TDR Targets

Basic information

Technical information

TDR Targets ID: 1635656
Name: 3-[(4-chlorophenyl)methyl]-7-(4-methoxyphenyl )-8H-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin- 4-one
MW: 398.866 | Formula: C19H15ClN4O2S
H donors: 0 H acceptors: 1 LogP: 4.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1=Nn2c(SC1)nnc(c2=O)Cc1ccc(cc1)Cl
InChi: 1S/C19H15ClN4O2S/c1-26-15-8-4-13(5-9-15)17-11-27-19-22-21-16(18(25)24(19)23-17)10-12-2-6-14(20)7-3-12/h2-9H,10-11H2,1H3
InChiKey: OWNXPHGDVWOTKG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-(4-chlorobenzyl)-7-(4-methoxyphenyl)-8H-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4-one
NSC713336
NCI60_039491

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Plasmodium falciparum	thioredoxin reductase	0.0097	0.1169	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0509	0.8812	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0245	0.3914	1
Loa Loa (eye worm)	glutathione reductase	0.0097	0.1169	0.1282
Plasmodium vivax	thioredoxin reductase, putative	0.0097	0.1169	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.024	0.3829	0.3829
Trichomonas vaginalis	mercuric reductase, putative	0.0033	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.024	0.3829	0.4346
Echinococcus granulosus	Nuclear hormone receptor HR96	0.024	0.3829	0.4346
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.022	0.3459	0.8837
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0269	0.4363	0.4951
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0033	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2183	0.2439
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0269	0.4363	0.4925
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0267	0.0303
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0509	0.8812	1
Brugia malayi	nuclear hormone receptor	0.0509	0.8812	1
Toxoplasma gondii	thioredoxin reductase	0.0097	0.1169	1
Brugia malayi	nuclear receptor RXR	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.024	0.3829	0.4346
Brugia malayi	Nuclear hormone receptor-like 1	0.0269	0.4363	0.4951
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0509	0.8812	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0509	0.8812	1
Treponema pallidum	NADH oxidase	0.0033	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0509	0.8812	0.8812
Onchocerca volvulus	Protein ultraspiracle homolog	0.0509	0.8812	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0245	0.3914	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0269	0.4363	0.4925
Loa Loa (eye worm)	hypothetical protein	0.0269	0.4363	0.4925
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0509	0.8812	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.024	0.3829	0.4317
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0509	0.8812	1
Echinococcus multilocularis	FTZ F1 alpha	0.0509	0.8812	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.072	0.0817
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.022	0.3459	0.8837
Schistosoma mansoni	hypothetical protein	0.0048	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0509	0.8812	1
Brugia malayi	MH2 domain containing protein	0.0122	0.1648	0.187
Brugia malayi	nuclear receptor NHR-88	0.024	0.3829	0.4346
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1648	0.1828
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0509	0.8812	1
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0144	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0509	0.8812	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1648	0.1828
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0033	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0509	0.8812	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0033	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0509	0.8812	1
Brugia malayi	conserved hypotetical protein	0.024	0.3829	0.4346
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0045	0.0051
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0097	0.1169	0.1326
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0509	0.8812	0.8812
Echinococcus granulosus	ecdysone induced protein 78C	0.0509	0.8812	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0509	0.8812	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0033	0	0.5
Brugia malayi	hypothetical protein	0.0072	0.072	0.0817
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0269	0.4363	0.4363
Schistosoma mansoni	RAR-like nuclear receptor	0.0509	0.8812	0.8812
Schistosoma mansoni	thyroid hormone receptor	0.0509	0.8812	0.8812
Schistosoma mansoni	nuclear hormone receptor	0.024	0.3829	0.3829
Loa Loa (eye worm)	hypothetical protein	0.0269	0.4363	0.4925
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0509	0.8812	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0267	0.0303
Brugia malayi	nuclear hormone receptor family member odr-7	0.024	0.3829	0.4346
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.1296	0.1471
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0509	0.8812	1
Schistosoma mansoni	nuclear hormone receptor	0.0509	0.8812	0.8812
Brugia malayi	jmjC domain containing protein	0.0036	0.0045	0.0051
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0045	0.0045
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0509	0.8812	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0245	0.3914	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.2183	0.2439
Trypanosoma brucei	trypanothione reductase	0.0097	0.1169	1
Brugia malayi	nuclear receptor NHR-88	0.0509	0.8812	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0509	0.8812	0.8812
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0509	0.8812	1
Brugia malayi	glutathione reductase	0.0097	0.1169	0.1326
Trichomonas vaginalis	glutathione reductase, putative	0.0033	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0509	0.8812	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.024	0.3829	0.4346
Brugia malayi	nuclear receptor RXR	0.0269	0.4363	0.4951
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.022	0.3459	0.8837
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0514	0.0535
Mycobacterium tuberculosis	Probable dehydrogenase	0.022	0.3459	0.8837
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0144	0.0164
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.072	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.024	0.3829	0.4346
Echinococcus multilocularis	nuclear receptor nhr 48	0.024	0.3829	0.4346
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0033	0	0.5
Brugia malayi	nuclear receptor NHR-67	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0509	0.8812	1
Brugia malayi	Nuclear hormone receptor E75	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1296	0.1427
Entamoeba histolytica	hypothetical protein	0.0072	0.072	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0509	0.8812	0.8812
