nuclear hormone receptor E75	0.0098	0.1032	0.2629
Brugia malayi	nuclear hormone receptor family member odr-7	0.0098	0.1032	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1818	0.4262
Schistosoma mansoni	thyroid hormone receptor	0.0208	0.2744	0.2744
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0208	0.2744	0.7776
Entamoeba histolytica	hypothetical protein	0.007	0.0594	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0078	0.0714	0.0714
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.1032	0.1032
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0285	0.0907
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0283	0.3926	0.3926
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0208	0.2744	0.2744

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2001125

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1635655