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0509	0.8812	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0267	0.0267
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0509	0.8812	1
Schistosoma mansoni	zinc finger protein	0.024	0.3829	0.3829
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0267	0.0303
Brugia malayi	orphan nuclear receptor NR2E1	0.024	0.3829	0.4346
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.024	0.3829	0.4346
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0509	0.8812	1
Entamoeba histolytica	hypothetical protein	0.0072	0.072	0.5
Schistosoma mansoni	nuclear hormone receptor	0.024	0.3829	0.3829
Schistosoma mansoni	nuclear receptor	0.024	0.3829	0.3829
Brugia malayi	nuclear hormone receptor family member nhr-6	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.024	0.3829	0.4346
Schistosoma mansoni	thyroid hormone receptor	0.0509	0.8812	0.8812
Plasmodium vivax	glutathione reductase, putative	0.0097	0.1169	1
Brugia malayi	ecdysteroid receptor	0.0509	0.8812	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0245	0.3914	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Entamoeba histolytica	hypothetical protein	0.0072	0.072	0.5
Entamoeba histolytica	hypothetical protein	0.0072	0.072	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0509	0.8812	1
Brugia malayi	Nuclear hormone receptor E75	0.024	0.3829	0.4346
Brugia malayi	nuclear hormone receptor	0.024	0.3829	0.4346
Schistosoma mansoni	nuclear receptor nhr-48	0.024	0.3829	0.3829
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0045	0.0045
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0509	0.8812	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0509	0.8812	1
Brugia malayi	hypothetical protein	0.0269	0.4363	0.4951
Loa Loa (eye worm)	nuclear receptor NHR-67	0.024	0.3829	0.4317
Schistosoma mansoni	hypothetical protein	0.0048	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1178	0.1337
Mycobacterium tuberculosis	Probable reductase	0.022	0.3459	0.8837
Brugia malayi	hypothetical protein	0.024	0.3829	0.4346
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.4363	0.4925
Onchocerca volvulus		0.0509	0.8812	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0269	0.4363	0.4363
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0509	0.8812	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.024	0.3829	0.4346
Brugia malayi	ecdysone receptor	0.024	0.3829	0.4346
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.022	0.3459	0.8837
Brugia malayi	tailless protein	0.024	0.3829	0.4346
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0509	0.8812	0.8812
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0509	0.8812	0.8812
Plasmodium falciparum	glutathione reductase	0.0097	0.1169	1
Brugia malayi	Steroid receptor seven-up type 2	0.0509	0.8812	1
Schistosoma mansoni	nuclear receptor	0.024	0.3829	0.3829
Echinococcus granulosus	GPCR family 2	0.0048	0.0267	0.0303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0045	0.0051
Brugia malayi	hypothetical protein	0.0269	0.4363	0.4951
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0033	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Loa Loa (eye worm)	nuclear hormone receptor	0.024	0.3829	0.4317
Brugia malayi	photoreceptor-specific nuclear receptor	0.0509	0.8812	1
Schistosoma mansoni	hypothetical protein	0.0103	0.1296	0.1296
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0509	0.8812	1
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0808	0.0808
Brugia malayi	Thioredoxin reductase	0.0097	0.1169	0.1326
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0509	0.8812	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0509	0.8812	0.8812
Brugia malayi	hypothetical protein	0.024	0.3829	0.4346
Echinococcus granulosus	thioredoxin glutathione reductase	0.0097	0.1169	0.1326
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0321	0.0316
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0509	0.8812	0.8812
Schistosoma mansoni	hypothetical protein	0.0072	0.072	0.072
Trypanosoma cruzi	trypanothione reductase, putative	0.0097	0.1169	1
Onchocerca volvulus	Bile acid receptor homolog	0.0509	0.8812	1
Leishmania major	trypanothione reductase	0.0097	0.1169	1
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.072	0.072
Brugia malayi	steroid hormone receptor	0.0509	0.8812	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.2183	0.2477
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0267	0.0254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0509	0.8812	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0269	0.4363	0.4951
Loa Loa (eye worm)	hypothetical protein	0.0269	0.4363	0.4925
Echinococcus granulosus	nuclear receptor nhr 48	0.024	0.3829	0.4346
Schistosoma mansoni	hypothetical protein	0.0048	0.0267	0.0267
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0509	0.8812	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0033	0	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0509	0.8812	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0267	0.0303
Loa Loa (eye worm)	thioredoxin reductase	0.0097	0.1169	0.1282
Loa Loa (eye worm)	steroid hormone receptor	0.0509	0.8812	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0267	0.0303
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0509	0.8812	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.024	0.3829	0.4346
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1178	0.1337
Brugia malayi	Nuclear hormone receptor-like 1	0.0269	0.4363	0.4951
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0267	0.0254
Echinococcus granulosus	FTZ F1 alpha	0.0509	0.8812	1
Loa Loa (eye worm)	hypothetical protein	0.0509	0.8812	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.2183	0.2477
Brugia malayi	jmjC domain containing protein	0.0097	0.1178	0.1337
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0267	0.0303
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0267	0.0303
Schistosoma mansoni	coup transcription factor	0.0509	0.8812	0.8812
Echinococcus granulosus	Nuclear hormone receptor HR96	0.024	0.3829	0.4346
Loa Loa (eye worm)	hypothetical protein	0.024	0.3829	0.4317
Loa Loa (eye worm)	DR-78	0.024	0.3829	0.4317
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0097	0.1169	0.2985

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.937	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.484	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.451	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.422	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.283	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.227	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.213	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.189	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2001126

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1635656